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Description Entry page for Effector - 'Raf1 protein kinase-Homo sapiens'
FamilySer Thr protein kinases
Sub-FamilyRAF protein kinases
TypeRaf1 protein kinase
Cross References:
References
UniProtP04049 | B0LPH8 | B2R5N3 | Q15278 | Q9UC20
EMBLX03484 | AY271661 | AK312248 | EU332868 | CH471055 | BC018119 | L00212 | L00206 | L00207 | L00208 | L00209 | L00210 | L00211 | L00213 | M11376 | X54851
InterProIPR020454 | IPR002219 | IPR000719 | IPR017441 | IPR003116 | IPR017442 | IPR008271
PRODOMPD000001
GENEID5894
MIM164760 | 611553 | 611554
PRINTSPR00008
PFAMPF00130 | PF00069 | PF02196
Details:
Details
NameRaf1 protein kinase-Homo sapiens
DescriptionRecName: Full=RAF proto-oncogene serine/threonine-protein kinase; EC=2.7.11.1;AltName: Full=C-RAF; Short=cRaf;AltName: Full=Raf-1
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneRAF1 | RA
FunctionInvolved in the transduction of mitogenic signals froms the cell membrane to the nucleus
Fragment0
Sequence
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
Interacting with G-proteins:
G-proteins
NoNameRegulationPubMed
1Ggamma-8_Homo sapiensSequestration of G15251227
2Ggamma-13_Homo sapiensSequestration of G15251227
3Ggamma-7_Homo sapiensSequestration of G15251227
4Ggamma-10_Homo sapiensSequestration of G15251227
5Ggamma-3_Homo sapiensSequestration of G15251227
6Gbeta-1_Homo sapiensSequestration of G15251227
7Gbeta-4_Homo sapiensSequestration of G15251227
8Ggamma-5_Homo sapiensSequestration of G15251227
9Gbeta-2_Homo sapiensSequestration of G15251227
10Gbeta-5_Homo sapiensSequestration of G15251227
11Ggamma-11_Homo sapiensSequestration of G15251227
12Ggamma-t1_Homo sapiensSequestration of G15251227
13Ggamma-t2_Homo sapiensSequestration of G15251227
14Ggamma-12_Homo sapiensSequestration of G15251227
15Gbeta-like_Homo sapiens_2Sequestration of G15251227
16Ggamma-2_Homo sapiensSequestration of G15251227
17Gbeta-3_Homo sapiensSequestration of G15251227
18Gbeta-like_Homo sapiens_1Sequestration of G15251227
19Ggamma-4_Homo sapiensSequestration of G15251227
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level