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Description Entry page for Effector - 'Ras specific nucleotide exchange factor CDC25-Homo sapiens'
FamilyGuanine nucleotide releasing factors
Sub-FamilyRas specific nucleotide releasing factors
TypeRas specific nucleotide exchange factor CDC25
Cross References:
References
UniProtQ13972 | Q16027
EMBLL26584 | S62035 | M91815
InterProIPR000219 | IPR001331 | IPR000048 | IPR011993 | IPR001849 | IPR000651 | IPR019804 | IPR008937 | IPR001895
PRODOM
GENEID5923
MIM606600
PRINTS
PFAMPF00612 | PF00169 | PF00617 | PF00618 | PF00621
Details:
Details
NameRas specific nucleotide exchange factor CDC25-Homo sapiens
DescriptionRecName: Full=Ras-specific guanine nucleotide-releasing factor 1; Short=Ras-GRF1; Short=Guanine nucleotide-releasing factor 1; Short=Guanine nucleotide-releasing protein;AltName: Full=Ras-specific nucleotide exchange factor CDC25
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneRASGRF1 | CDC25,GNRP,GRF
FunctionPromotes the exchange of Ras-bound GDP by GTP
Fragment0
Sequence
MQKAIRLNDGHVAPLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS
RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW
VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS
LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK
RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH
QIFYQGLKARISSWPTLVLADLLDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL
KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHDVLAHTPHEHVERNSLDYAKSKLEELS
RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG
SLSLEKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG
QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS
KVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL
TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNN
KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLISLNIPIITGGKALDLAGSLSCN
SNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSM
REESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRS
ALSAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVL
RHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQIT
LEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPY
IMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNR
SAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLA
FIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEE
SLYESSLRIEPKLPT
Interacting with G-proteins:
G-proteins
NoNameRegulationPubMed
1Gbeta-4_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
2Gbeta-5_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
3Ggamma-2_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
4Ggamma-3_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
5Ggamma-t1_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
6Gbeta-1_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
7Ggamma-t2_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
8Ggamma-13_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
9Ggamma-4_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
10Ggamma-5_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
11Gbeta-3_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
12Gbeta-2_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
13Ggamma-11_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
14Gbeta-like_Homo sapiens_1Stimulation (indirect activation of ras)15251227 | 8717044
15Gbeta-like_Homo sapiens_2Stimulation (indirect activation of ras)15251227 | 8717044
16Ggamma-12_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
17Ggamma-7_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
18Ggamma-8_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
19Ggamma-10_Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level