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Description Entry page for Effector - 'Voltage dependent N type calcium channel-Homo sapiens'
FamilyIon channels
Sub-FamilyVoltage dependent calcium channels
TypeVoltage dependent N type calcium channel
Cross References:
References
UniProtQ00975 | B1AQK5
EMBLM94172 | M94173 | AL591424 | AL772363 | AL772363 | AL591424 | U76666
InterProIPR018249 | IPR005821 | IPR014873 | IPR005447 | IPR002077
PRODOM
GENEID774
MIM601012
PRINTSPR00167 | PR01631
PFAMPF08763 | PF00520
Details:
Details
NameVoltage dependent N type calcium channel-Homo sapiens
Description"RecName: Full=Voltage-dependent N-type calcium channel subunit alpha-1B;AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.2;AltName: Full=Calcium channel, L type, alpha-1 polypeptide isoform 5;AltName: Full=Brain calcium channel III; Short=BIII;"
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneCACNA1B | CACH5,CACNL1A
FunctionVoltage-sensitive calcium channels (VSCC) mediate thes entry of calcium ions into excitable cells and are also involveds in a variety of calcium-dependent processes, including muscles contraction, hormone or neurotransmitter release, gene expression,s cell motility, cell division and cell death
Fragment0
Sequence
MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYN
PIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPD
GDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA
TAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAII
GLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNI
LFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA
KERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAA
TKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVK
AQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRS
YFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVV
SLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQIL
TGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK
DEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNL
RASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKARPEAAE
APEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPP
EARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRG
GPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEKELRNH
QPREPHCDLETSGTVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDPNTIVHI
PVMLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLR
RFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVI
KMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLK
TIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELER
DCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE
EQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACI
DFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYE
LMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNN
FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV
FGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECG
SDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAA
CGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIR
TALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMI
FDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSL
SNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSI
TRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPD
RPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRR
ERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGP
HPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSL
PAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTF
EEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDHWC
Interacting with G-proteins:
G-proteins
NoNameRegulationPubMed
1Galpha-o_Homo sapiensInhibition15251227 | 11031246
2Ggamma-4_Homo sapiensInhibition15251227 | 11031246
3Ggamma-t1_Homo sapiensInhibition15251227 | 11031246
4Ggamma-2_Homo sapiensInhibition15251227 | 11031246
5Ggamma-7_Homo sapiensInhibition15251227 | 11031246
6Gbeta-5_Homo sapiensInhibition15251227 | 11031246
7Ggamma-t2_Homo sapiensInhibition15251227 | 11031246
8Ggamma-8_Homo sapiensInhibition15251227 | 11031246
9Ggamma-3_Homo sapiensInhibition15251227 | 11031246
10Ggamma-13_Homo sapiensInhibition15251227 | 11031246
11Gbeta-2_Homo sapiensInhibition15251227 | 11031246
12Ggamma-12_Homo sapiensInhibition15251227 | 11031246
13Gbeta-1_Homo sapiensInhibition15251227 | 11031246
14Gbeta-like_Homo sapiens_2Inhibition15251227 | 11031246
15Ggamma-10_Homo sapiensInhibition15251227 | 11031246
16Gbeta-3_Homo sapiensInhibition15251227 | 11031246
17Ggamma-5_Homo sapiensInhibition15251227 | 11031246
18Gbeta-4_Homo sapiensInhibition15251227 | 11031246
19Gbeta-like_Homo sapiens_1Inhibition15251227 | 11031246
20Ggamma-11_Homo sapiensInhibition15251227 | 11031246
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level