Quick search:







Description Entry page for GPCR - 'NICOTINIC ACID RECEPTORS_NIACR1_Homo sapiens'
ClassCLASS A
FamilyNICOTINIC ACID RECEPTORS
Sub-FamilyNIACR1
Cross References:
References
UniProtQ8TDS4 | A0PJL5 | A7LGG3
EMBLAY148884 | AB083632 | AB065876 | EU012026 | BC027965 | BC056419
InterProIPR000276 | IPR017452 | IPR002286
PRODOM
GENEID338442
MIM609163
PRINTSPR00237 | PR01157
PFAMPF00001
Other GPCR resourcesGPCRDB | GPCR-OKB | GLIDA
Details:
Details
NameNICOTINIC ACID RECEPTORS_NIACR1_Homo sapiens
DescriptionRecName: Full=Niacin receptor 1;AltName: Full=Nicotinic acid receptor;AltName: Full=G-protein coupled receptor 109A;AltName: Full=G-protein coupled receptor HM74A
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneNIACR1 | GPR109A,HM74
FunctionActs as a high affinity receptor for both nicotinic acids (also known as niacin) and (D)-beta-hydroxybutyrate and mediatess increased adiponectin secretion and decreased lipolysis throughs G(i)-protein-mediated inhibition of adenylyl cyclase
Fragment0
Sequence
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
Interacting with G-proteins:
G-proteins
NoNameCouplingPubMed
1Galpha-i1_Homo sapiensGi/o15183629 | 12563315
2Galpha-z_Homo sapiensGi/o15183629 | 12563315
3Galpha-i3_Homo sapiensGi/o15183629 | 12563315
4Galpha-i2_Homo sapiensGi/o15183629 | 12563315
5Galpha-o_Homo sapiensGi/o15183629 | 12563315
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level