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Description Entry page for G-protein - 'Gbeta-1_Homo sapiens'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-1
Cross References:
References
UniProtP62873 | B1AJZ7 | P04697 | P04901
EMBLX04526 | AF501882 | BT007305 | CR456784 | AL031282 | AL109917 | AL109917 | AL031282 | CH471183 | BC004186 | BC005888 | BC008991 | M36430
InterProIPR020472 | IPR001632 | IPR016346 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID2782
MIM139380
PRINTSPR00319 | PR00320
PFAMPF00400
Details:
Details
NameGbeta-1_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;AltName: Full=Transducin beta chain 1
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Effectors:
Effectors
NoNameRegulationPubMed
1Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
2Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
3ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
4Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
5Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
6Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
7Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
8ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
9Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
10Rho-Homo sapiens-2Recruitment to plasma membrane15251227
11Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
12Protein kinase D-Homo sapiensStimulation15251227
13Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
14Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
15Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
16SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
17GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
18Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
19PI3K alpha-Homo sapiensPropable Inhibition16182515
20Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
21Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
22Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
23Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
24ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
25Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
26Rho-Homo sapiens-1Recruitment to plasma membrane15251227
27ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
28Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
29Rho-Homo sapiens-3Recruitment to plasma membrane15251227
30Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
31Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
32GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
33Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
34Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
35ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
36Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
37SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
38Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
39Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
40Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
41Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
42PI3K gamma-Homo sapiensActivation12502714
43SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
44Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
45Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
46Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
47Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
48Raf1 protein kinase-Homo sapiensSequestration of G15251227
49Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
50Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
52Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
53PI3K beta-Homo sapiensActivation9305878 | 12502714
54Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
55Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
56Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
57ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
58Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
59Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
60Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
61Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
63Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
64Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
65Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
66Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
67ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
68Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
69Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed