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Description Entry page for G-protein - 'Gbeta-1_Homo sapiens'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-1
Cross References:
References
UniProtP62873 | B1AJZ7 | P04697 | P04901
EMBLX04526 | AF501882 | BT007305 | CR456784 | AL031282 | AL109917 | AL109917 | AL031282 | CH471183 | BC004186 | BC005888 | BC008991 | M36430
InterProIPR020472 | IPR001632 | IPR016346 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID2782
MIM139380
PRINTSPR00319 | PR00320
PFAMPF00400
Details:
Details
NameGbeta-1_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;AltName: Full=Transducin beta chain 1
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Effectors:
Effectors
NoNameRegulationPubMed
1Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
2Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
3Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
4Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
5Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
6ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
7Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
8Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
9ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
10Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
11Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
12Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
13Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
14Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
15Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
16Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
18Rho-Homo sapiens-3Recruitment to plasma membrane15251227
19ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
20Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
21Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
22Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
23Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
24Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
25Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
26Protein kinase D-Homo sapiensStimulation15251227
27Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
28Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
29PI3K alpha-Homo sapiensPropable Inhibition16182515
30Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
31Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
32Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
33Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
34Rho-Homo sapiens-1Recruitment to plasma membrane15251227
35ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
36Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
37SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
38ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
39Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
40GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
41Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
42Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
43Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
44GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
45Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
46Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
47Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
48Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
49Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
50ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
51PI3K beta-Homo sapiensActivation9305878 | 12502714
52Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
53SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
54Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
55Raf1 protein kinase-Homo sapiensSequestration of G15251227
56Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
57Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
58Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
59Rho-Homo sapiens-2Recruitment to plasma membrane15251227
60Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
61Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
63PI3K gamma-Homo sapiensActivation12502714
64Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
65Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
66Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
67ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
68Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
69SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed