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Description Entry page for G-protein - 'Gbeta-1_Homo sapiens'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-1
Cross References:
References
UniProtP62873 | B1AJZ7 | P04697 | P04901
EMBLX04526 | AF501882 | BT007305 | CR456784 | AL031282 | AL109917 | AL109917 | AL031282 | CH471183 | BC004186 | BC005888 | BC008991 | M36430
InterProIPR020472 | IPR001632 | IPR016346 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID2782
MIM139380
PRINTSPR00319 | PR00320
PFAMPF00400
Details:
Details
NameGbeta-1_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;AltName: Full=Transducin beta chain 1
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Effectors:
Effectors
NoNameRegulationPubMed
1Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
2Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
3Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
4GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
5ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
6ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
7Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
8Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
9Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
10Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
11SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
12GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
13Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
14Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
15Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
16Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17Rho-Homo sapiens-3Recruitment to plasma membrane15251227
18Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
19Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
20Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
21Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
22SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
23Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
24Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
25Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
26Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
27Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
28Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
29Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
30Raf1 protein kinase-Homo sapiensSequestration of G15251227
31ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
32Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
33Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
34Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
35Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
36Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
37Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
38SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
39ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
40Rho-Homo sapiens-1Recruitment to plasma membrane15251227
41Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
42Rho-Homo sapiens-2Recruitment to plasma membrane15251227
43Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
44Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
45ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
46PI3K beta-Homo sapiensActivation9305878 | 12502714
47Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
48Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
49Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
51Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
52Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
53Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
54Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
55PI3K alpha-Homo sapiensPropable Inhibition16182515
56Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
57Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
58ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
59ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
60Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
61Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
63Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
64PI3K gamma-Homo sapiensActivation12502714
65Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
66Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
67Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
68Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
69Protein kinase D-Homo sapiensStimulation15251227
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed