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Description Entry page for G-protein - 'Gbeta-1_Homo sapiens'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-1
Cross References:
References
UniProtP62873 | B1AJZ7 | P04697 | P04901
EMBLX04526 | AF501882 | BT007305 | CR456784 | AL031282 | AL109917 | AL109917 | AL031282 | CH471183 | BC004186 | BC005888 | BC008991 | M36430
InterProIPR020472 | IPR001632 | IPR016346 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID2782
MIM139380
PRINTSPR00319 | PR00320
PFAMPF00400
Details:
Details
NameGbeta-1_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;AltName: Full=Transducin beta chain 1
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Effectors:
Effectors
NoNameRegulationPubMed
1Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
2Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
3Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
4Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
5Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
6Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
7Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
8Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
9Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
10Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
11Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
12Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
13GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
14Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
15Protein kinase D-Homo sapiensStimulation15251227
16Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
18Rho-Homo sapiens-2Recruitment to plasma membrane15251227
19Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
20Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
21GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
22Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
23Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
24Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
25Raf1 protein kinase-Homo sapiensSequestration of G15251227
26PI3K beta-Homo sapiensActivation9305878 | 12502714
27Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
28Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
29Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
30Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
31Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
32Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
33Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
34PI3K gamma-Homo sapiensActivation12502714
35Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
36Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
37SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
38ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
39PI3K alpha-Homo sapiensPropable Inhibition16182515
40Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
41Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
42ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
43Rho-Homo sapiens-1Recruitment to plasma membrane15251227
44SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
45Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
46Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
47ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
48Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
49Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
51ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
52Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
53ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
54Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
55Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
56Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
57SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
58ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
59Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
60Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
61Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
63Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
64Rho-Homo sapiens-3Recruitment to plasma membrane15251227
65Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
66Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
67Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
68Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
69Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed