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Description Entry page for G-protein - 'Gbeta-2_Homo sapiens'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-2
Cross References:
References
UniProtP62879 | P11016 | P54312
EMBLM16514 | M36429 | M16538 | AF053356 | AF501883 | BC010073 | BC012348 | BC068003
InterProIPR020472 | IPR001632 | IPR016346 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID2783
MIM139390
PRINTSPR00319 | PR00320
PFAMPF00400
Details:
Details
NameGbeta-2_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;AltName: Full=Transducin beta chain 2;AltName: Full=G protein subunit beta-2
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNI
CSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGF
AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA
FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM
KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Effectors:
Effectors
NoNameRegulationPubMed
1Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
2SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
3Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
4Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
5Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
6Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
7Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
8Rho-Homo sapiens-2Recruitment to plasma membrane15251227
9Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
10Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
11Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
12Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
13ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
14PI3K beta-Homo sapiensActivation9305878 | 12502714
15Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
16Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
18GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
19ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
20Raf1 protein kinase-Homo sapiensSequestration of G15251227
21Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
22Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
23Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
24ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
25Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
26Rho-Homo sapiens-3Recruitment to plasma membrane15251227
27Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
28SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
29Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
30GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
31Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
32Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
33PI3K alpha-Homo sapiensPropable Inhibition16182515
34Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
35Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
36Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
37Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
38Rho-Homo sapiens-1Recruitment to plasma membrane15251227
39Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
40ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
41Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
42Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
43ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
44Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
45Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
46Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
47ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
48PI3K gamma-Homo sapiensActivation12502714
49Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
51Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
52Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
53SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
54Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
55Protein kinase D-Homo sapiensStimulation15251227
56Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
57Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
58Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
59Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
60Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
61Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
62Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
63Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
64Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
65Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
66Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
67Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
68Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
69Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed