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Description Entry page for G-protein - 'Gbeta-3_Homo sapiens'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-3
Cross References:
References
UniProtP16520 | Q9BQC0
EMBLM31328 | U47924 | U47930 | Y12050 | Y12051 | Y12052 | Y12053 | Y12054 | Y12055 | Y12056 | Y12057 | Y12058 | AF501884 | BT009800 | AY631872 | BC000115 | BC002454
InterProIPR020472 | IPR001632 | IPR016346 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID2784
MIM139130
PRINTSPR00319 | PR00320
PFAMPF00400
Details:
Details
NameGbeta-3_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;AltName: Full=Transducin beta chain 3
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA
MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM
CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF
VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA
ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM
KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN
Effectors:
Effectors
NoNameRegulationPubMed
1Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
2Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
3Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
4Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
5Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
6Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
7Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
8Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
9Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
10Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
11Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
12GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
13Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
14ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
15Rho-Homo sapiens-1Recruitment to plasma membrane15251227
16PI3K alpha-Homo sapiensPropable Inhibition16182515
17Rho-Homo sapiens-3Recruitment to plasma membrane15251227
18Raf1 protein kinase-Homo sapiensSequestration of G15251227
19Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
20Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
21Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
22Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
23Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
24Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
25Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
26Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
27ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
28SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
29Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
30ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
31Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
32Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
33Rho-Homo sapiens-2Recruitment to plasma membrane15251227
34Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
35Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
36SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
37Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
38PI3K gamma-Homo sapiensActivation12502714
39Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
40Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
41Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
42Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
43GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
44Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
45PI3K beta-Homo sapiensActivation9305878 | 12502714
46Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
47Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
48Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
49Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
51Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
52Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
53ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
54ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
55Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
56Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
57Protein kinase D-Homo sapiensStimulation15251227
58Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
59ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
60Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
61Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
62Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
63Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
64Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
65ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
66Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
67Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
68Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
69Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed