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Description Entry page for G-protein - 'Gbeta-4_Homo sapiens'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-4
Cross References:
References
UniProtQ9HAV0
EMBLAF300648 | BC000873
InterProIPR020472 | IPR001632 | IPR016346 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID59345
MIM610863
PRINTSPR00319 | PR00320
PFAMPF00400
Details:
Details
NameGbeta-4_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein subunit beta-4;AltName: Full=Transducin beta chain 4
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA
MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF
TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA
FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL
KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN
Effectors:
Effectors
NoNameRegulationPubMed
1Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
2Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
3SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
4Rho-Homo sapiens-3Recruitment to plasma membrane15251227
5Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
6Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
7SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
8Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
9Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
10Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
11Rho-Homo sapiens-2Recruitment to plasma membrane15251227
12Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
13Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
14Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
15GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
16Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
17Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
18Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
19Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
20ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
21Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
22PI3K alpha-Homo sapiensPropable Inhibition16182515
23Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
24Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
25ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
26Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
27Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
28Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
29Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
30Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
31Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
32Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
33Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
34Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
35ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
36Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
37Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
38Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
39SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
40ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
41Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
42Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
43ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
44Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
45Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
46Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
47Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
48GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
49Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51PI3K beta-Homo sapiensActivation9305878 | 12502714
52Raf1 protein kinase-Homo sapiensSequestration of G15251227
53Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
54Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
55ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
56Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
57Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
58Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
59PI3K gamma-Homo sapiensActivation12502714
60Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
61Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62Protein kinase D-Homo sapiensStimulation15251227
63Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
64ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
65Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
66Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
67Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
68Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
69Rho-Homo sapiens-1Recruitment to plasma membrane15251227
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed