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Description Entry page for G-protein - 'Gbeta-4_Homo sapiens'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-4
Cross References:
References
UniProtQ9HAV0
EMBLAF300648 | BC000873
InterProIPR020472 | IPR001632 | IPR016346 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID59345
MIM610863
PRINTSPR00319 | PR00320
PFAMPF00400
Details:
Details
NameGbeta-4_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein subunit beta-4;AltName: Full=Transducin beta chain 4
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA
MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF
TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA
FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL
KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN
Effectors:
Effectors
NoNameRegulationPubMed
1Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
2ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
3SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
4Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
5Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
6PI3K beta-Homo sapiensActivation9305878 | 12502714
7Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
8PI3K alpha-Homo sapiensPropable Inhibition16182515
9Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
10Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
11GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
12Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
13Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
14ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
15ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
16Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
17SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
18Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
19Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
20Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
21Raf1 protein kinase-Homo sapiensSequestration of G15251227
22Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
23Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
24Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
25Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
26Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
27ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
28Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
29Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
30ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
31Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
32Rho-Homo sapiens-3Recruitment to plasma membrane15251227
33Rho-Homo sapiens-2Recruitment to plasma membrane15251227
34Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
35Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
36ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
37Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
38Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
39Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
40Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
41Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
42Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
43Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
44Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
45Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
46GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
47Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
48Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
49Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
52Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
53Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
54PI3K gamma-Homo sapiensActivation12502714
55Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
56Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
57Protein kinase D-Homo sapiensStimulation15251227
58SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
59Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
60Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
61Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
62Rho-Homo sapiens-1Recruitment to plasma membrane15251227
63Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
64Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
65Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
66Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
67Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
68ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
69Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed