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Description Entry page for G-protein - 'Gbeta-4_Homo sapiens'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-4
Cross References:
References
UniProtQ9HAV0
EMBLAF300648 | BC000873
InterProIPR020472 | IPR001632 | IPR016346 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID59345
MIM610863
PRINTSPR00319 | PR00320
PFAMPF00400
Details:
Details
NameGbeta-4_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein subunit beta-4;AltName: Full=Transducin beta chain 4
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA
MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF
TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA
FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL
KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN
Effectors:
Effectors
NoNameRegulationPubMed
1Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
2Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
3ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
4Protein kinase D-Homo sapiensStimulation15251227
5GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
6Rho-Homo sapiens-1Recruitment to plasma membrane15251227
7Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
8SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
9Rho-Homo sapiens-3Recruitment to plasma membrane15251227
10Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
11PI3K alpha-Homo sapiensPropable Inhibition16182515
12Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
13PI3K gamma-Homo sapiensActivation12502714
14Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
15Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
16Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
18Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
19Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
20Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
21ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
22Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
23Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
24Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
25Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
26Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
27Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
28Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
29Raf1 protein kinase-Homo sapiensSequestration of G15251227
30GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
31Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
32Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
33Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
34Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
35PI3K beta-Homo sapiensActivation9305878 | 12502714
36ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
37Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
38Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
39SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
40Rho-Homo sapiens-2Recruitment to plasma membrane15251227
41SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
42Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
43Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
44Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
45ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
46Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
47Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
48Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
49ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
50Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
52Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
53Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
54Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
55Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
56Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
57Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
58Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
59Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
60Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
61Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
63Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
64Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
65Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
66ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
67Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
68Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
69ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed