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Description Entry page for G-protein - 'Gbeta-4_Homo sapiens'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-4
Cross References:
References
UniProtQ9HAV0
EMBLAF300648 | BC000873
InterProIPR020472 | IPR001632 | IPR016346 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID59345
MIM610863
PRINTSPR00319 | PR00320
PFAMPF00400
Details:
Details
NameGbeta-4_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein subunit beta-4;AltName: Full=Transducin beta chain 4
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA
MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF
TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA
FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL
KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN
Effectors:
Effectors
NoNameRegulationPubMed
1PI3K alpha-Homo sapiensPropable Inhibition16182515
2Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
3Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
4GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
5SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
6Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
7Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
8Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
9ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
10Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
11Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
12Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
13SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
14Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
15Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
16ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
17ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
18ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
19Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
20Protein kinase D-Homo sapiensStimulation15251227
21Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
22Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
23Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
24Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
25Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
26Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
27Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
28Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
29Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
30Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
31Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
32Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
33Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
34PI3K gamma-Homo sapiensActivation12502714
35Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
36Rho-Homo sapiens-1Recruitment to plasma membrane15251227
37Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
38Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
39Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
40Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
41Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
42Rho-Homo sapiens-3Recruitment to plasma membrane15251227
43Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
44SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
45Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
46Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
47Rho-Homo sapiens-2Recruitment to plasma membrane15251227
48Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
49Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
50Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
52Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
53Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
54Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
55Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
56Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
57PI3K beta-Homo sapiensActivation9305878 | 12502714
58Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
59Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
60ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
61Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
63Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
64Raf1 protein kinase-Homo sapiensSequestration of G15251227
65GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
66ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
67Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
68Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
69Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed