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Description Entry page for G-protein - 'Gbeta-like_Homo sapiens_1'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-like
Cross References:
References
UniProtP63244 | B3KTJ0 | P25388 | P99049 | Q53HU2 | Q5J8M6 | Q5VLR4 | Q6FH47
EMBLM24194 | AY159316 | AY336089 | AK095666 | CR456978 | CR541909 | AK222488 | CH471165 | BC000214 | BC000366 | BC010119 | BC014256 | BC014788 | BC017287 | BC019093 | BC019362 | BC021993 | BC032006
InterProIPR020472 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID10399
MIM176981
PRINTSPR00320
PFAMPF00400
Details:
Details
NameGbeta-like_Homo sapiens_1
DescriptionRecName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1;AltName: Full=Guanine nucleotide-binding protein subunit beta-like protein 12.3;AltName: Full=Receptor of activated protein kinase C 1; Short=RACK1;AltName: Full=Receptor for activated C kinase;AltName: Full=Cell proliferation-inducing gene 21 protein;AltName: Full=Human lung cancer oncogene 7 protein; Short=HLC-7
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB2L1 | HLC7,PIG2
FunctionSeems to bind protein kinase C acting as ans intracellular receptor to anchor the activated PKC to thes cytoskeleton
Fragment0
Sequence
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR
GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI
VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA
NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC
FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA
GYTDNLVRVWQVTIGTR
Effectors:
Effectors
NoNameRegulationPubMed
1GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
2Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
3Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
4Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
5Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
6Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
7Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
8Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
9Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
10PI3K beta-Homo sapiensActivation9305878 | 12502714
11Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
12Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
13Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
14Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
15ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
16Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17PI3K gamma-Homo sapiensActivation12502714
18Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
19Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
20Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
21Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
22ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
23Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
24Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
25PI3K alpha-Homo sapiensPropable Inhibition16182515
26Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
27Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
28ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
29Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
30Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
31Raf1 protein kinase-Homo sapiensSequestration of G15251227
32Rho-Homo sapiens-2Recruitment to plasma membrane15251227
33Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
34Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
35Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
36Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
37Rho-Homo sapiens-3Recruitment to plasma membrane15251227
38Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
39Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
40ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
41Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
42Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
43SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
44Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
45SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
46ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
47Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
48Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
49Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
52Rho-Homo sapiens-1Recruitment to plasma membrane15251227
53Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
54Protein kinase D-Homo sapiensStimulation15251227
55Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
56Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
57Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
58Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
59Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
60Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
61GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
62ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
63Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
64ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
65SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
66Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
67Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
68Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
69Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed