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Description Entry page for G-protein - 'Gbeta-like_Homo sapiens_1'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-like
Cross References:
References
UniProtP63244 | B3KTJ0 | P25388 | P99049 | Q53HU2 | Q5J8M6 | Q5VLR4 | Q6FH47
EMBLM24194 | AY159316 | AY336089 | AK095666 | CR456978 | CR541909 | AK222488 | CH471165 | BC000214 | BC000366 | BC010119 | BC014256 | BC014788 | BC017287 | BC019093 | BC019362 | BC021993 | BC032006
InterProIPR020472 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID10399
MIM176981
PRINTSPR00320
PFAMPF00400
Details:
Details
NameGbeta-like_Homo sapiens_1
DescriptionRecName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1;AltName: Full=Guanine nucleotide-binding protein subunit beta-like protein 12.3;AltName: Full=Receptor of activated protein kinase C 1; Short=RACK1;AltName: Full=Receptor for activated C kinase;AltName: Full=Cell proliferation-inducing gene 21 protein;AltName: Full=Human lung cancer oncogene 7 protein; Short=HLC-7
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB2L1 | HLC7,PIG2
FunctionSeems to bind protein kinase C acting as ans intracellular receptor to anchor the activated PKC to thes cytoskeleton
Fragment0
Sequence
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR
GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI
VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA
NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC
FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA
GYTDNLVRVWQVTIGTR
Effectors:
Effectors
NoNameRegulationPubMed
1Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
2Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
3Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
4Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
5Rho-Homo sapiens-3Recruitment to plasma membrane15251227
6Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
7Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
8Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
9Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
10Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
11Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
12Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
13Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
14ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
15Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
16Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
18Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
19Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
20Protein kinase D-Homo sapiensStimulation15251227
21SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
22ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
23PI3K gamma-Homo sapiensActivation12502714
24Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
25Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
26Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
27Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
28Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
29Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
30Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
31SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
32Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
33Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
34ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
35Rho-Homo sapiens-2Recruitment to plasma membrane15251227
36Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
37Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
38Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
39Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
40Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
41ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
42Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
43Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
44Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
45GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
46Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
47Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
48Rho-Homo sapiens-1Recruitment to plasma membrane15251227
49Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
51Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
52Raf1 protein kinase-Homo sapiensSequestration of G15251227
53PI3K beta-Homo sapiensActivation9305878 | 12502714
54PI3K alpha-Homo sapiensPropable Inhibition16182515
55Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
56ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
57Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
58SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
59Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
60ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
61Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
62Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
63ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
64Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
65Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
66Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
67Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
68GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
69Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed