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Description Entry page for G-protein - 'Gbeta-like_Homo sapiens_1'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-like
Cross References:
References
UniProtP63244 | B3KTJ0 | P25388 | P99049 | Q53HU2 | Q5J8M6 | Q5VLR4 | Q6FH47
EMBLM24194 | AY159316 | AY336089 | AK095666 | CR456978 | CR541909 | AK222488 | CH471165 | BC000214 | BC000366 | BC010119 | BC014256 | BC014788 | BC017287 | BC019093 | BC019362 | BC021993 | BC032006
InterProIPR020472 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID10399
MIM176981
PRINTSPR00320
PFAMPF00400
Details:
Details
NameGbeta-like_Homo sapiens_1
DescriptionRecName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1;AltName: Full=Guanine nucleotide-binding protein subunit beta-like protein 12.3;AltName: Full=Receptor of activated protein kinase C 1; Short=RACK1;AltName: Full=Receptor for activated C kinase;AltName: Full=Cell proliferation-inducing gene 21 protein;AltName: Full=Human lung cancer oncogene 7 protein; Short=HLC-7
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB2L1 | HLC7,PIG2
FunctionSeems to bind protein kinase C acting as ans intracellular receptor to anchor the activated PKC to thes cytoskeleton
Fragment0
Sequence
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR
GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI
VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA
NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC
FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA
GYTDNLVRVWQVTIGTR
Effectors:
Effectors
NoNameRegulationPubMed
1Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
2ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
3Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
4Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
5SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
6Rho-Homo sapiens-3Recruitment to plasma membrane15251227
7Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
8Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
9Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
10PI3K alpha-Homo sapiensPropable Inhibition16182515
11Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
12Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
13Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
14Rho-Homo sapiens-1Recruitment to plasma membrane15251227
15Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
16Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
18Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
19GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
20Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
21Protein kinase D-Homo sapiensStimulation15251227
22ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
23ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
24Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
25Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
26Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
27Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
28Raf1 protein kinase-Homo sapiensSequestration of G15251227
29Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
30ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
31Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
32Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
33Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
34PI3K beta-Homo sapiensActivation9305878 | 12502714
35Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
36Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
37Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
38SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
39PI3K gamma-Homo sapiensActivation12502714
40Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
41Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
42Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
43Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
44Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
45Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
46Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
47SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
48Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
49Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
52Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
53Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
54Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
55GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
56Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
57ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
58Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
59Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
60Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
61Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
63Rho-Homo sapiens-2Recruitment to plasma membrane15251227
64Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
65ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
66Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
67ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
68Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
69Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed