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Description Entry page for G-protein - 'Ggamma-12_Homo sapiens'
ClassGgamma
FamilyGgamma
Sub-FamilyGgamma
TypeGgamma-12
Cross References:
References
UniProtQ9UBI6 | Q9BRV5
EMBLAF188181 | AF119663 | AF365871 | AF493879 | BC005940
InterProIPR015898 | IPR001770
PRODOMPD003783
GENEID55970
MIM
PRINTSPR00321
PFAMPF00631
Details:
Details
NameGgamma-12_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12;Flags: Precursor
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNG1
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSSKTASTNNIAQARRTVQQLRLEASIERIKVSKASADLMSYCEEHARSDPLLIGIPTSE
NPFKDKKTCIIL
Effectors:
Effectors
NoNameRegulationPubMed
1Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
2Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
3Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
4ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
5Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
6Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
7PI3K gamma-Homo sapiensActivation12502714
8Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
9Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
10Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
11Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
12Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
13SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
14Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
15Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
16Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
18Raf1 protein kinase-Homo sapiensSequestration of G15251227
19SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
20Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
21ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
22ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
23Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
24GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
25Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
26Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
27Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
28Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
29Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
30Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
31Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
32Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
33Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
34Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
35Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
36Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
37Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
38Protein kinase D-Homo sapiensStimulation15251227
39PI3K alpha-Homo sapiensPropable Inhibition16182515
40Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
41Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
42SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
43Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
44Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
45Rho-Homo sapiens-1Recruitment to plasma membrane15251227
46ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
47Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
48Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
49Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51Rho-Homo sapiens-3Recruitment to plasma membrane15251227
52ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
53GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
54Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
55Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
56Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
57PI3K beta-Homo sapiensActivation9305878 | 12502714
58Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
59Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
60Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
61Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
63Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
64Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
65ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
66Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
67ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
68Rho-Homo sapiens-2Recruitment to plasma membrane15251227
69Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed