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Description Entry page for G-protein - 'Ggamma-4_Homo sapiens'
ClassGgamma
FamilyGgamma
Sub-FamilyGgamma
TypeGgamma-4
Cross References:
References
UniProtP50150
EMBLU31382 | AF493872 | BC022485
InterProIPR015898 | IPR001770
PRODOMPD003783
GENEID2786
MIM604388
PRINTSPR00321
PFAMPF00631
Details:
Details
NameGgamma-4_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Flags: Precursor
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNG4 | GNGT
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MKEGMSNNSTTSISQARKAVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPVPA
SENPFREKKFFCTIL
Effectors:
Effectors
NoNameRegulationPubMed
1SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
2ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
3Rho-Homo sapiens-2Recruitment to plasma membrane15251227
4Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
5Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
6Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
7Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
8PI3K gamma-Homo sapiensActivation12502714
9Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
10Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
11Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
12Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
13Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
14Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
15PI3K beta-Homo sapiensActivation9305878 | 12502714
16Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
17Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
18Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
19PI3K alpha-Homo sapiensPropable Inhibition16182515
20Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
21Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
22ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
23Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
24Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
25GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
26Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
27Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
28Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
29Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
30Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
31SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
32Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
33Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
34Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
35Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
36Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
37Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
38Rho-Homo sapiens-3Recruitment to plasma membrane15251227
39ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
40Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
41ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
42Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
43SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
44Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
45Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
46Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
47ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
48Protein kinase D-Homo sapiensStimulation15251227
49Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
52ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
53Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
54Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
55Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
56Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
57Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
58Raf1 protein kinase-Homo sapiensSequestration of G15251227
59GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
60Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
61ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
62Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
63Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
64Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
65Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
66Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
67Rho-Homo sapiens-1Recruitment to plasma membrane15251227
68Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
69Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed