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Description Entry page for G-protein - 'Ggamma-4_Homo sapiens'
ClassGgamma
FamilyGgamma
Sub-FamilyGgamma
TypeGgamma-4
Cross References:
References
UniProtP50150
EMBLU31382 | AF493872 | BC022485
InterProIPR015898 | IPR001770
PRODOMPD003783
GENEID2786
MIM604388
PRINTSPR00321
PFAMPF00631
Details:
Details
NameGgamma-4_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;Flags: Precursor
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNG4 | GNGT
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MKEGMSNNSTTSISQARKAVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPVPA
SENPFREKKFFCTIL
Effectors:
Effectors
NoNameRegulationPubMed
1ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
2Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
3Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
4Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
5Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
6Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
7Protein kinase D-Homo sapiensStimulation15251227
8Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
9Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
10Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
11Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
12ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
13SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
14Raf1 protein kinase-Homo sapiensSequestration of G15251227
15Rho-Homo sapiens-1Recruitment to plasma membrane15251227
16Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
18Rho-Homo sapiens-2Recruitment to plasma membrane15251227
19PI3K gamma-Homo sapiensActivation12502714
20Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
21Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
22Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
23Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
24Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
25Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
26Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
27SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
28Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
29Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
30Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
31Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
32GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
33Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
34Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
35Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
36Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
37Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
38ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
39Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
40PI3K alpha-Homo sapiensPropable Inhibition16182515
41SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
42Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
43Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
44Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
45Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
46PI3K beta-Homo sapiensActivation9305878 | 12502714
47Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
48Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
49Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
50Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
51GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
52Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
53ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
54Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
55Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
56Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
57ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
58Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
59Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
60Rho-Homo sapiens-3Recruitment to plasma membrane15251227
61Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
63ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
64Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
65Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
66Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
67Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
68ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
69Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed