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Description Entry page for G-protein - 'Ggamma-8_Homo sapiens'
ClassGgamma
FamilyGgamma
Sub-FamilyGgamma
TypeGgamma-8
Cross References:
References
UniProtQ9UK08 | Q4VBM5
EMBLAF188179 | AF493875 | BC095514
InterProIPR015898 | IPR001770
PRODOMPD003783
GENEID94235
MIM
PRINTSPR00321
PFAMPF00631
Details:
Details
NameGgamma-8_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8;AltName: Full=Gamma-9;Flags: Precursor
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNG8 | GNG9,GNGT
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSNNMAKIAEARKTVEQLKLEVNIDRMKVSQAAAELLAFCETHAKDDPLVTPVPAAENPF
RDKRLFCVLL
Effectors:
Effectors
NoNameRegulationPubMed
1Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
2Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
3Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
4Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
5Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
6Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
7Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
8Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
9Rho-Homo sapiens-1Recruitment to plasma membrane15251227
10Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
11Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
12Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
13Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
14Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
15Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
16Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17PI3K alpha-Homo sapiensPropable Inhibition16182515
18Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
19Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
20Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
21Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
22ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
23Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
24Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
25Raf1 protein kinase-Homo sapiensSequestration of G15251227
26Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
27Rho-Homo sapiens-2Recruitment to plasma membrane15251227
28Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
29Protein kinase D-Homo sapiensStimulation15251227
30Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
31Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
32Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
33Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
34Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
35Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
36PI3K beta-Homo sapiensActivation9305878 | 12502714
37Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
38Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
39ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
40ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
41Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
42Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
43Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
44Rho-Homo sapiens-3Recruitment to plasma membrane15251227
45ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
46Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
47GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
48Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
49PI3K gamma-Homo sapiensActivation12502714
50Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
52ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
53GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
54Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
55Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
56Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
57Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
58SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
59Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
60Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
61SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
62Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
63Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
64Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
65ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
66ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
67Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
68Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
69Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed