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Description Entry page for G-protein - 'Ggamma-8_Homo sapiens'
ClassGgamma
FamilyGgamma
Sub-FamilyGgamma
TypeGgamma-8
Cross References:
References
UniProtQ9UK08 | Q4VBM5
EMBLAF188179 | AF493875 | BC095514
InterProIPR015898 | IPR001770
PRODOMPD003783
GENEID94235
MIM
PRINTSPR00321
PFAMPF00631
Details:
Details
NameGgamma-8_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8;AltName: Full=Gamma-9;Flags: Precursor
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNG8 | GNG9,GNGT
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSNNMAKIAEARKTVEQLKLEVNIDRMKVSQAAAELLAFCETHAKDDPLVTPVPAAENPF
RDKRLFCVLL
Effectors:
Effectors
NoNameRegulationPubMed
1Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
2ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
3ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
4Protein kinase D-Homo sapiensStimulation15251227
5Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
6PI3K gamma-Homo sapiensActivation12502714
7ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
8PI3K beta-Homo sapiensActivation9305878 | 12502714
9Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
10PI3K alpha-Homo sapiensPropable Inhibition16182515
11Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
12Rho-Homo sapiens-3Recruitment to plasma membrane15251227
13Rho-Homo sapiens-1Recruitment to plasma membrane15251227
14SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
15GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
16Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
17Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
18Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
19Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
20Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
21Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
22Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
23Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
24Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
25ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
26Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
27Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
28Raf1 protein kinase-Homo sapiensSequestration of G15251227
29Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
30Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
31Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
32Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
33Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
34Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
35Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
36Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
37Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
38SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
39Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
40Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
41GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
42Rho-Homo sapiens-2Recruitment to plasma membrane15251227
43ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
44ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
45Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
46SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
47Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
48Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
49Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
52Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
53Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
54Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
55Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
56Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
57Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
58Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
59Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
60ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
61Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
63Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
64Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
65Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
66Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
67Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
68Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
69Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed