Quick search:







Description Entry page for G-protein - 'Ggamma-8_Homo sapiens'
ClassGgamma
FamilyGgamma
Sub-FamilyGgamma
TypeGgamma-8
Cross References:
References
UniProtQ9UK08 | Q4VBM5
EMBLAF188179 | AF493875 | BC095514
InterProIPR015898 | IPR001770
PRODOMPD003783
GENEID94235
MIM
PRINTSPR00321
PFAMPF00631
Details:
Details
NameGgamma-8_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8;AltName: Full=Gamma-9;Flags: Precursor
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNG8 | GNG9,GNGT
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSNNMAKIAEARKTVEQLKLEVNIDRMKVSQAAAELLAFCETHAKDDPLVTPVPAAENPF
RDKRLFCVLL
Effectors:
Effectors
NoNameRegulationPubMed
1Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
2Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
3ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
4PI3K beta-Homo sapiensActivation9305878 | 12502714
5Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
6Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
7Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
8Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
9Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
10Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
11Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
12ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
13Raf1 protein kinase-Homo sapiensSequestration of G15251227
14Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
15Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
16Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
17Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
18Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
19ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
20Protein kinase D-Homo sapiensStimulation15251227
21Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
22SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
23Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
24Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
25Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
26Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
27ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
28Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
29Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
30Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
31Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
32Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
33Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
34Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
35Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
36Rho-Homo sapiens-2Recruitment to plasma membrane15251227
37Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
38Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
39Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
40GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
41Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
42ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
43Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
44Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
45Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
46Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
47Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
48Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
49Rho-Homo sapiens-1Recruitment to plasma membrane15251227
50GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
51Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
52Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
53ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
54PI3K gamma-Homo sapiensActivation12502714
55SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
56Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
57Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
58Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
59Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
60Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
61Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
62SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
63Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
64ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
65PI3K alpha-Homo sapiensPropable Inhibition16182515
66Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
67Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
68Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
69Rho-Homo sapiens-3Recruitment to plasma membrane15251227
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed