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Summary sheet information for Effector 'Brutons tyrosine kinase-Homo sapiens'
Name Brutons tyrosine kinase-Homo sapiens
Description RecName: Full=Tyrosine-protein kinase BTK; EC=2.7.10.2;AltName: Full=Bruton tyrosine kinase;AltName: Full=Agammaglobulinaemia tyrosine kinase; Short=ATK;AltName: Full=B-cell progenitor kinase; Short=BPK
Class
Family Tyr protein kinases
Sub_family Tyr protein kinases
type Brutons tyrosine kinase
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: X
Gene Start: 100491091
Gene End: 100527838
Ensembl Contig View

Ensembl Genes:
ENSG00000010671

EMBL:
EMBL ID  Description
AF153364  Homo sapiens Bruton's tyrosine kinase mRNA, complete cds.
AF153755  Homo sapiens Bruton's tyrosine kinase mRNA, partial cds.
AF153756  Homo sapiens Bruton's tyrosine kinase mRNA, complete cds.
AF153757  Homo sapiens Bruton's tyrosine kinase mRNA, complete cds.
AF153758  Homo sapiens Bruton's tyrosine kinase mRNA, complete cds.
AF153759  Homo sapiens Bruton's tyrosine kinase mRNA, complete cds.
AF153760  Homo sapiens Bruton's tyrosine kinase mRNA, complete cds.
AF153761  Homo sapiens Bruton's tyrosine kinase mRNA, complete cds.
AF153762  Homo sapiens Bruton's tyrosine kinase mRNA, complete cds.
AF153763  Homo sapiens Bruton's tyrosine kinase mRNA, partial cds.
AF153764  Homo sapiens Bruton's tyrosine kinase mRNA, partial cds.
AJ888376  Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform 65 (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia
AJ888378  Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform 52 (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia
AJ888380  Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform (lacking exon 15 to 18) (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia
AK314382  Homo sapiens cDNA, FLJ95155, highly similar to Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), mRNA.
AL035422  Human DNA sequence from clone RP1-164F3 on chromosome Xq21.33-23 Contains a ribosomal protein L21 (RPL21) pseudogene, the TIMM8A gene for translocase of inner mitochondrial membrane 8 homolog A (yeast), the BTK gene for Bruton agammaglobulinemia tyrosine kinase, the RPL36A gene for ribosomal protein L36a, the GLA gene for alpha galactosidase, the HNRPH2 gene for heterogeneous nuclear ribonucleoprotein H2 (H'), the gene for a novel protein, a peptidylprolyl isomerase A (cyclophilin A) (PPIA) pseudogene and two CpG islands.
AM051276  Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 2 (BTK kinase deficient isoform 2 gene), cell type MLL-AF4+ leukemia cells
AM051277  Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 3 (BTK kinase deficient isoform 3 gene), cell type MLL-AF4+ leukemia cells
AM051278  Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 4 (BTK kinase deficient isoform 4 gene), cell type BCR-ABL1+ leukemia cells
AM051279  Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 5 (BTK kinase deficient isoform 5 gene), cell type BCR-ABL1+ leukemia cells
AM051280  Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 6 (BTK kinase deficient isoform 6 gene), cell type BCR-ABL1+ leukemia cells
AM051283  Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 9 (BTK kinase deficient isoform 9 gene), cell type TEL-AML1+ leukemia cells
AM051284  Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 10 (BTK kinase deficient isoform 10 gene), cell type TEL-AML1+ leukemia cells
AM051285  Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 11 (BTK kinase deficient isoform 11 gene), cell type E2A-PBX1+ leukemia cells
BC109079  Homo sapiens Bruton agammaglobulinemia tyrosine kinase, mRNA (cDNA clone MGC:126261 IMAGE:40034287), complete cds.
BC109080  Homo sapiens Bruton agammaglobulinemia tyrosine kinase, mRNA (cDNA clone MGC:126262 IMAGE:40034289), complete cds.
CH471115  Homo sapiens 211000035842956 genomic scaffold, whole genome shotgun sequence.
L31557  Human Bruton agammaglobulinemia (BTK) gene, exon 2.
L31558  Human Bruton agammaglobulinemia (BTK) gene, exon 3.
L31559  Human Bruton agammaglobulinemia (BTK) gene, exon 4.
L31561  Human Bruton agammaglobulinemia (BTK) gene, exons 6-7.
L31563  Human Bruton agammaglobulinemia (BTK) gene, exon 8.
L31564  Human Bruton agammaglobulinemia (BTK) gene, exon 9.
L31565  Human Bruton agammaglobulinemia (BTK) gene, exons 10-12.
L31566  Human Bruton agammaglobulinemia (BTK) gene, exon 13.
L31567  Human Bruton agammaglobulinemia (BTK) gene, exon 14.
L31568  Human Bruton agammaglobulinemia (BTK) gene, exon 15.
L31569  Human Bruton agammaglobulinemia (BTK) gene, exon 16.
L31570  Human Bruton agammaglobulinemia (BTK) gene, exon 17.
L31571  Human Bruton agammaglobulinemia (BTK) gene, exon 18.
L31572  Human Bruton agammaglobulinemia (BTK) gene exon 19, complete cds.
U10084  Human Bruton agammaglobulinemia tyrosine kinase (BTK) gene, exons 2 and 3.
U10085  Human Bruton agammaglobulinemia tyrosine kinase (BTK) gene, exon 4.
U10086  Human Bruton agammaglobulinemia tyrosine kinase (BTK) gene, exon 5.
U10087  Human Bruton agammaglobulinemia tyrosine kinase (BTK) gene, exons 6-19 and complete cds.
U13410  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 2.
U13412  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 3.
U13413  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 4.
U13414  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 5.
U13415  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 6.
U13416  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 7.
U13417  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 8.
U13422  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 9.
U13423  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 10.
U13424  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 11.
U13425  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 12.
U13427  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 13.
U13428  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 14.
U13429  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 15.
U13430  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 16.
U13431  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 17.
U13432  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 18.
U13433  Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 19 and complete cds.
U78027  Homo sapiens Bruton's tyrosine kinase (BTK), alpha-D-galactosidase A (GLA), L44-like ribosomal protein (L44L) and FTP3 (FTP3) genes, complete cds.
X58957  H.sapiens atk mRNA for agammaglobulinaemia tyrosine kinase

EntrezGene:
ID  Description
BTK  Bruton agammaglobulinemia tyrosine kinase

RefSeq DNA:
ID  Description
NM_000061  Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), mRNA.

UniGene:
ID  Description
Hs.159494  Atk mRNA for agammaglobulinaemia tyrosine kinase

Proteins
Ensembl Proteins:
ENSP00000378608; ENSP00000361950; ENSP00000361946; ENSP00000361951; ENSP00000361971; ENSP00000361960; ENSP00000308176

Entrez Proteins:
AAA61479.1; AAB60639.1; AAB64205.1; AAC51347.1; AAF37332.1; AAF37333.1; AAF37334.1; AAF37335.1; AAF37336.1; AAF37337.1; AAF37338.1; AAF37339.1; AAF37340.1; AAF37341.1; AAF61477.1; AAI09080.1; AAI09081.1; BAG37008.1; CAA41728.1; CAB55876.1; CAI42359.1; CAI59837.1; CAI59839.1; CAI59842.1; CAJ19682.1; CAJ19683.1; CAJ19684.1; CAJ19685.1; CAJ19686.1; CAJ19689.1; CAJ19690.1; CAJ19691.1; EAX02857.1

RefSeq Proteins:
ID  Description
NP_000052  Bruton agammaglobulinemia tyrosine kinase [Homo sapiens].

UniProt:
ID  Description
B2RAW1  SubName: Full=cDNA, FLJ95155, highly similar to Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), mRNA;
Q3MS87  SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 11; Flags: Fragment;
Q3MS88  SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 10; Flags: Fragment;
Q3MS89  SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 9; Flags: Fragment;
Q3MS92  SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 6; Flags: Fragment;
Q3MS93  SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 5; Flags: Fragment;
Q3MS94  SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 4; Flags: Fragment;
Q3MS95  SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 3; Flags: Fragment;
Q3MS96  SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 2; Flags: Fragment;
Q572P1  SubName: Full=Tyrosine-protein kinase BTK isoform (Lacking exon 15 to 18); Flags: Fragment;
Q572P3  SubName: Full=Tyrosine-protein kinase BTK isoform 52; Flags: Fragment;
Q572P5  SubName: Full=Tyrosine-protein kinase BTK isoform 65; Flags: Fragment;
Q5JY90  SubName: Full=cDNA FLJ32543 fis, clone SMINT2000538, highly similar to Tyrosine-protein kinase BTK (EC 2.7.10.2); SubName: Full=Bruton agammaglobulinemia tyrosine kinase; SubName: Full=Bruton agammaglobulinemia tyrosine kinase, isoform CRA_b;
Q9NPI2  SubName: Full=Bruton's tyrosine kinase;
Q9NPI3  SubName: Full=Bruton's tyrosine kinase;
Q9P0L3  SubName: Full=Bruton's tyrosine kinase; Flags: Fragment;
Q9P0L4  SubName: Full=Bruton's tyrosine kinase; Flags: Fragment;
Q9P0L5  SubName: Full=Bruton's tyrosine kinase;
Q9P0L6  SubName: Full=Bruton's tyrosine kinase;
Q9P0L7  SubName: Full=Bruton's tyrosine kinase;
Q9P0L8  SubName: Full=Bruton's tyrosine kinase; Flags: Fragment;
Q9P0M0  SubName: Full=Bruton's tyrosine kinase;
Q06187  RecName: Full=Tyrosine-protein kinase BTK; EC=2.7.10.2; AltName: Full=Bruton tyrosine kinase; AltName: Full=Agammaglobulinaemia tyrosine kinase; Short=ATK; AltName: Full=B-cell progenitor kinase; Short=BPK;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Brutons tyrosine kinase-Homo sapiens    

InterPro:
ID  Name
IPR001562  Znf_Btk_motif
IPR017441  Protein_kinase_ATP_bd_CS
IPR008266  Tyr_pkinase_AS
IPR001245  Tyr_pkinase
IPR011993  PH_type
IPR001849  Pleckstrin_homology
IPR000980  SH2
IPR001452  SH3_domain
IPR000719  Prot_kinase_core

Pfam:
ID  Description
SH2  SH2 domain
SH3_1  SH3 domain
PH  PH domain
BTK  BTK motif
Pkinase_Tyr  Protein tyrosine kinase
Pkinase_Tyr  Protein tyrosine kinase

Structure
PDB:
ID
1AWW
1AWX
1B55
1BTK
1BWN
1K2P
1QLY
2GE9
2Z0P

HSSP:
ID  Description
1a07  COMPLEX (TRANSFERASE/PEPTIDE)
1a08  COMPLEX (TRANSFERASE/PEPTIDE)
1a09  COMPLEX (TRANSFERASE/PEPTIDE)
1a0n  COMPLEX (PHOSPHOTRANSFERASE/PEPTIDE)
1a1a  COMPLEX (TRANSFERASE/PEPTIDE)
1a1b  COMPLEX (TRANSFERASE/PEPTIDE)
1a1c  COMPLEX (TRANSFERASE/PEPTIDE)
1a1e  COMPLEX (TRANSFERASE/PEPTIDE)
1ab2  TRANSFERASE(PHOSPHOTRANSFERASE)
1ad5  TYROSINE-PROTEIN KINASE
1aot  COMPLEX (PROTO-ONCOGENE/EARLY PROTEIN)
1aou  COMPLEX (PROTO-ONCOGENE/EARLY PROTEIN)
1avz  COMPLEX (MYRISTYLATION/TRANSFERASE)
1awj  TRANSFERASE
1aww  TRANSFERASE
1awx  TRANSFERASE
1aya  HYDROLASE(SH2 DOMAIN)
1ayb  HYDROLASE(SH2 DOMAIN)
1ayc  HYDROLASE(SH2 DOMAIN)
1ayd  HYDROLASE(SH2 DOMAIN)
1azg  COMPLEX (PHOSPHOTRANSFERASE/PEPTIDE)
1b07  SH3 DOMAIN
1b55  TRANSFERASE
1bfi  SH2 DOMAIN
1bfj  SH2 DOMAIN
1bk2  SH3-DOMAIN
1bkl  V-SRC SH2 DOMAIN
1bkm  TRANSFORMING PROTEIN
1btk  TRANSFERASE
1bu1  TRANSFERASE
1bwn  TRANSFERASE
1byg  TRANSFERASE
1cka  COMPLEX (ONCOGENE PROTEIN/PEPTIDE)
1ckb  COMPLEX (ONCOGENE PROTEIN/PEPTIDE)
1csk  PHOSPHOTRANSFERASE
1d1z  GENE REGULATION
1d4t  SIGNALING PROTEIN
1d4w  SIGNALING PROTEIN
1efn  COMPLEX (SH3 DOMAIN/VIRAL ENHANCER)
1f1w  TRANSFERASE
1f2f  TRANSFERASE
1fmk  PHOSPHOTRANSFERASE
1fpu  TRANSFERASE
1fvr  TRANSFERASE
1fyn  TRANSFERASE
1g83  TRANSFERASE
1gag  TRANSFERASE, SIGNALING PROTEIN
1gcq  SIGNALING PROTEIN/SIGNALING PROTEIN
1gfc  ADAPTOR PROTEIN CONTAINING SH2 AND SH3
1gfd  ADAPTOR PROTEIN CONTAINING SH2 AND SH3
1gjo  TRANSFERASE
1gl5  TRANSFERASE
1h92  TRANSFERASE
1h9o  COMPLEX (PHOSPHOTRANSFERASE/RECEPTOR)
1hcs  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1hct  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1hd3  CYTOSKELETON
1i44  TRANSFERASE
1iep  TRANSFERASE
1io6  SIGNALING PROTEIN
1ir3  COMPLEX (TRANSFERASE/SUBSTRATE)
1irk  TRANSFERASE (PHOSPHOTRANSFERASE)
1is0  TRANSFERASE
1jeg  TRANSFERASE/HYDROLASE
1jpa  TRANSFERASE
1jqh  TRANSFERASE
1jqq  PROTEIN TRANSPORT, MEMBRANE PROTEIN
1ju5  PROTEIN BINDING/TRANSFERASE
1k2p  TRANSFERASE
1k3a  TRANSFERASE
1k9a  TRANSFERASE
1ka6  IMMUNE SYSTEM
1ka7  IMMUNE SYSTEM
1kc2  TRANSFERASE
1kik  TRANSFERASE
1ksw  TRANSFERASE
1lck  COMPLEX (KINASE/PEPTIDE)
1luf  TRANSFERASE
1lui  TRANSFERASE
1luk  TRANSFERASE
1lum  TRANSFERASE
1lun  TRANSFERASE
1m14  TRANSFERASE
1m17  TRANSFERASE
1m27  SIGNALING PROTEIN, TRANSFERASE
1m30  PROTEIN BINDING
1m3a  PROTEIN BINDING
1m3b  PROTEIN BINDING
1m3c  PROTEIN BINDING
1m52  TRANSFERASE
1m7n  TRANSFERASE
1mqb  TRANSFERASE
1n5z  PROTEIN TRANSPORT
1nlo  COMPLEX (TRANSFERASE/PEPTIDE)
1nlp  COMPLEX (TRANSFERASE/PEPTIDE)
1nm7  PROTEIN TRANSPORT
1nyf  PHOSPHOTRANSFERASE
1nyg  PHOSPHOTRANSFERASE
1nzl  TRANSFERASE
1nzv  TRANSFERASE
1o41  SIGNALING PROTEIN
1o42  SIGNALING PROTEIN
1o43  SIGNALING PROTEIN
1o44  SIGNALING PROTEIN
1o45  SIGNALING PROTEIN
1o46  SIGNALING PROTEIN
1o47  SIGNALING PROTEIN
1o48  SIGNALING PROTEIN
1o49  SIGNALING PROTEIN
1o4a  SIGNALING PROTEIN
1o4b  SIGNALING PROTEIN
1o4c  SIGNALING PROTEIN
1o4d  SIGNALING PROTEIN
1o4e  SIGNALING PROTEIN
1o4f  SIGNALING PROTEIN
1o4g  SIGNALING PROTEIN
1o4h  SIGNALING PROTEIN
1o4i  SIGNALING PROTEIN
1o4j  SIGNALING PROTEIN
1o4k  SIGNALING PROTEIN
1o4l  SIGNALING PROTEIN
1o4m  SIGNALING PROTEIN
1o4n  SIGNALING PROTEIN
1o4o  SIGNALING PROTEIN
1o4p  SIGNALING PROTEIN
1o4q  SIGNALING PROTEIN
1o4r  SIGNALING PROTEIN
1oec  TRANSFERASE
1oot  STRUCTURAL GENOMICS
1opj  TRANSFERASE
1opk  TRANSFERASE
1opl  TRANSFERASE
1p13  TRANSFERASE
1p14  TRANSFERASE
1p4o  HORMONE/GROWTH FACTOR
1pic  COMPLEX (PHOSPHOTRANSFERASE/RECEPTOR)
1pkg  TRANSFERASE ACTIVATOR
1prl  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1prm  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1qcf  TYROSINE KINASE
1qly  TYROSINE-PROTEIN KINASE
1qpc  TRANSFERASE
1qpd  TRANSFERASE
1qpe  TRANSFERASE
1qpj  TRANSFERASE
1qwe  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1qwf  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1r0p  TRANSFERASE
1r1p  PEPTIDE BINDING PROTEIN
1r1q  PEPTIDE BINDING PROTEIN
1r1s  PEPTIDE BINDING PROTEIN
1r1w  TRANSFERASE
1rja  TRANSFERASE
1rjb  TRANSFERASE
1rlp  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1rlq  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1rqq  TRANSFERASE/SIGNALING PROTEIN
1sha  PHOSPHOTRANSFERASE
1shb  PHOSPHOTRANSFERASE
1shd  COMPLEX(TRANSFERASE/PEPTIDE)
1shf  PHOSPHOTRANSFERASE
1skj  TYROSINE-PROTEIN KINASE
1sm2  TRANSFERASE
1snu  TRANSFERASE
1snx  TRANSFERASE
1spr  TRANSFERASE(PHOSPHOTRANSFERASE)
1sps  TRANSFERASE(PHOSPHOTRANSFERASE)
1srl  PHOSPHOTRANSFERASE
1srm  PHOSPHOTRANSFERASE
1ssh  CONTRACTILE PROTEIN
1t45  TRANSFERASE ACTIVATOR
1t46  TRANSFERASE ACTIVATOR
1u46  TRANSFERASE
1u4d  TRANSFERASE
1u54  TRANSFERASE
1u59  TRANSFERASE
1uue  SH3-DOMAIN
1uwh  KINASE
1uwj  KINASE
1vr2  TRANSFERASE
1w1f  SH3-DOMAIN
1wa7  SH3 DOMAIN
1wxb  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
1x27  SIGNALING PROTEIN
1x2k  SIGNALING PROTEIN
1xba  TRANSFERASE
1xbb  TRANSFERASE
1xbc  TRANSFERASE
1xkk  TRANSFERASE
1y57  TRANSFERASE
1y6a  TRANSFERASE
1y6b  TRANSFERASE
1yi6  TRANSFERASE
1yn8  UNKNOWN FUNCTION
1ynz  PROTEIN BINDING
1yoj  TRANSFERASE
1yol  TRANSFERASE
1yom  TRANSFERASE
1yvj  TRANSFERASE
1ywn  TRANSFERASE
1z3k  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
1zbj  TRANSFERASE
1zlm  SIGNALING PROTEIN
1zx6  PROTEIN BINDING
2abl  TRANSFERASE
2auh  TRANSFERASE/SIGNALING PROTEIN
2b7a  TRANSFERASE
2b86  SIGNALING PROTEIN
2bdf  TRANSFERASE
2bdj  TRANSFERASE
2c0i  TRANSFERASE
2c0o  TRANSFERASE
2c0t  TRANSFERASE
2ci8  SH2-DOMAIN
2ci9  SH2-DOMAIN/COMPLEX
2cia  SH2-DOMAIN
2cub  SIGNALING PROTEIN
2d8j  TRANSFERASE
2dl4  SIGNALING PROTEIN
2dly  TRANSFERASE
2dm0  TRANSFERASE
2dq7  TRANSFERASE
2e2b  TRANSFERASE
2e6i  TRANSFERASE
2eb2  TRANSFERASE
2eb3  TRANSFERASE
2ecd  SIGNALING PROTEIN
2ekx  SIGNALING PROTEIN
2eo6  SIGNALING PROTEIN
2etz  TRANSFERASE
2eu0  TRANSFERASE
2eyw  SIGNALING PROTEIN
2f4j  TRANSFERASE
2fb8  TRANSFERASE
2fei  STRUCTURAL PROTEIN
2fgi  TRANSFERASE
2fo0  TRANSFERASE
2frw  PROTEIN BINDING
2g15  TRANSFERASE
2g1t  TRANSFERASE
2g2f  TRANSFERASE
2g2h  TRANSFERASE
2g2i  TRANSFERASE
2ge9  TRANSFERASE
2gqg  TRANSFERASE
2gs2  TRANSFERASE
2gs6  TRANSFERASE
2gs7  TRANSFERASE
2gsf  TRANSFERASE
2h8h  TRANSFERASE
2hck  TRANSFERASE
2hda  TRANSFERASE
2hel  SIGNALING PROTEIN, TRANSFERASE
2hen  TRANSFERASE
2hiw  TRANSFERASE
2hk5  TRANSFERASE
2hwo  TRANSFERASE
2hwp  TRANSFERASE
2hyy  TRANSFERASE
2hz0  TRANSFERASE
2hz4  TRANSFERASE
2hzi  TRANSFERASE
2hzn  TRANSFERASE
2i0v  TRANSFERASE
2i0y  TRANSFERASE
2i1m  TRANSFERASE
2iim  SIGNALING PROTEIN
2itn  TRANSFERASE
2ito  TRANSFERASE
2itp  TRANSFERASE
2itq  TRANSFERASE
2itt  TRANSFERASE
2itu  TRANSFERASE
2itv  TRANSFERASE
2itw  TRANSFERASE
2itx  TRANSFERASE
2ity  TRANSFERASE
2itz  TRANSFERASE
2iui  TRANSFERASE
2ivs  TRANSFERASE
2ivu  TRANSFERASE
2j5e  TRANSFERASE
2j5f  TRANSFERASE
2j6m  TRANSFERASE
2jit  TRANSFERASE
2jiu  TRANSFERASE
2jiv  TRANSFERASE
2js0  SIGNALING PROTEIN
2js2  SIGNALING PROTEIN
2jxb  SIGNALING PROTEIN COMPLEX
2jyq  TRANSFERASE
2of2  TRANSFERASE
2of4  TRANSFERASE
2ofu  TRANSFERASE
2ofv  TRANSFERASE
2og8  TRANSFERASE
2ogv  TRANSFERASE
2oh4  TRANSFERASE
2oi3  TRANSFERASE
2oiq  TRANSFERASE
2oj2  SIGNALING PROTEIN,TRANSFERASE/INHIBITOR
2oj9  TRANSFERASE
2oo8  TRANSFERASE
2osc  TRANSFERASE
2ozo  TRANSFERASE
2p0c  TRANSFERASE
2p2h  TRANSFERASE
2p2i  TRANSFERASE
2p4i  TRANSFERASE
2pl0  TRANSFERASE
2psq  TRANSFERASE
2ptk  TYROSINE-PROTEIN KINASE
2pvf  TRANSFERASE
2pvy  TRANSFERASE
2pwl  TRANSFERASE
2py3  TRANSFERASE
2pz5  TRANSFERASE
2pzp  TRANSFERASE
2pzr  TRANSFERASE
2q0b  TRANSFERASE
2qi8  SIGNALING PROTEIN, TRANSFERASE
2qlq  TRANSFERASE
2qo2  TRANSFERASE
2qo7  TRANSFERASE
2qo9  TRANSFERASE
2qob  TRANSFERASE
2qoc  TRANSFERASE
2qod  TRANSFERASE
2qof  TRANSFERASE
2qoh  TRANSFERASE
2qoi  TRANSFERASE
2qok  TRANSFERASE
2qol  TRANSFERASE
2qon  TRANSFERASE
2qoo  TRANSFERASE
2qoq  TRANSFERASE
2qq7  TRANSFERASE
2qu5  TRANSFERASE
2qu6  TRANSFERASE
2r2p  TRANSFERASE
2r4b  TRANSFERASE
2rei  TRANSFERASE
2rf9  TRANSFERASE
2rfd  TRANSFERASE
2rfe  TRANSFERASE
2rfn  TRANSFERASE
2rfs  TRANSFERASE
2rgp  TRANSFERASE
2rl5  TRANSFERASE
2rn8  TRANSFERASE
2rna  TRANSFERASE
2src  TYROSINE-PROTEIN KINASE
2v1r  PROTEIN TRANSPORT
2v7a  TRANSFERASE
2vkn  MEMBRANE PROTEIN
2vwu  TRANSFERASE
2vwv  TRANSFERASE
2vww  TRANSFERASE
2vwx  TRANSFERASE
2vwy  TRANSFERASE
2vwz  TRANSFERASE
2vx0  TRANSFERASE
2vx1  TRANSFERASE
2w1i  TRANSFERASE
2ys2  TRANSFERASE
2yt6  CELL CYCLE
2yuq  TRANSFERASE
2z0p  SIGNALING PROTEIN
2z60  TRANSFERASE
2z8c  TRANSFERASE
2zm1  TRANSFERASE
2zm3  TRANSFERASE
2zm4  TRANSFERASE
2zv7  TRANSFERASE
2zv8  TRANSFERASE
2zv9  TRANSFERASE
2zva  TRANSFERASE
2zyb  TRANSFERASE
3b2t  TRANSFERASE
3b2w  TRANSFERASE
3b8q  TRANSFERASE
3b8r  TRANSFERASE
3bbt  TRANSFERASE
3bbw  TRANSFERASE
3bce  TRANSFERASE
3be2  TRANSFERASE
3bea  TRANSFERASE
3bel  TRANSFERASE
3bkb  TRANSFERASE
3bpr  TRANSFERASE
3brb  TRANSFERASE
3bu3  TRANSFERASE
3bu5  TRANSFERASE
3bu6  TRANSFERASE
3bym  TRANSFERASE
3byo  TRANSFERASE
3bys  TRANSFERASE
3byu  TRANSFERASE
3bz3  TRANSFERASE
3c1x  TRANSFERASE
3c4c  TRANSFERASE
3c4d  TRANSFERASE
3c4f  TRANSFERASE
3c7q  TRANSFERASE
3cbl  TRANSFERASE
3cc6  TRANSFERASE
3ccn  TRANSFERASE
3cd3  TRANSFERASE
3cd8  TRANSFERASE
3ce3  TRANSFERASE
3cjf  TRANSFERASE
3cjg  TRANSFERASE
3cly  TRANSFERASE
3cp9  TRANSFERASE
3cpb  TRANSFERASE
3cpc  TRANSFERASE
3cqt  TRANSFERASE
3cs9  TRANSFERASE
3cth  TRANSFERASE
3ctj  TRANSFERASE
3d4q  TRANSFERASE
3d7t  TRANSFERASE
3d7u  TRANSFERASE
3d94  TRANSFERASE
3dk3  TRANSFERASE
3dk6  TRANSFERASE
3dk7  TRANSFERASE
3dko  TRANSFERASE
3dqw  TRANSFERASE
3dqx  TRANSFERASE
3dtw  TRANSFERASE
3dzq  TRANSFERASE
3e62  TRANSFERASE
3e63  TRANSFERASE
3e64  TRANSFERASE
3efj  TRANSFERASE
3efk  TRANSFERASE
3ekk  TRANSFERASE
3ekn  TRANSFERASE
3el7  TRANSFERASE
3el8  TRANSFERASE
3emg  TRANSFERASE
3en4  TRANSFERASE
3en5  TRANSFERASE
3en6  TRANSFERASE
3en7  TRANSFERASE
3eqp  TRANSFERASE
3eqr  TRANSFERASE
3eyg  TRANSFERASE
3eyh  TRANSFERASE
3f5p  TRANSFERASE
3f66  TRANSFERASE
3f6x  TRANSFERASE
3fup  TRANSFERASE
3fxx  TRANSFERASE
3fy2  TRANSFERASE
3hck  TRANSFERASE
3lck  TYROSINE-PROTEIN KINASE
4hck  TRANSFERASE
5hck  TRANSFERASE

PSSH:
ID  Description
Q572P5  UNKNOWN
Q572P1  UNKNOWN
Q572P3  UNKNOWN
Q5JY90  UNKNOWN
Q9NPI2  UNKNOWN
Q9NPI3  UNKNOWN
Q9P0L4  UNKNOWN
Q9P0M0  UNKNOWN
Q9P0L7  UNKNOWN
Q9P0L6  UNKNOWN
Q9P0L5  UNKNOWN
Q9P0L3  UNKNOWN
Q9P0L8  UNKNOWN
Q06187  UNKNOWN
Q3MS88  UNKNOWN
Q3MS93  UNKNOWN
Q3MS96  UNKNOWN
Q3MS94  UNKNOWN
Q3MS87  UNKNOWN
Q3MS95  UNKNOWN
Q3MS92  UNKNOWN
Q3MS89  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
300300  BRUTON AGAMMAGLOBULINEMIA TYROSINE KINASE; BTK   AGAMMAGLOBULINEMIA TYROSINE KINASE; ATK B-CELL PROGENITOR KINASE; BPK

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0005515  protein binding
GO:0005524  ATP binding
GO:0005634  nucleus
GO:0005737  cytoplasm
GO:0006468  protein amino acid phosphorylation
GO:0007242  intracellular signaling cascade
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0007498  mesoderm development
GO:0008270  zinc ion binding
GO:0008624  induction of apoptosis by extracellular signals
GO:0016020  membrane
GO:0016301  kinase activity
GO:0016740  transferase activity
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0019722  calcium-mediated signaling
GO:0031410  cytoplasmic vesicle
GO:0042802  identical protein binding
GO:0045121  membrane raft
GO:0046872  metal ion binding
GO:0048469  cell maturation

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa05340  Primary immunodeficiency

Panther:
ID  Description
P00010  B cell activation

Chemicals
DrugBank:
ID  Name  Synonyms
DB03265  Inositol-(1,3,4,5)-Tetrakisphosphate  
DB01863  Inositol 1,3,4,5-Tetrakisphosphate  
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000010671 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187] Pan_troglodytesone2one ENSPTRG00000022104Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]BTK
Pongo_pygmaeusone2one ENSPPYG00000020552Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Macaca_mulattaone2one ENSMMUG00000019573Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Equus_caballusone2one ENSECAG00000020984Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]LOC100057626
Tarsius_syrichtaone2one ENSTSYG00000009216Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Otolemur_garnettiione2one ENSOGAG00000004545Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Myotis_lucifugusone2one ENSMLUG00000004336Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Tursiops_truncatusone2one ENSTTRG00000012776Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Felis_catusone2one ENSFCAG00000015395Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000001567Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Canis_familiarisone2one ENSCAFG00000017669Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]BTK
Microcebus_murinusone2one ENSMICG00000015601Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000010621Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Bos_taurusone2one ENSBTAG00000019250Bruton agammaglobulinemia tyrosine kinase [Source:RefSeq_peptide;Acc:NP_001029761][hgnc]BTK
Dasypus_novemcinctusone2one ENSDNOG00000015948Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000004722Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Cavia_porcellusone2one ENSCPOG00000000549Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Dipodomys_ordiione2one ENSDORG00000009983Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Kinase EMB) [Source:UniProtKB/Swiss-Prot;Acc:P35991][hgnc]
Echinops_telfairione2one ENSETEG00000008404Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Sorex_araneusone2one ENSSARG00000014162Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000015649Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Mus_musculusone2one ENSMUSG00000031264Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Kinase EMB) [Source:UniProtKB/Swiss-Prot;Acc:P35991][hgnc]Btk
Rattus_norvegicusone2one ENSRNOG00000011331Bruton agammaglobulinemia tyrosine kinase [Source:RefSeq_peptide;Acc:NP_001007799][hgnc]Btk
Monodelphis_domesticaone2one ENSMODG00000011651Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000004224Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]100080912
Gallus_gallusone2one ENSGALG00000004958Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase). [Source:UniProtKB/Swiss-Prot;Acc:Q8JH64][hgnc]BTK