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Summary sheet information for Effector 'E cadherin-Homo sapiens'
Name E cadherin-Homo sapiens
Description RecName: Full=Cadherin-1;AltName: Full=Epithelial cadherin; Short=E-cadherin;AltName: Full=Uvomorulin;AltName: Full=CAM 120/80;AltName: CD_antigen=CD324;Contains: RecName: Full=E-Cad/CTF1;Contains: RecName: Full=E-Cad/CTF2;Contains: RecName: Full=E-Cad/CTF3;Flags: Precursor
Class
Family Cadherins
Sub_family Cadherins
type E cadherin
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 16
Gene Start: 67328696
Gene End: 67426943
Ensembl Contig View

Ensembl Genes:
ENSG00000039068

EMBL:
EMBL ID  Description
AB025105  Homo sapiens mRNA for E-cadherin, complete cds.
AB025106  Homo sapiens mRNA for E-cadherin, complete cds.
AK290012  Homo sapiens cDNA FLJ78203 complete cds, highly similar to Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1), mRNA.
AK312551  Homo sapiens cDNA, FLJ92924, Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1),mRNA.
BC141838  Homo sapiens cadherin 1, type 1, E-cadherin (epithelial), mRNA (cDNA clone MGC:165111 IMAGE:40148986), complete cds.
BC146662  Homo sapiens cadherin 1, type 1, E-cadherin (epithelial), mRNA (cDNA clone MGC:164884 IMAGE:40148047), complete cds.
CH471092  Homo sapiens 211000035837073 genomic scaffold, whole genome shotgun sequence.
D49685  Homo sapiens gene for E-cadherin invasion-suppressor, partial cds.
DQ090940  Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1) gene, complete cds.
EU709494  Homo sapiens truncated E-cadherin (CDH1) mRNA, complete cds.
L08599  Human uvomorulin (E-cadherin) (UVO) mRNA, complete cds.
L34545  Human E-cadherin gene, promoter region and 5' end.
S72397  E-cadherin [human, Genomic, 248 nt, segment 1 of 3].
S72491  E-cadherin [human, Genomic, 315 nt, segment 2 of 3].
S72492  E-cadherin [human, Genomic, 153 nt, segment 3 of 3].
X12790  Human mRNA for uvomorulin (put. CAM 120/80)
X52279  H.sapiens mRNA for ARC-1/uvomorulin
Z13009  H.sapiens mRNA for E-cadherin
Z18923  H.sapiens mRNA for E-cadherin
Z35402  H.sapiens gene encoding E-cadherin, exon 3 and joined CDS
Z35403  H.sapiens gene encoding E-cadherin, exon 4
Z35404  H.sapiens gene encoding E-cadherin, exon 5
Z35405  H.sapiens gene encoding E-cadherin, exon 6
Z35406  H.sapiens gene encoding E-cadherin, exon 7
Z35407  H.sapiens gene encoding E-cadherin, exon 8
Z35408  H.sapiens gene encoding E-cadherin, exon 9
Z35409  H.sapiens gene encoding E-cadherin, exon 10
Z35410  H.sapiens gene encoding E-cadherin, exon 11
Z35411  H.sapiens gene encoding E-cadherin, exon 12
Z35412  H.sapiens gene encoding E-cadherin, exon 13
Z35413  H.sapiens gene encoding E-cadherin, exon 14
Z35414  H.sapiens gene encoding E-cadherin, exon 15
Z35415  H.sapiens gene encoding E-cadherin, exon 16

EntrezGene:
ID  Description
CDH1  cadherin 1, type 1, E-cadherin (epithelial)

RefSeq DNA:
ID  Description
NM_004360  Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1), mRNA.

UniGene:
ID  Description
Hs.461086  Uvomorulin (put. CAM 120/80)

Proteins
Ensembl Proteins:
ENSP00000368415; ENSP00000261769; ENSP00000268794

Entrez Proteins:
AAA21764.1; AAA61259.1; AAD14108.1; AAI41839.1; AAI46663.1; AAY68225.1; ACD87624.1; BAA08537.1; BAA88956.1; BAA88957.1; BAF82701.1; BAG35448.1; CAA31279.1; CAA36522.1; CAA78353.1; CAA79356.1; CAA84586.1; EAW83243.1; EAW83244.1

RefSeq Proteins:
ID  Description
NP_004351  cadherin 1, type 1 preproprotein [Homo sapiens].

UniProt:
ID  Description
A5D8W4  SubName: Full=CDH1 protein;
A8K1U7  SubName: Full=cDNA FLJ78203, highly similar to Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1), mRNA; SubName: Full=Cadherin 1, type 1, E-cadherin (Epithelial), isoform CRA_b; SubName: Full=cDNA, FLJ92924, Homo sapiens cadherin 1, type 1, E-cadherin (epithelial) (CDH1),mRNA;
B3GN61  SubName: Full=Truncated E-cadherin;
Q9UII7  SubName: Full=E-cadherin;
Q9UII8  SubName: Full=E-cadherin; SubName: Full=Cadherin 1, type 1, E-cadherin (Epithelial), isoform CRA_c;
P12830  RecName: Full=Epithelial cadherin; Short=E-cadherin; AltName: Full=Cadherin-1; AltName: Full=Uvomorulin; AltName: Full=CAM 120/80; AltName: CD_antigen=CD324; Contains: RecName: Full=E-Cad/CTF1; Contains: RecName: Full=E-Cad/CTF2; Contains: RecName: Full=E-Cad/CTF3; Flags: Precursor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     E cadherin-Homo sapiens    

InterPro:
ID  Name
IPR002126  Cadherin
IPR000233  Cadherin_C_term
IPR014868  Cadherin_pro

Pfam:
ID  Description
Cadherin  Cadherin domain
Cadherin  Cadherin domain
Cadherin_C  Cadherin cytoplasmic region
Cadherin_pro  Cadherin prodomain like

Structure
PDB:
ID
1O6S
2O72
2OMT
2OMU
2OMV
2OMX
2OMY
2OMZ
3FF7
3FF8

HSSP:
ID  Description
1edh  CELL ADHESION PROTEIN
1ff5  CELL ADHESION
1i7w  CELL ADHESION
1i7x  CELL ADHESION
1l3w  CELL ADHESION, METAL BINDING PROTEIN
1ncg  CELL ADHESION PROTEIN
1nch  CELL ADHESION PROTEIN
1nci  CELL ADHESION PROTEIN
1ncj  CELL ADHESION PROTEIN
1o6s  BACTERIAL INFECTION
1op4  CELL ADHESION
1q1p  CELL ADHESION
1q55  STRUCTURAL PROTEIN
1q5a  STRUCTURAL PROTEIN
1q5b  STRUCTURAL PROTEIN
1q5c  STRUCTURAL PROTEIN
1suh  CELL ADHESION
1zvn  ----
1zxk  CELL ADHESION
2a4c  CELL ADHESION
2a4e  CELL ADHESION
2a62  CELL ADHESION
2ee0  SIGNALING PROTEIN
2o72  CELL ADHESION, METAL BINDING PROTEIN
2omt  CELL INVASION/CELL ADHESION
2omu  CELL INVASION/CELL ADHESION
2omv  CELL INVASION/CELL ADHESION
2omw  CELL INVASION/CELL ADHESION
2omx  CELL INVASION/CELL ADHESION
2omy  CELL INVASION/CELL ADHESION
2omz  CELL INVASION/CELL ADHESION
2qvf  CELL ADHESION
2qvi  CELL ADHESION
2v37  CELL ADHESION
2yqg  CELL ADHESION

PSSH:
ID  Description
Q9UII7  UNKNOWN
Q9UII8  UNKNOWN
A5D8W4  UNKNOWN
P12830  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
192090  CADHERIN 1; CDH1   CADHERIN, EPITHELIAL E-CADHERIN; CDHE; ECAD UVOMORULIN; UVO CALCIUM-DEPENDENT ADHESION PROTEIN, EPITHELIAL LIVER CELL ADHESION MOLECULE; LCAM GASTRIC CANCER, FAMILIAL DIFFUSE, AND CLEFT LIP WITH OR WITHOUT CLEFT PALATE, INCLUDED BREAST CANCER, LOBULAR, INCLUDED

Gene Ontology
GO:
GO ID  Description
GO:0005509  calcium ion binding
GO:0005515  protein binding
GO:0005886  plasma membrane
GO:0005911  cell-cell junction
GO:0005912  adherens junction
GO:0005913  cell-cell adherens junction
GO:0007155  cell adhesion
GO:0007156  homophilic cell adhesion
GO:0008013  beta-catenin binding
GO:0015629  actin cytoskeleton
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0016323  basolateral plasma membrane
GO:0016328  lateral plasma membrane
GO:0016337  cell-cell adhesion
GO:0016563  transcription activator activity
GO:0019538  protein metabolic process
GO:0030054  cell junction
GO:0042993  positive regulation of transcription factor import into nucleus
GO:0043281  regulation of caspase activity
GO:0045177  apical part of cell
GO:0048471  perinuclear region of cytoplasm
GO:0050839  cell adhesion molecule binding
GO:0051260  protein homooligomerization

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04520  Adherens junction
hsa05219  Bladder cancer
hsa04514  Cell adhesion molecules (CAMs)
hsa05213  Endometrial cancer
hsa05218  Melanoma
hsa05130  Pathogenic Escherichia coli infection
hsa05200  Pathways in cancer
hsa05216  Thyroid cancer

Panther:
ID  Description
P00012  Cadherin signaling pathway
P00057  Wnt signaling pathway
P00004  Alzheimer disease-presenilin pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000039068 Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830] Pan_troglodytesone2one ENSPTRG00000008270Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]CDH1
Pongo_pygmaeusone2one ENSPPYG00000007494Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Macaca_mulattaone2one ENSMMUG00000011850Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Otolemur_garnettiione2one ENSOGAG00000009584Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Microcebus_murinusone2one ENSMICG00000009601Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Equus_caballusone2one ENSECAG00000021418Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]LOC100066844
Tupaia_belangerione2one ENSTBEG00000001373Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Felis_catusone2one ENSFCAG00000014019Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Vicugna_pacosone2one ENSVPAG00000001310Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000006068Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Loxodonta_africanaone2one ENSLAFG00000016667Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000015968Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Tursiops_truncatusone2one ENSTTRG00000015988Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000014570Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Cavia_porcellusone2one ENSCPOG00000012100Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Canis_familiarisone2one ENSCAFG00000020305E-cadherin (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q95LE0][hgnc]
Bos_taurusone2one ENSBTAG00000015991Epithelial cadherin precursor (E-cadherin) (Cadherin-1) (CD324 antigen) [Contains: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]. [Source:UniProtKB/Swiss-Prot;Acc:Q6R8F2][hgnc]CDH1
Myotis_lucifugusone2one ENSMLUG00000006492Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Procavia_capensisone2one ENSPCAG00000001549Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Dipodomys_ordiione2one ENSDORG00000002066Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (ARC-1) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P09803][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000004006Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Echinops_telfairione2one ENSETEG00000018149Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Mus_musculusone2one ENSMUSG00000000303Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (ARC-1) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P09803][hgnc]Cdh1
Rattus_norvegicusone2one ENSRNOG00000020151Epithelial cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1) (CD324 antigen) [Contains: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]. [Source:UniProtKB/Swiss-Prot;Acc:Q9R0T4][hgnc]Cdh1
Oryctolagus_cuniculusone2one ENSOCUG00000008805Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Ochotona_princepsone2one ENSOPRG00000012827Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Sorex_araneusone2one ENSSARG00000007439Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Monodelphis_domesticaone2one ENSMODG00000003256Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000002356Epithelial cadherin (E-cadherin) (Cadherin-1) (Uvomorulin) (CAM 120/80) (CD324 antigen)[E-Cad/CTF1][E-Cad/CTF2] [Source:UniProtKB/Swiss-Prot;Acc:P12830][hgnc]
Gallus_gallusone2one ENSGALG00000000608Epithelial-cadherin precursor (E-cadherin) (Cadherin-1) (Liver cell adhesion molecule) (L-CAM). [Source:UniProtKB/Swiss-Prot;Acc:P08641][hgnc]CDH1
Xenopus_tropicalismany2many ENSXETG00000025992[hgnc]
Xenopus_tropicalismany2many ENSXETG00000016379[hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000002297Cadherin-3 Precursor (Placental cadherin) (P-cadherin) [Source:UniProtKB/Swiss-Prot;Acc:P22223][hgnc]
Danio_reriomany2many ENSDARG00000035796[hgnc]LOC567602
Danio_reriomany2many ENSDARG00000068137Novel protein similar to E-cadherin (Cdh1) (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q7ZYY8][hgnc]LOC791686
Takifugu_rubripesmany2many ENSTRUG00000002439[hgnc]
Danio_reriomany2many ENSDARG00000068142hypothetical LOC568483 (LOC568483), mRNA [Source:RefSeq_dna;Acc:XR_029421][hgnc]LOC100008524
Danio_reriomany2many ENSDARG00000024371cadherin 1, epithelial [Source:RefSeq_peptide;Acc:NP_571895][hgnc]cdh1
Takifugu_rubripesmany2many ENSTRUG00000004713[hgnc]
Takifugu_rubripesmany2many ENSTRUG00000002491[hgnc]
Tetraodon_nigroviridismany2many ENSTNIG00000003590[hgnc]
Tetraodon_nigroviridismany2many ENSTNIG00000003591[hgnc]
Tetraodon_nigroviridismany2many ENSTNIG00000005512[hgnc]
Oryzias_latipesmany2many ENSORLG00000020326[hgnc]
Oryzias_latipesmany2many ENSORLG00000020295[hgnc]
Oryzias_latipesmany2many ENSORLG00000020315[hgnc]