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Summary sheet information for Effector 'Ras specific nucleotide exchange factor CDC25-Homo sapiens'
Name Ras specific nucleotide exchange factor CDC25-Homo sapiens
Description RecName: Full=Ras-specific guanine nucleotide-releasing factor 1; Short=Ras-GRF1; Short=Guanine nucleotide-releasing factor 1; Short=Guanine nucleotide-releasing protein;AltName: Full=Ras-specific nucleotide exchange factor CDC25
Class
Family Guanine nucleotide releasing factors
Sub_family Ras specific nucleotide releasing factors
type Ras specific nucleotide exchange factor CDC25
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 15
Gene Start: 77041341
Gene End: 77169895
Ensembl Contig View

Ensembl Genes:
ENSG00000058335

EMBL:
EMBL ID  Description
AK290135  Homo sapiens cDNA FLJ77032 partial cds, highly similar to Homo sapiens Ras protein-specific guanine nucleotide-releasing factor 1 (RASGRF1), transcript variant 1, mRNA.
BC040275  Homo sapiens Ras protein-specific guanine nucleotide-releasing factor 1, mRNA (cDNA clone MGC:35460 IMAGE:5192914), complete cds.
CH471136  Homo sapiens 211000035841687 genomic scaffold, whole genome shotgun sequence.
L26584  Human (CDC25) mRNA, complete cds.
M91815  Human (cdc25) mRNA.
S62035  Ras-specific guanine nucleotide-releasing factor=CDC25 homolog [human, brain stem, mRNA, 2861 nt].

EntrezGene:
ID  Description
RASGRF1  Ras protein-specific guanine nucleotide-releasing factor 1

RefSeq DNA:
ID  Description
NM_002891  Homo sapiens Ras protein-specific guanine nucleotide-releasing factor 1 (RASGRF1), transcript variant 1, mRNA.
NM_153815  Homo sapiens Ras protein-specific guanine nucleotide-releasing factor 1 (RASGRF1), transcript variant 2, mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000378224; ENSP00000378228; ENSP00000261752

Entrez Proteins:
AAA58417.1; AAB26881.1; AAH40275.1; BAF82824.1; EAW99142.1

RefSeq Proteins:
ID  Description
NP_002882  Ras protein-specific guanine nucleotide-releasing factor 1 isoform 1 [Homo sapiens].
NP_722522  Ras protein-specific guanine nucleotide-releasing factor 1 isoform 2 [Homo sapiens].

UniProt:
ID  Description
Q13972-2  UNKNOWN
A8K270  SubName: Full=cDNA FLJ77032, highly similar to Homo sapiens Ras protein-specific guanine nucleotide-releasing factor 1 (RASGRF1), transcript variant 1, mRNA; Flags: Fragment;
Q8IUU5  SubName: Full=RASGRF1 protein; SubName: Full=Ras protein-specific guanine nucleotide-releasing factor 1, isoform CRA_b;
Q13972  RecName: Full=Ras-specific guanine nucleotide-releasing factor 1; Short=Ras-GRF1; Short=Guanine nucleotide-releasing factor 1; Short=Guanine nucleotide-releasing protein; AltName: Full=Ras-specific nucleotide exchange factor CDC25;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Ras specific nucleotide exchange factor CDC25-Homo sapiens    

InterPro:
ID  Name
IPR001895  RasGRF_CDC25
IPR000651  RasGef_N
IPR011993  PH_type
IPR000048  IQ_CaM_bd_region
IPR001849  Pleckstrin_homology
IPR001331  GDS_CDC24_CS
IPR008937  Ras_GEF
IPR000219  DH-domain

Pfam:
ID  Description
PH  PH domain
IQ  IQ calmodulin-binding motif
RasGEF  RasGEF domain
RasGEF_N  Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
RhoGEF  RhoGEF domain

Structure
PDB:
ID

HSSP:
ID  Description
1fao  SIGNALING PROTEIN
1fhw  SIGNALING PROTEIN
1u2b  LIPID BINDING PROTEIN
1xdv  SIGNALING PROTEIN
2d9x  LIPID TRANSPORT
2ije  SIGNALING PROTEIN

PSSH:
ID  Description
Q8IUU5  UNKNOWN
Q13972  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
606600  RAS PROTEIN-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; RASGRF1   GUANINE NUCLEOTIDE-RELEASING FACTOR, 55-KD; GRF55

Gene Ontology
GO:
GO ID  Description
GO:0005085  guanyl-nucleotide exchange factor activity
GO:0005089  Rho guanyl-nucleotide exchange factor activity
GO:0005515  protein binding
GO:0005622  intracellular
GO:0005829  cytosol
GO:0005886  plasma membrane
GO:0007242  intracellular signaling cascade
GO:0007264  small GTPase mediated signal transduction
GO:0007616  long-term memory
GO:0008283  cell proliferation
GO:0019717  synaptosome
GO:0030426  growth cone
GO:0031175  neurite development
GO:0032320  positive regulation of Ras GTPase activity
GO:0032863  activation of Rac GTPase activity
GO:0035020  regulation of Rac protein signal transduction
GO:0035023  regulation of Rho protein signal transduction
GO:0035254  glutamate receptor binding
GO:0048168  regulation of neuronal synaptic plasticity
GO:0051056  regulation of small GTPase mediated signal transduction

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04510  Focal adhesion
hsa04010  MAPK signaling pathway

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000058335 Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972] Pan_troglodytesone2one ENSPTRG00000007353Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]RASGRF1
Pongo_pygmaeusone2one ENSPPYG00000006705Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Macaca_mulattaone2one ENSMMUG00000022299Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000014265Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Otolemur_garnettiione2one ENSOGAG00000013664Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Equus_caballusone2one ENSECAG00000013967Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]LOC100050202
Tursiops_truncatusone2one ENSTTRG00000016608Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000008644Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Loxodonta_africanaone2one ENSLAFG00000012659Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000012626Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Bos_taurusone2one ENSBTAG00000019940Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Procavia_capensisone2one ENSPCAG00000010358Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Canis_familiarisone2one ENSCAFG00000014053Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Felis_catusone2one ENSFCAG00000012199Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Echinops_telfairione2one ENSETEG00000011873Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000002109Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Cavia_porcellusone2one ENSCPOG00000005363Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Ochotona_princepsone2one ENSOPRG00000004889Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Dipodomys_ordiione2one ENSDORG00000008781Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm) [Source:UniProtKB/Swiss-Prot;Acc:P27671][hgnc]
Sorex_araneusone2one ENSSARG00000007425Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000002238Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]100084214
Mus_musculusone2one ENSMUSG00000032356Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm) [Source:UniProtKB/Swiss-Prot;Acc:P27671][hgnc]Rasgrf1
Rattus_norvegicusone2one ENSRNOG00000014025Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (P140 Ras-GRF). [Source:UniProtKB/Swiss-Prot;Acc:P28818][hgnc]
Monodelphis_domesticaone2one ENSMODG00000019438Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Gallus_gallusone2one ENSGALG00000008262Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000016457Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000010861Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Oryzias_latipesone2many ENSORLG00000008149Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Oryzias_latipesone2many ENSORLG00000012565Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000019244Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Takifugu_rubripesone2one ENSTRUG00000005281Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000011363Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Xenopus_tropicalisone2one ENSXETG00000007848Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing factor 1) (Guanine nucleotide-releasing protein) (Ras-specific nucleotide exchange factor CDC25) [Source:UniProtKB/Swiss-Prot;Acc:Q13972][hgnc]
Anopheles_gambiaeone2many AGAP001238[hgnc]AgaP_ENSANGG00000024049
Aedes_aegyptimany2many AAEL011226ras GTP exchange factor[hgnc]
Aedes_aegyptimany2many AAEL011225conserved hypothetical protein[hgnc]