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Summary sheet information for GPCR 'LYSOPHOSPHOLIPID RECEPTORS_LPA2_Homo sapiens'
Name LYSOPHOSPHOLIPID RECEPTORS_LPA2_Homo sapiens
Description RecName: Full=Lysophosphatidic acid receptor 2; Short=LPA receptor 2; Short=LPA-2;AltName: Full=Lysophosphatidic acid receptor Edg-4
Class CLASS A
Family LYSOPHOSPHOLIPID RECEPTORS
Sub_family LPA2
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 19
Gene Start: 19595477
Gene End: 19600018
Ensembl Contig View

Ensembl Genes:
ENSG00000064547

EMBL:
EMBL ID  Description
AC002306  Homo sapiens DNA from chromosome 19-cosmid R33799, genomic sequence, complete sequence.
AF011466  Homo sapiens G protein-coupled receptor Edg-4 mRNA, complete cds.
AF197929  Homo sapiens short form lysophosphatidic acid receptor EDG4 (EDG4) mRNA, complete cds.
AF233092  Homo sapiens lysophosphatidic acid G protein-coupled receptor 4 (EDG4) mRNA, complete cds.
AK316573  Homo sapiens cDNA, FLJ93869, highly similar to Homo sapiens endothelial differentiation, lysophosphatidic acidG-protein-coupled receptor, 4 (EDG4), mRNA.
AY322548  Homo sapiens endothelial differentiation G-protein-coupled receptor 4 mRNA, complete cds.
BC025695  Homo sapiens lysophosphatidic acid receptor 2, mRNA (cDNA clone MGC:34227 IMAGE:5209267), complete cds.

EntrezGene:
ID  Description
LPAR2  lysophosphatidic acid receptor 2

RefSeq DNA:
ID  Description
NM_004720  Homo sapiens lysophosphatidic acid receptor 2 (LPAR2), mRNA.

UniGene:
ID  Description
Hs.122575  G protein-coupled receptor Edg-4

Proteins
Ensembl Proteins:
ENSP00000384665; ENSP00000351659

Entrez Proteins:
AAB61528.1; AAC27728.1; AAF43409.1; AAG28521.1; AAH25695.1; AAP84361.1; BAG38162.1

RefSeq Proteins:
ID  Description
NP_004711  lysophosphatidic acid receptor 2 [Homo sapiens].

UniProt:
ID  Description
B2RE65  SubName: Full=cDNA, FLJ93869, highly similar to Homo sapiens endothelial differentiation, lysophosphatidic acidG-protein-coupled receptor, 4 (EDG4), mRNA;
Q9HBW0  RecName: Full=Lysophosphatidic acid receptor 2; Short=LPA receptor 2; Short=LPA-2; AltName: Full=Lysophosphatidic acid receptor Edg-4;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR000276  GPCR_Rhodpsn
IPR017452  GPCR_Rhodpsn_supfam
IPR004065  LPA_rcpt
IPR004066  LPA_rcpt_EDG4

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID

HSSP:
ID  Description

PSSH:
ID  Description

Diseases
OMIM:
OMIM ID  Name  Alt Name
605110  LYSOPHOSPHATIDIC ACID RECEPTOR 2; LPAR2   LPA2 ENDOTHELIAL DIFFERENTIATION GENE 4; EDG4 LYSOPHOSPHATIDIC ACID RECEPTOR EDG4 LPA RECEPTOR EDG4

Gene Ontology
GO:
GO ID  Description
GO:0001584  rhodopsin-like receptor activity
GO:0001619  lysosphingolipid and lysophosphatidic acid receptor activity
GO:0004872  receptor activity
GO:0004930  G-protein coupled receptor activity
GO:0004949  cannabinoid receptor activity
GO:0004977  melanocortin receptor activity
GO:0005515  protein binding
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007202  activation of phospholipase C activity
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0008289  lipid binding
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0030274  LIM domain binding

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04080  Neuroactive ligand-receptor interaction

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB07854   LPA(18:0/0:0)   Not Available
HMDB07852   LPA(0:0/18:2(9Z,12Z))   Not Available
HMDB07851   LPA(0:0/18:1(9Z))   Not Available
HMDB07849   LPA(0:0/16:0)   Not Available
HMDB07856   LPA(18:2(9Z,12Z)/0:0)   Not Available
HMDB07853   LPA(16:0/0:0)   Not Available
HMDB07855   LPA(18:1(9Z)/0:0)   Not Available
HMDB00443   1-Oleoyl-lysophosphatidic acid   1-Oleoyl-lyso-phosphatidate; 1-Oleoyl-lyso-phosphatidic acid; 1-Oleoyl-lysophosphatidate; 1-Oleoyl-lysophosphatidic acid; 1-Oleyllysophosphatidate; 1-Oleyllysophosphatidic acid; Monooleylphosphatidate; Monooleylphosphatidic acid; Oleoyl lysophosphatidate; Oleoyl lysophosphatidic acid
HMDB00327   1-Palmitoyl lysophosphatidic acid   1-Palmitoyl lysophosphatidate; 1-Palmitoyl lysophosphatidic acid; 1-Palmitoylglycerol 3-phosphate; 1-Palmitoyllysophosphatidate; 1-Palmitoyllysophosphatidic acid
HMDB07850   LPA(0:0/18:0)   Not Available
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000064547 Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0] Pan_troglodytesone2one ENSPTRG00000010745Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]LPAR2
Pongo_pygmaeusone2one ENSPPYG00000009774Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Macaca_mulattaone2one ENSMMUG00000000654Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Microcebus_murinusone2one ENSMICG00000005943Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Canis_familiarisone2one ENSCAFG00000014181Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]EDG4
Felis_catusone2one ENSFCAG00000014538Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Loxodonta_africanaone2one ENSLAFG00000008384Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Tursiops_truncatusone2one ENSTTRG00000009889Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Echinops_telfairione2one ENSETEG00000005309Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000017460Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Tupaia_belangerione2one ENSTBEG00000000014Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Equus_caballusone2one ENSECAG00000009148Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]LOC100071198
Procavia_capensisone2one ENSPCAG00000012025Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Bos_taurusone2one ENSBTAG00000004652Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]LPAR2
Cavia_porcellusone2one ENSCPOG00000012652Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Myotis_lucifugusone2one ENSMLUG00000007886Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Rattus_norvegicusone2one ENSRNOG00000010758pre-B-cell leukemia transcription factor 4 [Source:RefSeq_peptide;Acc:NP_001102579][hgnc]Pbx4_predicted
Mus_musculusone2one ENSMUSG00000031861Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9JL06][hgnc]Lpar2
Oryctolagus_cuniculusone2one ENSOCUG00000012408Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Ochotona_princepsone2one ENSOPRG00000002006Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Sorex_araneusone2one ENSSARG00000000375Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Monodelphis_domesticaone2one ENSMODG00000004466Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Gallus_gallusone2one ENSGALG00000013417Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]LOC426086
Xenopus_tropicalisone2one ENSXETG00000020627Lysophosphatidic acid receptor 2. [Source:UniProtKB/TrEMBL;Acc:Q68PF6][hgnc]
Danio_rerioone2many ENSDARG00000042561hypothetical protein LOC567956 [Source:RefSeq_peptide;Acc:NP_001032783][hgnc]zgc:123246
Gasterosteus_aculeatusone2many ENSGACG00000019874Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000003514Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Takifugu_rubripesone2many ENSTRUG00000015976Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000010121Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Danio_rerioone2many ENSDARG00000042338hypothetical protein LOC445184 [Source:RefSeq_peptide;Acc:NP_001003578][hgnc]zgc:101053
Oryzias_latipesone2many ENSORLG00000010296Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Oryzias_latipesone2many ENSORLG00000006496Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000004329Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]
Takifugu_rubripesone2many ENSTRUG00000014744Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) [Source:UniProtKB/Swiss-Prot;Acc:Q9HBW0][hgnc]