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Summary sheet information for Effector 'Cdc42-Homo sapiens'
Name Cdc42-Homo sapiens
Description RecName: Full=Cell division control protein 42 homolog;AltName: Full=G25K GTP-binding protein;Flags: Precursor
Class
Family Small GTP-binding proteins
Sub_family Rho small GTPases
type Cdc42
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 1
Gene Start: 22235157
Gene End: 22292024
Ensembl Contig View

Ensembl Genes:
ENSG00000070831

EMBL:
EMBL ID  Description
AF498962  Homo sapiens small GTP binding protein CDC42 (CDC42) mRNA, complete cds.
AF498963  Homo sapiens small GTP binding protein CDC42 placental isoform (CDC42) mRNA, complete cds.
AL031281  Human DNA sequence from clone RP1-224A6 on chromosome 1p35.1-36.23 Contains the 3' UTR of the ELA3A gene for elastase 3A (pancreatic (protease E)), three novel genes, the CDC42 gene for cell division cycle 42 (GTP binding protein, 25kDa), the 3' end of the WNT4 gene for wingless-type MMTV integration site family (member 4) and a CpG island.
AL121734  Isoform of human GTP-binding protein G25K
AL121735  Isoform of human GTP-binding protein G25K
AL121736  Isoform of human GTP-binding protein G25K
AL121737  Isoform of human GTP-binding protein G25K
AY673602  Homo sapiens cell division cycle 42 (GTP binding protein, 25kDa) (CDC42) gene, complete cds.
BC002711  Homo sapiens cell division cycle 42 (GTP binding protein, 25kDa), mRNA (cDNA clone MGC:3497 IMAGE:3626647), complete cds.
BC003682  Homo sapiens cell division cycle 42 (GTP binding protein, 25kDa), mRNA (cDNA clone MGC:5044 IMAGE:3457085), complete cds.
BC018266  Homo sapiens cell division cycle 42 (GTP binding protein, 25kDa), mRNA (cDNA clone MGC:17253 IMAGE:3449526), complete cds.
M35543  Human GTP-binding protein (G25K) mRNA, complete cds.
M57298  Human GTP-binding protein G25K mRNA, complete cds.

EntrezGene:
ID  Description
641992  similar to cell division cycle 42
CDC42P2  cell division cycle 42 pseudogene 2
CDC42  cell division cycle 42 (GTP binding protein, 25kDa)

RefSeq DNA:
ID  Description
NM_001039802  Homo sapiens cell division cycle 42 (GTP binding protein, 25kDa) (CDC42), transcript variant 3, mRNA.
NM_001791  Homo sapiens cell division cycle 42 (GTP binding protein, 25kDa) (CDC42), transcript variant 1, mRNA.
NM_044472  Homo sapiens cell division cycle 42 (GTP binding protein, 25kDa) (CDC42), transcript variant 2, mRNA.
XM_001717940  PREDICTED: Homo sapiens similar to hCG1985303 (LOC643336), mRNA.
XM_001718563  PREDICTED: Homo sapiens similar to hCG1985303 (LOC643336), mRNA.
XM_001719976  PREDICTED: Homo sapiens similar to hCG1985303 (LOC643336), mRNA.
XM_001726350  PREDICTED: Homo sapiens similar to hCG1985303 (LOC641992), mRNA.
XR_036850  PREDICTED: Homo sapiens misc_RNA (LOC100128627), miscRNA.
XR_037070  PREDICTED: Homo sapiens misc_RNA (LOC100128627), miscRNA.
XR_038463  PREDICTED: Homo sapiens misc_RNA (LOC100128627), miscRNA.

UniGene:
ID  Description
Hs.631528  UNKNOWN
Hs.690198  Isoform of human GTP-binding protein G25K
Hs.712160  Transcribed locus, moderately similar to NP_033991.1 cell division cycle 42 [Mus musculus]

Proteins
Ensembl Proteins:
ENSP00000314458; ENSP00000341072; ENSP00000383118; ENSP00000337669

Entrez Proteins:
AAA52494.1; AAA52592.1; AAH02711.1; AAH03682.1; AAH18266.1; AAM21109.1; AAM21110.1; AAT70721.1; CAB52602.1; CAB57325.1; CAB57326.1; CAB57327.1; CAB57328.1; CAD92551.1; CAI19851.1

RefSeq Proteins:
ID  Description
NP_001034891  cell division cycle 42 isoform 1 [Homo sapiens].
NP_001782  cell division cycle 42 isoform 1 [Homo sapiens].
NP_426359  cell division cycle 42 isoform 2 [Homo sapiens].
XP_001717992  PREDICTED: similar to hCG1985303 [Homo sapiens].
XP_001718615  PREDICTED: similar to hCG1985303 [Homo sapiens].
XP_001720028  PREDICTED: similar to hCG1985303 [Homo sapiens].
XP_001726402  PREDICTED: similar to hCG1985303 [Homo sapiens].

UniProt:
ID  Description
P60953-2  UNKNOWN
Q5JYX0  SubName: Full=Cell division cycle 42 (GTP binding protein, 25kDa); Flags: Fragment;
Q9UJM0  SubName: Full=Putative uncharacterized protein; Flags: Fragment;
Q9UJM1  SubName: Full=Putative uncharacterized protein; Flags: Fragment;
P60953  RecName: Full=Cell division control protein 42 homolog; AltName: Full=G25K GTP-binding protein; Flags: Precursor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Cdc42-Homo sapiens    

InterPro:
ID  Name
IPR005225  Small_GTP_bd
IPR013753  Ras
IPR003578  GTPase_Rho
IPR001806  Ras_trnsfrmng

Pfam:
ID  Description
Ras  Ras family

Structure
PDB:
ID
1A4R
1AJE
1AM4
1AN0
1CEE
1CF4
1DOA
1E0A
1EES
1GRN
1GZS
1KI1
1KZ7
1KZG
1NF3
2ASE
2DFK
2NGR
2ODB
2QRZ
2WM9
2WMN
2WMO
3GCG

HSSP:
ID  Description
1a2b  ONCOGENE PROTEIN
1a4r  HYDROLASE
1aje  G-PROTEIN
1am4  COMPLEX (GTPASE-ACTIVATING/GTP-BINDING)
1an0  GTPASE
1cc0  SIGNALING PROTEIN
1cee  STRUCTURAL PROTEIN REGULATION
1cf4  TRANSFERASE
1cxz  SIGNALING PROTEIN
1doa  CELL CYCLE
1dpf  GENE REGULATION/SIGNALING PROTEIN
1ds6  SIGNALING PROTEIN
1e0a  SIGNALLING PROTEIN
1e96  SIGNALLING COMPLEX
1ees  STRUCTURAL PROTEIN
1foe  SIGNALING PROTEIN, IMMUNE SYSTEM/SIGNALI
1ftn  PROTO-ONCOGENE
1g4u  SIGNALING PROTEIN
1grn  GENE REGULATION
1gwn  GTPASE
1gzs  COMPLEX (TOXIN/CELL CYCLE PROTEIN)
1he1  SIGNALLING COMPLEX
1hh4  SINGAL PROTEIN INHIBITOR COMPLEX
1i4d  SIGNALING PROTEIN
1i4l  SIGNALING PROTEIN
1i4t  SIGNALING PROTEIN
1ki1  SIGNALING PROTEIN
1kmq  SIGNALING PROTEIN
1kz7  SIGNALING PROTEIN
1kzg  SIGNALING PROTEIN
1lb1  SIGNALING PROTEIN
1m7b  SIGNALING PROTEIN
1mh1  GTP-BINDING
1nf3  SIGNALING PROTEIN
1ow3  GENE REGULATION/SIGNALING PROTEIN
1ryf  HYDROLASE
1ryh  HYDROLASE
1s1c  SIGNALING PROTEIN
1tx4  COMPLEX(GTPASE ACTIVATN/PROTO-ONCOGENE)
1x86  SIGNALING PROTEIN/MEMBRANE PROTEIN
1xcg  SIGNALING PROTEIN ACTIVATOR/SIGNALING PR
1z2c  SIGNALING PROTEIN
2ase  SIGNALING PROTEIN
2atx  HYDROLASE
2c2h  SIGNALING PROTEIN
2cls  NUCLEOTIDE BINDING PROTEIN
2dfk  CELL CYCLE
2fju  SIGNALING PROTEIN,APOPTOSIS/HYDROLASE
2fv8  SIGNALING PROTEIN
2g0n  SIGNALING PROTEIN
2gcn  SIGNALING PROTEIN
2gco  SIGNALING PROTEIN
2gcp  SIGNALING PROTEIN
2h7v  SIGNALING PROTEIN
2ic5  SIGNALING PROTEIN
2j0v  NUCLEOTIDE-BINDING PROTEIN
2j1l  HYDROLASE
2ngr  HYDROLASE
2nty  SIGNALING PROTEIN
2nz8  SIGNALING PROTEIN,CELL CYCLE
2odb  PROTEIN BINDING
2ov2  PROTEIN BINDING/TRANSFERASE
2p2l  UNKNOWN FUNCTION
2q3h  STRUCTURAL GENOMICS
2qme  SIGNALING PROTEIN/TRANSFERASE
2qrz  CELL CYCLE
2rex  SIGNALING PROTEIN/LIPOPROTEIN
2rgn  SIGNALING PROTEIN COMPLEX
2rmk  MEMBRANE PROTEIN/TRANSFERASE
2v55  TRANSFERASE
2vrw  SIGNALING PROTEIN
3bji  SIGNALING PROTEIN
3bwd  PLANT PROTEIN
3eg5  SIGNALING PROTEIN

PSSH:
ID  Description
Q5JYX0  UNKNOWN
Q9UJM0  UNKNOWN
Q9UJM1  UNKNOWN
P60953  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
116952  CELL DIVISION CYCLE 42; CDC42   GTP-BINDING PROTEIN, 25-KD; G25K

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005515  protein binding
GO:0005525  GTP binding
GO:0005622  intracellular
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005886  plasma membrane
GO:0006813  potassium ion transport
GO:0006886  intracellular protein transport
GO:0006913  nucleocytoplasmic transport
GO:0007097  nuclear migration
GO:0007163  establishment or maintenance of cell polarity
GO:0007165  signal transduction
GO:0007264  small GTPase mediated signal transduction
GO:0008324  cation transmembrane transporter activity
GO:0015031  protein transport
GO:0030036  actin cytoskeleton organization
GO:0030175  filopodium
GO:0030225  macrophage differentiation
GO:0030742  GTP-dependent protein binding
GO:0031274  positive regulation of pseudopodium formation
GO:0031333  negative regulation of protein complex assembly
GO:0042995  cell projection
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0046847  filopodium formation
GO:0051301  cell division

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04520  Adherens junction
hsa04360  Axon guidance
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa04666  Fc gamma R-mediated phagocytosis
hsa04510  Focal adhesion
hsa04912  GnRH signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04010  MAPK signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa05212  Pancreatic cancer
hsa05130  Pathogenic Escherichia coli infection
hsa05200  Pathways in cancer
hsa04810  Regulation of actin cytoskeleton
hsa05211  Renal cell carcinoma
hsa04660  T cell receptor signaling pathway
hsa04530  Tight junction
hsa04370  VEGF signaling pathway

Panther:
ID  Description
P05918  p38 MAPK pathway
P00008  Axon guidance mediated by Slit/Robo
P00053  T cell activation
P00031  Inflammation mediated by chemokine and cytokine signaling pathway
P04393  Ras Pathway
P00034  Integrin signalling pathway
P00009  Axon guidance mediated by netrin
P00016  Cytoskeletal regulation by Rho GTPase

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000070831 Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953] Equus_caballusone2one ENSECAG00000019180Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]LOC100058188
Tarsius_syrichtaone2one ENSTSYG00000000679Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Vicugna_pacosone2one ENSVPAG00000006919Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000004685Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Canis_familiarisone2one ENSCAFG00000014707Cell division control protein 42 homolog precursor (G25K GTP-binding protein). [Source:UniProtKB/Swiss-Prot;Acc:P60952][hgnc]LOC611052
Dipodomys_ordiione2one ENSDORG00000010374Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60766][hgnc]
Pan_troglodytesapprent_one2one ENSPTRG00000024145PREDICTED: Pan troglodytes similar to cell division cycle 42 (LOC742400), mRNA. [Source:RefSeq_dna;Acc:XR_021615][hgnc]CDC42
Pongo_pygmaeusapprent_one2one ENSPPYG00000001755Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Tupaia_belangeriapprent_one2one ENSTBEG00000002614Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Felis_catusapprent_one2one ENSFCAG00000004853Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Oryctolagus_cuniculusapprent_one2one ENSOCUG00000009986Small GTP binding protein CDC42 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q5U814][hgnc]
Ochotona_princepsapprent_one2one ENSOPRG00000005331Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Mus_musculusapprent_one2one ENSMUSG00000006699Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60766][hgnc]Cdc42
Spermophilus_tridecemlineatusapprent_one2one ENSSTOG00000000805Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Rattus_norvegicusapprent_one2one ENSRNOG00000013536Cell division control protein 42 homolog precursor. [Source:UniProtKB/Swiss-Prot;Acc:Q8CFN2][hgnc]Cdc42
Procavia_capensisapprent_one2one ENSPCAG00000011442Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Tursiops_truncatusapprent_one2one ENSTTRG00000005708Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Loxodonta_africanaapprent_one2one ENSLAFG00000005817Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Gallus_gallusapprent_one2one ENSGALG00000004796Cell division control protein 42 homolog precursor (G25K GTP-binding protein). [Source:UniProtKB/Swiss-Prot;Acc:Q90694][hgnc]CDC42
Bos_taurusapprent_one2one ENSBTAG00000001700Bos taurus similar to cell division cycle 42 (MGC128612), mRNA. [Source:RefSeq_dna;Acc:NM_001046332][hgnc]CDC42
Xenopus_tropicalisapprent_one2one ENSXETG00000004743Cdc42-prov protein. [Source:UniProtKB/TrEMBL;Acc:Q66JI0][hgnc]
Danio_rerioone2one ENSDARG00000042240cell division cycle 42 [Source:RefSeq_peptide;Acc:NP_001018130][hgnc]cdc42
Ornithorhynchus_anatinusapprent_one2one ENSOANG00000010284Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000007372Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000010913Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Oryzias_latipesapprent_one2one ENSORLG00000012048Cell division control protein 42 homolog Precursor (G25K GTP-binding protein) [Source:UniProtKB/Swiss-Prot;Acc:P60953][hgnc]
Ciona_intestinalisone2many ENSCING00000000822cell division cycle 42 [Source:RefSeq_peptide;Acc:NP_001027691][hgnc]445701
Ciona_intestinalisone2many ENSCING00000016916[hgnc]
Ciona_savignyione2one ENSCSAVG00000011760CsCDC42. [Source:UniProtKB/TrEMBL;Acc:O61287][hgnc]
Caenorhabditis_elegansone2one R07G3.1cdc-42 encodes a RHO GTPase which controls polarity of both individual cells and developing embryos by regulating the localization of PAR proteins. CDC-42 is expressed at hypodermal cell boundaries. cdc-42 expression levels are unusually stable, with relatively little variation between adults, dauers, and L3 larvae, or between wild-type and daf-2(e1370ts) or daf-16(m26) mutant adults. [Source: WormBase][hgnc]cdc-42
Aedes_aegyptione2one AAEL008543rac GTPase[hgnc]
Drosophila_melanogasterone2one FBgn0010341[hgnc]Cdc42
Anopheles_gambiaeone2one AGAP002440CDC42 homolog precursor (25 kDa GTP-binding protein). [Source:UniProtKB/Swiss-Prot;Acc:Q17031][hgnc]AgaP_ENSANGG00000020872
Saccharomyces_cerevisiaeone2one YLR229CCell division control protein 42 precursor (Suppressor of RHO3 protein 2). [Source:UniProtKB/Swiss-Prot;Acc:P19073][hgnc]CDC42