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Summary sheet information for Effector 'Tubulin-Homo sapiens-4'
Name Tubulin-Homo sapiens-4
Description RecName: Full=Tubulin alpha-3C/D chain;AltName: Full=Alpha-tubulin 3C/D;AltName: Full=Tubulin alpha-2 chain;AltName: Full=Alpha-tubulin 2
Class
Family Tubulins
Sub_family Tubulins
type Tubulin
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 2
Gene Start: 131950136
Gene End: 131956975
Ensembl Contig View

Ensembl Genes:
ENSG00000075886

EMBL:
EMBL ID  Description
AF005392  Homo sapiens alpha tubulin (TUBA2) gene, partial cds.
AK292253  Homo sapiens cDNA FLJ77591 complete cds, highly similar to Homo sapiens tubulin, alpha 2 (TUBA2), transcript variant 1, mRNA.
AL139327  Human DNA sequence from clone RP11-408E5 on chromosome 13q11-12.2 Contains an FSH primary respone homolog 1 (FSHPRH1) pseudogene, a paraspeckle protein 1 alpha pseudogene,a novel gene, the TUBA2 gene for tubulin alpha 2, two novel pseudogenes and a gene for a novel protein similar to DMPK-like CDC42-binding protein kinase beta (CDC42BPB).
BC011721  Homo sapiens tubulin, alpha 3c, mRNA (cDNA clone MGC:19829 IMAGE:4025942), complete cds.
BC057810  Homo sapiens tubulin, alpha 3d, mRNA (cDNA clone MGC:71736 IMAGE:5268074), complete cds.
CH471075  Homo sapiens 211000035844449 genomic scaffold, whole genome shotgun sequence.
DQ422808  Homo sapiens tubulin, alpha 2 (TUBA2) gene, complete cds.
K03460  Human alpha-tubulin isotype H2-alpha gene, last exon.
L11645  Homo sapiens alpha-tubulin mRNA, complete cds.

EntrezGene:
ID  Description
TUBA3C  tubulin, alpha 3c
TUBA3D  tubulin, alpha 3d

RefSeq DNA:
ID  Description
NM_080386  Homo sapiens tubulin, alpha 3d (TUBA3D), mRNA.

UniGene:
ID  Description
Hs.503749  CDNA FLJ35797 fis, clone TESTI2005892, highly similar to TUBULIN ALPHA-3/ALPHA-7 CHAIN

Proteins
Ensembl Proteins:
ENSP00000326042; ENSP00000344440

Entrez Proteins:
AAA35521.1; AAA36785.1; AAC39578.1; AAH11721.1; AAH57810.1; ABD72607.1; BAF84942.1; CAH73534.1; EAX08210.1; EAX08211.1

RefSeq Proteins:
ID  Description
NP_005992  tubulin, alpha 3c [Homo sapiens].
NP_525125  tubulin, alpha 3d [Homo sapiens].

UniProt:
ID  Description
Q13748-2  UNKNOWN
Q15670  SubName: Full=Alpha-tubulin isotype H2-alpha; Flags: Fragment;
Q1ZYQ1  SubName: Full=cDNA FLJ77591, highly similar to Homo sapiens tubulin, alpha 2 (TUBA2), transcript variant 1, mRNA; SubName: Full=Tubulin, alpha 2; SubName: Full=Tubulin, alpha 2, isoform CRA_b;
Q13748  RecName: Full=Tubulin alpha-3C/D chain; AltName: Full=Alpha-tubulin 3C/D; AltName: Full=Tubulin alpha-2 chain; AltName: Full=Alpha-tubulin 2;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Tubulin-Homo sapiens-4    

InterPro:
ID  Name
IPR000217  Tubulin
IPR002452  Alpha_tubulin
IPR003008  Tubulin_FtsZ
IPR008280  Tub_FtsZ_C
IPR017975  Tubulin_CS

Pfam:
ID  Description
Tubulin  Tubulin/FtsZ family, GTPase domain
Tubulin_C  Tubulin/FtsZ family, C-terminal domain

Structure
PDB:
ID

HSSP:
ID  Description
1ffx  STRUCTURAL PROTEIN
1ia0  TRANSPORT PROTEIN
1jff  STRUCTURAL PROTEIN
1sa0  CELL CYCLE
1sa1  CELL CYCLE
1tub  MICROTUBULES
1tvk  CELL CYCLE, STRUCTURAL PROTEIN
1z2b  CELL CYCLE
2bto  CYTOSKELETAL PROTEIN
2btq  CYTOSKELETAL PROTEIN/COMPLEX
2hxf  TRANSPORT PROTEIN
2hxh  TRANSPORT PROTEIN
2p4n  TRANSPORT PROTEIN
3dco  MOTOR PROTEIN
3du7  CELL CYCLE
3e22  CELL CYCLE
3edl  STRUCTURAL PROTEIN

PSSH:
ID  Description
A6NJQ0  UNKNOWN
Q13748  UNKNOWN
Q15670  UNKNOWN
Q1ZYQ1  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
602528  TUBULIN, ALPHA-3C; TUBA3C   TUBULIN, ALPHA-2; TUBA2

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005198  structural molecule activity
GO:0005515  protein binding
GO:0005525  GTP binding
GO:0005737  cytoplasm
GO:0005874  microtubule
GO:0007017  microtubule-based process
GO:0007018  microtubule-based movement
GO:0043234  protein complex
GO:0051258  protein polymerization

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
DB01873  Epothilone D  KOS-862; epothilone D
DB03010  Epothilone B  EPO 906; EPO906; patupilone
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000075886 Tubulin alpha-3C/D chain (Alpha-tubulin 3C/D) (Tubulin alpha-2 chain) (Alpha-tubulin 2) [Source:UniProtKB/Swiss-Prot;Acc:Q13748] Pan_troglodytesone2one ENSPTRG00000004900Tubulin alpha-3C/D chain (Alpha-tubulin 3C/D) (Tubulin alpha-2 chain) (Alpha-tubulin 2) [Source:UniProtKB/Swiss-Prot;Acc:Q13748][hgnc]TUBA3D
Pongo_pygmaeusone2one ENSPPYG00000019949Tubulin alpha-3C/D chain (Alpha-tubulin 3C/D) (Tubulin alpha-2 chain) (Alpha-tubulin 2) [Source:UniProtKB/Swiss-Prot;Acc:Q13748][hgnc]
Macaca_mulattaone2one ENSMMUG00000013574Tubulin alpha-3C/D chain (Alpha-tubulin 3C/D) (Tubulin alpha-2 chain) (Alpha-tubulin 2) [Source:UniProtKB/Swiss-Prot;Acc:Q13748][hgnc]
Felis_catusmany2many ENSFCAG00000010749[hgnc]
Felis_catusmany2many ENSFCAG00000003826[hgnc]
Oryctolagus_cuniculusone2many ENSOCUG00000005221[hgnc]
Mus_musculusmany2many ENSMUSG00000067702Tubulin alpha-3 chain (Tubulin alpha-3/alpha-7 chain) (Alpha-tubulin 3/7) (Alpha-tubulin isotype M-alpha-3/7) [Source:UniProtKB/Swiss-Prot;Acc:P05214][hgnc]Tuba3b
Bos_taurusone2many ENSBTAG00000030979Tubulin alpha-3 chain (Alpha-tubulin 3). [Source:UniProtKB/Swiss-Prot;Acc:Q32KN8][hgnc]TUBA3D
Mus_musculusmany2many ENSMUSG00000067338Tubulin alpha-3 chain (Tubulin alpha-3/alpha-7 chain) (Alpha-tubulin 3/7) (Alpha-tubulin isotype M-alpha-3/7) [Source:UniProtKB/Swiss-Prot;Acc:P05214][hgnc]Tuba3b
Sorex_araneusone2many ENSSARG00000009727[hgnc]
Monodelphis_domesticaone2many ENSMODG00000023336[hgnc]
Gallus_gallusone2many ENSGALG00000010439Tubulin alpha-1 chain (Fragment). [Source:UniProtKB/Swiss-Prot;Acc:P02552][hgnc]TUBA3D
Ciona_savignyione2many ENSCSAVG00000009895[hgnc]
Ciona_intestinalismany2many ENSCING00000001070Alpha-tubulin 1 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q8MVT7][hgnc]
Ciona_intestinalismany2many ENSCING00000008913Alpha-tubulin 1 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q8MVT7][hgnc]
Ciona_intestinalismany2many ENSCING00000001080Alpha-tubulin 1 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q8MVT7][hgnc]
Caenorhabditis_elegansone2many C44B11.3mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation. MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons. mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis. MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons. [Source: WormBase][hgnc]mec-12
Saccharomyces_cerevisiaemany2many YML085CTubulin alpha-1 chain. [Source:UniProtKB/Swiss-Prot;Acc:P09733][hgnc]TUB1
Saccharomyces_cerevisiaemany2many YML124CTubulin alpha-3 chain. [Source:UniProtKB/Swiss-Prot;Acc:P09734][hgnc]TUB3