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Summary sheet information for Effector 'p115 RhoGEF-Homo sapiens'
Name p115 RhoGEF-Homo sapiens
Description RecName: Full=Rho guanine nucleotide exchange factor 1;AltName: Full=115 kDa guanine nucleotide exchange factor;AltName: Full=p115-RhoGEF;AltName: Full=p115RhoGEF;AltName: Full=Sub1.5
Class
Family Guanine nucleotide exchange factors
Sub_family RhoGEFs
type p115 RhoGEF
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 19
Gene Start: 47079106
Gene End: 47103437
Ensembl Contig View

Ensembl Genes:
ENSG00000076928

EMBL:
EMBL ID  Description
AK090448  Homo sapiens mRNA for FLJ00369 protein.
BC005155  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1, mRNA (cDNA clone IMAGE:3530329), partial cds.
BC011726  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1, mRNA (cDNA clone MGC:19628 IMAGE:4138058), complete cds.
BC015652  Homo sapiens cDNA clone IMAGE:4763067, containing frame-shift errors.
BC034013  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1, mRNA (cDNA clone MGC:21456 IMAGE:3451036), complete cds.
BC035127  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1, mRNA (cDNA clone IMAGE:5263614), complete cds.
BC067262  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1, mRNA (cDNA clone MGC:74807 IMAGE:6502165), complete cds.
BT007421  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1 mRNA, complete cds.
CH471126  Homo sapiens 211000035831425 genomic scaffold, whole genome shotgun sequence.
U64105  Human guanine nucleotide exchange factor p115-RhoGEF mRNA, partial cds.
Y09160  H.sapiens Sub1.5 mRNA

EntrezGene:
ID  Description
ARHGEF1  Rho guanine nucleotide exchange factor (GEF) 1

RefSeq DNA:
ID  Description
NM_004706  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1 (ARHGEF1), transcript variant 2, mRNA.
NM_198977  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1 (ARHGEF1), transcript variant 3, mRNA.
NM_199002  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 1 (ARHGEF1), transcript variant 1, mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000375841; ENSP00000344429; ENSP00000346532; ENSP00000367394; ENSP00000337261; ENSP00000323044

Entrez Proteins:
AAB17896.1; AAH05155.2; AAH11726.1; AAH34013.2; AAH35127.1; AAH67262.1; AAP36089.1; BAC03429.1; CAA70356.1; EAW57084.1

RefSeq Proteins:
ID  Description
NP_004697  Rho guanine nucleotide exchange factor 1 isoform 2 [Homo sapiens].
NP_945328  Rho guanine nucleotide exchange factor 1 isoform 3 [Homo sapiens].
NP_945353  Rho guanine nucleotide exchange factor 1 isoform 1 [Homo sapiens].

UniProt:
ID  Description
Q92888-2  UNKNOWN
Q49AN3  SubName: Full=ARHGEF1 protein;
Q6NX52  SubName: Full=ARHGEF1 protein; SubName: Full=Rho guanine nucleotide exchange factor (GEF) 1, isoform CRA_g;
Q8NF33  SubName: Full=FLJ00369 protein; Flags: Fragment;
Q92888  RecName: Full=Rho guanine nucleotide exchange factor 1; AltName: Full=115 kDa guanine nucleotide exchange factor; AltName: Full=p115-RhoGEF; AltName: Full=p115RhoGEF; AltName: Full=Sub1.5;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     p115 RhoGEF-Homo sapiens    

InterPro:
ID  Name
IPR001331  GDS_CDC24_CS
IPR001849  Pleckstrin_homology
IPR015212  Regulat_G_prot_signal-like
IPR015721  RhoGEF_like
IPR011993  PH_type
IPR000219  DH-domain

Pfam:
ID  Description
RhoGEF  RhoGEF domain
RGS-like  Regulator of G protein signalling-like domain

Structure
PDB:
ID
1IAP
1SHZ

HSSP:
ID  Description
1htj  SIGNALING PROTEIN
1iap  SIGNALING PROTEIN
1ki1  SIGNALING PROTEIN
1shz  SIGNALING PROTEIN
1txd  SIGNALING PROTEIN
1x86  SIGNALING PROTEIN/MEMBRANE PROTEIN
1xcg  SIGNALING PROTEIN ACTIVATOR/SIGNALING PR
3cx6  SIGNALING PROTEIN
3cx7  SIGNALING PROTEIN
3cx8  SIGNALING PROTEIN
3eo2  SPLICING

PSSH:
ID  Description
Q6NX52  UNKNOWN
Q8NF33  UNKNOWN
Q92888  UNKNOWN
Q49AN3  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
601855  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; ARHGEF1   GUANINE NUCLEOTIDE EXCHANGE FACTOR, 115-KD p115-RhoGEF LSC, MOUSE, HOMOLOG OF; LSC

Gene Ontology
GO:
GO ID  Description
GO:0005085  guanyl-nucleotide exchange factor activity
GO:0005089  Rho guanyl-nucleotide exchange factor activity
GO:0005096  GTPase activator activity
GO:0005515  protein binding
GO:0005622  intracellular
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005886  plasma membrane
GO:0008283  cell proliferation
GO:0035023  regulation of Rho protein signal transduction

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04810  Regulation of actin cytoskeleton
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description
P00007  Axon guidance mediated by semaphorins
P00027  Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P00016  Cytoskeletal regulation by Rho GTPase

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000076928 Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888] Ciona_savignyione2many ENSCSAVG00000003345[hgnc]
Tupaia_belangerione2one ENSTBEG00000003489Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000008982Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Myotis_lucifugusone2one ENSMLUG00000012943Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Bos_taurusone2one ENSBTAG00000018912Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]ARHGEF1
Macaca_mulattaone2one ENSMMUG00000022305Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Procavia_capensisone2one ENSPCAG00000014377Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Mus_musculusone2one ENSMUSG00000040940Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin) [Source:UniProtKB/Swiss-Prot;Acc:Q61210][hgnc]Arhgef1
Felis_catusone2one ENSFCAG00000008128Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000013661Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Ochotona_princepsone2one ENSOPRG00000002940Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Pan_troglodytesone2one ENSPTRG00000011039Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Dipodomys_ordiione2one ENSDORG00000010815Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin) [Source:UniProtKB/Swiss-Prot;Acc:Q61210][hgnc]
Echinops_telfairione2one ENSETEG00000013071Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Tursiops_truncatusone2one ENSTTRG00000008288Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000004911Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Takifugu_rubripesone2one ENSTRUG00000001155Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Microcebus_murinusone2one ENSMICG00000009512Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Loxodonta_africanaone2one ENSLAFG00000009353Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000010031Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Canis_familiarisone2one ENSCAFG00000004976Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]LOC484482
Spermophilus_tridecemlineatusone2one ENSSTOG00000003526Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Rattus_norvegicusone2one ENSRNOG00000020130Rho guanine nucleotide exchange factor 1 (Lbc's second cousin). [Source:UniProtKB/Swiss-Prot;Acc:Q9Z1I6][hgnc]Arhgef1
Oryzias_latipesone2one ENSORLG00000013538Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) [Source:UniProtKB/Swiss-Prot;Acc:Q92888][hgnc]
Ciona_intestinalisone2many ENSCING00000007425[hgnc]