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Summary sheet information for Effector 'Tubulin-Homo sapiens-11'
Name Tubulin-Homo sapiens-11
Description RecName: Full=Tubulin beta-1 chain
Class
Family Tubulins
Sub_family Tubulins
type Tubulin
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 20
Gene Start: 57027704
Gene End: 57035104
Ensembl Contig View

Ensembl Genes:
ENSG00000101162

EMBL:
EMBL ID  Description
AJ292757  Homo sapiens TUBB1 gene for human beta tubulin 1, class VI
AL109840  Human DNA sequence from clone RP4-543J19 on chromosome 20 Contains the 3' end of the GNAS complex locus, the CTSZ gene for cathepsin Z, the ATP5E gene for ATP synthase (H+ transporting, mitochondrial F1 complex, epsilon subunit), the TH1L gene for TH1-like (Drosophila), the gene for tubulin beta 1 class VI (TUBB1), the C20orf45 gene encoding the CGI-107 protein (LOC51012) and four CpG islands.
BC033679  Homo sapiens tubulin, beta 1, mRNA (cDNA clone MGC:44928 IMAGE:5180793), complete cds.

EntrezGene:
ID  Description
TUBB1  tubulin, beta 1

RefSeq DNA:
ID  Description
NM_030773  Homo sapiens tubulin, beta 1 (TUBB1), mRNA.

UniGene:
ID  Description
Hs.303023  Transcribed locus
Hs.592143  Tubulin, beta 1, mRNA (cDNA clone MGC:44928 IMAGE:5180793)

Proteins
Ensembl Proteins:
ENSP00000217133

Entrez Proteins:
AAH33679.1; CAC09371.2; CAC16605.1

RefSeq Proteins:
ID  Description
NP_110400  beta tubulin 1, class VI [Homo sapiens].

UniProt:
ID  Description
Q9H4B7  RecName: Full=Tubulin beta-1 chain;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Tubulin-Homo sapiens-11    

InterPro:
ID  Name
IPR000217  Tubulin
IPR013838  Beta-tubulin_BS
IPR002453  Beta_tubulin
IPR008280  Tub_FtsZ_C
IPR003008  Tubulin_FtsZ

Pfam:
ID  Description
Tubulin  Tubulin/FtsZ family, GTPase domain
Tubulin_C  Tubulin/FtsZ family, C-terminal domain

Structure
PDB:
ID

HSSP:
ID  Description
1ffx  STRUCTURAL PROTEIN
1jff  STRUCTURAL PROTEIN
1tub  MICROTUBULES
1tvk  CELL CYCLE, STRUCTURAL PROTEIN
1z5v  STRUCTURAL PROTEIN
1z5w  STRUCTURAL PROTEIN
2bto  CYTOSKELETAL PROTEIN
2btq  CYTOSKELETAL PROTEIN/COMPLEX
3cb2  STRUCTURAL PROTEIN, HYDROLASE

PSSH:
ID  Description

Diseases
OMIM:
OMIM ID  Name  Alt Name

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005198  structural molecule activity
GO:0005200  structural constituent of cytoskeleton
GO:0005525  GTP binding
GO:0005737  cytoplasm
GO:0005874  microtubule
GO:0007017  microtubule-based process
GO:0007018  microtubule-based movement
GO:0043234  protein complex
GO:0051225  spindle assembly
GO:0051258  protein polymerization

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection

Panther:
ID  Description
P00016  Cytoskeletal regulation by Rho GTPase
P00029  Huntington disease

Chemicals
DrugBank:
ID  Name  Synonyms
DB01229  Paclitaxel  7-Epipaclitaxel; 7-Epitaxol; 7-epi-Paclitaxel; 7-epi-Taxol
DB03010  Epothilone B  EPO 906; EPO906; patupilone
DB01394  Colchicine  Colchicin; Colchicina; Colchicinum
DB01248  Docetaxel  Docetaxel anhydrous; Docetaxel, Trihydrate; TXL; docetaxel
DB01873  Epothilone D  KOS-862; epothilone D
DB00309  Vindesine  Desacetylvinblastine Amide Sulfate; Vindesine Sulfate
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000101162 Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7] Pan_troglodytesone2one ENSPTRG00000013680Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]TUBB1
Pongo_pygmaeusone2one ENSPPYG00000011180Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Macaca_mulattaone2one ENSMMUG00000013187Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Microcebus_murinusone2one ENSMICG00000014890Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000012530Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Otolemur_garnettiione2one ENSOGAG00000013378Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Tupaia_belangerione2one ENSTBEG00000009258Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000015969Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Cavia_porcellusone2one ENSCPOG00000012388Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Myotis_lucifugusone2one ENSMLUG00000014902Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000010925Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000010771Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Ochotona_princepsone2one ENSOPRG00000002529Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Loxodonta_africanaone2one ENSLAFG00000000296Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Mus_musculusone2one ENSMUSG00000016255tubulin, beta 1 [Source:RefSeq_peptide;Acc:NP_001074440][hgnc]Tubb1
Tursiops_truncatusone2one ENSTTRG00000008404Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000000207Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Sorex_araneusone2one ENSSARG00000004580Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Bos_taurusone2one ENSBTAG00000018785Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]TUBB1
Erinaceus_europaeusone2one ENSEEUG00000003608Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Equus_caballusone2one ENSECAG00000025099Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Canis_familiarisone2one ENSCAFG00000012194Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]TUBB1
Procavia_capensisone2one ENSPCAG00000003842Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]
Dipodomys_ordiione2one ENSDORG00000014668tubulin, beta 1 [Source:RefSeq_peptide;Acc:NP_001074440][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000009278Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]100080473
Monodelphis_domesticaone2one ENSMODG00000016603Tubulin beta-1 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B7][hgnc]