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Summary sheet information for Effector 'Tubulin-Homo sapiens-16'
Name Tubulin-Homo sapiens-16
Description RecName: Full=Tubulin beta-4 chain;AltName: Full=Tubulin 5 beta
Class
Family Tubulins
Sub_family Tubulins
type Tubulin
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 19
Gene Start: 6445331
Gene End: 6453330
Ensembl Contig View

Ensembl Genes:
ENSG00000104833

EMBL:
EMBL ID  Description
BC006570  Homo sapiens tubulin, beta 4, mRNA (cDNA clone MGC:4270 IMAGE:3603726), complete cds.
BC013683  Homo sapiens tubulin, beta 4, mRNA (cDNA clone MGC:18193 IMAGE:4155617), complete cds.
X00734  Human beta-tubulin gene (5-beta) with ten Alu family members

EntrezGene:
ID  Description
TUBB4  tubulin, beta 4

RefSeq DNA:
ID  Description
NM_006087  Homo sapiens tubulin, beta 4 (TUBB4), mRNA.

UniGene:
ID  Description
Hs.110837  CDNA FLJ90826 fis, clone Y79AA1001530, highly similar to Tubulin beta-4 chain

Proteins
Ensembl Proteins:
ENSP00000264071

Entrez Proteins:
AAH06570.1; AAH13683.1; CAA25318.1

RefSeq Proteins:
ID  Description
NP_006078  tubulin, beta 4 [Homo sapiens].

UniProt:
ID  Description
P04350  RecName: Full=Tubulin beta-4 chain; AltName: Full=Tubulin 5 beta;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Tubulin-Homo sapiens-16    

InterPro:
ID  Name
IPR008280  Tub_FtsZ_C
IPR002453  Beta_tubulin
IPR000217  Tubulin
IPR003008  Tubulin_FtsZ
IPR013838  Beta-tubulin_BS

Pfam:
ID  Description
Tubulin  Tubulin/FtsZ family, GTPase domain
Tubulin_C  Tubulin/FtsZ family, C-terminal domain

Structure
PDB:
ID

HSSP:
ID  Description
1z2b  CELL CYCLE
1z5v  STRUCTURAL PROTEIN
1z5w  STRUCTURAL PROTEIN
2btq  CYTOSKELETAL PROTEIN/COMPLEX
3cb2  STRUCTURAL PROTEIN, HYDROLASE
3e22  CELL CYCLE

PSSH:
ID  Description

Diseases
OMIM:
OMIM ID  Name  Alt Name
602662  TUBULIN, BETA-4; TUBB4   TUBB5

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005198  structural molecule activity
GO:0005525  GTP binding
GO:0005737  cytoplasm
GO:0005874  microtubule
GO:0005929  cilium
GO:0007017  microtubule-based process
GO:0007018  microtubule-based movement
GO:0033269  internode region of axon
GO:0042995  cell projection
GO:0043025  cell soma
GO:0043209  myelin sheath
GO:0043234  protein complex
GO:0051258  protein polymerization

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection

Panther:
ID  Description
P00016  Cytoskeletal regulation by Rho GTPase
P00029  Huntington disease

Chemicals
DrugBank:
ID  Name  Synonyms
DB03010  Epothilone B  EPO 906; EPO906; patupilone
DB01873  Epothilone D  KOS-862; epothilone D
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000104833 Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350] Pan_troglodytesone2one ENSPTRG00000010369Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]TUBB4
Canis_familiarisone2one ENSCAFG00000018634Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]TUBB4
Pteropus_vampyrusone2one ENSPVAG00000007258Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]
Tursiops_truncatusone2one ENSTTRG00000007829Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]
Equus_caballusone2one ENSECAG00000013659Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]LOC100065776
Bos_taurusone2one ENSBTAG00000021013Tubulin beta-4 chain. [Source:UniProtKB/Swiss-Prot;Acc:Q3ZBU7][hgnc]TUBB4
Ochotona_princepsone2one ENSOPRG00000017153Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]
Cavia_porcellusone2one ENSCPOG00000003237Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]
Otolemur_garnettiione2one ENSOGAG00000015296Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]
Mus_musculusone2one ENSMUSG00000062591Tubulin beta-4 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9D6F9][hgnc]Tubb4
Ornithorhynchus_anatinusone2one ENSOANG00000008406Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000018863Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000010471Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]
Danio_rerioone2many ENSDARG00000038198hypothetical protein LOC767746 [Source:RefSeq_peptide;Acc:NP_001070183][hgnc]zgc:153426
Takifugu_rubripesone2one ENSTRUG00000012675Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]
Oryzias_latipesone2one ENSORLG00000007053Tubulin beta-4 chain (Tubulin 5 beta) [Source:UniProtKB/Swiss-Prot;Acc:P04350][hgnc]
Danio_rerioone2many ENSDARG00000016301hypothetical protein LOC335798 [Source:RefSeq_peptide;Acc:NP_956269][hgnc]zgc:65894
Xenopus_tropicalisone2one ENSXETG00000021860Hypothetical protein. [Source:UniProtKB/TrEMBL;Acc:Q5BL39][hgnc]
Drosophila_melanogastermany2many FBgn0003889[hgnc]betaTub85D
Drosophila_melanogastermany2many FBgn0003887[hgnc]betaTub56D
Anopheles_gambiaeone2many AGAP010929[hgnc]AgaP_ENSANGG00000010545
Aedes_aegyptione2many AAEL002851tubulin beta chain[hgnc]
Ciona_savignyione2one ENSCSAVG00000009381[hgnc]
Ciona_intestinalisone2one ENSCING00000006957[hgnc]
Saccharomyces_cerevisiaeone2many YFL037WTubulin beta chain (Beta-tubulin). [Source:UniProtKB/Swiss-Prot;Acc:P02557][hgnc]TUB2