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Summary sheet information for Effector 'Dynamin 1-Homo sapiens'
Name Dynamin 1-Homo sapiens
Description RecName: Full=Dynamin-1; EC=3.6.5.5
Class
Family Dynamins
Sub_family Dynamins
type Dynamin 1
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 9
Gene Start: 130005480
Gene End: 130057348
Ensembl Contig View

Ensembl Genes:
ENSG00000106976

EMBL:
EMBL ID  Description
AB209124  Homo sapiens mRNA for dynamin 1 isoform 2 variant protein.
AL590708  Human DNA sequence from clone RP11-395P17 on chromosome 9 Contains the SLC25A25 gene for solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25, a novel gene, the PTGES2 gene for prostaglandin E synthase 2, the LCN2 gene for lipocalin 2, the C9orf16 gene for chromosome 9 open reading frame 16, the CIZ1 gene for Cip1-interacting zinc finger protein 1, the DNM1 gene for dynamin 1, the GOLGA2 gene for golgi autoantigen, golgin subfamily a, 2, the C9orf119 gene for chromosome 9 open reading frame 119 and seven CpG islands.
BC050279  Homo sapiens dynamin 1, mRNA (cDNA clone MGC:33790 IMAGE:5284480), complete cds.
BC063850  Homo sapiens dynamin 1, mRNA (cDNA clone MGC:75115 IMAGE:6184100), complete cds.
L07807  Human dynamin mRNA, alternative exons and complete cds.
L07808  Human dynamin mRNA, alternative exon and partial cds.
L07809  Human dynamin mRNA, alternative exon and 3' end of cds.
L07810  Human dynamin mRNA, alternative exon and 3' end of cds.

EntrezGene:
ID  Description
DNM1  dynamin 1

RefSeq DNA:
ID  Description
NM_004408  Homo sapiens dynamin 1 (DNM1), transcript variant 1, mRNA.

UniGene:
ID  Description
Hs.635295  Transcribed locus

Proteins
Ensembl Proteins:
ENSP00000377214; ENSP00000351969; ENSP00000377219; ENSP00000362014; ENSP00000345680

Entrez Proteins:
AAA02803.1; AAA02804.1; AAA02805.1; AAA02806.1; AAH50279.2; AAH63850.1; BAD92361.1; CAI13837.1; CAI13839.2

RefSeq Proteins:
ID  Description
NP_001005336  dynamin 1 isoform 2 [Homo sapiens].
NP_004399  dynamin 1 isoform 1 [Homo sapiens].

UniProt:
ID  Description
Q05193-2  UNKNOWN
Q05193-3  UNKNOWN
Q05193-4  UNKNOWN
Q05193-5  UNKNOWN
A8MZB0  SubName: Full=Putative uncharacterized protein DNM1;
Q59GI5  SubName: Full=Dynamin 1 isoform 2 variant; Flags: Fragment;
Q05193  RecName: Full=Dynamin-1; EC=3.6.5.5;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Dynamin 1-Homo sapiens    

InterPro:
ID  Name
IPR003130  GED
IPR000375  Dynamin_central
IPR001849  Pleckstrin_homology
IPR001401  Dynamin_GTPase
IPR011993  PH_type

Pfam:
ID  Description
PH  PH domain
Dynamin_N  Dynamin family
Dynamin_M  Dynamin central region
GED  Dynamin GTPase effector domain

Structure
PDB:
ID
1DYN
2DYN

HSSP:
ID  Description
1dyn  SIGNAL TRANSDUCTION PROTEIN
1jwy  HYDROLASE
1jx2  HYDROLASE
2aka  CONTRACTILE PROTEIN
2dyn  SIGNAL TRANSDUCTION
2ys1  SIGNALING PROTEIN

PSSH:
ID  Description
Q59GI5  UNKNOWN
Q5SYX0  UNKNOWN
Q5SYX2  UNKNOWN
Q6P3T6  UNKNOWN
Q86VD2  UNKNOWN
A6NLM6  UNKNOWN
Q05193  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
602377  DYNAMIN 1; DNM1   UNKNOWN

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003774  motor activity
GO:0003924  GTPase activity
GO:0005515  protein binding
GO:0005525  GTP binding
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005874  microtubule
GO:0006898  receptor-mediated endocytosis
GO:0016787  hydrolase activity

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04144  Endocytosis
hsa04666  Fc gamma R-mediated phagocytosis

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000106976 Dynamin-1 (EC 3.6.5.5) [Source:UniProtKB/Swiss-Prot;Acc:Q05193] Pan_troglodytesone2many ENSPTRG00000021418[hgnc]DNM1
Macaca_mulattaone2many ENSMMUG00000013717[hgnc]
Pongo_pygmaeusone2many ENSPPYG00000019646[hgnc]
Microcebus_murinusone2many ENSMICG00000003416[hgnc]
Tursiops_truncatusone2many ENSTTRG00000016483[hgnc]
Spermophilus_tridecemlineatusone2many ENSSTOG00000007980[hgnc]
Dasypus_novemcinctusone2many ENSDNOG00000012541[hgnc]
Cavia_porcellusone2many ENSCPOG00000022899[hgnc]
Pteropus_vampyrusone2many ENSPVAG00000001220[hgnc]
Otolemur_garnettiione2many ENSOGAG00000003491[hgnc]
Equus_caballusone2many ENSECAG00000022878[hgnc]
Felis_catusone2many ENSFCAG00000005837[hgnc]
Loxodonta_africanaone2many ENSLAFG00000005112[hgnc]
Myotis_lucifugusone2many ENSMLUG00000016237[hgnc]
Vicugna_pacosone2many ENSVPAG00000009258[hgnc]
Tupaia_belangerione2many ENSTBEG00000005702[hgnc]
Oryctolagus_cuniculusone2many ENSOCUG00000012908[hgnc]
Canis_familiarisone2many ENSCAFG00000020082[hgnc]
Erinaceus_europaeusone2many ENSEEUG00000011090[hgnc]
Dipodomys_ordiione2many ENSDORG00000016214Dynamin-1 (EC 3.6.5.5) [Source:UniProtKB/Swiss-Prot;Acc:P39053][hgnc]
Procavia_capensisone2many ENSPCAG00000016115[hgnc]
Mus_musculusone2many ENSMUSG00000026825Dynamin-1 (EC 3.6.5.5) [Source:UniProtKB/Swiss-Prot;Acc:P39053][hgnc]Dnm1
Bos_taurusone2many ENSBTAG00000011307Dynamin-1 (EC 3.6.5.5). [Source:UniProtKB/Swiss-Prot;Acc:Q08DF4][hgnc]DNM1
Echinops_telfairione2many ENSETEG00000017333[hgnc]
Rattus_norvegicusone2many ENSRNOG00000033835Dynamin-1 (EC 3.6.5.5) (D100) (Dynamin, brain) (B-dynamin). [Source:UniProtKB/Swiss-Prot;Acc:P21575][hgnc]Dnm1
Ochotona_princepsone2many ENSOPRG00000016448[hgnc]
Sorex_araneusone2many ENSSARG00000013534[hgnc]
Danio_reriomany2many ENSDARG00000067508[hgnc]
Monodelphis_domesticaone2many ENSMODG00000005868[hgnc]
Gallus_gallusone2many ENSGALG00000004852[hgnc]LOC429989
Ornithorhynchus_anatinusone2many ENSOANG00000000394[hgnc]
Oryzias_latipesmany2many ENSORLG00000017638[hgnc]
Gasterosteus_aculeatusmany2many ENSGACG00000016647[hgnc]
Danio_reriomany2many ENSDARG00000010042hypothetical LOC565715 (LOC565715), mRNA [Source:RefSeq_dna;Acc:XR_029065][hgnc]
Tetraodon_nigroviridismany2many ENSTNIG00000002474[hgnc]
Takifugu_rubripesmany2many ENSTRUG00000018652[hgnc]
Gasterosteus_aculeatusmany2many ENSGACG00000010735[hgnc]
Tetraodon_nigroviridismany2many ENSTNIG00000009014[hgnc]
Oryzias_latipesmany2many ENSORLG00000007019[hgnc]
Xenopus_tropicalisone2many ENSXETG00000024756Dynamin 1. [Source:UniProtKB/TrEMBL;Acc:Q6GL48][hgnc]
Takifugu_rubripesmany2many ENSTRUG00000018313[hgnc]
Danio_reriomany2many ENSDARG00000009281[hgnc]LOC558705
Anopheles_gambiaeone2many AGAP003018Dynamin (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q95PB7][hgnc]AgaP_ENSANGG00000027850
Drosophila_melanogasterone2many FBgn0003392[hgnc]shi
Caenorhabditis_elegansone2many C02C6.1dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase][hgnc]dyn-1
Aedes_aegyptione2many AAEL007288dynamin[hgnc]
Ciona_savignyione2many ENSCSAVG00000006353[hgnc]
Ciona_intestinalisone2many ENSCING00000002282[hgnc]
Saccharomyces_cerevisiaeone2many YKR001CVacuolar protein sorting-associated protein 1. [Source:UniProtKB/Swiss-Prot;Acc:P21576][hgnc]VPS1