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Summary sheet information for Effector 'Rho-Homo sapiens-2'
Name Rho-Homo sapiens-2
Description RecName: Full=Rho-related GTP-binding protein RhoN;AltName: Full=Rho family GTPase 2;AltName: Full=Rnd2;AltName: Full=Rho7;Flags: Precursor
Class
Family Small GTP-binding proteins
Sub_family Rho small GTPases
type Rho
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 17
Gene Start: 38430784
Gene End: 38437583
Ensembl Contig View

Ensembl Genes:
ENSG00000108830

EMBL:
EMBL ID  Description
AB209778  Homo sapiens mRNA for GTP-binding protein Rho7 variant protein.
AF498968  Homo sapiens small GTP binding protein Rho7 (Rho7) mRNA, complete cds.
AK290199  Homo sapiens cDNA FLJ75191 complete cds, highly similar to Homo sapiens Rho family GTPase 2 (RND2), mRNA.
BC094842  Homo sapiens Rho family GTPase 2, mRNA (cDNA clone MGC:104852 IMAGE:6599102), complete cds.
BC104986  Homo sapiens Rho family GTPase 2, mRNA (cDNA clone MGC:132646 IMAGE:8143989), complete cds.
BC104990  Homo sapiens Rho family GTPase 2, mRNA (cDNA clone MGC:132650 IMAGE:8143993), complete cds.
BT019394  Homo sapiens ras homolog gene family, member N mRNA, complete cds.
CH471152  Homo sapiens 211000035832008 genomic scaffold, whole genome shotgun sequence.
L78833  Homo sapiens BRCA1 (BRCA1) gene, complete cds; ribosomal protein L21-like protein (rpL21) pseudogene, complete sequence; Rho7 (Rho7) and VatI (VatI) genes, complete cds; and unknown (ifp35) gene, exons 1 through 3 and partial cds.
X95456  H.sapiens mRNA for Rho7 protein

EntrezGene:
ID  Description
RND2  Rho family GTPase 2

RefSeq DNA:
ID  Description
NM_005440  Homo sapiens Rho family GTPase 2 (RND2), mRNA.

UniGene:
ID  Description
Hs.603111  Rho7 protein

Proteins
Ensembl Proteins:
ENSP00000225973

Entrez Proteins:
AAC37595.1; AAH94842.1; AAI04987.1; AAI04991.1; AAM21115.1; AAV38201.1; BAD93015.1; BAF82888.1; CAA64726.1; EAW60920.1

RefSeq Proteins:
ID  Description
NP_005431  Rho family GTPase 2 [Homo sapiens].

UniProt:
ID  Description
A8K2D4  SubName: Full=cDNA FLJ75191, highly similar to Homo sapiens Rho family GTPase 2 (RND2), mRNA; SubName: Full=Rho family GTPase 2, isoform CRA_b;
Q59EN3  SubName: Full=GTP-binding protein Rho7 variant; Flags: Fragment;
P52198  RecName: Full=Rho-related GTP-binding protein RhoN; AltName: Full=Rho family GTPase 2; AltName: Full=Rnd2; AltName: Full=Rho7; Flags: Precursor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Rho-Homo sapiens-2    

InterPro:
ID  Name
IPR001806  Ras_trnsfrmng
IPR005225  Small_GTP_bd
IPR003578  GTPase_Rho
IPR013753  Ras

Pfam:
ID  Description
Ras  Ras family

Structure
PDB:
ID

HSSP:
ID  Description
1a2b  ONCOGENE PROTEIN
1a4r  HYDROLASE
1aje  G-PROTEIN
1an0  GTPASE
1cc0  SIGNALING PROTEIN
1cee  STRUCTURAL PROTEIN REGULATION
1cf4  TRANSFERASE
1cxz  SIGNALING PROTEIN
1doa  CELL CYCLE
1dpf  GENE REGULATION/SIGNALING PROTEIN
1ds6  SIGNALING PROTEIN
1e0a  SIGNALLING PROTEIN
1e96  SIGNALLING COMPLEX
1ees  STRUCTURAL PROTEIN
1ftn  PROTO-ONCOGENE
1g4u  SIGNALING PROTEIN
1gwn  GTPASE
1gzs  COMPLEX (TOXIN/CELL CYCLE PROTEIN)
1he1  SIGNALLING COMPLEX
1hh4  SINGAL PROTEIN INHIBITOR COMPLEX
1i4d  SIGNALING PROTEIN
1i4l  SIGNALING PROTEIN
1i4t  SIGNALING PROTEIN
1kmq  SIGNALING PROTEIN
1kz7  SIGNALING PROTEIN
1lb1  SIGNALING PROTEIN
1m7b  SIGNALING PROTEIN
1mh1  GTP-BINDING
1ow3  GENE REGULATION/SIGNALING PROTEIN
1ryf  HYDROLASE
1ryh  HYDROLASE
1s1c  SIGNALING PROTEIN
1tx4  COMPLEX(GTPASE ACTIVATN/PROTO-ONCOGENE)
1x86  SIGNALING PROTEIN/MEMBRANE PROTEIN
1xcg  SIGNALING PROTEIN ACTIVATOR/SIGNALING PR
1z2c  SIGNALING PROTEIN
2ase  SIGNALING PROTEIN
2atx  HYDROLASE
2c2h  SIGNALING PROTEIN
2cls  NUCLEOTIDE BINDING PROTEIN
2fju  SIGNALING PROTEIN,APOPTOSIS/HYDROLASE
2fv8  SIGNALING PROTEIN
2g0n  SIGNALING PROTEIN
2gcn  SIGNALING PROTEIN
2gco  SIGNALING PROTEIN
2gcp  SIGNALING PROTEIN
2h7v  SIGNALING PROTEIN
2ic5  SIGNALING PROTEIN
2j0v  NUCLEOTIDE-BINDING PROTEIN
2j1l  HYDROLASE
2nty  SIGNALING PROTEIN
2nz8  SIGNALING PROTEIN,CELL CYCLE
2odb  PROTEIN BINDING
2ov2  PROTEIN BINDING/TRANSFERASE
2p2l  UNKNOWN FUNCTION
2q3h  STRUCTURAL GENOMICS
2qme  SIGNALING PROTEIN/TRANSFERASE
2qrz  CELL CYCLE
2rex  SIGNALING PROTEIN/LIPOPROTEIN
2rmk  MEMBRANE PROTEIN/TRANSFERASE
2v55  TRANSFERASE
3bwd  PLANT PROTEIN
3eg5  SIGNALING PROTEIN

PSSH:
ID  Description
Q59EN3  UNKNOWN
P52198  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
601555  RHO FAMILY GTPase 2; RND2   RAS HOMOLOG GENE FAMILY, MEMBER N; RHON ARHN GTP-BINDING PROTEIN RHO7; RHO7

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005515  protein binding
GO:0005525  GTP binding
GO:0005622  intracellular
GO:0005886  plasma membrane
GO:0006886  intracellular protein transport
GO:0006913  nucleocytoplasmic transport
GO:0007165  signal transduction
GO:0007264  small GTPase mediated signal transduction
GO:0015031  protein transport

Pathway
KEGG:
KEGG PATHWAY ID  Name

Panther:
ID  Description
P00034  Integrin signalling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000108830 Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198] Pan_troglodytesone2one ENSPTRG00000009235Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]RND2
Macaca_mulattaone2one ENSMMUG00000029963Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Equus_caballusone2one ENSECAG00000014817Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Canis_familiarisone2one ENSCAFG00000014610Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]RND2
Microcebus_murinusone2one ENSMICG00000014252Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Tursiops_truncatusone2one ENSTTRG00000011742Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000008365Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Myotis_lucifugusone2one ENSMLUG00000004129Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000008823Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Bos_taurusone2one ENSBTAG00000007393Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]RND2
Otolemur_garnettiione2one ENSOGAG00000003947Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Felis_catusone2one ENSFCAG00000013145Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Loxodonta_africanaone2one ENSLAFG00000015512Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Tupaia_belangerione2one ENSTBEG00000012925Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Procavia_capensisone2one ENSPCAG00000013345Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000002704Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Ochotona_princepsone2one ENSOPRG00000010875Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000000492Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Rattus_norvegicusone2one ENSRNOG00000020698Rho family GTPase 2 [Source:RefSeq_peptide;Acc:NP_001010953][hgnc]Rnd2
Oryctolagus_cuniculusone2one ENSOCUG00000009277Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Vicugna_pacosone2one ENSVPAG00000002576Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Mus_musculusone2one ENSMUSG00000001313Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:Q9QYM5][hgnc]Rnd2
Dipodomys_ordiione2one ENSDORG00000004234Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:Q9QYM5][hgnc]
Echinops_telfairione2one ENSETEG00000002824Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Sorex_araneusone2one ENSSARG00000004567Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Cavia_porcellusone2one ENSCPOG00000013607Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Monodelphis_domesticaone2one ENSMODG00000015141Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Gallus_gallusone2one ENSGALG00000002804Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]RND2
Takifugu_rubripesone2many ENSTRUG00000016385Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000011726Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000009070Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Oryzias_latipesone2many ENSORLG00000003210Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Danio_rerioone2one ENSDARG00000070735hypothetical protein LOC751645 [Source:RefSeq_peptide;Acc:NP_001038829][hgnc]LOC100005936
Oryzias_latipesone2many ENSORLG00000004571Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Takifugu_rubripesone2many ENSTRUG00000009210Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000010245Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000006378Rho-related GTP-binding protein RhoN Precursor (Rho family GTPase 2) (Rnd2) (Rho7) [Source:UniProtKB/Swiss-Prot;Acc:P52198][hgnc]
Saccharomyces_cerevisiaemany2many YIL118WGTP-binding protein RHO3 precursor. [Source:UniProtKB/Swiss-Prot;Acc:Q00245][hgnc]RHO3
Saccharomyces_cerevisiaemany2many YNL090WGTP-binding protein RHO2 precursor. [Source:UniProtKB/Swiss-Prot;Acc:P06781][hgnc]RHO2