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Summary sheet information for GPCR 'HISTAMINE RECEPTORS_H2_Homo sapiens'
Name HISTAMINE RECEPTORS_H2_Homo sapiens
Description RecName: Full=Histamine H2 receptor; Short=H2R;AltName: Full=Gastric receptor I
Class CLASS A
Family HISTAMINE RECEPTORS
Sub_family H2
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 5
Gene Start: 175017637
Gene End: 175045851
Ensembl Contig View

Ensembl Genes:
ENSG00000113749

EMBL:
EMBL ID  Description
AB023486  Homo sapiens gene for histamine H2 receptor, promoter region and complete cds.
AB041384  Homo sapiens gene for histamine H2 receptor, complete cds.
AY136744  Homo sapiens histamine receptor H2 (HRH2) mRNA, complete cds.
BC054510  Homo sapiens histamine receptor H2, mRNA (cDNA clone MGC:60198 IMAGE:6146988), complete cds.
D49783  Homo sapiens gene for histamine H2 receptor, complete cds.
M64799  Human histamine H2 receptor gene, complete cds.
X98133  H.sapiens gene encoding histamine H2 receptor

EntrezGene:
ID  Description
HRH2  histamine receptor H2

RefSeq DNA:
ID  Description
NM_022304  Homo sapiens histamine receptor H2 (HRH2), transcript variant 2, mRNA.

UniGene:
ID  Description
Hs.247885  Histamine receptor H2 (HRH2), transcript variant 1, mRNA

Proteins
Ensembl Proteins:
ENSP00000231683; ENSP00000377350; ENSP00000366506

Entrez Proteins:
AAA58647.1; AAH54510.1; AAN01270.1; BAA08618.1; BAA84279.1; BAA94469.1; CAA66832.1

RefSeq Proteins:
ID  Description
NP_071640  histamine receptor H2 isoform 2 [Homo sapiens].

UniProt:
ID  Description
Q7Z5R9  SubName: Full=HRH2 protein;
P25021  RecName: Full=Histamine H2 receptor; Short=H2R; AltName: Full=Gastric receptor I;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR000503  Histamine_H2_recept
IPR017452  GPCR_Rhodpsn_supfam
IPR000276  GPCR_Rhodpsn

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID

HSSP:
ID  Description
2r4r  SIGNALING PROTEIN
2r4s  SIGNALING PROTEIN
2rh1  MEMBRANE PROTEIN / HYDROLASE
2vt4  RECEPTOR
3d4s  MEMBRANE PROTEIN
3eml  MEMBRANE PROTEIN, RECEPTOR

PSSH:
ID  Description
Q7Z5R9  UNKNOWN
P25021  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
142703  HISTAMINE RECEPTOR H2; HRH2   UNKNOWN

Gene Ontology
GO:
GO ID  Description
GO:0001584  rhodopsin-like receptor activity
GO:0004872  receptor activity
GO:0004935  adrenoceptor activity
GO:0004952  dopamine receptor activity
GO:0004969  histamine receptor activity
GO:0004981  muscarinic acetylcholine receptor activity
GO:0004983  neuropeptide Y receptor activity
GO:0004984  olfactory receptor activity
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0006955  immune response
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007187  G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0008188  neuropeptide receptor activity
GO:0016020  membrane
GO:0016021  integral to membrane

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction

Panther:
ID  Description
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P04386  Histamine H2 receptor mediated signaling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
DB01142  Doxepin  Doxepin Hcl; Doxepin, Hydrochloride; Doxepina [INN-Spanish]; Doxepine; Doxepinum [INN-Latin]
DB00272  Betazole  Ametazole; Betazol [INN-Spanish]; Betazolo [DCIT]; Betazolum [INN-Latin]
DB00927  Famotidine  Famotidina [Spanish]; Famotidinum [Latin]
DB00501  Cimetidine  Cimetidine A/AB; Cimetidine Hcl
DB00667  Histamine Phosphate  
DB00585  Nizatidine  
DB00863  Ranitidine  Ranitidine Base; Ranitidine HCL; Ranitidine hydrochloride; Rantidine HCL
DB00751  Epinastine  Epinastina [Spanish]; Epinastinum [Latin]; epinastine
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000113749 Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021] Pan_troglodytesone2one ENSPTRG00000017551Histamine H2 receptor (H2R) (Gastric receptor I). [Source:UniProtKB/Swiss-Prot;Acc:P60021][hgnc]HRH2
Pongo_pygmaeusone2one ENSPPYG00000016150Histamine H2 receptor (H2R) (Gastric receptor I). [Source:UniProtKB/Swiss-Prot;Acc:P61752][hgnc]
Macaca_mulattaone2one ENSMMUG00000014245Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Microcebus_murinusone2one ENSMICG00000003318Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Canis_familiarisone2one ENSCAFG00000016718Histamine H2 receptor (H2R) (Gastric receptor I). [Source:UniProtKB/Swiss-Prot;Acc:P17124][hgnc]HRH2
Cavia_porcellusone2one ENSCPOG00000003473Histamine H2 receptor (H2R) (Gastric receptor I). [Source:UniProtKB/Swiss-Prot;Acc:P47747][hgnc]
Tursiops_truncatusone2one ENSTTRG00000000456Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Felis_catusone2one ENSFCAG00000015411Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000007422Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Procavia_capensisone2one ENSPCAG00000007528Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Vicugna_pacosone2one ENSVPAG00000009965Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Ochotona_princepsone2one ENSOPRG00000001147Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Rattus_norvegicusone2one ENSRNOG00000018260Histamine H2 receptor (H2R) (Gastric receptor I). [Source:UniProtKB/Swiss-Prot;Acc:P25102][hgnc]Hrh2
Myotis_lucifugusone2one ENSMLUG00000007517Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Loxodonta_africanaone2one ENSLAFG00000004764Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Equus_caballusone2one ENSECAG00000016581Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Mus_musculusone2one ENSMUSG00000034987Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P97292][hgnc]Hrh2
Pteropus_vampyrusone2one ENSPVAG00000014807Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Monodelphis_domesticaone2one ENSMODG00000005373Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000009335Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Gallus_gallusone2one ENSGALG00000024171Histamine H2 receptor (Fragment). [Source:UniProtKB/TrEMBL;Acc:A2ICM8][hgnc]HRH2
Gasterosteus_aculeatusone2many ENSGACG00000017883Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000013110Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Oryzias_latipesone2many ENSORLG00000003959Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000020317Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Takifugu_rubripesone2many ENSTRUG00000010410Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Danio_rerioone2one ENSDARG00000057479[hgnc]LOC100005590
Tetraodon_nigroviridisone2many ENSTNIG00000010771Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Takifugu_rubripesone2many ENSTRUG00000007773Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Oryzias_latipesone2many ENSORLG00000010128Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
Anopheles_gambiaeone2many AGAP004613putative dopamine receptor 1 [Source:Anopheles_symbol;Acc:GPRDOP1][hgnc]GPRDOP1