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Summary sheet information for G-protein 'Galpha-t1_Homo sapiens'
Name Galpha-t1_Homo sapiens
Description RecName: Full=Guanine nucleotide-binding protein G(t) subunit alpha-1;AltName: Full=Transducin alpha-1 chain
Class Galpha
Family Gi/o
Sub_family Galpha-t
type Galpha-t1
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 3
Gene Start: 50204047
Gene End: 50208953
Ensembl Contig View

Ensembl Genes:
ENSG00000114349

EMBL:
EMBL ID  Description
AC002077  Human cosmid clone LUCA17 from 3p21.3, complete sequence.
AF493908  Homo sapiens guanine nucleotide binding protein alpha transducin rod (GNATR) mRNA, complete cds.
BC095505  Homo sapiens guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1, mRNA (cDNA clone MGC:111716 IMAGE:6519160), complete cds.
X15088  Human GNAT1 mRNA for transducin alpha-chain
X63749  H.sapiens DNA for Rod transducin alpha-subunit

EntrezGene:
ID  Description
GNAT1  guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1

RefSeq DNA:
ID  Description
NM_000172  Homo sapiens guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 (GNAT1), transcript variant 2, mRNA.
NM_144499  Homo sapiens guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 (GNAT1), transcript variant 1, mRNA.

UniGene:
ID  Description
Hs.517978  GNAT1 mRNA for transducin alpha-chain

Proteins
Ensembl Proteins:
ENSP00000384624; ENSP00000232461

Entrez Proteins:
AAB54048.1; AAH95505.1; AAM12622.1; CAA33196.1; CAB37839.2

RefSeq Proteins:
ID  Description
NP_000163  guanine nucleotide binding protein, alpha transducing activity polypeptide 1 [Homo sapiens].
NP_653082  guanine nucleotide binding protein, alpha transducing activity polypeptide 1 [Homo sapiens].

UniProt:
ID  Description
P11488  RecName: Full=Guanine nucleotide-binding protein G(t) subunit alpha-1; AltName: Full=Transducin alpha-1 chain;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR001019  Gprotein_alph_bd
IPR001408  Gprotein_alpha_I

Pfam:
ID  Description
G-alpha  G-protein alpha subunit

Structure
PDB:
ID

HSSP:
ID  Description
1agr  COMPLEX (SIGNAL TRANSDUCTION/REGULATOR)
1as0  SIGNAL TRANSDUCTION
1as2  SIGNAL TRANSDUCTION
1as3  SIGNAL TRANSDUCTION
1azs  COMPLEX (LYASE/HYDROLASE)
1azt  HYDROLASE
1bh2  SIGNAL TRANSDUCTION PROTEIN
1bof  SIGNAL TRANSDUCTION PROTEIN
1cip  HYDROLASE
1cjk  LYASE/LYASE/SIGNALING PROTEIN
1cjt  LYASE/LYASE/SIGNALING PROTEIN
1cju  LYASE/LYASE/SIGNALING PROTEIN
1cjv  LYASE/LYASE/SIGNALING PROTEIN
1cs4  LYASE/LYASE/SIGNALING PROTEIN
1cul  LYASE/LYASE/SIGNALING PROTEIN
1fqj  SIGNALING PROTEIN
1fqk  SIGNALING PROTEIN
1gdd  SIGNAL TRANSDUCTION PROTEIN
1gfi  SIGNAL TRANSDUCTION PROTEIN
1gg2  COMPLEX (GTP-BINDING/TRANSDUCER)
1gia  SIGNAL TRANSDUCTION PROTEIN
1gil  GTP-BINDING PROTEIN
1git  GTP-BINDING PROTEIN
1got  COMPLEX (GTP-BINDING/TRANSDUCER)
1gp2  COMPLEX (GTP-BINDING/TRANSDUCER)
1kjy  SIGNALING PROTEIN
1shz  SIGNALING PROTEIN
1svk  HYDROLASE, SIGNALING PROTEIN
1svs  HYDROLASE, SIGNALING PROTEIN
1tad  GTP-BINDING PROTEIN
1tag  GTP-BINDING PROTEIN
1tl7  LYASE
1tnd  BINDING PROTEIN(GTP)
1u0h  LYASE
1y3a  SIGNALING PROTEIN
1zca  SIGNALING PROTEIN
1zcb  SIGNALING PROTEIN
2bcj  TRANSFERASE/HYDROLASE
2ebc  SIGNALING PROTEIN
2g83  SIGNALING PROTEIN
2gtp  SIGNALING PROTEIN
2gvd  LYASE
2gvz  LYASE
2hlb  SIGNALING PROTEIN
2ihb  SIGNALING PROTEIN
2ik8  SIGNALING PROTEIN
2ode  SIGNALING PROTEIN
2om2  SIGNALING PROTEIN
2pz2  HYDROLASE
2pz3  HYDROLASE
2rgn  SIGNALING PROTEIN COMPLEX
2v4z  CELL CYCLE
3c14  LYASE/LYASE INHIBITOR
3c15  LYASE/LYASE INHIBITOR
3c16  LYASE/LYASE INHIBITOR
3c7k  SIGNALING PROTEIN
3cx6  SIGNALING PROTEIN
3cx7  SIGNALING PROTEIN
3cx8  SIGNALING PROTEIN

PSSH:
ID  Description
P11488  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
139330  GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-TRANSDUCING ACTIVITY POLYPEPTIDE 1; GNAT1   G PROTEIN, ALPHA-TRANSDUCING 1 TRANSDUCIN, ROD-SPECIFIC, ALPHA POLYPEPTIDE

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0004871  signal transducer activity
GO:0005525  GTP binding
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007264  small GTPase mediated signal transduction
GO:0007601  visual perception
GO:0007602  phototransduction
GO:0008283  cell proliferation
GO:0019001  guanyl nucleotide binding
GO:0050896  response to stimulus

Pathway
KEGG:
KEGG PATHWAY ID  Name

Panther:
ID  Description
P00048  PI3 kinase pathway
P00028  Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000114349 Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488] Caenorhabditis_elegansmany2many T07A9.7gpa-4 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases. it is expressed in ASI. [Source: WormBase][hgnc]gpa-4
Caenorhabditis_elegansmany2many Y95B8A.5gpa-16 (also known as spn-1) encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects spindle position and orientation in embryos. it is expressed in AVM, PDE, PLM, BDU, PVC, and RIP, and weakly expressed in the pharynx, body-wall muscle, and vulval muscle. [Source: WormBase][hgnc]G-protein
Pan_troglodytesone2one ENSPTRG00000014949Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]GNAT1
Pongo_pygmaeusone2one ENSPPYG00000013853Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Macaca_mulattaone2one ENSMMUG00000010339Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Equus_caballusone2one ENSECAG00000018589Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]LOC100062183
Tursiops_truncatusone2one ENSTTRG00000007722Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000017089Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Canis_familiarisone2one ENSCAFG00000010764Guanine nucleotide-binding protein G(t), alpha-1 subunit (Transducin alpha-1 chain). [Source:UniProtKB/Swiss-Prot;Acc:Q28300][hgnc]GNAT1
Bos_taurusone2one ENSBTAG00000018020Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain). [Source:UniProtKB/Swiss-Prot;Acc:P04695][hgnc]GNAT1
Cavia_porcellusone2one ENSCPOG00000008168Alpha-transducin. [Source:UniProtKB/TrEMBL;Acc:A9LS49][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000001885Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Felis_catusone2one ENSFCAG00000007006Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Tupaia_belangerione2one ENSTBEG00000012902Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Myotis_lucifugusone2one ENSMLUG00000002053Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000011681Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Sorex_araneusone2one ENSSARG00000008774Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Microcebus_murinusone2one ENSMICG00000016240Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Procavia_capensisone2one ENSPCAG00000005787Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Ochotona_princepsone2one ENSOPRG00000015253Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Otolemur_garnettiione2one ENSOGAG00000012515Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Dipodomys_ordiione2one ENSDORG00000000373Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P20612][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000013406Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Loxodonta_africanaone2one ENSLAFG00000006239Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Mus_musculusone2one ENSMUSG00000034837Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P20612][hgnc]Gnat1
Rattus_norvegicusone2one ENSRNOG00000017589guanine nucleotide binding protein, alpha transducing 1 [Source:RefSeq_peptide;Acc:NP_001102250][hgnc]Gnat1_predicted
Spermophilus_tridecemlineatusone2one ENSSTOG00000016186Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Monodelphis_domesticaone2one ENSMODG00000012279Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000014749Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Danio_rerioone2one ENSDARG00000044199guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 [Source:RefSeq_peptide;Acc:NP_571943][hgnc]gnat1
Takifugu_rubripesone2one ENSTRUG00000011180Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Xenopus_tropicalisone2one ENSXETG00000007315Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Oryzias_latipesone2one ENSORLG00000018998Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000012301Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000005463Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]100077091
Anopheles_gambiaeone2many AGAP005904G(Alpha)i. [Source:UniProtKB/TrEMBL;Acc:A0EJE8][hgnc]AgaP_ENSANGG00000011071
Aedes_aegyptimany2many AAEL009037GTP-binding protein (i) alpha subunit, gnai[hgnc]
Aedes_aegyptimany2many AAEL011168GTP-binding protein (i) alpha subunit, gnai[hgnc]
Drosophila_melanogasterone2many FBgn0001104[hgnc]G-ialpha65A
Ciona_savignyione2many ENSCSAVG00000001800[hgnc]
Ciona_intestinalisone2many ENSCING00000005305G protein alpha subunit Gi splicing variant CiGi1a [Source:RefSeq_peptide;Acc:NP_001027619][hgnc]445618