Quick search:







Summary sheet information for Effector 'Phosphodiesterase 1A-Homo sapiens'
Name Phosphodiesterase 1A-Homo sapiens
Description "RecName: Full=Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Short=Cam-PDE 1A; EC=3.1.4.17;AltName: Full=61 kDa Cam-PDE; Short=hCam-1;"
Class
Family Phosphodiesterases
Sub_family Calmodium/calcium-dependent PDEases
type Phosphodiesterase 1A
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
Expand All Collapse All
Genes
Gene Location:
Chromosome: 2
Gene Start: 182715428
Gene End: 183095348
Ensembl Contig View

Ensembl Genes:
ENSG00000115252

EMBL:
EMBL ID  Description
AB038224  Homo sapiens HSPDE1A gene for calmodulin-dependent phosphodiesterase, complete cds, spliced variants.
AB038228  Homo sapiens HSPDE1A mRNA for calmodulin-dependent phosphodiesterase, partial cds, N-terminal variant.
AC010888  Homo sapiens BAC clone RP11-418N16 from 2, complete sequence.
AC012500  Homo sapiens BAC clone RP11-434M17 from 2, complete sequence.
AF110235  Homo sapiens clone L34 calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1A) mRNA, partial cds.
AF110236  Homo sapiens clone L42 calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1A) mRNA, partial cds.
AF110237  Homo sapiens clone C1 calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1A) mRNA, partial cds.
AF110238  Homo sapiens clone H8-3 calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1A) mRNA, partial cds.
AF110239  Homo sapiens calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1A) gene, partial cds.
AJ401610  Homo sapiens mRNA for 3'5' cyclic nucleotide phosphodiesterase (PDE1A5 gene)
AL110263  Homo sapiens mRNA; cDNA DKFZp586G0221 (from clone DKFZp586G0221)
BC022480  Homo sapiens phosphodiesterase 1A, calmodulin-dependent, mRNA (cDNA clone MGC:26303 IMAGE:4814064), complete cds.
U40370  Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1A3A) mRNA, complete cds.

EntrezGene:
ID  Description
PDE1A  phosphodiesterase 1A, calmodulin-dependent

RefSeq DNA:
ID  Description
NM_001003683  Homo sapiens phosphodiesterase 1A, calmodulin-dependent (PDE1A), transcript variant 2, mRNA.
NM_005019  Homo sapiens phosphodiesterase 1A, calmodulin-dependent (PDE1A), transcript variant 1, mRNA.

UniGene:
ID  Description
Hs.191046  Clone L42 calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1A)

Proteins
Ensembl Proteins:
ENSP00000329112; ENSP00000350858; ENSP00000309269; ENSP00000331574

Entrez Proteins:
AAC50436.1; AAD40737.1; AAD40738.1; AAD40739.1; AAD40740.1; AAD40741.1; AAH22480.1; AAY14812.1; AAY14837.1; BAB20038.1; BAB20049.1; BAB20050.1; BAB20051.1; BAB20052.1; BAB20053.1; BAB20054.1; BAB20055.1; BAB20056.1; BAB20057.1; CAB53703.1; CAC82208.1

RefSeq Proteins:
ID  Description
NP_001003683  phosphodiesterase 1A, calmodulin-dependent isoform 2 [Homo sapiens].
NP_005010  phosphodiesterase 1A, calmodulin-dependent isoform 1 [Homo sapiens].

UniProt:
ID  Description
P54750-2  UNKNOWN
P54750-3  UNKNOWN
P54750-4  UNKNOWN
P54750-5  UNKNOWN
P54750-6  UNKNOWN
P54750-7  UNKNOWN
P54750-8  UNKNOWN
P54750-9  UNKNOWN
Q53T15  SubName: Full=Putative uncharacterized protein PDE1A; Flags: Fragment;
Q53TB0  SubName: Full=Putative uncharacterized protein PDE1A; Flags: Fragment;
Q9H3Q8  SubName: Full=Calmodulin-dependent phosphodiesterase; Flags: Fragment;
Q9UNL9  SubName: Full=Calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; Flags: Fragment;
Q9Y246  SubName: Full=Calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; Flags: Fragment;
Q9Y633  SubName: Full=Calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; Flags: Fragment;
Q9Y634  SubName: Full=Calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; Flags: Fragment;
P54750  RecName: Full=Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Short=Cam-PDE 1A; EC=3.1.4.17; AltName: Full=61 kDa Cam-PDE; Short=hCam-1;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Phosphodiesterase 1A-Homo sapiens    

InterPro:
ID  Name
IPR003607  Met-dep_phosphohydro_HD
IPR002073  PDEase
IPR013706  PDEase_N

Pfam:
ID  Description
PDEase_I  3'5'-cyclic nucleotide phosphodiesterase
PDEase_I_N  3'5'-cyclic nucleotide phosphodiesterase N-terminal

Structure
PDB:
ID
1LXQ

HSSP:
ID  Description
1f0j  HYDROLASE
1mkd  HYDROLASE
1oyn  HYDROLASE
1ptw  HYDROLASE
1q9m  HYDROLASE
1ro6  HYDROLASE
1ro9  HYDROLASE
1ror  HYDROLASE
1so2  HYDROLASE
1soj  HYDROLASE
1taz  HYDROLASE
1tb5  HYDROLASE
1tb7  HYDROLASE
1tbb  HYDROLASE
1xlx  HYDROLASE
1xlz  HYDROLASE
1xm4  HYDROLASE
1xm6  HYDROLASE
1xmu  HYDROLASE
1xmy  HYDROLASE
1xn0  HYDROLASE
1xom  HYDROLASE
1xon  HYDROLASE
1xoq  HYDROLASE
1xor  HYDROLASE
1xos  HYDROLASE
1xot  HYDROLASE
1y2b  HYDROLASE
1y2c  HYDROLASE
1y2d  HYDROLASE
1y2e  HYDROLASE
1y2h  HYDROLASE
1y2j  HYDROLASE
1y2k  HYDROLASE
1zkl  HYDROLASE
1zkn  HYDROLASE
2fm0  HYDROLASE
2fm5  HYDROLASE
2pw3  HYDROLASE
2qyk  HYDROLASE
2qyl  HYDROLASE
2qym  HYDROLASE
2qyn  HYDROLASE
2r8q  HYDROLASE
3ecm  HYDROLASE
3ecn  HYDROLASE

PSSH:
ID  Description
P54750  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
171890  PHOSPHODIESTERASE 1A; PDE1A   HCAM1

Gene Ontology
GO:
GO ID  Description
GO:0003824  catalytic activity
GO:0004114  3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004117  calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516  calmodulin binding
GO:0005575  cellular_component
GO:0007165  signal transduction
GO:0016787  hydrolase activity

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa00230  Purine metabolism
hsa04742  Taste transduction

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB00058   Cyclic AMP   Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
HMDB01397   GMP   5'-GMP; E 626; GMP; Guanidine monophosphate; Guanosine 5'-monophosphate; Guanosine 5'-phosphate; Guanosine 5'-phosphorate; Guanosine 5'-phosphoric acid; guanosine monophosphate; guanosine-5'-monophosphate; guanosine-5'-phosphate; guanosine-monophosphate; guanosine-phosphate; guanylate; guanylic acid
HMDB00045   Adenosine monophosphate   5'-AMP; 5'-adenosine monophosphate; 5'-adenylate; 5'-adenylic acid; AMP; Adenosine 5'-monophosphate; Adenosine 5'-phosphate; Adenosine 5'-phosphorate; Adenosine 5'-phosphoric acid; Adenosine phosphate; Adenosine-5'-monophosphorate; Adenosine-5'-monophosphoric acid; Adenosine-5-monophosphorate; Adenosine-5-monophosphoric acid; Adenovite; Adenylate; Adenylic acid; Cardiomone; Lycedan; Muscle adenylate; Muscle adenylic acid; My-B-Den; Phosaden; Phosphaden; Phosphentaside; adenosine-monophosphate; adenosine-phosphate; My-beta-Den
HMDB01314   Cyclic GMP   3',5'-cyclic GMP; 3',5'-guanosine; 3',5'-guanosine monophosphate; cGMP; cyclic 3',5'-guanosine monophosphate; cyclic GMP; cyclic-GMP; cyclic guanosine 3',5'-monophosphate; guanosine 3',5'-cyclic phosphate; guanosine 3',5'-cyclic-monophosphate; guanosine 3',5'-monophosphate; guanosine cyclic-monophosphate; guanosine-cyclic-phosphoric-acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000115252 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750] Pan_troglodytesone2one ENSPTRG00000012706Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]PDE1A
Pongo_pygmaeusone2one ENSPPYG00000012993Putative uncharacterized protein DKFZp459K071. [Source:UniProtKB/TrEMBL;Acc:Q5R9Z0][hgnc]
Macaca_mulattaone2one ENSMMUG00000001163Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Microcebus_murinusone2one ENSMICG00000001911Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Otolemur_garnettiione2one ENSOGAG00000012388Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Tursiops_truncatusone2one ENSTTRG00000015186Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000001574Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Bos_taurusone2one ENSBTAG00000012100Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE). [Source:UniProtKB/Swiss-Prot;Acc:P14100][hgnc]PDE1A
Vicugna_pacosone2one ENSVPAG00000003967Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Myotis_lucifugusone2one ENSMLUG00000009939Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000014285Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Ochotona_princepsone2one ENSOPRG00000012361Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Felis_catusone2one ENSFCAG00000005261Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000000575Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000005903Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Sorex_araneusone2one ENSSARG00000004897Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Loxodonta_africanaone2one ENSLAFG00000013038Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Mus_musculusone2one ENSMUSG00000059173Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q61481][hgnc]Pde1a
Oryctolagus_cuniculusone2one ENSOCUG00000016522Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Cavia_porcellusone2one ENSCPOG00000004164Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Procavia_capensisone2one ENSPCAG00000000107Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Canis_familiarisone2one ENSCAFG00000014245calmodulin-activated cyclic nucleotide phosphodiesterase [Source:RefSeq_peptide;Acc:NP_001003091][hgnc]PDE1A
Tupaia_belangerione2one ENSTBEG00000000913Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Equus_caballusone2one ENSECAG00000022509Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000007008Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Echinops_telfairione2one ENSETEG00000010628Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Dipodomys_ordiione2one ENSDORG00000000875Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q61481][hgnc]
Monodelphis_domesticaone2one ENSMODG00000010443Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Gallus_gallusone2one ENSGALG00000008885Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]PDE1A
Ornithorhynchus_anatinusone2one ENSOANG00000003627Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]100085441
Rattus_norvegicusone2one ENSRNOG00000006154Phosphodiesterase 1A (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q9EPS1][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000008155Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Oryzias_latipesone2one ENSORLG00000013825Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Takifugu_rubripesone2one ENSTRUG00000004307Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000019700Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1) [Source:UniProtKB/Swiss-Prot;Acc:P54750][hgnc]
Anopheles_gambiaeone2many AGAP008967[hgnc]AgaP_ENSANGG00000016879
Caenorhabditis_elegansone2many T04D3.3Probable 3',5'-cyclic phosphodiesterase pde-1 (EC 3.1.4.17). [Source:UniProtKB/Swiss-Prot;Acc:O18696][hgnc]pde-1
Aedes_aegyptione2many AAEL010539calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase[hgnc]
Drosophila_melanogasterone2many FBgn0032379[hgnc]Pde1c
Ciona_savignyione2many ENSCSAVG00000007004[hgnc]
Ciona_intestinalisone2many ENSCING00000006658[hgnc]