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Summary sheet information for Effector 'Rho-Homo sapiens-3'
Name Rho-Homo sapiens-3
Description RecName: Full=Rho-related GTP-binding protein RhoE;AltName: Full=Rho family GTPase 3;AltName: Full=Rnd3;AltName: Full=Rho8;AltName: Full=MemB protein;Flags: Precursor
Class
Family Small GTP-binding proteins
Sub_family Rho small GTPases
type Rho
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 2
Gene Start: 151032955
Gene End: 151052427
Ensembl Contig View

Ensembl Genes:
ENSG00000115963

EMBL:
EMBL ID  Description
AC074097  Homo sapiens BAC clone RP11-333M19 from 2, complete sequence.
AC093738  Homo sapiens BAC clone RP11-21M18 from 2, complete sequence.
AF498969  Homo sapiens small GTP binding protein Rho8 (Rho8) mRNA, complete cds.
AK313224  Homo sapiens cDNA, FLJ93726, highly similar to Homo sapiens ras homolog gene family, member E (ARHE), mRNA.
BC012513  Homo sapiens Rho family GTPase 3, mRNA (cDNA clone MGC:21328 IMAGE:4453777), complete cds.
BT006769  Homo sapiens ras homolog gene family, member E mRNA, complete cds.
CR542038  Homo sapiens full open reading frame cDNA clone RZPDo834C0136D for gene ARHE, ras homolog gene family, member E; complete cds, incl. stopcodon.
CR542070  Homo sapiens full open reading frame cDNA clone RZPDo834F0736D for gene ARHE, ras homolog gene family, member E; complete cds, without stopcodon.
S82240  RhoE=26 kda GTPase homolog [human, HeLa cell line, mRNA, 833 nt].
X95282  H.sapiens mRNA for Rho8 protein
X97758  H.sapiens memB mRNA encoding polypeptide identical to Rho 8 protein

EntrezGene:
ID  Description
RND3  Rho family GTPase 3

RefSeq DNA:
ID  Description
NM_005168  Homo sapiens Rho family GTPase 3 (RND3), mRNA.

UniGene:
ID  Description
Hs.6838  Rho8 protein
Hs.713765  Transcribed locus

Proteins
Ensembl Proteins:
ENSP00000263895; ENSP00000364886

Entrez Proteins:
AAB47133.1; AAH12513.1; AAM21116.1; AAP35415.1; AAX88953.1; AAY15014.1; BAG36035.1; CAA64603.1; CAA66352.1; CAG46835.1; CAG46867.1

RefSeq Proteins:
ID  Description
NP_005159  ras homolog gene family, member E [Homo sapiens].

UniProt:
ID  Description
B2R838  SubName: Full=cDNA, FLJ93726, highly similar to Homo sapiens ras homolog gene family, member E (ARHE), mRNA;
Q4ZFY0  SubName: Full=Putative uncharacterized protein ARHE; Flags: Fragment;
Q53RZ3  SubName: Full=Putative uncharacterized protein ARHE; Flags: Fragment;
Q6FGN7  SubName: Full=ARHE protein; Flags: Fragment;
Q6FGR9  SubName: Full=ARHE protein;
P61587  RecName: Full=Rho-related GTP-binding protein RhoE; AltName: Full=Rho family GTPase 3; AltName: Full=Rnd3; AltName: Full=Rho8; AltName: Full=MemB protein; Flags: Precursor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Rho-Homo sapiens-3    

InterPro:
ID  Name
IPR005225  Small_GTP_bd
IPR003578  GTPase_Rho
IPR001806  Ras_trnsfrmng
IPR013753  Ras

Pfam:
ID  Description
Ras  Ras family

Structure
PDB:
ID
1M7B
2V55

HSSP:
ID  Description
1a2b  ONCOGENE PROTEIN
1a4r  HYDROLASE
1aje  G-PROTEIN
1an0  GTPASE
1cc0  SIGNALING PROTEIN
1cee  STRUCTURAL PROTEIN REGULATION
1cf4  TRANSFERASE
1cxz  SIGNALING PROTEIN
1doa  CELL CYCLE
1dpf  GENE REGULATION/SIGNALING PROTEIN
1ds6  SIGNALING PROTEIN
1e0a  SIGNALLING PROTEIN
1e96  SIGNALLING COMPLEX
1ees  STRUCTURAL PROTEIN
1ftn  PROTO-ONCOGENE
1g4u  SIGNALING PROTEIN
1gwn  GTPASE
1gzs  COMPLEX (TOXIN/CELL CYCLE PROTEIN)
1he1  SIGNALLING COMPLEX
1hh4  SINGAL PROTEIN INHIBITOR COMPLEX
1i4d  SIGNALING PROTEIN
1i4l  SIGNALING PROTEIN
1i4t  SIGNALING PROTEIN
1kmq  SIGNALING PROTEIN
1kz7  SIGNALING PROTEIN
1lb1  SIGNALING PROTEIN
1m7b  SIGNALING PROTEIN
1mh1  GTP-BINDING
1ow3  GENE REGULATION/SIGNALING PROTEIN
1ryf  HYDROLASE
1ryh  HYDROLASE
1s1c  SIGNALING PROTEIN
1tx4  COMPLEX(GTPASE ACTIVATN/PROTO-ONCOGENE)
1x86  SIGNALING PROTEIN/MEMBRANE PROTEIN
1xcg  SIGNALING PROTEIN ACTIVATOR/SIGNALING PR
1z2c  SIGNALING PROTEIN
2ase  SIGNALING PROTEIN
2atx  HYDROLASE
2c2h  SIGNALING PROTEIN
2cls  NUCLEOTIDE BINDING PROTEIN
2fju  SIGNALING PROTEIN,APOPTOSIS/HYDROLASE
2fv8  SIGNALING PROTEIN
2g0n  SIGNALING PROTEIN
2gcn  SIGNALING PROTEIN
2gco  SIGNALING PROTEIN
2gcp  SIGNALING PROTEIN
2h7v  SIGNALING PROTEIN
2ic5  SIGNALING PROTEIN
2j0v  NUCLEOTIDE-BINDING PROTEIN
2j1l  HYDROLASE
2nty  SIGNALING PROTEIN
2nz8  SIGNALING PROTEIN,CELL CYCLE
2odb  PROTEIN BINDING
2ov2  PROTEIN BINDING/TRANSFERASE
2p2l  UNKNOWN FUNCTION
2q3h  STRUCTURAL GENOMICS
2qme  SIGNALING PROTEIN/TRANSFERASE
2qrz  CELL CYCLE
2rex  SIGNALING PROTEIN/LIPOPROTEIN
2rgn  SIGNALING PROTEIN COMPLEX
2rmk  MEMBRANE PROTEIN/TRANSFERASE
2v55  TRANSFERASE
3bwd  PLANT PROTEIN
3eg5  SIGNALING PROTEIN

PSSH:
ID  Description
Q4ZFY0  UNKNOWN
Q53RZ3  UNKNOWN
Q6FGR9  UNKNOWN
Q6FGN7  UNKNOWN
P61587  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
602924  RHO FAMILY GTPase 3; RND3   RAS HOMOLOG GENE FAMILY, MEMBER E; RHOE ARHE

Gene Ontology
GO:
GO ID  Description
GO:0000139  Golgi membrane
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005515  protein binding
GO:0005525  GTP binding
GO:0005622  intracellular
GO:0005794  Golgi apparatus
GO:0006886  intracellular protein transport
GO:0006913  nucleocytoplasmic transport
GO:0007155  cell adhesion
GO:0007165  signal transduction
GO:0007264  small GTPase mediated signal transduction
GO:0015031  protein transport
GO:0016020  membrane
GO:0030036  actin cytoskeleton organization

Pathway
KEGG:
KEGG PATHWAY ID  Name

Panther:
ID  Description
P00034  Integrin signalling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000115963 Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587] Pan_troglodytesone2one ENSPTRG00000012527Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]RND3
Pongo_pygmaeusone2one ENSPPYG00000012842Rho-related GTP-binding protein RhoE precursor (Rho family GTPase 3) (Rnd3). [Source:UniProtKB/Swiss-Prot;Acc:Q5R9F4][hgnc]
Macaca_mulattaone2one ENSMMUG00000016040Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000010971Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Microcebus_murinusone2one ENSMICG00000002522Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Tupaia_belangerione2one ENSTBEG00000008684Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Otolemur_garnettiione2one ENSOGAG00000006980Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000009798Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Dipodomys_ordiione2one ENSDORG00000012267Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) [Source:UniProtKB/Swiss-Prot;Acc:P61588][hgnc]
Tursiops_truncatusone2one ENSTTRG00000006101Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Equus_caballusone2one ENSECAG00000021310Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]LOC100050088
Oryctolagus_cuniculusone2one ENSOCUG00000001751Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000004736Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Felis_catusone2one ENSFCAG00000004396Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000002813Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Bos_taurusone2many ENSBTAG00000040522MGC148524 protein. [Source:UniProtKB/TrEMBL;Acc:A5PKJ7][hgnc]LOC790776
Bos_taurusone2many ENSBTAG00000039731MGC148524 protein. [Source:UniProtKB/TrEMBL;Acc:A5PKJ7][hgnc]LOC790776
Myotis_lucifugusone2one ENSMLUG00000014656Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Procavia_capensisone2one ENSPCAG00000006176Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Vicugna_pacosone2one ENSVPAG00000009769Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Cavia_porcellusone2one ENSCPOG00000026122Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Loxodonta_africanaone2one ENSLAFG00000010712Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Echinops_telfairione2one ENSETEG00000004538Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000003237Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Ochotona_princepsone2one ENSOPRG00000009428Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Mus_musculusone2one ENSMUSG00000017144Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) [Source:UniProtKB/Swiss-Prot;Acc:P61588][hgnc]Rnd3
Rattus_norvegicusone2one ENSRNOG00000004624Rho-related GTP-binding protein RhoE precursor (Rho family GTPase 3) (Rnd3). [Source:UniProtKB/Swiss-Prot;Acc:Q6SA80][hgnc]Rnd3
Canis_familiarisone2one ENSCAFG00000005644Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]RND3
Monodelphis_domesticaone2one ENSMODG00000003575Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Sorex_araneusone2one ENSSARG00000010183Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000006074Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]100076929
Gallus_gallusone2one ENSGALG00000012478Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]RND3
Xenopus_tropicalisone2one ENSXETG00000025335MGC89092 protein. [Source:UniProtKB/TrEMBL;Acc:Q6DJ10][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000010361Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Takifugu_rubripesone2one ENSTRUG00000002950Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000014917Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Oryzias_latipesone2one ENSORLG00000004278Rho-related GTP-binding protein RhoE Precursor (Rho family GTPase 3) (Rnd3) (Rho8) (MemB protein) [Source:UniProtKB/Swiss-Prot;Acc:P61587][hgnc]
Danio_rerioone2one ENSDARG00000007396Rho family GTPase 3b [Source:RefSeq_peptide;Acc:NP_001002591][hgnc]rnd3b
Saccharomyces_cerevisiaemany2many YIL118WGTP-binding protein RHO3 precursor. [Source:UniProtKB/Swiss-Prot;Acc:Q00245][hgnc]RHO3
Saccharomyces_cerevisiaemany2many YNL090WGTP-binding protein RHO2 precursor. [Source:UniProtKB/Swiss-Prot;Acc:P06781][hgnc]RHO2