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Summary sheet information for Effector 'Adenylate cyclase 7-Homo sapiens'
Name Adenylate cyclase 7-Homo sapiens
Description RecName: Full=Adenylate cyclase type 7; EC=4.6.1.1;AltName: Full=Adenylate cyclase type VII;AltName: Full=ATP pyrophosphate-lyase 7;AltName: Full=Adenylyl cyclase 7
Class
Family Cyclases
Sub_family Adenylate cyclases
type Adenylate cyclase 7
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 16
Gene Start: 48857979
Gene End: 48909547
Ensembl Contig View

Ensembl Genes:
ENSG00000121281

EMBL:
EMBL ID  Description
BC039891  Homo sapiens adenylate cyclase 7, mRNA (cDNA clone IMAGE:5211601), complete cds.
BC126271  Homo sapiens adenylate cyclase 7, mRNA (cDNA clone MGC:161549 IMAGE:8991987), complete cds.
D25538  Homo sapiens KIAA0037 mRNA, partial cds.

EntrezGene:
ID  Description
ADCY7  adenylate cyclase 7

RefSeq DNA:
ID  Description
NM_001114  Homo sapiens adenylate cyclase 7 (ADCY7), mRNA.

UniGene:
ID  Description
Hs.708878  Transcribed locus

Proteins
Ensembl Proteins:
ENSP00000378187; ENSP00000254235

Entrez Proteins:
AAH39891.1; AAI26272.1; BAA05021.2

RefSeq Proteins:
ID  Description
NP_001105  adenylate cyclase 7 [Homo sapiens].

UniProt:
ID  Description
Q86YI0  SubName: Full=ADCY7 protein;
P51828  RecName: Full=Adenylate cyclase type 7; EC=4.6.1.1; AltName: Full=Adenylate cyclase type VII; AltName: Full=ATP pyrophosphate-lyase 7; AltName: Full=Adenylyl cyclase 7;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR001054  A/G_cyclase
IPR009398  Aden_cycl_like

Pfam:
ID  Description
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
DUF1053  Domain of Unknown Function (DUF1053)

Structure
PDB:
ID

HSSP:
ID  Description
1ab8  LYASE
1azs  COMPLEX (LYASE/HYDROLASE)
1cjk  LYASE/LYASE/SIGNALING PROTEIN
1cjt  LYASE/LYASE/SIGNALING PROTEIN
1cju  LYASE/LYASE/SIGNALING PROTEIN
1cjv  LYASE/LYASE/SIGNALING PROTEIN
1cs4  LYASE/LYASE/SIGNALING PROTEIN
1cul  LYASE/LYASE/SIGNALING PROTEIN
1tl7  LYASE
1u0h  LYASE
1yk9  LYASE
2gvd  LYASE
2gvz  LYASE
3c14  LYASE/LYASE INHIBITOR
3c15  LYASE/LYASE INHIBITOR
3c16  LYASE/LYASE INHIBITOR
3et6  LYASE

PSSH:
ID  Description
Q86YI0  UNKNOWN
P51828  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
600385  ADENYLATE CYCLASE 7; ADCY7   ADENYLYL CYCLASE 7

Gene Ontology
GO:
GO ID  Description
GO:0000287  magnesium ion binding
GO:0004016  adenylate cyclase activity
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0006171  cAMP biosynthetic process
GO:0007190  activation of adenylate cyclase activity
GO:0007242  intracellular signaling cascade
GO:0009190  cyclic nucleotide biosynthetic process
GO:0016021  integral to membrane
GO:0016849  phosphorus-oxygen lyase activity

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04062  Chemokine signaling pathway
hsa05414  Dilated cardiomyopathy
hsa04540  Gap junction
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa00230  Purine metabolism
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description
P05916  Opioid prodynorphin pathway
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P05731  GABA-B receptor II signaling
P04379  Beta3 adrenergic receptor signaling pathway
P04376  5HT4 type receptor mediated signaling pathway
P04386  Histamine H2 receptor mediated signaling pathway
P05912  Dopamine receptor mediated signaling pathway
P00019  Endothelin signaling pathway
P04377  Beta1 adrenergic receptor signaling pathway
P04378  Beta2 adrenergic receptor signaling pathway
P05913  Enkephalin release
P04373  5HT1 type receptor mediated signaling pathway
P05915  Opioid proenkephalin pathway
P05917  Opioid proopiomelanocortin pathway

Chemicals
DrugBank:
ID  Name  Synonyms
DB01497  Etorphine  19-Propylorvinol; 7-alpha-Etorphine; DEA No. 9056; Etorphine HCl; Etorphine Hydrochloride; Etorphinum [INN-Latin]; M99
DB01200  Bromocriptine  Bromergocryptine; Bromocriptin; Bromocriptina [INN-Spanish]; Bromocriptine Mesylate; Bromocriptine Methanesulfonate; Bromocriptinum [INN-Latin]; Bromocryptine; Bromocryptine Mesylate; Bromoergocriptine; Bromoergocryptine; bromocriptine
HMDB:
ID  Name  Synonyms
HMDB00250   Pyrophosphate   (4-)Diphosphoric acid ion; (P2O74-)Diphosphate; Diphosphate; Pyrometaphosphate; Pyrophosphate; Pyrophosphate tetraanion; Pyrophosphate(4-) ion; Pyrophosphic acid
HMDB00058   Cyclic AMP   Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
HMDB00538   Adenosine triphosphate   5'-(tetrahydrogen triphosphate) Adenosine; 5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine triphosphic acid; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adetol; Adynol; Atipi; Atriphos; Cardenosine; Fosfobion; Glucobasin; Myotriphos; Phosphobion; Striadyne; Triadenyl; Triphosphaden; Triphosphoric acid adenosine ester
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000121281 Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828] Procavia_capensisone2one ENSPCAG00000010039Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000016722Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Tetraodon_nigroviridisapprent_one2one ENSTNIG00000003784Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000007338Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Macaca_mulattaone2one ENSMMUG00000003118Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Pan_troglodytesone2one ENSPTRG00000008102Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Microcebus_murinusone2one ENSMICG00000011063Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Tursiops_truncatusone2one ENSTTRG00000013377Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Tupaia_belangerione2one ENSTBEG00000012943Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000001042Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Otolemur_garnettiione2one ENSOGAG00000011284Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Bos_taurusone2one ENSBTAG00000006208Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7). [Source:UniProtKB/Swiss-Prot;Acc:Q29450][hgnc]ADCY7
Canis_familiarisone2one ENSCAFG00000009913Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000004170Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Loxodonta_africanaone2one ENSLAFG00000009995Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000011328Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000001199Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Dipodomys_ordiione2one ENSDORG00000010503Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51829][hgnc]
Cavia_porcellusone2one ENSCPOG00000003271Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Equus_caballusone2one ENSECAG00000007149Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Rattus_norvegicusone2one ENSRNOG00000014776Adenylyl cyclase 7 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q8CFM9][hgnc]Adcy7
Oryctolagus_cuniculusone2one ENSOCUG00000003091Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Echinops_telfairione2one ENSETEG00000014843Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Mus_musculusone2one ENSMUSG00000031659Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51829][hgnc]Adcy7
Sorex_araneusone2one ENSSARG00000005596Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Ochotona_princepsone2one ENSOPRG00000014210Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Monodelphis_domesticaone2one ENSMODG00000013047Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Gallus_gallusone2one ENSGALG00000003837Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]LOC769333
Takifugu_rubripesone2one ENSTRUG00000007114Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Oryzias_latipesone2one ENSORLG00000013973Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Xenopus_tropicalisone2one ENSXETG00000018459Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Danio_rerioapprent_one2one ENSDARG00000060070Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]
Ornithorhynchus_anatinusapprent_one2one ENSOANG00000000590Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7) [Source:UniProtKB/Swiss-Prot;Acc:P51828][hgnc]100076221