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Summary sheet information for Effector 'ATP-sensitive inward rectifier potassium channel 8-Homo sapiens'
Name ATP-sensitive inward rectifier potassium channel 8-Homo sapiens
Description "RecName: Full=ATP-sensitive inward rectifier potassium channel 8;AltName: Full=Potassium channel, inwardly rectifying subfamily J member 8;AltName: Full=Inwardly rectifier K(+) channel Kir6.1;AltName: Full=uKATP-1;"
Class
Family Ion channels
Sub_family ATP-sensitive inward rectifier potassium channels
type ATP-sensitive inward rectifier potassium channel 8
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 12
Gene Start: 21809156
Gene End: 21819014
Ensembl Contig View

Ensembl Genes:
ENSG00000121361

EMBL:
EMBL ID  Description
AK291821  Homo sapiens cDNA FLJ75271 complete cds, highly similar to Human mRNA for uKATP-1.
BC000544  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 8, mRNA (cDNA clone MGC:1462 IMAGE:3161776), complete cds.
D50312  Homo sapiens mRNA for uKATP-1, complete cds.
D50315  Homo sapiens KCNJ8 gene for uKATP-1, complete cds.

EntrezGene:
ID  Description
KCNJ8  potassium inwardly-rectifying channel, subfamily J, member 8

RefSeq DNA:
ID  Description
NM_004982  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 8 (KCNJ8), mRNA.

UniGene:
ID  Description
Hs.102308  CDNA FLJ75271 complete cds, highly similar to Human mRNA for uKATP-1
Hs.619408  Transcribed locus

Proteins
Ensembl Proteins:
ENSP00000240662

Entrez Proteins:
AAH00544.1; BAA08851.1; BAA08852.1; BAF84510.1

RefSeq Proteins:
ID  Description
NP_004973  potassium inwardly-rectifying channel J8 [Homo sapiens].

UniProt:
ID  Description
A8K706  SubName: Full=cDNA FLJ75271, highly similar to Human uKATP-1;
Q15842  RecName: Full=ATP-sensitive inward rectifier potassium channel 8; AltName: Full=Potassium channel, inwardly rectifying subfamily J member 8; AltName: Full=Inwardly rectifier K(+) channel Kir6.1; AltName: Full=uKATP-1;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     ATP-sensitive inward rectifier potassium channel 8-Homo sapiens    

InterPro:
ID  Name
IPR003278  K_chnl_inward-rec_Kir6.1
IPR016449  K_chnl_inward-rec_Kir
IPR013521  K_chnl_inward-rec_Kir_Cr2
IPR001838  K_chnl_inward-rec_Kir-like
IPR013518  K_chnl_inward-rec_Kir_cyto

Pfam:
ID  Description
IRK  Inward rectifier potassium channel

Structure
PDB:
ID

HSSP:
ID  Description
1n9p  METAL TRANSPORT
1p7b  METAL TRANSPORT
1u4e  METAL TRANSPORT
1u4f  ALLERGEN
1xl4  METAL TRANSPORT
1xl6  METAL TRANSPORT
2e4f  TRANSPORT PROTEIN
2gix  METAL TRANSPORT
2qks  METAL TRANSPORT

PSSH:
ID  Description
Q15842  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
600935  POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 8; KCNJ8   INWARDLY RECTIFYING POTASSIUM CHANNEL Kir6.1

Gene Ontology
GO:
GO ID  Description
GO:0001822  kidney development
GO:0005244  voltage-gated ion channel activity
GO:0005515  protein binding
GO:0005524  ATP binding
GO:0005739  mitochondrion
GO:0005792  microsome
GO:0006811  ion transport
GO:0006813  potassium ion transport
GO:0007507  heart development
GO:0008076  voltage-gated potassium channel complex
GO:0008282  ATP-sensitive potassium channel complex
GO:0009268  response to pH
GO:0010107  potassium ion import
GO:0015272  ATP-activated inward rectifier potassium channel activity
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0030016  myofibril
GO:0030955  potassium ion binding
GO:0032496  response to lipopolysaccharide
GO:0042311  vasodilation
GO:0042383  sarcolemma
GO:0043330  response to exogenous dsRNA
GO:0051607  defense response to virus

Pathway
KEGG:
KEGG PATHWAY ID  Name

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
DB00922  Levosimendan  Levosimedan
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000121361 ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842] Caenorhabditis_elegansmany2many M02A10.2irk-2 encodes an inwardly rectifying potassium channel based on sequence homology to the the human potassium channel genes KCNJ1/KCNJ2. [Source: WormBase][hgnc]irk-2
Takifugu_rubripesone2one ENSTRUG00000009953ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Aedes_aegyptimany2many AAEL008931inwardly rectifying k+ channel,[hgnc]
Caenorhabditis_elegansmany2many R03E9.4Inward rectifier potassium channel irk-1. [Source:UniProtKB/Swiss-Prot;Acc:P52192][hgnc]irk-1
Aedes_aegyptimany2many AAEL013373inwardly rectifying k+ channel,[hgnc]
Pan_troglodytesone2one ENSPTRG00000004763ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]KCNJ8
Pongo_pygmaeusone2one ENSPPYG00000004357ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Macaca_mulattaone2one ENSMMUG00000020805ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000009049ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Equus_caballusone2one ENSECAG00000016950ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]LOC100064325
Pteropus_vampyrusone2one ENSPVAG00000002463ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Canis_familiarisone2one ENSCAFG00000012190ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]KCNJ8
Myotis_lucifugusone2one ENSMLUG00000005051ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Echinops_telfairione2one ENSETEG00000009805ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000001502ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Cavia_porcellusone2one ENSCPOG00000011535Inward rectifier potassium channel Kir6.1. [Source:UniProtKB/TrEMBL;Acc:Q99N30][hgnc]
Tursiops_truncatusone2one ENSTTRG00000017218ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Procavia_capensisone2one ENSPCAG00000001464ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Bos_taurusone2one ENSBTAG00000002551potassium inwardly-rectifying channel, subfamily J, member 8 [Source:RefSeq_peptide;Acc:NP_001035572][hgnc]KCNJ8
Tupaia_belangerione2one ENSTBEG00000000546ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Mus_musculusone2one ENSMUSG00000030247ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:P97794][hgnc]Kcnj8
Ochotona_princepsone2one ENSOPRG00000016675ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Rattus_norvegicusone2one ENSRNOG00000013463ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1). [Source:UniProtKB/Swiss-Prot;Acc:Q63664][hgnc]Kcnj8
Oryctolagus_cuniculusone2one ENSOCUG00000008019Inwardly rectifying potassium channel Kir6.1 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q9BED5][hgnc]
Vicugna_pacosone2one ENSVPAG00000007551ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Sorex_araneusone2one ENSSARG00000010493ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Monodelphis_domesticaone2one ENSMODG00000017782ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000000450ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000011551ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Dipodomys_ordiione2one ENSDORG00000002924ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:P97794][hgnc]
Gallus_gallusone2one ENSGALG00000013251ATP-sensitive potassium channel Kir6.1 (Fragment). [Source:UniProtKB/TrEMBL;Acc:O42508][hgnc]KCNJ8
Ornithorhynchus_anatinusone2one ENSOANG00000010537ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]100090648
Xenopus_tropicalisone2one ENSXETG00000011920ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000001115ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000006480ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Oryzias_latipesone2one ENSORLG00000017094ATP-sensitive inward rectifier potassium channel 8 (Potassium channel, inwardly rectifying subfamily J member 8) (Inwardly rectifier K(+) channel Kir6.1) (uKATP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15842][hgnc]
Danio_rerioone2one ENSDARG00000045589potassium inwardly-rectifying channel, subfamily J, member 8 [Source:RefSeq_peptide;Acc:NP_001025324][hgnc]kcnj8
Aedes_aegyptimany2many AAEL008932inwardly rectifying k+ channel,[hgnc]
Drosophila_melanogastermany2many FBgn0039061[hgnc]Ir
Anopheles_gambiaemany2many AGAP001280[hgnc]AgaP_ENSANGG00000017854
Drosophila_melanogastermany2many FBgn0039081[hgnc]Irk2
Aedes_aegyptimany2many AAEL008928inwardly rectifying k+ channel,[hgnc]
Anopheles_gambiaemany2many AGAP001283[hgnc]AgaP_ENSANGG00000017795
Anopheles_gambiaemany2many AGAP001281[hgnc]AgaP_ENSANGG00000020396
Anopheles_gambiaemany2many AGAP001284[hgnc]AgaP_ENSANGG00000024811