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Summary sheet information for Effector 'Phosphodiesterase 1B-Homo sapiens'
Name Phosphodiesterase 1B-Homo sapiens
Description "RecName: Full=Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Short=Cam-PDE 1B; EC=3.1.4.17;AltName: Full=63 kDa Cam-PDE;"
Class
Family Phosphodiesterases
Sub_family Calmodium/calcium-dependent PDEases
type Phosphodiesterase 1B
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 12
Gene Start: 53229671
Gene End: 53259290
Ensembl Contig View

Ensembl Genes:
ENSG00000123360

EMBL:
EMBL ID  Description
AJ401609  Homo sapiens mRNA for 3'5' cyclic nucleotide phosphodiesterase 1B2 (PDE1B2 gene)
BC032226  Homo sapiens phosphodiesterase 1B, calmodulin-dependent, mRNA (cDNA clone MGC:34576 IMAGE:5200139), complete cds.
BX538092  Homo sapiens mRNA; cDNA DKFZp686L23131 (from clone DKFZp686L23131)
CH471054  Homo sapiens 211000035840223 genomic scaffold, whole genome shotgun sequence.
M94539  Homo sapiens cyclic nucleotide phosphodiesterase (CaM-PDE) mRNA, partial cds.
U40584  Human calcium/calmodulin stimulated cyclic nucleotide phosphodiesterase (PDE1B) mRNA, partial cds.
U56976  Human calmodulin dependent phosphodiesterase PDE1B1 mRNA, complete cds.
U86077  Homo sapiens calmodulin-stimulated phosphodiesterase PDE1B1 gene, partial cds.
U86078  Homo sapiens calmodulin-stimulated phosphodiesterase PDE1B1 mRNA, complete cds.

EntrezGene:
ID  Description
PDE1B  phosphodiesterase 1B, calmodulin-dependent

RefSeq DNA:
ID  Description
NM_000924  Homo sapiens phosphodiesterase 1B, calmodulin-dependent (PDE1B), mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000377818; ENSP00000243052

Entrez Proteins:
AAA58405.1; AAB50018.1; AAC50769.1; AAC51871.1; AAC51872.1; AAH32226.1; CAC82207.1; CAD98011.1; EAW96790.1

RefSeq Proteins:
ID  Description
NP_000915  phosphodiesterase 1B, calmodulin-dependent [Homo sapiens].

UniProt:
ID  Description
O15307  SubName: Full=Calmodulin-stimulated phosphodiesterase PDE1B1; Flags: Fragment;
Q16713  SubName: Full=Calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; EC=3.1.4.17; Flags: Fragment;
Q7Z364  SubName: Full=Putative uncharacterized protein DKFZp686L23131; SubName: Full=cDNA FLJ54120, highly similar to Calcium/calmodulin-dependent 3',5'-cyclicnucleotide phosphodiesterase 1B (EC 3.1.4.17);
Q96KP3  SubName: Full=3'5' cyclic nucleotide phosphodiesterase 1B2; SubName: Full=cDNA FLJ53684, highly similar to Calcium/calmodulin-dependent 3',5'-cyclicnucleotide phosphodiesterase 1B (EC 3.1.4.17); SubName: Full=Phosphodiesterase 1B, calmodulin-dependent, isoform CRA_b;
Q01064  RecName: Full=Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Short=Cam-PDE 1B; EC=3.1.4.17; AltName: Full=63 kDa Cam-PDE;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Phosphodiesterase 1B-Homo sapiens    

InterPro:
ID  Name
IPR002073  PDEase
IPR013706  PDEase_N
IPR003607  Met-dep_phosphohydro_HD

Pfam:
ID  Description
PDEase_I  3'5'-cyclic nucleotide phosphodiesterase
PDEase_I_N  3'5'-cyclic nucleotide phosphodiesterase N-terminal

Structure
PDB:
ID
1LXR
1TAZ

HSSP:
ID  Description
1f0j  HYDROLASE
1mkd  HYDROLASE
1oyn  HYDROLASE
1ptw  HYDROLASE
1q9m  HYDROLASE
1ro6  HYDROLASE
1ro9  HYDROLASE
1ror  HYDROLASE
1so2  HYDROLASE
1soj  HYDROLASE
1t9s  HYDROLASE
1taz  HYDROLASE
1tb5  HYDROLASE
1tb7  HYDROLASE
1tbb  HYDROLASE
1tbf  HYDROLASE
1xlx  HYDROLASE
1xlz  HYDROLASE
1xm4  HYDROLASE
1xm6  HYDROLASE
1xmu  HYDROLASE
1xmy  HYDROLASE
1xn0  HYDROLASE
1xom  HYDROLASE
1xon  HYDROLASE
1xoq  HYDROLASE
1xor  HYDROLASE
1xos  HYDROLASE
1xot  HYDROLASE
1xoz  HYDROLASE
1xp0  HYDROLASE
1y2b  HYDROLASE
1y2c  HYDROLASE
1y2d  HYDROLASE
1y2e  HYDROLASE
1y2h  HYDROLASE
1y2j  HYDROLASE
1y2k  HYDROLASE
1z1l  HYDROLASE
1zkl  HYDROLASE
1zkn  HYDROLASE
2chm  HYDROLASE
2fm0  HYDROLASE
2fm5  HYDROLASE
2hd1  HYDROLASE
2pw3  HYDROLASE
2qyk  HYDROLASE
2qyl  HYDROLASE
2qym  HYDROLASE
2qyn  HYDROLASE
2r8q  HYDROLASE
2yy2  HYDROLASE
3dy8  HYDROLASE
3dyl  HYDROLASE
3dyn  HYDROLASE
3dyq  HYDROLASE
3dys  HYDROLASE
3ecm  HYDROLASE
3ecn  HYDROLASE

PSSH:
ID  Description
Q7Z364  UNKNOWN
Q96KP3  UNKNOWN
O15307  UNKNOWN
Q01064  UNKNOWN
Q16713  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
171891  PHOSPHODIESTERASE 1B; PDE1B   PDE1B1

Gene Ontology
GO:
GO ID  Description
GO:0003824  catalytic activity
GO:0004112  cyclic-nucleotide phosphodiesterase activity
GO:0004114  3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004117  calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516  calmodulin binding
GO:0005737  cytoplasm
GO:0006915  apoptosis
GO:0007165  signal transduction
GO:0007626  locomotory behavior
GO:0008542  visual learning
GO:0016787  hydrolase activity

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa00230  Purine metabolism

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB01314   Cyclic GMP   3',5'-cyclic GMP; 3',5'-guanosine; 3',5'-guanosine monophosphate; cGMP; cyclic 3',5'-guanosine monophosphate; cyclic GMP; cyclic-GMP; cyclic guanosine 3',5'-monophosphate; guanosine 3',5'-cyclic phosphate; guanosine 3',5'-cyclic-monophosphate; guanosine 3',5'-monophosphate; guanosine cyclic-monophosphate; guanosine-cyclic-phosphoric-acid
HMDB00045   Adenosine monophosphate   5'-AMP; 5'-adenosine monophosphate; 5'-adenylate; 5'-adenylic acid; AMP; Adenosine 5'-monophosphate; Adenosine 5'-phosphate; Adenosine 5'-phosphorate; Adenosine 5'-phosphoric acid; Adenosine phosphate; Adenosine-5'-monophosphorate; Adenosine-5'-monophosphoric acid; Adenosine-5-monophosphorate; Adenosine-5-monophosphoric acid; Adenovite; Adenylate; Adenylic acid; Cardiomone; Lycedan; Muscle adenylate; Muscle adenylic acid; My-B-Den; Phosaden; Phosphaden; Phosphentaside; adenosine-monophosphate; adenosine-phosphate; My-beta-Den
HMDB01397   GMP   5'-GMP; E 626; GMP; Guanidine monophosphate; Guanosine 5'-monophosphate; Guanosine 5'-phosphate; Guanosine 5'-phosphorate; Guanosine 5'-phosphoric acid; guanosine monophosphate; guanosine-5'-monophosphate; guanosine-5'-phosphate; guanosine-monophosphate; guanosine-phosphate; guanylate; guanylic acid
HMDB00058   Cyclic AMP   Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000123360 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064] Pan_troglodytesone2one ENSPTRG00000005043Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]PDE1B
Pongo_pygmaeusone2one ENSPPYG00000004607Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Macaca_mulattaone2one ENSMMUG00000000111Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Otolemur_garnettiione2one ENSOGAG00000017229Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Microcebus_murinusone2one ENSMICG00000008475Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Tursiops_truncatusone2one ENSTTRG00000004455Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Tupaia_belangerione2one ENSTBEG00000009433Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Equus_caballusone2one ENSECAG00000022552Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]LOC100064711
Pteropus_vampyrusone2one ENSPVAG00000000336Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Cavia_porcellusone2one ENSCPOG00000015102Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000008136Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Bos_taurusone2one ENSBTAG00000004337Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE). [Source:UniProtKB/Swiss-Prot;Acc:Q01061][hgnc]PDE1B
Felis_catusone2one ENSFCAG00000010158Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Dipodomys_ordiione2one ENSDORG00000002126Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01065][hgnc]
Rattus_norvegicusone2one ENSRNOG00000036828Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE). [Source:UniProtKB/Swiss-Prot;Acc:Q01066][hgnc]Pde1b
Dasypus_novemcinctusone2one ENSDNOG00000001449Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Procavia_capensisone2one ENSPCAG00000009475Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Mus_musculusone2one ENSMUSG00000022489Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01065][hgnc]Pde1b
Tarsius_syrichtaone2one ENSTSYG00000008530Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000015934Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Myotis_lucifugusone2one ENSMLUG00000012983Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000013538Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Ochotona_princepsone2one ENSOPRG00000017280Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000006946Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Takifugu_rubripesone2one ENSTRUG00000009342Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Oryzias_latipesone2one ENSORLG00000004927Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Xenopus_tropicalisone2one ENSXETG00000004298Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000014823Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000003121Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064][hgnc]
Anopheles_gambiaeone2many AGAP008967[hgnc]AgaP_ENSANGG00000016879
Caenorhabditis_elegansone2many T04D3.3Probable 3',5'-cyclic phosphodiesterase pde-1 (EC 3.1.4.17). [Source:UniProtKB/Swiss-Prot;Acc:O18696][hgnc]pde-1
Aedes_aegyptione2many AAEL010539calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase[hgnc]
Drosophila_melanogasterone2many FBgn0032379[hgnc]Pde1c
Ciona_savignyione2many ENSCSAVG00000007004[hgnc]
Ciona_intestinalisone2many ENSCING00000006658[hgnc]