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Summary sheet information for Effector 'GRK4-Homo sapiens'
Name GRK4-Homo sapiens
Description RecName: Full=G protein-coupled receptor kinase 4; EC=2.7.11.16;AltName: Full=G protein-coupled receptor kinase GRK4;AltName: Full=ITI1
Class
Family Ser Thr protein kinases
Sub_family G protein coupled receptor kinases
type GRK4
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 4
Gene Start: 2935096
Gene End: 3012270
Ensembl Contig View

Ensembl Genes:
ENSG00000125388

EMBL:
EMBL ID  Description
AK223581  Homo sapiens mRNA for G protein-coupled receptor kinase 2-like isoform 2 variant, clone: FCC130B05.
AK292390  Homo sapiens cDNA FLJ76938 complete cds, highly similar to Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant 1, mRNA.
BC117320  Homo sapiens G protein-coupled receptor kinase 4, mRNA (cDNA clone MGC:150929 IMAGE:40125871), complete cds.
L03718  Human G protein-coupled receptor (kinase-like) gene, complete cds.
U33054  Human G protein-coupled receptor kinase GRK4 mRNA, alpha splice variant, complete cds.
U33055  Human G protein-coupled receptor kinase GRK4 mRNA, beta splice variant, complete cds.
U33056  Human G protein-coupled receptor kinase GRK4 mRNA, gamma splice variant, complete cds.
U33153  Human G protein-coupled receptor kinase GRK4 gene, exon 1.
U33154  Human G protein-coupled receptor kinase GRK4 gene, exon 2.
U33155  Human G protein-coupled receptor kinase GRK4 gene, exon 3.
U33156  Human G protein-coupled receptor kinase GRK4 gene, exon 4.
U33157  Human G protein-coupled receptor kinase GRK4 gene, exon 5.
U33158  Human G protein-coupled receptor kinase GRK4 gene, exon 6.
U33159  Human G protein-coupled receptor kinase GRK4 gene, exon 7.
U33160  Human G protein-coupled receptor kinase GRK4 gene, exon 8.
U33161  Human G protein-coupled receptor kinase GRK4 gene, exon 9.
U33162  Human G protein-coupled receptor kinase GRK4 gene, exon 10.
U33163  Human G protein-coupled receptor kinase GRK4 gene, exon 11.
U33164  Human G protein-coupled receptor kinase GRK4 gene, exon 12.
U33165  Human G protein-coupled receptor kinase GRK4 gene, exon 13.
U33166  Human G protein-coupled receptor kinase GRK4 gene, exon 14.
U33167  Human G protein-coupled receptor kinase GRK4 gene, exon 15.
U33168  Human G protein-coupled receptor kinase GRK4 gene, alpha, beta, gamma and delta splice variants, exon 16 and complete cds.
X75897  H.sapiens mRNA for G-protein coupled kinase 4
X97879  H.sapiens mRNA for G protein coupled receptor kinase, GRK4B
X97880  H.sapiens mRNA for G protein coupled receptor kinase, GRK4C
X97881  H.sapiens mRNA for G protein coupled receptor kinase, GRK4D
X98118  H.sapiens GRK4A gene
Z68192  Human DNA sequence from clone LA04NC01-195C9 on chromosome 4

EntrezGene:
ID  Description
GRK4  G protein-coupled receptor kinase 4

RefSeq DNA:
ID  Description
NM_001004056  Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant 2, mRNA.
NM_001004057  Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant 3, mRNA.
NM_182982  Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant 1, mRNA.

UniGene:
ID  Description
Hs.32959  G protein coupled receptor kinase, GRK4D

Proteins
Ensembl Proteins:
ENSP00000381125; ENSP00000381128; ENSP00000381129; ENSP00000264764

Entrez Proteins:
AAB04045.1; AAC50406.1; AAC50407.1; AAC50408.1; AAC50409.1; AAC50410.1; AAC50411.1; AAC50412.1; AAI17321.1; BAD97301.1; BAF85079.1; CAA53506.1; CAA66468.1; CAA66469.1; CAA66470.1; CAA66802.1; CAA92341.1

RefSeq Proteins:
ID  Description
NP_001004056  G protein-coupled receptor kinase 4 isoform beta [Homo sapiens].
NP_001004057  G protein-coupled receptor kinase 4 isoform gamma [Homo sapiens].
NP_892027  G protein-coupled receptor kinase 4 isoform alpha [Homo sapiens].

UniProt:
ID  Description
P32298-2  UNKNOWN
P32298-3  UNKNOWN
P32298-4  UNKNOWN
A8K8M5  SubName: Full=cDNA FLJ76938, highly similar to Homo sapiens G protein-coupled receptor kinase 4 (GRK4), transcript variant 1, mRNA;
Q53EQ8  UNKNOWN
P32298  RecName: Full=G protein-coupled receptor kinase 4; EC=2.7.11.16; AltName: Full=G protein-coupled receptor kinase GRK4; AltName: Full=ITI1;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     GRK4-Homo sapiens    

InterPro:
ID  Name
IPR002290  Ser_thr_pkinase
IPR000239  GPCR_kinase
IPR000719  Prot_kinase_core
IPR017441  Protein_kinase_ATP_bd_CS
IPR000342  Regulat_G_prot_signal
IPR000961  Pkinase_C
IPR008271  Ser_thr_pkin_AS
IPR017442  Se/Thr_pkinase-rel

Pfam:
ID  Description
Pkinase  Protein kinase domain
RGS  Regulator of G protein signaling domain

Structure
PDB:
ID

HSSP:
ID  Description
1gzk  KINASE
1gzn  KINASE
1gzo  KINASE
1mrv  TRANSFERASE
1mry  TRANSFERASE
1o6k  TRANSFERASE
1o6l  TRANSFERASE
1omw  TRANSFERASE
1xjd  TRANSFERASE
1ym7  TRANSFERASE
2acx  TRANSFERASE
2bcj  TRANSFERASE/HYDROLASE
2i0e  TRANSFERASE
2jdo  TRANSFERASE
2jdr  TRANSFERASE
2jed  TRANSFERASE
2uw9  TRANSFERASE/INHIBITOR COMPLEX
3c4w  TRANSFERASE
3c4x  TRANSFERASE
3c4y  TRANSFERASE
3c4z  TRANSFERASE
3c50  TRANSFERASE
3c51  TRANSFERASE
3cqu  TRANSFERASE
3cqw  TRANSFERASE
3e88  TRANSFERASE
3e8d  TRANSFERASE

PSSH:
ID  Description
Q53EQ8  UNKNOWN
P32298  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
137026  G PROTEIN-COUPLED RECEPTOR KINASE 2 (DROSOPHILA)-LIKE; GPRK2L   G PROTEIN-DEPENDENT RECEPTOR KINASE 4; GPRK4; GRK4

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004703  G-protein coupled receptor kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0004871  signal transducer activity
GO:0004872  receptor activity
GO:0005524  ATP binding
GO:0006468  protein amino acid phosphorylation
GO:0007165  signal transduction
GO:0008277  regulation of G-protein coupled receptor protein signaling pathway
GO:0016740  transferase activity

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000125388 G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298] Pan_troglodytesone2one ENSPTRG00000015853G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]GRK4
Pongo_pygmaeusone2one ENSPPYG00000014550G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000009085G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Microcebus_murinusone2one ENSMICG00000006863G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Equus_caballusone2one ENSECAG00000018979G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]LOC100053624
Spermophilus_tridecemlineatusone2one ENSSTOG00000009753G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000005838G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Otolemur_garnettiione2one ENSOGAG00000005619G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Cavia_porcellusone2one ENSCPOG00000012872G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000011311G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Canis_familiarisone2one ENSCAFG00000014693G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]GRK4
Dipodomys_ordiione2one ENSDORG00000001194G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) [Source:UniProtKB/Swiss-Prot;Acc:O70291][hgnc]
Rattus_norvegicusone2one ENSRNOG00000011847G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4). [Source:UniProtKB/Swiss-Prot;Acc:P70507][hgnc]Gprk2l
Mus_musculusone2one ENSMUSG00000052783G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) [Source:UniProtKB/Swiss-Prot;Acc:O70291][hgnc]Grk4
Dasypus_novemcinctusone2one ENSDNOG00000018613G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Felis_catusone2one ENSFCAG00000004606G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Ornithorhynchus_anatinusone2many ENSOANG00000021584[hgnc]
Myotis_lucifugusone2one ENSMLUG00000005068G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Ochotona_princepsone2one ENSOPRG00000002372G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Bos_taurusone2one ENSBTAG00000001505G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]GRK4
Procavia_capensisone2one ENSPCAG00000016284G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Macaca_mulattaone2one ENSMMUG00000008390G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Monodelphis_domesticaone2one ENSMODG00000003693G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Echinops_telfairione2one ENSETEG00000018959G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Ornithorhynchus_anatinusone2many ENSOANG00000021583[hgnc]100074050
Gallus_gallusone2one ENSGALG00000015645G protein-coupled receptor kinase 4 [Source:RefSeq_peptide;Acc:NP_001006459][hgnc]GRK4
Xenopus_tropicalisone2one ENSXETG00000014715G protein-coupled receptor kinase 4. [Source:UniProtKB/TrEMBL;Acc:Q6DF20][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000018346G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Takifugu_rubripesone2one ENSTRUG00000005782G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Oryzias_latipesone2one ENSORLG00000014627G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000012051G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) [Source:UniProtKB/Swiss-Prot;Acc:P32298][hgnc]
Danio_rerioone2many ENSDARG00000070460G protein-coupled receptor kinase 4 [Source:RefSeq_peptide;Acc:NP_001073455][hgnc]zgc:153020
Danio_rerioone2many ENSDARG00000070448G protein-coupled receptor kinase 4 [Source:RefSeq_peptide;Acc:NP_001073455][hgnc]zgc:153020
Ciona_intestinalisone2many ENSCING00000003418[hgnc]
Ciona_savignyione2many ENSCSAVG00000011388[hgnc]
Drosophila_melanogasterone2many FBgn0004834[hgnc]Gprk2
Anopheles_gambiaeone2many AGAP004117[hgnc]AgaP_ENSANGG00000017908
Aedes_aegyptione2many AAEL006110g protein-coupled receptor kinase 6 and[hgnc]
Caenorhabditis_elegansone2many F19C6.1grk-1 encodes a serine/threonine protein kinase that is most closely related to G protein-coupled receptor (GPCR) kinases. [Source: WormBase][hgnc]grk-1