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Summary sheet information for Effector 'Tubulin-Homo sapiens-6'
Name Tubulin-Homo sapiens-6
Description RecName: Full=Tubulin alpha-4A chain;AltName: Full=Tubulin alpha-1 chain;AltName: Full=Alpha-tubulin 1;AltName: Full=Testis-specific alpha-tubulin;AltName: Full=Tubulin H2-alpha
Class
Family Tubulins
Sub_family Tubulins
type Tubulin
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 2
Gene Start: 219822677
Gene End: 219827514
Ensembl Contig View

Ensembl Genes:
ENSG00000127824

EMBL:
EMBL ID  Description
AC068946  Homo sapiens BAC clone RP11-803J6 from 2, complete sequence.
AY895018  Homo sapiens tubulin, alpha 1 (testis specific) (TUBA1) gene, complete cds.
BC009238  Homo sapiens tubulin, alpha 4a, mRNA (cDNA clone MGC:2379 IMAGE:2820121), complete cds.
BT006731  Homo sapiens tubulin, alpha 1 (testis specific) mRNA, complete cds.
CH471063  Homo sapiens 211000035834619 genomic scaffold, whole genome shotgun sequence.
X06956  Human HALPHA44 gene for alpha-tubulin, exons 1-3

EntrezGene:
ID  Description
TUBA4A  tubulin, alpha 4a

RefSeq DNA:
ID  Description
NM_006000  Homo sapiens tubulin, alpha 4a (TUBA4A), mRNA.

UniGene:
ID  Description
Hs.657153  UNKNOWN
Hs.75318  Tubulin, alpha 4a (TUBA4A), mRNA

Proteins
Ensembl Proteins:
ENSP00000248437; ENSP00000375938; ENSP00000330131

Entrez Proteins:
AAH09238.1; AAP35377.1; AAW65371.1; CAA30026.1; EAW70718.1

RefSeq Proteins:
ID  Description
NP_005991  tubulin, alpha 4a [Homo sapiens].

UniProt:
ID  Description
A6NHY4  SubName: Full=Putative uncharacterized protein TUBA4A;
A8MUB1  SubName: Full=Putative uncharacterized protein TUBA4A; SubName: Full=Tubulin, alpha 1 (Testis specific), isoform CRA_a;
P68366  RecName: Full=Tubulin alpha-4A chain; AltName: Full=Tubulin alpha-1 chain; AltName: Full=Alpha-tubulin 1; AltName: Full=Testis-specific alpha-tubulin; AltName: Full=Tubulin H2-alpha;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Tubulin-Homo sapiens-6    

InterPro:
ID  Name
IPR000217  Tubulin
IPR003008  Tubulin_FtsZ
IPR017975  Tubulin_CS
IPR008280  Tub_FtsZ_C
IPR002452  Alpha_tubulin

Pfam:
ID  Description
Tubulin  Tubulin/FtsZ family, GTPase domain
Tubulin_C  Tubulin/FtsZ family, C-terminal domain

Structure
PDB:
ID

HSSP:
ID  Description
1ffx  STRUCTURAL PROTEIN
1ia0  TRANSPORT PROTEIN
1jff  STRUCTURAL PROTEIN
1sa0  CELL CYCLE
1sa1  CELL CYCLE
1tub  MICROTUBULES
1tvk  CELL CYCLE, STRUCTURAL PROTEIN
1z2b  CELL CYCLE
2bto  CYTOSKELETAL PROTEIN
2btq  CYTOSKELETAL PROTEIN/COMPLEX
2hxf  TRANSPORT PROTEIN
2hxh  TRANSPORT PROTEIN
2p4n  TRANSPORT PROTEIN
3dco  MOTOR PROTEIN
3du7  CELL CYCLE
3e22  CELL CYCLE
3edl  STRUCTURAL PROTEIN

PSSH:
ID  Description
A6NHY4  UNKNOWN
P68366  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
191110  TUBULIN, ALPHA-4A; TUBA4A   TUBULIN, ALPHA-1; TUBA1 TUBULIN, ALPHA, TESTIS-SPECIFIC H2-ALPHA

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005198  structural molecule activity
GO:0005515  protein binding
GO:0005525  GTP binding
GO:0005737  cytoplasm
GO:0005874  microtubule
GO:0007017  microtubule-based process
GO:0007018  microtubule-based movement
GO:0043234  protein complex
GO:0051258  protein polymerization

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
DB01873  Epothilone D  KOS-862; epothilone D
DB03010  Epothilone B  EPO 906; EPO906; patupilone
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000127824 Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366] Takifugu_rubripesone2many ENSTRUG00000014124Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Pan_troglodytesone2one ENSPTRG00000012949Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]TUBA4A
Pongo_pygmaeusone2one ENSPPYG00000013203Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Macaca_mulattaone2one ENSMMUG00000019628Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Microcebus_murinusone2one ENSMICG00000000804Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000011750Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000011106Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Equus_caballusone2one ENSECAG00000014514Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]LOC100059249
Pteropus_vampyrusone2one ENSPVAG00000010798Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Felis_catusone2one ENSFCAG00000011250Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000014145Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Tursiops_truncatusone2one ENSTTRG00000010042Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Dipodomys_ordiione2one ENSDORG00000000154Tubulin alpha-4A chain (Tubulin alpha-4 chain) (Alpha-tubulin 4) (Alpha-tubulin isotype M-alpha-4) [Source:UniProtKB/Swiss-Prot;Acc:P68368][hgnc]
Myotis_lucifugusone2one ENSMLUG00000008082Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Bos_taurusone2one ENSBTAG00000030974Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1). [Source:UniProtKB/Swiss-Prot;Acc:P81948][hgnc]TUBA4A
Loxodonta_africanaone2one ENSLAFG00000009054Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Procavia_capensisone2one ENSPCAG00000002485Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Tupaia_belangerione2one ENSTBEG00000015435Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Canis_familiarisone2one ENSCAFG00000015209Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]TUBA4A
Cavia_porcellusone2one ENSCPOG00000004604Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Otolemur_garnettiione2one ENSOGAG00000009955Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Mus_musculusone2one ENSMUSG00000026202Tubulin alpha-4A chain (Tubulin alpha-4 chain) (Alpha-tubulin 4) (Alpha-tubulin isotype M-alpha-4) [Source:UniProtKB/Swiss-Prot;Acc:P68368][hgnc]Tuba4a
Rattus_norvegicusone2one ENSRNOG00000003597Tubulin alpha-4A chain (Tubulin alpha-4 chain) (Alpha-tubulin 4). [Source:UniProtKB/Swiss-Prot;Acc:Q5XIF6][hgnc]Tuba4a
Echinops_telfairione2one ENSETEG00000010296Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Sorex_araneusone2one ENSSARG00000013255Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Monodelphis_domesticaone2one ENSMODG00000015260Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Xenopus_tropicalisone2one ENSXETG00000019288[hgnc]
Gallus_gallusone2many ENSGALG00000011324Tubulin alpha-5 chain. [Source:UniProtKB/Swiss-Prot;Acc:P09644][hgnc]
Gallus_gallusone2many ENSGALG00000000433[hgnc]LOC424201
Tetraodon_nigroviridisone2many ENSTNIG00000016442Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000006424Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000010618Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Danio_rerioone2one ENSDARG00000031164tubulin, alpha 8 like 2 [Source:RefSeq_peptide;Acc:NP_956985][hgnc]tuba8l2
Tetraodon_nigroviridisone2many ENSTNIG00000010619Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Oryzias_latipesone2many ENSORLG00000016100Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000014965Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Oryzias_latipesone2many ENSORLG00000000046Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Takifugu_rubripesone2many ENSTRUG00000003135Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Takifugu_rubripesone2many ENSTRUG00000003526Tubulin alpha-4A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P68366][hgnc]
Caenorhabditis_elegansone2many C44B11.3mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation. MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons. mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis. MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons. [Source: WormBase][hgnc]mec-12
Saccharomyces_cerevisiaemany2many YML085CTubulin alpha-1 chain. [Source:UniProtKB/Swiss-Prot;Acc:P09733][hgnc]TUB1
Saccharomyces_cerevisiaemany2many YML124CTubulin alpha-3 chain. [Source:UniProtKB/Swiss-Prot;Acc:P09734][hgnc]TUB3