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Summary sheet information for Effector 'Adenylate cyclase 4-Homo sapiens'
Name Adenylate cyclase 4-Homo sapiens
Description RecName: Full=Adenylate cyclase type 4; EC=4.6.1.1;AltName: Full=Adenylate cyclase type IV;AltName: Full=ATP pyrophosphate-lyase 4;AltName: Full=Adenylyl cyclase 4
Class
Family Cyclases
Sub_family Adenylate cyclases
type Adenylate cyclase 4
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 14
Gene Start: 23857395
Gene End: 23874117
Ensembl Contig View

Ensembl Genes:
ENSG00000129467

EMBL:
EMBL ID  Description
AF497516  Homo sapiens adenylate cyclase type IV (ADCY4) mRNA, complete cds.
AK056745  Homo sapiens cDNA FLJ32183 fis, clone PLACE6001886, highly similar to ADENYLATE CYCLASE, TYPE IV (EC 4.6.1.1).
AK126468  Homo sapiens cDNA FLJ44504 fis, clone UTERU3001240, highly similar to Adenylate cyclase, type IV (EC 4.6.1.1).
AK131333  Homo sapiens cDNA FLJ16344 fis, clone TESTI2032643, moderately similar to ADENYLATE CYCLASE, TYPE IV (EC 4.6.1.1).
BC015982  Homo sapiens adenylate cyclase 4, mRNA (cDNA clone IMAGE:4070784), partial cds.
BC117473  Homo sapiens adenylate cyclase 4, mRNA (cDNA clone MGC:151082 IMAGE:40126024), complete cds.
BC117475  Homo sapiens adenylate cyclase 4, mRNA (cDNA clone MGC:151084 IMAGE:40126026), complete cds.
BX248285  human full-length cDNA clone CS0DI063YK23 of Placenta of Homo sapiens (human)
CH471078  Homo sapiens 211000035833619 genomic scaffold, whole genome shotgun sequence.

EntrezGene:
ID  Description
ADCY4  adenylate cyclase 4

RefSeq DNA:
ID  Description
NM_139247  Homo sapiens adenylate cyclase 4 (ADCY4), mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000379971; ENSP00000312126

Entrez Proteins:
AAH15982.2; AAI17474.1; AAI17476.1; AAM94373.1; BAB71270.1; BAC86560.1; BAD18492.1; CAD62613.1; EAW66028.1

RefSeq Proteins:
ID  Description
NP_640340  adenylate cyclase 4 [Homo sapiens].

UniProt:
ID  Description
Q6ZN83  SubName: Full=cDNA FLJ16344 fis, clone TESTI2032643, moderately similar to ADENYLATE CYCLASE, TYPE IV (EC 4.6.1.1);
Q6ZTM6  SubName: Full=cDNA FLJ44504 fis, clone UTERU3001240, highly similar to Adenylate cyclase, type IV (EC 4.6.1.1); SubName: Full=Adenylate cyclase 4, isoform CRA_d;
Q86TZ7  SubName: Full=Full-length cDNA clone CS0DI063YK23 of Placenta of Homo sapiens (human); Flags: Fragment;
Q96KY6  SubName: Full=ADCY4 protein; Flags: Fragment;
Q8NFM4  RecName: Full=Adenylate cyclase type 4; EC=4.6.1.1; AltName: Full=Adenylate cyclase type IV; AltName: Full=ATP pyrophosphate-lyase 4; AltName: Full=Adenylyl cyclase 4;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Adenylate cyclase 4-Homo sapiens    

InterPro:
ID  Name
IPR001054  A/G_cyclase
IPR009398  Aden_cycl_like

Pfam:
ID  Description
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
DUF1053  Domain of Unknown Function (DUF1053)

Structure
PDB:
ID

HSSP:
ID  Description
1ab8  LYASE
1azs  COMPLEX (LYASE/HYDROLASE)
1cjk  LYASE/LYASE/SIGNALING PROTEIN
1cjt  LYASE/LYASE/SIGNALING PROTEIN
1cju  LYASE/LYASE/SIGNALING PROTEIN
1cjv  LYASE/LYASE/SIGNALING PROTEIN
1cs4  LYASE/LYASE/SIGNALING PROTEIN
1cul  LYASE/LYASE/SIGNALING PROTEIN
1tl7  LYASE
1u0h  LYASE
1yk9  LYASE
2gvd  LYASE
2gvz  LYASE
3c14  LYASE/LYASE INHIBITOR
3c15  LYASE/LYASE INHIBITOR
3c16  LYASE/LYASE INHIBITOR
3et6  LYASE

PSSH:
ID  Description
Q6ZTM6  UNKNOWN
Q86TZ7  UNKNOWN
Q8NFM4  UNKNOWN
Q96KY6  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
600292  ADENYLATE CYCLASE 4; ADCY4   ADENYLYL CYCLASE 4

Gene Ontology
GO:
GO ID  Description
GO:0000287  magnesium ion binding
GO:0004016  adenylate cyclase activity
GO:0005622  intracellular
GO:0006171  cAMP biosynthetic process
GO:0007188  G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0007242  intracellular signaling cascade
GO:0009190  cyclic nucleotide biosynthetic process
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0016849  phosphorus-oxygen lyase activity
GO:0030425  dendrite

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04062  Chemokine signaling pathway
hsa05414  Dilated cardiomyopathy
hsa04540  Gap junction
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa00230  Purine metabolism
hsa04742  Taste transduction
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description
P00019  Endothelin signaling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB00058   Cyclic AMP   Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
HMDB00538   Adenosine triphosphate   5'-(tetrahydrogen triphosphate) Adenosine; 5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine triphosphic acid; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adetol; Adynol; Atipi; Atriphos; Cardenosine; Fosfobion; Glucobasin; Myotriphos; Phosphobion; Striadyne; Triadenyl; Triphosphaden; Triphosphoric acid adenosine ester
HMDB00250   Pyrophosphate   (4-)Diphosphoric acid ion; (P2O74-)Diphosphate; Diphosphate; Pyrometaphosphate; Pyrophosphate; Pyrophosphate tetraanion; Pyrophosphate(4-) ion; Pyrophosphic acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000129467 Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4] Ornithorhynchus_anatinusone2one ENSOANG00000015072Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Pan_troglodytesone2one ENSPTRG00000006216Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]ADCY4
Pongo_pygmaeusone2one ENSPPYG00000005702Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Microcebus_murinusone2one ENSMICG00000001771Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Macaca_mulattaone2one ENSMMUG00000020698Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000014218Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Equus_caballusone2one ENSECAG00000013004Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]LOC100054305
Tursiops_truncatusone2one ENSTTRG00000008640Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000010612Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Vicugna_pacosone2one ENSVPAG00000000236Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000002958Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Loxodonta_africanaone2one ENSLAFG00000012126Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Procavia_capensisone2one ENSPCAG00000002729Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Tupaia_belangerione2one ENSTBEG00000007724Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000007040Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Felis_catusone2one ENSFCAG00000005600Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Echinops_telfairione2one ENSETEG00000011518Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Canis_familiarisone2one ENSCAFG00000012293Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Mus_musculusone2one ENSMUSG00000022220Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q91WF3][hgnc]Adcy4
Myotis_lucifugusone2one ENSMLUG00000014814Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Rattus_norvegicusone2one ENSRNOG00000020401Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4). [Source:UniProtKB/Swiss-Prot;Acc:P26770][hgnc]Adcy4
Bos_taurusone2one ENSBTAG00000018419MGC152565 protein. [Source:UniProtKB/TrEMBL;Acc:A5PKE5][hgnc]ADCY4
Otolemur_garnettiione2one ENSOGAG00000006079Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000012349Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000002428Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Sorex_araneusone2one ENSSARG00000006932Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Dipodomys_ordiione2one ENSDORG00000012293Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q91WF3][hgnc]
Cavia_porcellusone2one ENSCPOG00000014412Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Monodelphis_domesticaone2one ENSMODG00000003033Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Xenopus_tropicalisone2one ENSXETG00000024681Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFM4][hgnc]
Ciona_intestinalisone2one ENSCING00000013036[hgnc]