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Summary sheet information for Effector 'Raf1 protein kinase-Homo sapiens'
Name Raf1 protein kinase-Homo sapiens
Description RecName: Full=RAF proto-oncogene serine/threonine-protein kinase; EC=2.7.11.1;AltName: Full=C-RAF; Short=cRaf;AltName: Full=Raf-1
Class
Family Ser Thr protein kinases
Sub_family RAF protein kinases
type Raf1 protein kinase
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 3
Gene Start: 12600108
Gene End: 12680678
Ensembl Contig View

Ensembl Genes:
ENSG00000132155

EMBL:
EMBL ID  Description
AK312248  Homo sapiens cDNA, FLJ92543, highly similar to Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1(RAF1), mRNA.
AY271661  Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene, complete cds.
BC018119  Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1, mRNA (cDNA clone MGC:9026 IMAGE:3904404), complete cds.
CH471055  Homo sapiens 211000035832932 genomic scaffold, whole genome shotgun sequence.
EU332868  Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene, complete cds.
L00206  Human c-raf-1 proto-oncogene, exon 3, clones lambda-(2,13).
L00207  Human c-raf-1 proto-oncogene, exon 4, clones lambda-(2,13).
L00208  Human c-raf-1 proto-oncogene, exon 5, clones lambda-(2,13).
L00209  Human c-raf-1 proto-oncogene, exon 6, clones lambda-(2,13).
L00210  Human c-raf-1 proto-oncogene, exon 7, clones lambda-(2,13).
L00211  Human c-raf-1 proto-oncogene, exon 8, clones lambda-(2,13).
L00212  Human c-raf-1 proto-oncogene (RAF1) gene, exons 9,10 and 11, clones lambda-(2,13).
L00213  Human c-raf-1 proto-oncogene, exon 2, clones lambda-(2,13).
M11376  Human c-raf-1 proto-oncogene, exon 1, clones lambda-(2,13).
X03484  Human mRNA for raf oncogene
X54851  H.sapiens C-raf-1 gene exon 7A

EntrezGene:
ID  Description
RAF1  v-raf-1 murine leukemia viral oncogene homolog 1

RefSeq DNA:
ID  Description
NM_002880  Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1), mRNA.

UniGene:
ID  Description
Hs.159130  Raf oncogene

Proteins
Ensembl Proteins:
ENSP00000251849

Entrez Proteins:
AAA60247.1; AAH18119.1; AAP03432.1; ABY87557.1; BAG35180.1; CAA27204.1; EAW64134.1

RefSeq Proteins:
ID  Description
NP_002871  v-raf-1 murine leukemia viral oncogene homolog 1 [Homo sapiens].

UniProt:
ID  Description
P04049-2  UNKNOWN
B2R5N3  UNKNOWN
P04049  RecName: Full=RAF proto-oncogene serine/threonine-protein kinase; EC=2.7.11.1; AltName: Full=C-RAF; Short=cRaf; AltName: Full=Raf-1;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Raf1 protein kinase-Homo sapiens    

InterPro:
ID  Name
IPR002219  DAG_PE_bd
IPR000719  Prot_kinase_core
IPR003116  Raf_like_ras_bd
IPR017441  Protein_kinase_ATP_bd_CS
IPR008271  Ser_thr_pkin_AS
IPR017442  Se/Thr_pkinase-rel

Pfam:
ID  Description
Pkinase  Protein kinase domain
C1_1  Phorbol esters/diacylglycerol binding domain (C1 domain)
RBD  Raf-like Ras-binding domain

Structure
PDB:
ID
1C1Y
1FAQ
1FAR
1GUA
1RFA
3CU8

HSSP:
ID  Description
1c1y  SIGNALING PROTEIN
1faq  SERINE/THREONINE PROTEIN KINASE
1far  SERINE/THREONINE PROTEIN KINASE
1gua  COMPLEX (GTP-BINDING/ATP-BINDING)
1ias  TRANSFERASE
1py5  TRANSFERASE
1rfa  SERINE/THREONINE-PROTEIN KINASE
1rrb  TRANSFERASE
1rw8  TRANSFERASE
1uwh  KINASE
1uwj  KINASE
1vjy  TRANSFERASE
1wxm  TRANSFERASE
2a19  PROTEIN SYNTHESIS/TRANSFERASE
2eva  TRANSFERASE/TRANSFERASE ACTIVATOR
2fb8  TRANSFERASE
3c4c  TRANSFERASE
3c4d  TRANSFERASE
3d4q  TRANSFERASE
3faa  TRANSFERASE

PSSH:
ID  Description
P04049  UNKNOWN
Q15278  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
164760  V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1; RAF1   ONCOGENE RAF1 TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV ONCOGENE MIL CRAF

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0005057  receptor signaling protein activity
GO:0005515  protein binding
GO:0005524  ATP binding
GO:0005741  mitochondrial outer membrane
GO:0005829  cytosol
GO:0005886  plasma membrane
GO:0006468  protein amino acid phosphorylation
GO:0006915  apoptosis
GO:0007010  cytoskeleton organization
GO:0007165  signal transduction
GO:0007242  intracellular signaling cascade
GO:0007265  Ras protein signal transduction
GO:0008270  zinc ion binding
GO:0008283  cell proliferation
GO:0016740  transferase activity
GO:0019992  diacylglycerol binding
GO:0046872  metal ion binding
GO:0048011  nerve growth factor receptor signaling pathway

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa05221  Acute myeloid leukemia
hsa04662  B cell receptor signaling pathway
hsa05219  Bladder cancer
hsa04062  Chemokine signaling pathway
hsa05220  Chronic myeloid leukemia
hsa05210  Colorectal cancer
hsa05213  Endometrial cancer
hsa04012  ErbB signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04510  Focal adhesion
hsa04540  Gap junction
hsa05214  Glioma
hsa04912  GnRH signaling pathway
hsa04910  Insulin signaling pathway
hsa04730  Long-term depression
hsa04720  Long-term potentiation
hsa04010  MAPK signaling pathway
hsa04916  Melanogenesis
hsa05218  Melanoma
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway
hsa05223  Non-small cell lung cancer
hsa05212  Pancreatic cancer
hsa05200  Pathways in cancer
hsa04914  Progesterone-mediated oocyte maturation
hsa05215  Prostate cancer
hsa04810  Regulation of actin cytoskeleton
hsa05211  Renal cell carcinoma
hsa04660  T cell receptor signaling pathway
hsa04370  VEGF signaling pathway
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description
P05911  Angiotensin II-stimulated signaling through G proteins and beta-arrestin
P00036  Interleukin signaling pathway
P00047  PDGF signaling pathway
P00019  Endothelin signaling pathway
P00010  B cell activation
P00053  T cell activation
P00031  Inflammation mediated by chemokine and cytokine signaling pathway
P04393  Ras Pathway
P00018  EGF receptor signaling pathway
P00032  Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
P00034  Integrin signalling pathway
P00056  VEGF signaling pathway
P00021  FGF signaling pathway
P00005  Angiogenesis

Chemicals
DrugBank:
ID  Name  Synonyms
DB00398  Sorafenib  Sorafenib tosylate; sorafenib
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000132155 RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049] Pan_troglodytesone2one ENSPTRG00000014635RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]RAF1
Pongo_pygmaeusone2one ENSPPYG00000013388RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf). [Source:UniProtKB/Swiss-Prot;Acc:Q5R5M7][hgnc]
Macaca_mulattaone2many ENSMMUG00000007450[hgnc]
Microcebus_murinusone2one ENSMICG00000012172RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Macaca_mulattaone2many ENSMMUG00000009202[hgnc]
Tarsius_syrichtaone2one ENSTSYG00000007438RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000005823RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Myotis_lucifugusone2one ENSMLUG00000017645RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Tupaia_belangerione2one ENSTBEG00000012253RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Equus_caballusone2many ENSECAG00000011807[hgnc]LOC100051110
Loxodonta_africanaone2one ENSLAFG00000011608RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000014175RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Felis_catusone2one ENSFCAG00000007975RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Procavia_capensisone2one ENSPCAG00000016080RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Equus_caballusone2many ENSECAG00000005116[hgnc]LOC100050968
Canis_familiarisone2one ENSCAFG00000004951RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]RAF1
Vicugna_pacosone2one ENSVPAG00000011066RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000009252RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Bos_taurusone2one ENSBTAG00000004514PREDICTED: Bos taurus hypothetical LOC521196 (LOC521196), mRNA. [Source:RefSeq_dna;Acc:XR_027356][hgnc]RAF1
Echinops_telfairione2one ENSETEG00000003974RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Mus_musculusone2one ENSMUSG00000000441RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:Q99N57][hgnc]Raf1
Rattus_norvegicusone2one ENSRNOG00000010153RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf). [Source:UniProtKB/Swiss-Prot;Acc:P11345][hgnc]Raf1
Ochotona_princepsone2one ENSOPRG00000003522RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Cavia_porcellusone2one ENSCPOG00000001210RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Dipodomys_ordiione2one ENSDORG00000015622RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:Q99N57][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000011360RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Sorex_araneusone2one ENSSARG00000007569RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Monodelphis_domesticaone2one ENSMODG00000006307RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Gallus_gallusone2one ENSGALG00000004998RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (RAF- 1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C- MIL). [Source:UniProtKB/Swiss-Prot;Acc:P05625][hgnc]RAF1
Takifugu_rubripesone2one ENSTRUG00000006611serine/threonine protein kinase RAF1 [Source:RefSeq_peptide;Acc:NP_001033078][hgnc]raf1
Tetraodon_nigroviridisone2one ENSTNIG00000012621RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Xenopus_tropicalisone2one ENSXETG00000020163RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Oryzias_latipesone2one ENSORLG00000011471RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
Danio_rerioone2one ENSDARG00000059406similar to protein kinase raf 1 (LOC557109), misc RNA [Source:RefSeq_dna;Acc:XR_029877][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000000060RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]