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Summary sheet information for Effector 'PDZ RhoGEF-Homo sapiens'
Name PDZ RhoGEF-Homo sapiens
Description RecName: Full=Rho guanine nucleotide exchange factor 11;AltName: Full=PDZ-RhoGEF
Class
Family Guanine nucleotide exchange factors
Sub_family RhoGEFs
type PDZ RhoGEF
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 1
Gene Start: 155171257
Gene End: 155281786
Ensembl Contig View

Ensembl Genes:
ENSG00000132694

EMBL:
EMBL ID  Description
AB002378  Homo sapiens ARHGEF11/KIAA0380 mRNA for KIAA0380 protein, partial cds.
AL157713  Human DNA sequence from clone RP11-110J1 on chromosome 1q23.3-24.3 Contains the ETV3 gene for ets variant gene 3, a cytochrome c somatic pseudogene (HCP2), a ets variant gene 3 (ETV3) pseudogene, a keratin 8 (KRT8) pseudogene, a smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) (SMU1) pseudogene, the 5' end of the ARHGEF11 gene for Rho guanine nucleotide exchange factor (GEF) 11 and two CPG islands.
AL356104  Human DNA sequence from clone RP11-356J7 on chromosome 1 Contains the 3' end of the ARHGEF11 gene for Rho guanine nucleotide exchange factor (GEF) 11, a novel gene (FLJ32884), the 3' end of the gene for a novel protein similar to mouse Jedi soluble isoform 736 and three CpG islands.
BC057394  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 11, mRNA (cDNA clone MGC:60344 IMAGE:6148684), complete cds.

EntrezGene:
ID  Description
ARHGEF11  Rho guanine nucleotide exchange factor (GEF) 11

RefSeq DNA:
ID  Description
NM_014784  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 11 (ARHGEF11), transcript variant 1, mRNA.
NM_198236  Homo sapiens Rho guanine nucleotide exchange factor (GEF) 11 (ARHGEF11), transcript variant 2, mRNA.

UniGene:
ID  Description
Hs.516954  ARHGEF11/KIAA0380 mRNA for KIAA0380 protein

Proteins
Ensembl Proteins:
ENSP00000357177; ENSP00000354644; ENSP00000313470

Entrez Proteins:
AAH57394.1; BAA20834.2; CAH70127.1; CAH70128.1; CAH72939.1; CAH72940.1

RefSeq Proteins:
ID  Description
NP_055599  Rho guanine nucleotide exchange factor (GEF) 11 isoform 1 [Homo sapiens].
NP_937879  Rho guanine nucleotide exchange factor (GEF) 11 isoform 2 [Homo sapiens].

UniProt:
ID  Description
A6NFK4  SubName: Full=Putative uncharacterized protein ARHGEF11; Flags: Fragment;
Q6PFW2  SubName: Full=Rho guanine nucleotide exchange factor (GEF) 11;
O15085  RecName: Full=Rho guanine nucleotide exchange factor 11; AltName: Full=PDZ-RhoGEF;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     PDZ RhoGEF-Homo sapiens    

InterPro:
ID  Name
IPR015721  RhoGEF_like
IPR001849  Pleckstrin_homology
IPR000342  Regulat_G_prot_signal
IPR015212  Regulat_G_prot_signal-like
IPR011993  PH_type
IPR001331  GDS_CDC24_CS
IPR001478  PDZ/DHR/GLGF
IPR000219  DH-domain

Pfam:
ID  Description
PDZ  PDZ domain (Also known as DHR or GLGF)
RhoGEF  RhoGEF domain
RGS-like  Regulator of G protein signalling-like domain

Structure
PDB:
ID
1HTJ
1XCG
2DLS

HSSP:
ID  Description
1d5g  HYDROLASE
1g9o  SIGNALING PROTEIN
1gq4  SIGNALING PROTEIN
1gq5  SIGNALING PROTEIN
1htj  SIGNALING PROTEIN
1i92  SIGNALING PROTEIN
1iap  SIGNALING PROTEIN
1ki1  SIGNALING PROTEIN
1q3o  PEPTIDE BINDING PROTEIN
1shz  SIGNALING PROTEIN
1txd  SIGNALING PROTEIN
1u39  PROTEIN TRANSPORT
1ueq  SIGNALING PROTEIN
1uew  SIGNALING PROTEIN
1uez  PROTEIN BINDING
1ujv  SIGNALING PROTEIN
1wfv  SIGNALING PROTEIN
1wha  SIGNALING PROTEIN
1x86  SIGNALING PROTEIN/MEMBRANE PROTEIN
1xcg  SIGNALING PROTEIN ACTIVATOR/SIGNALING PR
1y7n  PROTEIN TRANSPORT
2byg  SIGNAL TRANSDUCTION
2csj  CELL ADHESION
2d90  PROTEIN BINDING
2dkr  PROTEIN TRANSPORT
2dls  SIGNALING PROTEIN
2eei  METAL BINDING PROTEIN
2eej  METAL BINDING PROTEIN
2egk  PROTEIN BINDING
2egn  PROTEIN BINDING
2ego  PROTEIN BINDING
2f5y  SIGNALING PROTEIN
2fe5  STRUCTURAL PROTEIN
2fne  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
2he4  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
2i04  PEPTIDE BINDING PROTEIN
2jil  MEMBRANE PROTEIN
2ogp  SIGNALING PROTEIN
2omj  CELL ADHESION
2os6  CELL ADHESION
2osg  CELL ADHESION
2pnt  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
2v90  PROTEIN-BINDING
2vz5  PROTEIN BINDING
2yuy  SIGNALING PROTEIN
3b76  LIGASE
3cx6  SIGNALING PROTEIN
3cx7  SIGNALING PROTEIN
3cx8  SIGNALING PROTEIN
3pdz  HYDROLASE

PSSH:
ID  Description
Q6PFW2  UNKNOWN
A6NFK4  UNKNOWN
O15085  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
605708  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11; ARHGEF11   PDZ-RHOGEF GLUTAMATE TRANSPORTER EAAT4-ASSOCIATED PROTEIN 48; GTRAP48 KIAA0380

Gene Ontology
GO:
GO ID  Description
GO:0000910  cytokinesis
GO:0001558  regulation of cell growth
GO:0004871  signal transducer activity
GO:0005085  guanyl-nucleotide exchange factor activity
GO:0005089  Rho guanyl-nucleotide exchange factor activity
GO:0005096  GTPase activator activity
GO:0005515  protein binding
GO:0005622  intracellular
GO:0005737  cytoplasm
GO:0006928  cell motion
GO:0006941  striated muscle contraction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0016020  membrane
GO:0030010  establishment of cell polarity
GO:0030036  actin cytoskeleton organization
GO:0035023  regulation of Rho protein signal transduction
GO:0045735  nutrient reservoir activity
GO:0045893  positive regulation of transcription, DNA-dependent

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000132694 Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085] Cavia_porcellusone2one ENSCPOG00000003214Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Otolemur_garnettiione2one ENSOGAG00000001540Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Ochotona_princepsone2one ENSOPRG00000000737Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Dipodomys_ordiione2one ENSDORG00000012872Rho guanine nucleotide exchange factor (GEF) 11 [Source:RefSeq_peptide;Acc:NP_001003912][hgnc]
Procavia_capensisone2one ENSPCAG00000015555Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000010592Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Equus_caballusone2one ENSECAG00000022117Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]LOC100064689
Sorex_araneusone2one ENSSARG00000011169Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000010731Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Myotis_lucifugusone2one ENSMLUG00000010956Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Rattus_norvegicusone2one ENSRNOG00000015026Rho guanine nucleotide exchange factor 11 (RhoGEF glutamate transport modulator GTRAP48). [Source:UniProtKB/Swiss-Prot;Acc:Q9ES67][hgnc]Arhgef11
Dasypus_novemcinctusone2one ENSDNOG00000015349Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Mus_musculusone2one ENSMUSG00000041977Rho guanine nucleotide exchange factor (GEF) 11 [Source:RefSeq_peptide;Acc:NP_001003912][hgnc]Arhgef11
Vicugna_pacosone2one ENSVPAG00000002787Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Canis_familiarisone2one ENSCAFG00000016484Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Pan_troglodytesone2one ENSPTRG00000024318Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]ARHGEF11
Tarsius_syrichtaone2one ENSTSYG00000005867Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Tupaia_belangerione2one ENSTBEG00000004195Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Felis_catusone2one ENSFCAG00000011367Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Xenopus_tropicalisone2one ENSXETG00000023808Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Microcebus_murinusone2one ENSMICG00000009042Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000000695Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000007433Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Loxodonta_africanaone2one ENSLAFG00000000541Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Macaca_mulattaone2one ENSMMUG00000012436Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Tursiops_truncatusone2one ENSTTRG00000014519Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Bos_taurusone2one ENSBTAG00000012361Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]ARHGEF11
Gallus_gallusone2one ENSGALG00000013261Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]ARHGEF11
Pteropus_vampyrusone2one ENSPVAG00000014912Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000010367Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Monodelphis_domesticaone2one ENSMODG00000016676Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Echinops_telfairione2one ENSETEG00000000064Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Takifugu_rubripesone2one ENSTRUG00000000678Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000018980Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:O15085][hgnc]
Ciona_intestinalisone2many ENSCING00000007425[hgnc]
Ciona_savignyione2many ENSCSAVG00000003345[hgnc]