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Summary sheet information for Effector 'Phosphodiesterase 6-Homo sapiens-1'
Name Phosphodiesterase 6-Homo sapiens-1
Description "RecName: Full=Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; Short=GMP-PDE alpha; EC=3.1.4.35;AltName: Full=PDE V-B1;"
Class
Family Phosphodiesterases
Sub_family Rhodopsin-sensitive cGMP-specific PDEases
type Phosphodiesterase 6
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 5
Gene Start: 149220421
Gene End: 149304549
Ensembl Contig View

Ensembl Genes:
ENSG00000132915

EMBL:
EMBL ID  Description
AF022380  Homo sapiens rod photoreceptor cGMP phosphodiesterase alpha subunit (PDE6A) gene, partial cds.
BC035909  Homo sapiens phosphodiesterase 6A, cGMP-specific, rod, alpha, mRNA (cDNA clone MGC:46181 IMAGE:5492027), complete cds.
CH471062  Homo sapiens 211000035832302 genomic scaffold, whole genome shotgun sequence.
M26061  Human cGMP phosphodiesterase alpha subunit (CGPR-A) mRNA, complete cds.

EntrezGene:
ID  Description
PDE6A  phosphodiesterase 6A, cGMP-specific, rod, alpha

RefSeq DNA:
ID  Description
NM_000440  Homo sapiens phosphodiesterase 6A, cGMP-specific, rod, alpha (PDE6A), mRNA.

UniGene:
ID  Description
Hs.567314  Phosphodiesterase 6A, cGMP-specific, rod, alpha, mRNA (cDNA clone MGC:46181 IMAGE:5492027)

Proteins
Ensembl Proteins:
ENSP00000255266

Entrez Proteins:
AAB69155.1; AAC33831.1; AAH35909.1; EAW61757.1

RefSeq Proteins:
ID  Description
NP_000431  phosphodiesterase 6A, alpha subunit [Homo sapiens].

UniProt:
ID  Description
O75316  SubName: Full=Rod photoreceptor cGMP phosphodiesterase alpha subunit; Flags: Fragment;
Q0P638  UNKNOWN
P16499  RecName: Full=Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; Short=GMP-PDE alpha; EC=3.1.4.35; AltName: Full=PDE V-B1;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Phosphodiesterase 6-Homo sapiens-1    

InterPro:
ID  Name
IPR003607  Met-dep_phosphohydro_HD
IPR002073  PDEase
IPR003018  GAF

Pfam:
ID  Description
PDEase_I  3'5'-cyclic nucleotide phosphodiesterase
GAF  GAF domain

Structure
PDB:
ID

HSSP:
ID  Description
1mkd  HYDROLASE
1oyn  HYDROLASE
1ptw  HYDROLASE
1q9m  HYDROLASE
1rkp  HYDROLASE
1t9r  HYDROLASE
1t9s  HYDROLASE
1tb5  HYDROLASE
1tb7  HYDROLASE
1tbb  HYDROLASE
1tbf  HYDROLASE
1udt  HYDROLASE
1udu  HYDROLASE
1uho  HYDROLASE
1xlx  HYDROLASE
1xlz  HYDROLASE
1xm4  HYDROLASE
1xm6  HYDROLASE
1xmu  HYDROLASE
1xmy  HYDROLASE
1xn0  HYDROLASE
1xom  HYDROLASE
1xon  HYDROLASE
1xoq  HYDROLASE
1xor  HYDROLASE
1xos  HYDROLASE
1xot  HYDROLASE
1xoz  HYDROLASE
1xp0  HYDROLASE
1y2b  HYDROLASE
1y2c  HYDROLASE
1y2d  HYDROLASE
1y2e  HYDROLASE
1y2h  HYDROLASE
1y2j  HYDROLASE
1y2k  HYDROLASE
1z1l  HYDROLASE
1zkn  HYDROLASE
2chm  HYDROLASE
2fm0  HYDROLASE
2fm5  HYDROLASE
2h40  HYDROLASE
2h42  HYDROLASE
2h44  HYDROLASE
2k31  HYDROLASE
2o8h  HYDROLASE
2oun  HYDROLASE
2oup  HYDROLASE
2ouq  HYDROLASE
2our  HYDROLASE
2ous  HYDROLASE
2ouu  HYDROLASE
2ouv  HYDROLASE
2ouy  HYDROLASE
2ovv  HYDROLASE
2ovy  HYDROLASE
2pw3  HYDROLASE
2qyk  HYDROLASE
2qyl  HYDROLASE
2qym  HYDROLASE
2qyn  HYDROLASE
3b2r  HYDROLASE
3bjc  HYDROLASE
3dba  HYDROLASE

PSSH:
ID  Description
P16499  UNKNOWN
Q0P638  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
180071  PHOSPHODIESTERASE 6A, cGMP-SPECIFIC, ROD, ALPHA; PDE6A   RETINAL ROD PHOTORECEPTOR cGMP PHOSPHODIESTERASE, ALPHA SUBUNIT; PDEA

Gene Ontology
GO:
GO ID  Description
GO:0003824  catalytic activity
GO:0004114  3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005886  plasma membrane
GO:0007165  signal transduction
GO:0007601  visual perception
GO:0016787  hydrolase activity
GO:0047555  3',5'-cyclic-GMP phosphodiesterase activity
GO:0050896  response to stimulus

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa00230  Purine metabolism

Panther:
ID  Description
P00028  Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB01397   GMP   5'-GMP; E 626; GMP; Guanidine monophosphate; Guanosine 5'-monophosphate; Guanosine 5'-phosphate; Guanosine 5'-phosphorate; Guanosine 5'-phosphoric acid; guanosine monophosphate; guanosine-5'-monophosphate; guanosine-5'-phosphate; guanosine-monophosphate; guanosine-phosphate; guanylate; guanylic acid
HMDB01314   Cyclic GMP   3',5'-cyclic GMP; 3',5'-guanosine; 3',5'-guanosine monophosphate; cGMP; cyclic 3',5'-guanosine monophosphate; cyclic GMP; cyclic-GMP; cyclic guanosine 3',5'-monophosphate; guanosine 3',5'-cyclic phosphate; guanosine 3',5'-cyclic-monophosphate; guanosine 3',5'-monophosphate; guanosine cyclic-monophosphate; guanosine-cyclic-phosphoric-acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000132915 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499] Pan_troglodytesone2one ENSPTRG00000017404Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]PDE6A
Pongo_pygmaeusone2one ENSPPYG00000015939Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Macaca_mulattaone2one ENSMMUG00000004752Phosphodiesterase 6A cGMP-specific rod alpha (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q4G412][hgnc]
Equus_caballusone2one ENSECAG00000024028CGMP specific phosphodiesterase 6A rod alpha subunit (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q95M95][hgnc]LOC100060489
Pteropus_vampyrusone2one ENSPVAG00000001309Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Canis_familiarisone2one ENSCAFG00000018251Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha). [Source:UniProtKB/Swiss-Prot;Acc:Q28263][hgnc]PDE6A
Myotis_lucifugusone2one ENSMLUG00000013174Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Cavia_porcellusone2one ENSCPOG00000001962Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Tursiops_truncatusone2one ENSTTRG00000008434Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000013850Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Vicugna_pacosone2one ENSVPAG00000006814Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Otolemur_garnettiione2one ENSOGAG00000015989Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Dipodomys_ordiione2one ENSDORG00000012607Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) [Source:UniProtKB/Swiss-Prot;Acc:P27664][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000008725Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000005998Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Ochotona_princepsone2one ENSOPRG00000010042Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Tupaia_belangerione2one ENSTBEG00000012307Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Felis_catusone2one ENSFCAG00000003630Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Microcebus_murinusone2one ENSMICG00000002710Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Rattus_norvegicusone2one ENSRNOG00000017816phosphodiesterase 6A, cGMP-specific, rod, alpha [Source:RefSeq_peptide;Acc:NP_001100856][hgnc]Pde6a_predicted
Procavia_capensisone2one ENSPCAG00000012330Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Mus_musculusone2one ENSMUSG00000024575Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) [Source:UniProtKB/Swiss-Prot;Acc:P27664][hgnc]Pde6a
Erinaceus_europaeusone2one ENSEEUG00000015079Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Bos_taurusone2one ENSBTAG00000012945Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1). [Source:UniProtKB/Swiss-Prot;Acc:P11541][hgnc]PDE6A
Echinops_telfairione2one ENSETEG00000009225Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Loxodonta_africanaone2one ENSLAFG00000009245Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Sorex_araneusone2one ENSSARG00000010841Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000012904Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000009367Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]100075073
Monodelphis_domesticaone2one ENSMODG00000009879Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Xenopus_tropicalisone2one ENSXETG00000012709Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Danio_rerioone2one ENSDARG00000000380phosphodiesterase 6A, cGMP-specific, rod, alpha [Source:RefSeq_peptide;Acc:NP_001007161][hgnc]pde6a
Gasterosteus_aculeatusone2one ENSGACG00000016811Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000006320Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1) [Source:UniProtKB/Swiss-Prot;Acc:P16499][hgnc]