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Summary sheet information for Effector 'Phosphodiesterase 6-Homo sapiens-2'
Name Phosphodiesterase 6-Homo sapiens-2
Description "RecName: Full=Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; Short=GMP-PDE beta; EC=3.1.4.35;Flags: Precursor;"
Class
Family Phosphodiesterases
Sub_family Rhodopsin-sensitive cGMP-specific PDEases
type Phosphodiesterase 6
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 4
Gene Start: 609373
Gene End: 654571
Ensembl Contig View

Ensembl Genes:
ENSG00000133256

EMBL:
EMBL ID  Description
BC000249  Homo sapiens phosphodiesterase 6B, cGMP-specific, rod, beta, mRNA (cDNA clone MGC:1689 IMAGE:3356353), complete cds.
BT009794  Homo sapiens phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant) mRNA, complete cds.
S41458  rod cGMP phosphodiesterase beta-subunit [human, mRNA, 3231 nt].
X62692  H.sapiens DNA for cGMP phosphodiesterase exon 1
X62693  H.sapiens DNA for cGMP phosphodiesterase exon 2
X62694  H.sapiens DNA for cGMP phosphodiesterase exon 3
X62695  H.sapiens DNA for cGMP phosphodiesterase (exons 4-22)
X66142  H.sapiens mRNA for rod cGMP phosphodiesterase
X90587  H.sapiens DNA for Rod cG-PDE gene (exons 4 to 10) and joined CDS
X90588  H.sapiens DNA for Rod cG-PDE gene (exons 11 & 12)
X90589  H.sapiens DNA for Rod cG-PDE gene (exons 13-21)
X90590  H.sapiens DNA for Rod cG-PDE gene (exon 22)

EntrezGene:
ID  Description
PDE6B  phosphodiesterase 6B, cGMP-specific, rod, beta

RefSeq DNA:
ID  Description
NM_000283  Homo sapiens phosphodiesterase 6B, cGMP-specific, rod, beta (PDE6B), mRNA.

UniGene:
ID  Description
Hs.654544  Rod cGMP phosphodiesterase beta-subunit [human, mRNA, 3231 nt]

Proteins
Ensembl Proteins:
ENSP00000255622

Entrez Proteins:
AAB22690.1; AAH00249.1; AAP88796.1; CAA44569.1; CAA46932.1; CAA62215.1

RefSeq Proteins:
ID  Description
NP_000274  phosphodiesterase 6B, cGMP-specific, rod, beta [Homo sapiens].

UniProt:
ID  Description
Q53XN5  SubName: Full=Phosphodiesterase 6B, cGMP-specific, rod, beta (Congenital stationary night blindness 3, autosomal dominant);
Q9UD49  SubName: Full=ROD photoreceptor cGMP-specific phosphodiesterase beta-subunit, beta PDE; Flags: Fragment;
P35913  RecName: Full=Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; Short=GMP-PDE beta; EC=3.1.4.35; Flags: Precursor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Phosphodiesterase 6-Homo sapiens-2    

InterPro:
ID  Name
IPR003607  Met-dep_phosphohydro_HD
IPR002073  PDEase
IPR003018  GAF

Pfam:
ID  Description
PDEase_I  3'5'-cyclic nucleotide phosphodiesterase
GAF  GAF domain

Structure
PDB:
ID

HSSP:
ID  Description
1rkp  HYDROLASE
1t9r  HYDROLASE
1t9s  HYDROLASE
1tb7  HYDROLASE
1tbb  HYDROLASE
1tbf  HYDROLASE
1udt  HYDROLASE
1udu  HYDROLASE
1uho  HYDROLASE
1xom  HYDROLASE
1xon  HYDROLASE
1xoq  HYDROLASE
1xor  HYDROLASE
1xoz  HYDROLASE
1xp0  HYDROLASE
1y2b  HYDROLASE
1y2e  HYDROLASE
1y2k  HYDROLASE
1z1l  HYDROLASE
2chm  HYDROLASE
2h40  HYDROLASE
2h42  HYDROLASE
2h44  HYDROLASE
2k31  HYDROLASE
2o8h  HYDROLASE
2oun  HYDROLASE
2oup  HYDROLASE
2ouq  HYDROLASE
2our  HYDROLASE
2ous  HYDROLASE
2ouu  HYDROLASE
2ouv  HYDROLASE
2ouy  HYDROLASE
2ovv  HYDROLASE
2ovy  HYDROLASE
2qyk  HYDROLASE
2qym  HYDROLASE
3b2r  HYDROLASE
3bjc  HYDROLASE
3dba  HYDROLASE

PSSH:
ID  Description
Q53XN5  UNKNOWN
Q9UD49  UNKNOWN
P35913  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
180072  PHOSPHODIESTERASE 6B, cGMP-SPECIFIC, ROD, BETA; PDE6B   RETINAL ROD PHOTORECEPTOR cGMP PHOSPHODIESTERASE, BETA SUBUNIT; PDEB RD, MOUSE, HOMOLOG OF RD1, MOUSE, HOMOLOG OF RETINITIS PIGMENTOSA 40, INCLUDED; RP40, INCLUDED

Gene Ontology
GO:
GO ID  Description
GO:0003824  catalytic activity
GO:0004114  3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0007165  signal transduction
GO:0007601  visual perception
GO:0007603  phototransduction, visible light
GO:0009583  detection of light stimulus
GO:0016020  membrane
GO:0016787  hydrolase activity
GO:0047555  3',5'-cyclic-GMP phosphodiesterase activity
GO:0050896  response to stimulus

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa00230  Purine metabolism

Panther:
ID  Description
P00028  Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB01397   GMP   5'-GMP; E 626; GMP; Guanidine monophosphate; Guanosine 5'-monophosphate; Guanosine 5'-phosphate; Guanosine 5'-phosphorate; Guanosine 5'-phosphoric acid; guanosine monophosphate; guanosine-5'-monophosphate; guanosine-5'-phosphate; guanosine-monophosphate; guanosine-phosphate; guanylate; guanylic acid
HMDB01314   Cyclic GMP   3',5'-cyclic GMP; 3',5'-guanosine; 3',5'-guanosine monophosphate; cGMP; cyclic 3',5'-guanosine monophosphate; cyclic GMP; cyclic-GMP; cyclic guanosine 3',5'-monophosphate; guanosine 3',5'-cyclic phosphate; guanosine 3',5'-cyclic-monophosphate; guanosine 3',5'-monophosphate; guanosine cyclic-monophosphate; guanosine-cyclic-phosphoric-acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000133256 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913] Pan_troglodytesone2one ENSPTRG00000015807Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Macaca_mulattaone2one ENSMMUG00000003282Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000010537Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000014504Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Otolemur_garnettiione2one ENSOGAG00000012260Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Microcebus_murinusone2one ENSMICG00000010725Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Tupaia_belangerione2one ENSTBEG00000005887Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Tursiops_truncatusone2one ENSTTRG00000002928Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000008777Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Procavia_capensisone2one ENSPCAG00000012269Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Dipodomys_ordiione2one ENSDORG00000009708Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P23440][hgnc]
Cavia_porcellusone2one ENSCPOG00000022569Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Equus_caballusone2one ENSECAG00000017337Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]LOC100050793
Ochotona_princepsone2one ENSOPRG00000015344Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Felis_catusone2one ENSFCAG00000008224Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000009058Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Rattus_norvegicusone2one ENSRNOG00000000065phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide [Source:RefSeq_peptide;Acc:NP_001099494][hgnc]Pde6b_predicted
Mus_musculusone2one ENSMUSG00000029491Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P23440][hgnc]Pde6b
Canis_familiarisone2one ENSCAFG00000016782Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta). [Source:UniProtKB/Swiss-Prot;Acc:P33726][hgnc]PDE6B
Echinops_telfairione2one ENSETEG00000016426Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000010439Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Bos_taurusone2one ENSBTAG00000017480Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta). [Source:UniProtKB/Swiss-Prot;Acc:P23439][hgnc]PDE6B
Monodelphis_domesticaone2one ENSMODG00000005968Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000006518Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]100083769
Gallus_gallusone2one ENSGALG00000015373Phosphodiesterase 6 beta subunit (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q802E5][hgnc]PDE6B
Xenopus_tropicalisone2one ENSXETG00000018012Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Danio_rerioone2one ENSDARG00000011671[hgnc]LOC100000610
Tetraodon_nigroviridisone2one ENSTNIG00000009135Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000017311Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]
Oryzias_latipesone2one ENSORLG00000009868Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Precursor (EC 3.1.4.35) (GMP-PDE beta) [Source:UniProtKB/Swiss-Prot;Acc:P35913][hgnc]