Quick search:







Summary sheet information for Effector 'Rac-Homo sapiens-1'
Name Rac-Homo sapiens-1
Description RecName: Full=Ras-related C3 botulinum toxin substrate 1;AltName: Full=p21-Rac1;AltName: Full=Ras-like protein TC25;AltName: Full=Cell migration-inducing gene 5 protein;Flags: Precursor
Class
Family Small GTP-binding proteins
Sub_family Rho small GTPases
type Rac
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
Expand All Collapse All
Genes
Gene Location:
Chromosome: 7
Gene Start: 6380651
Gene End: 6410123
Ensembl Contig View

Ensembl Genes:
ENSG00000136238

EMBL:
EMBL ID  Description
AC009412  Homo sapiens BAC clone RP11-425P5 from 7, complete sequence.
AF136373  Homo sapiens ras-related C3 botulinum toxin substrate isoform mRNA, complete cds.
AF498964  Homo sapiens small GTP binding protein RAC1 (RAC1) mRNA, complete cds.
AJ132694  Homo sapiens mRNA for small GTPase rac1b
AJ132695  Homo sapiens rac1 gene
AK291806  Homo sapiens cDNA FLJ75553 complete cds, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
AK291815  Homo sapiens cDNA FLJ77333 complete cds, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1b, mRNA.
AY279384  Homo sapiens migration-inducing protein 5 (MIG5) mRNA, complete cds.
BC004247  Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), mRNA (cDNA clone MGC:10547 IMAGE:3610745), complete cds.
BC050687  Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), mRNA (cDNA clone MGC:60264 IMAGE:6149377), complete cds.
BC107748  Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), mRNA (cDNA clone MGC:111543 IMAGE:6699945), complete cds.
BT007121  Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) mRNA, complete cds.
CH236963  Homo sapiens chromosome 7 Scaffold22, whole genome shotgun sequence.
CH878731  Homo sapiens 211000035831099 genomic scaffold, whole genome shotgun sequence.
DQ165078  Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1) gene, complete cds.
M29870  Human ras-related C3 botulinum toxin substrate (rac) mRNA, complete cds.
M31467  Human ras-like protein mRNA, complete cds, clone TC25.

EntrezGene:
ID  Description
RAC1  ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

RefSeq DNA:
ID  Description
NM_006908  Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
NM_018890  Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1b, mRNA.
NM_198829  Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1c, mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000379955; ENSP00000258737; ENSP00000348461

Entrez Proteins:
AAA36537.1; AAA36544.1; AAD30547.1; AAH04247.1; AAH50687.1; AAI07749.1; AAM21111.1; AAP35785.1; AAQ16632.1; AAS07511.1; AAS07512.1; AAZ80485.1; BAF84495.1; BAF84504.1; CAA10732.1; CAA10733.6; CAB53579.5; EAL23718.1; EAL23719.1; EAL23720.1; EAW55039.1; EAW55040.1; EAW55044.1

RefSeq Proteins:
ID  Description
NP_008839  ras-related C3 botulinum toxin substrate 1 isoform Rac1 [Homo sapiens].
NP_061485  ras-related C3 botulinum toxin substrate 1 isoform Rac1b [Homo sapiens].
NP_942126  ras-related C3 botulinum toxin substrate 1 isoform Rac1c [Homo sapiens].

UniProt:
ID  Description
P63000-2  UNKNOWN
A4D2P0  SubName: Full=cDNA FLJ77333, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1b, mRNA; SubName: Full=Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1); SubName: Full=Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_e;
A4D2P1  SubName: Full=Ras-related C3 botulinum toxin substrate 1 isoform Rac1; SubName: Full=cDNA FLJ30431 fis, clone BRACE2008968, highly similar to Ras-related C3 botulinum toxin substrate 1; SubName: Full=cDNA FLJ75553, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA; SubName: Full=Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1); SubName: Full=Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_a;
A4D2P2  SubName: Full=Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1) (Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_b);
P63000  RecName: Full=Ras-related C3 botulinum toxin substrate 1; AltName: Full=p21-Rac1; AltName: Full=Ras-like protein TC25; AltName: Full=Cell migration-inducing gene 5 protein; Flags: Precursor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Rac-Homo sapiens-1    

InterPro:
ID  Name
IPR003578  GTPase_Rho
IPR005225  Small_GTP_bd
IPR013753  Ras
IPR001806  Ras_trnsfrmng

Pfam:
ID  Description
Ras  Ras family

Structure
PDB:
ID
1E96
1FOE
1G4U
1HE1
1HH4
1I4D
1I4L
1I4T
1MH1
1RYF
1RYH
2FJU
2H7V
2NZ8
2P2L
2RMK
2VRW
2WKP
2WKQ
2WKR
3BJI

HSSP:
ID  Description
1a2b  ONCOGENE PROTEIN
1a4r  HYDROLASE
1aje  G-PROTEIN
1am4  COMPLEX (GTPASE-ACTIVATING/GTP-BINDING)
1an0  GTPASE
1cc0  SIGNALING PROTEIN
1cee  STRUCTURAL PROTEIN REGULATION
1cf4  TRANSFERASE
1cxz  SIGNALING PROTEIN
1doa  CELL CYCLE
1dpf  GENE REGULATION/SIGNALING PROTEIN
1ds6  SIGNALING PROTEIN
1e0a  SIGNALLING PROTEIN
1e96  SIGNALLING COMPLEX
1ees  STRUCTURAL PROTEIN
1foe  SIGNALING PROTEIN, IMMUNE SYSTEM/SIGNALI
1ftn  PROTO-ONCOGENE
1g4u  SIGNALING PROTEIN
1grn  GENE REGULATION
1gwn  GTPASE
1gzs  COMPLEX (TOXIN/CELL CYCLE PROTEIN)
1he1  SIGNALLING COMPLEX
1hh4  SINGAL PROTEIN INHIBITOR COMPLEX
1i4d  SIGNALING PROTEIN
1i4l  SIGNALING PROTEIN
1i4t  SIGNALING PROTEIN
1ki1  SIGNALING PROTEIN
1kmq  SIGNALING PROTEIN
1kz7  SIGNALING PROTEIN
1kzg  SIGNALING PROTEIN
1lb1  SIGNALING PROTEIN
1m7b  SIGNALING PROTEIN
1mh1  GTP-BINDING
1nf3  SIGNALING PROTEIN
1ow3  GENE REGULATION/SIGNALING PROTEIN
1ryf  HYDROLASE
1ryh  HYDROLASE
1s1c  SIGNALING PROTEIN
1tx4  COMPLEX(GTPASE ACTIVATN/PROTO-ONCOGENE)
1x86  SIGNALING PROTEIN/MEMBRANE PROTEIN
1xcg  SIGNALING PROTEIN ACTIVATOR/SIGNALING PR
1z2c  SIGNALING PROTEIN
2ase  SIGNALING PROTEIN
2atx  HYDROLASE
2c2h  SIGNALING PROTEIN
2cls  NUCLEOTIDE BINDING PROTEIN
2dfk  CELL CYCLE
2fju  SIGNALING PROTEIN,APOPTOSIS/HYDROLASE
2fv8  SIGNALING PROTEIN
2g0n  SIGNALING PROTEIN
2gcn  SIGNALING PROTEIN
2gco  SIGNALING PROTEIN
2gcp  SIGNALING PROTEIN
2h7v  SIGNALING PROTEIN
2ic5  SIGNALING PROTEIN
2j0v  NUCLEOTIDE-BINDING PROTEIN
2j1l  HYDROLASE
2ngr  HYDROLASE
2nty  SIGNALING PROTEIN
2nz8  SIGNALING PROTEIN,CELL CYCLE
2odb  PROTEIN BINDING
2ov2  PROTEIN BINDING/TRANSFERASE
2p2l  UNKNOWN FUNCTION
2q3h  STRUCTURAL GENOMICS
2qme  SIGNALING PROTEIN/TRANSFERASE
2qrz  CELL CYCLE
2rex  SIGNALING PROTEIN/LIPOPROTEIN
2rgn  SIGNALING PROTEIN COMPLEX
2rmk  MEMBRANE PROTEIN/TRANSFERASE
2v55  TRANSFERASE
2vrw  SIGNALING PROTEIN
3bji  SIGNALING PROTEIN
3bwd  PLANT PROTEIN
3c5c  SIGNALING PROTEIN
3eg5  SIGNALING PROTEIN

PSSH:
ID  Description
A4D2P0  UNKNOWN
A4D2P1  UNKNOWN
A4D2P2  UNKNOWN
P63000  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
602048  RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1; RAC1   RHO FAMILY, SMALL GTP-BINDING PROTEIN RAC1 CED10, C. ELEGANS, HOMOLOG OF

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005515  protein binding
GO:0005525  GTP binding
GO:0005622  intracellular
GO:0005624  membrane fraction
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005886  plasma membrane
GO:0006886  intracellular protein transport
GO:0006897  endocytosis
GO:0006913  nucleocytoplasmic transport
GO:0006928  cell motion
GO:0006935  chemotaxis
GO:0006954  inflammatory response
GO:0006972  hyperosmotic response
GO:0007010  cytoskeleton organization
GO:0007155  cell adhesion
GO:0007165  signal transduction
GO:0007264  small GTPase mediated signal transduction
GO:0007411  axon guidance
GO:0008283  cell proliferation
GO:0009653  anatomical structure morphogenesis
GO:0010310  regulation of hydrogen peroxide metabolic process
GO:0015031  protein transport
GO:0016020  membrane
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0016358  dendrite development
GO:0016477  cell migration
GO:0019897  extrinsic to plasma membrane
GO:0019899  enzyme binding
GO:0021799  cerebral cortex radially oriented cell migration
GO:0021831  embryonic olfactory bulb interneuron precursor migration
GO:0030027  lamellipodium
GO:0030032  lamellipodium assembly
GO:0030036  actin cytoskeleton organization
GO:0030041  actin filament polymerization
GO:0030334  regulation of cell migration
GO:0030742  GTP-dependent protein binding
GO:0030838  positive regulation of actin filament polymerization
GO:0031529  ruffle organization
GO:0035025  positive regulation of Rho protein signal transduction
GO:0042470  melanosome
GO:0042995  cell projection
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0045453  bone resorption
GO:0048261  negative regulation of receptor-mediated endocytosis
GO:0051668  localization within membrane
GO:0060263  regulation of respiratory burst

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04520  Adherens junction
hsa05014  Amyotrophic lateral sclerosis (ALS)
hsa04360  Axon guidance
hsa04662  B cell receptor signaling pathway
hsa04062  Chemokine signaling pathway
hsa05210  Colorectal cancer
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04510  Focal adhesion
hsa04670  Leukocyte transendothelial migration
hsa04010  MAPK signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway
hsa05212  Pancreatic cancer
hsa05200  Pathways in cancer
hsa04810  Regulation of actin cytoskeleton
hsa05211  Renal cell carcinoma
hsa04620  Toll-like receptor signaling pathway
hsa04370  VEGF signaling pathway
hsa05416  Viral myocarditis
hsa04310  Wnt signaling pathway

Panther:
ID  Description
P05918  p38 MAPK pathway
P00008  Axon guidance mediated by Slit/Robo
P00010  B cell activation
P00053  T cell activation
P00031  Inflammation mediated by chemokine and cytokine signaling pathway
P00007  Axon guidance mediated by semaphorins
P04393  Ras Pathway
P00018  EGF receptor signaling pathway
P00034  Integrin signalling pathway
P00021  FGF signaling pathway
P00009  Axon guidance mediated by netrin
P00016  Cytoskeletal regulation by Rho GTPase
P00029  Huntington disease

Chemicals
DrugBank:
ID  Name  Synonyms
DB00175  Pravastatin  Pravastatin Sodium; Pravastatina [Spanish]; Pravastatine [French]; Pravastatinum [Latin]
DB00641  Simvastatin  Simvastatin [Usan:Ban:Inn]; Simvastatina [Spanish]; Simvastatine [French]; Simvastatinum [Latin]
DB04315  Guanosine-5'-Diphosphate  
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000136238 Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000] Anopheles_gambiaeone2many AGAP005445[hgnc]AgaP_ENSANGG00000011739
Ciona_intestinalismany2many ENSCING00000002335Rac4 protein [Source:RefSeq_peptide;Acc:NP_001027963][hgnc]448957
Pan_troglodytesone2one ENSPTRG00000018910PREDICTED: Pan troglodytes hypothetical protein LOC741907 (LOC741907), mRNA. [Source:RefSeq_dna;Acc:XR_020627][hgnc]LOC741907
Pongo_pygmaeusone2one ENSPPYG00000017348Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000006784Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Procavia_capensisone2one ENSPCAG00000000530Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Microcebus_murinusone2one ENSMICG00000004366Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Cavia_porcellusone2one ENSCPOG00000008590Ras-related C3 botulinum toxin substrate 1 (p21-Rac1) (Sigma 1 component protein p22) (Fragment). [Source:UniProtKB/Swiss-Prot;Acc:P80236][hgnc]
Macaca_mulattaone2one ENSMMUG00000021075Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Dipodomys_ordiione2one ENSDORG00000014388Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) [Source:UniProtKB/Swiss-Prot;Acc:P63001][hgnc]
Myotis_lucifugusone2one ENSMLUG00000009701Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000001618Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Mus_musculusone2one ENSMUSG00000001847Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) [Source:UniProtKB/Swiss-Prot;Acc:P63001][hgnc]Rac1
Otolemur_garnettiiapprent_one2one ENSOGAG00000017027Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Loxodonta_africanaapprent_one2one ENSLAFG00000012844Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Equus_caballusapprent_one2one ENSECAG00000009727Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]LOC100061732
Felis_catusapprent_one2one ENSFCAG00000011361Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Rattus_norvegicusapprent_one2one ENSRNOG00000001068Ras-related C3 botulinum toxin substrate 1 precursor (p21-Rac1). [Source:UniProtKB/Swiss-Prot;Acc:Q6RUV5][hgnc]Rac1
Canis_familiarisapprent_one2one ENSCAFG00000015716Ras-related C3 botulinum toxin substrate 1 precursor (p21-Rac1) (Rac2). [Source:UniProtKB/Swiss-Prot;Acc:P62999][hgnc]RAC1
Bos_taurusapprent_one2one ENSBTAG00000009233Ras-related C3 botulinum toxin substrate 1 precursor (p21-Rac1). [Source:UniProtKB/Swiss-Prot;Acc:P62998][hgnc]RAC1
Tupaia_belangeriapprent_one2one ENSTBEG00000017336Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Ochotona_princepsapprent_one2one ENSOPRG00000005077Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000016440Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Echinops_telfairiapprent_one2one ENSETEG00000001830Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Ornithorhynchus_anatinusapprent_one2one ENSOANG00000003275Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]100076220
Erinaceus_europaeusapprent_one2one ENSEEUG00000012554Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Monodelphis_domesticaapprent_one2one ENSMODG00000007914Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Xenopus_tropicalisapprent_one2one ENSXETG00000027593MGC69529 protein. [Source:UniProtKB/TrEMBL;Acc:Q6GL60][hgnc]
Gallus_gallusapprent_one2one ENSGALG00000007130Gallus gallus ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), mRNA. [Source:RefSeq_dna;Acc:NM_205017][hgnc]RAC1
Sorex_araneusone2one ENSSARG00000014557Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Vicugna_pacosapprent_one2one ENSVPAG00000011395Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Drosophila_melanogastermany2many FBgn0010333[hgnc]Rac1
Aedes_aegyptione2many AAEL009732rac GTPase[hgnc]
Oryzias_latipesapprent_one2one ENSORLG00000008757Ras-related C3 botulinum toxin substrate 1 Precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000][hgnc]
Drosophila_melanogastermany2many FBgn0014011[hgnc]Rac2
Ciona_intestinalismany2many ENSCING00000002330Rac2 protein [Source:RefSeq_peptide;Acc:NP_001027787][hgnc]448954
Caenorhabditis_elegansmany2many C09G12.8ced-10 encodes a GTPase orthologous to human RAC1 (OMIM:602048) that is required for phagocytosis during programmed cell death and for migration of the distal tip cells of the somatic gonad. CED-10 functions in the engulfing cell during apoptosis, and is activated by a complex of CED-2(CrkII) and CED-5(DOCK180) to promote formation of the polarized cell extensions associated with cell corpse engulfment. [Source: WormBase][hgnc]ced-10
Ciona_intestinalismany2many ENSCING00000002350Rac1 protein [Source:RefSeq_peptide;Acc:NP_001027692][hgnc]445702
Caenorhabditis_elegansmany2many K03D3.10rac-2 encodes a small Rho family GTPase that, along with CED-10 and MIG-2, is one of three C. elegans Rac-related proteins. genetic studies indicate that rac-2 functions redundantly with mig-2 and ced-10 to regulate CAN and PDE axon pathfinding and CAN cell migration. in addition, rac-2 functions slightly redundant with mig-2 during distal tip cell movement and slightly redundant with ced-10 during cell-corpse phagocytosis. as unc-73 mutations enhance rac-2 defects in axon pathfinding and CAN cell migration, UNC-73/Trio is a likely candidate to act upstream of RAC-2 and positively regulate its GTPase activity in vivo. further, as UNC-115 activity is required to mediate the morphogenetic effects of constitutively active RAC-2(G12V), UNC-115, an actin-binding protein, is likely to be a downstream effector of RAC-2. GFP::RAC-2 reporters expressed in neurons and neuroblasts reveal localization at cell margins and the nerve ring, the latter suggesting that GFP::RAC-2 associates with the axonal plasma membrane. [Source: WormBase][hgnc]rac-2
Ciona_intestinalismany2many ENSCING00000002345Rac5 protein [Source:RefSeq_peptide;Acc:NP_001027789][hgnc]448958
Ciona_intestinalismany2many ENSCING00000002339Rac3b protein (EC 3.6.1.47) (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q7YT76][hgnc]