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Summary sheet information for Effector 'Tubulin-Homo sapiens-12'
Name Tubulin-Homo sapiens-12
Description RecName: Full=Tubulin beta-2A chain
Class
Family Tubulins
Sub_family Tubulins
type Tubulin
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 6
Gene Start: 3098918
Gene End: 3102808
Ensembl Contig View

Ensembl Genes:
ENSG00000137267

EMBL:
EMBL ID  Description
AK312621  Homo sapiens cDNA, FLJ93005, highly similar to Homo sapiens tubulin, beta polypeptide (TUBB), mRNA.
AL031963  Human DNA sequence from clone RP1-40E16 on chromosome 6p24.1-25.3 Contains the gene for a novel protein similar to D. melanogaster CG5327, a pseudogene similar to serine proteinase inhibitor (SERPINB8), two putative novel genes, the RIPK1 gene for receptor (TNFRSF)-interacting serine-threonine kinase 1, the BPHL gene for biphenyl hydrolase-like protein (serine hydrolase), the gene for a novel protein similar to tubulin beta polypeptide (TUBB), a tubulin beta polypeptide (TUBB) pseudogene, the 3' end of a novel gene and CpG islands.
AY159127  Homo sapiens cell-line MCF7 class II beta tubulin isotype mRNA, complete cds.
BC001194  Homo sapiens tubulin, beta 2A, mRNA (cDNA clone MGC:3167 IMAGE:3355410), complete cds.
BC018780  Homo sapiens tubulin, beta 2A, mRNA (cDNA clone MGC:32077 IMAGE:4870519), complete cds.
BC141924  Homo sapiens tubulin, beta 2A, mRNA (cDNA clone IMAGE:40131584), partial cds.
BC141925  Homo sapiens tubulin, beta 2A, mRNA (cDNA clone IMAGE:40131585), partial cds.
CR541958  Homo sapiens full open reading frame cDNA clone RZPDo834F0534D for gene TUBB, tubulin, beta polypeptide; complete cds, without stopcodon.
X79535  H.sapiens mRNA for beta tubulin, clone nuk_278

EntrezGene:
ID  Description
TUBB2A  tubulin, beta 2A

RefSeq DNA:
ID  Description
NM_001069  Homo sapiens tubulin, beta 2A (TUBB2A), mRNA.

UniGene:
ID  Description
Hs.703021  Transcribed locus, strongly similar to XP_001788648.1 PREDICTED: hypothetical protein [Bos taurus]

Proteins
Ensembl Proteins:
ENSP00000369703

Entrez Proteins:
AAH01194.1; AAH18780.1; AAI41925.1; AAI41926.1; AAN85571.1; BAG35507.1; CAA56071.1; CAD70628.1; CAG46756.1

RefSeq Proteins:
ID  Description
NP_001060  tubulin, beta 2 [Homo sapiens].

UniProt:
ID  Description
A5D906  SubName: Full=TUBB2A protein; Flags: Fragment;
A5D907  SubName: Full=TUBB2A protein; Flags: Fragment;
B2R6L0  SubName: Full=cDNA, FLJ93005, highly similar to Homo sapiens tubulin, beta polypeptide (TUBB), mRNA;
Q13885  RecName: Full=Tubulin beta-2A chain;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Tubulin-Homo sapiens-12    

InterPro:
ID  Name
IPR003008  Tubulin_FtsZ
IPR013838  Beta-tubulin_BS
IPR002453  Beta_tubulin
IPR017975  Tubulin_CS
IPR008280  Tub_FtsZ_C
IPR000217  Tubulin
IPR000158  Cell_division_FtsZ_N

Pfam:
ID  Description
Tubulin  Tubulin/FtsZ family, GTPase domain
Tubulin_C  Tubulin/FtsZ family, C-terminal domain

Structure
PDB:
ID

HSSP:
ID  Description
1sa0  CELL CYCLE
1z2b  CELL CYCLE
1z5v  STRUCTURAL PROTEIN
1z5w  STRUCTURAL PROTEIN
2btq  CYTOSKELETAL PROTEIN/COMPLEX
3cb2  STRUCTURAL PROTEIN, HYDROLASE
3du7  CELL CYCLE
3e22  CELL CYCLE

PSSH:
ID  Description
A5D907  UNKNOWN
A5D906  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005198  structural molecule activity
GO:0005515  protein binding
GO:0005525  GTP binding
GO:0005737  cytoplasm
GO:0005874  microtubule
GO:0007017  microtubule-based process
GO:0007018  microtubule-based movement
GO:0007067  mitosis
GO:0030182  neuron differentiation
GO:0043234  protein complex
GO:0051258  protein polymerization

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection

Panther:
ID  Description
P00016  Cytoskeletal regulation by Rho GTPase
P00029  Huntington disease

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000137267 Tubulin beta-2A chain [Source:UniProtKB/Swiss-Prot;Acc:Q13885] Drosophila_melanogastermany2many FBgn0003887[hgnc]betaTub56D
Microcebus_murinusone2one ENSMICG00000010647Tubulin beta-2A chain [Source:UniProtKB/Swiss-Prot;Acc:Q13885][hgnc]
Ochotona_princepsone2one ENSOPRG00000000400Tubulin beta-2A chain [Source:UniProtKB/Swiss-Prot;Acc:Q13885][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000009827Tubulin beta-2A chain [Source:UniProtKB/Swiss-Prot;Acc:Q13885][hgnc]
Dipodomys_ordiione2one ENSDORG00000012892Tubulin beta-2A chain [Source:UniProtKB/Swiss-Prot;Acc:Q7TMM9][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000002955Tubulin beta-2A chain [Source:UniProtKB/Swiss-Prot;Acc:Q13885][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000004797Tubulin beta-2A chain [Source:UniProtKB/Swiss-Prot;Acc:Q13885][hgnc]100079040
Tupaia_belangerione2many ENSTBEG00000004854[hgnc]
Rattus_norvegicusone2one ENSRNOG00000017558Tubulin beta-2A chain. [Source:UniProtKB/Swiss-Prot;Acc:P85108][hgnc]LOC498736
Mus_musculusone2one ENSMUSG00000058672Tubulin beta-2A chain [Source:UniProtKB/Swiss-Prot;Acc:Q7TMM9][hgnc]Tubb2a
Gallus_gallusmany2many ENSGALG00000012821Tubulin beta-2 chain (Beta-tubulin class-II). [Source:UniProtKB/Swiss-Prot;Acc:P32882][hgnc]LOC768337
Gallus_gallusmany2many ENSGALG00000013855Gallus gallus tubulin, beta 2B (TUBB2B), mRNA. [Source:RefSeq_dna;Acc:NM_001004400][hgnc]TUBB2B
Xenopus_tropicalisone2many ENSXETG00000018032Tubulin, beta 2. [Source:UniProtKB/TrEMBL;Acc:Q6P367][hgnc]
Drosophila_melanogastermany2many FBgn0003889[hgnc]betaTub85D
Ciona_intestinalisone2many ENSCING00000007589[hgnc]
Ciona_savignyione2many ENSCSAVG00000004683[hgnc]
Anopheles_gambiaeone2many AGAP010929[hgnc]AgaP_ENSANGG00000010545
Aedes_aegyptione2many AAEL002851tubulin beta chain[hgnc]
Saccharomyces_cerevisiaeone2many YFL037WTubulin beta chain (Beta-tubulin). [Source:UniProtKB/Swiss-Prot;Acc:P02557][hgnc]TUB2