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Summary sheet information for Effector 'Adenylate cyclase 3-Homo sapiens'
Name Adenylate cyclase 3-Homo sapiens
Description "RecName: Full=Adenylate cyclase type 3; EC=4.6.1.1;AltName: Full=Adenylate cyclase type III; Short=AC-III;AltName: Full=ATP pyrophosphate-lyase 3;AltName: Full=Adenylyl cyclase 3; Short=AC3;AltName: Full=Adenylate cyclase, olfactive type;"
Class
Family Cyclases
Sub_family Adenylate cyclases
type Adenylate cyclase 3
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 2
Gene Start: 24895545
Gene End: 24995559
Ensembl Contig View

Ensembl Genes:
ENSG00000138031

EMBL:
EMBL ID  Description
AB011083  Homo sapiens mRNA for KIAA0511 protein, partial cds.
AC012073  Homo sapiens BAC clone RP11-443B20 from 2, complete sequence.
AF033861  Homo sapiens type III adenylyl cyclase (AC-III) mRNA, complete cds.
AK075424  Homo sapiens cDNA PSEC0115 fis, clone PLACE1000086, highly similar to ADENYLATE CYCLASE, OLFACTIVE TYPE (EC 4.6.1.1).
BC126235  Homo sapiens adenylate cyclase 3, mRNA (cDNA clone MGC:161513 IMAGE:8991951), complete cds.

EntrezGene:
ID  Description
ADCY3  adenylate cyclase 3

RefSeq DNA:
ID  Description
NM_004036  Homo sapiens adenylate cyclase 3 (ADCY3), mRNA.

UniGene:
ID  Description
Hs.467898  CDNA FLJ14953 fis, clone PLACE3000160
Hs.681728  Transcribed locus, strongly similar to NP_004027.2 adenylate cyclase 3 [Homo sapiens]

Proteins
Ensembl Proteins:
ENSP00000384484; ENSP00000260600

Entrez Proteins:
AAD13403.1; AAI26236.1; AAY14787.1; BAA25437.1; BAC11613.1

RefSeq Proteins:
ID  Description
NP_004027  adenylate cyclase 3 [Homo sapiens].

UniProt:
ID  Description
Q8NBM1  SubName: Full=cDNA PSEC0115 fis, clone PLACE1000086, highly similar to ADENYLATE CYCLASE, OLFACTIVE TYPE (EC 4.6.1.1);
O60266  RecName: Full=Adenylate cyclase type 3; EC=4.6.1.1; AltName: Full=Adenylate cyclase type III; Short=AC-III; AltName: Full=ATP pyrophosphate-lyase 3; AltName: Full=Adenylyl cyclase 3; Short=AC3; AltName: Full=Adenylate cyclase, olfactive type;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Adenylate cyclase 3-Homo sapiens    

InterPro:
ID  Name
IPR001054  A/G_cyclase

Pfam:
ID  Description
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain

Structure
PDB:
ID

HSSP:
ID  Description
1ab8  LYASE
1azs  COMPLEX (LYASE/HYDROLASE)
1cjk  LYASE/LYASE/SIGNALING PROTEIN
1cjt  LYASE/LYASE/SIGNALING PROTEIN
1cju  LYASE/LYASE/SIGNALING PROTEIN
1cjv  LYASE/LYASE/SIGNALING PROTEIN
1cs4  LYASE/LYASE/SIGNALING PROTEIN
1cul  LYASE/LYASE/SIGNALING PROTEIN
1tl7  LYASE
1u0h  LYASE
1yk9  LYASE
2gvd  LYASE
2gvz  LYASE
3c14  LYASE/LYASE INHIBITOR
3c15  LYASE/LYASE INHIBITOR
3c16  LYASE/LYASE INHIBITOR
3et6  LYASE

PSSH:
ID  Description
Q8NBM1  UNKNOWN
O60266  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
600291  ADENYLATE CYCLASE 3; ADCY3   ADENYLYL CYCLASE 3 KIAA0511

Gene Ontology
GO:
GO ID  Description
GO:0000287  magnesium ion binding
GO:0005515  protein binding
GO:0005516  calmodulin binding
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0006171  cAMP biosynthetic process
GO:0007143  female meiosis
GO:0007242  intracellular signaling cascade
GO:0007608  sensory perception of smell
GO:0008294  calcium- and calmodulin-responsive adenylate cyclase activity
GO:0009190  cyclic nucleotide biosynthetic process
GO:0016849  phosphorus-oxygen lyase activity
GO:0045121  membrane raft
GO:0050896  response to stimulus

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04062  Chemokine signaling pathway
hsa05414  Dilated cardiomyopathy
hsa04540  Gap junction
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04740  Olfactory transduction
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa00230  Purine metabolism
hsa04270  Vascular smooth muscle contraction
hsa04962  Vasopressin-regulated water reabsorption
hsa05110  Vibrio cholerae infection

Panther:
ID  Description
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019  Endothelin signaling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB00250   Pyrophosphate   (4-)Diphosphoric acid ion; (P2O74-)Diphosphate; Diphosphate; Pyrometaphosphate; Pyrophosphate; Pyrophosphate tetraanion; Pyrophosphate(4-) ion; Pyrophosphic acid
HMDB00058   Cyclic AMP   Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
HMDB00538   Adenosine triphosphate   5'-(tetrahydrogen triphosphate) Adenosine; 5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine triphosphic acid; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adetol; Adynol; Atipi; Atriphos; Cardenosine; Fosfobion; Glucobasin; Myotriphos; Phosphobion; Striadyne; Triadenyl; Triphosphaden; Triphosphoric acid adenosine ester
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000138031 Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266] Pan_troglodytesone2one ENSPTRG00000011718Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]ADCY3
Pongo_pygmaeusone2one ENSPPYG00000012595Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Macaca_mulattaone2one ENSMMUG00000009600Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000010032Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Microcebus_murinusone2one ENSMICG00000001584Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Otolemur_garnettiione2one ENSOGAG00000000758Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Equus_caballusone2one ENSECAG00000008344Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]LOC100055961
Bos_taurusone2one ENSBTAG00000018705Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]ADCY3
Spermophilus_tridecemlineatusone2one ENSSTOG00000006049Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000009972Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000017518Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Dipodomys_ordiione2one ENSDORG00000007778Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:Q8VHH7][hgnc]
Procavia_capensisone2one ENSPCAG00000007573Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Loxodonta_africanaone2one ENSLAFG00000014458Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Myotis_lucifugusone2one ENSMLUG00000014135Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Tursiops_truncatusone2one ENSTTRG00000015147Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Canis_familiarisone2one ENSCAFG00000004090Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]ADCY3
Felis_catusone2one ENSFCAG00000003651Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Mus_musculusone2one ENSMUSG00000020654Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:Q8VHH7][hgnc]Adcy3
Rattus_norvegicusone2one ENSRNOG00000003999Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3) (Adenylate cyclase, olfactive type). [Source:UniProtKB/Swiss-Prot;Acc:P21932][hgnc]Adcy3
Tupaia_belangerione2one ENSTBEG00000007613Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000004393Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Cavia_porcellusone2one ENSCPOG00000005564Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Vicugna_pacosone2one ENSVPAG00000005559Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000015443Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Ochotona_princepsone2one ENSOPRG00000008617Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Echinops_telfairione2one ENSETEG00000007357Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Monodelphis_domesticaone2one ENSMODG00000015887Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Gallus_gallusone2one ENSGALG00000016608Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Takifugu_rubripesone2many ENSTRUG00000007837Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000011677Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000014041Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Xenopus_tropicalisone2one ENSXETG00000021179Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000013394Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Danio_rerioone2one ENSDARG00000017437Novel protein similar to vertebrate adenylate cyclase 3 (ADCY3) (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q5SP66][hgnc]si:ch211-153j24.5
Takifugu_rubripesone2many ENSTRUG00000015342Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Oryzias_latipesone2one ENSORLG00000016865Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000006752Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]