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Summary sheet information for Effector 'Phosphodiesterase 6-Homo sapiens-5'
Name Phosphodiesterase 6-Homo sapiens-5
Description "RecName: Full=Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Short=GMP-PDE gamma; EC=3.1.4.17;"
Class
Family Phosphodiesterases
Sub_family Rhodopsin-sensitive cGMP-specific PDEases
type Phosphodiesterase 6
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 12
Gene Start: 15017245
Gene End: 15026066
Ensembl Contig View

Ensembl Genes:
ENSG00000139053

EMBL:
EMBL ID  Description
BC069774  Homo sapiens phosphodiesterase 6H, cGMP-specific, cone, gamma, mRNA (cDNA clone MGC:97226 IMAGE:7262475), complete cds.
BC069800  Homo sapiens phosphodiesterase 6H, cGMP-specific, cone, gamma, mRNA (cDNA clone MGC:97238 IMAGE:7262487), complete cds.
BC093738  Homo sapiens phosphodiesterase 6H, cGMP-specific, cone, gamma, mRNA (cDNA clone MGC:120773 IMAGE:7939583), complete cds.
BC093740  Homo sapiens phosphodiesterase 6H, cGMP-specific, cone, gamma, mRNA (cDNA clone MGC:120775 IMAGE:7939585), complete cds.
D45399  Homo sapiens mRNA for cone-specific cGMP phosphodiesterase gamma subunit, complete cds.

EntrezGene:
ID  Description
PDE6H  phosphodiesterase 6H, cGMP-specific, cone, gamma

RefSeq DNA:
ID  Description
NM_006205  Homo sapiens phosphodiesterase 6H, cGMP-specific, cone, gamma (PDE6H), mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000266395

Entrez Proteins:
AAH69774.1; AAH69800.1; AAH93738.1; AAH93740.1; BAA08241.1

RefSeq Proteins:
ID  Description
NP_006196  phosphodiesterase 6H, cGMP-specific, cone, gamma [Homo sapiens].

UniProt:
ID  Description
Q13956  RecName: Full=Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Short=GMP-PDE gamma; EC=3.1.4.17;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR006952  PDE6_gamma

Pfam:
ID  Description
PDE6_gamma  Retinal cGMP phosphodiesterase, gamma subunit

Structure
PDB:
ID

HSSP:
ID  Description
1fqj  SIGNALING PROTEIN
2ju4  HYDROLASE

PSSH:
ID  Description
Q13956  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
601190  PHOSPHODIESTERASE 6H, cGMP-SPECIFIC, CONE, GAMMA; PDE6H   UNKNOWN

Gene Ontology
GO:
GO ID  Description
GO:0000187  activation of MAPK activity
GO:0004114  3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004857  enzyme inhibitor activity
GO:0007601  visual perception
GO:0016787  hydrolase activity
GO:0030553  cGMP binding
GO:0045742  positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745  positive regulation of G-protein coupled receptor protein signaling pathway
GO:0050896  response to stimulus

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa00230  Purine metabolism

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB01397   GMP   5'-GMP; E 626; GMP; Guanidine monophosphate; Guanosine 5'-monophosphate; Guanosine 5'-phosphate; Guanosine 5'-phosphorate; Guanosine 5'-phosphoric acid; guanosine monophosphate; guanosine-5'-monophosphate; guanosine-5'-phosphate; guanosine-monophosphate; guanosine-phosphate; guanylate; guanylic acid
HMDB01314   Cyclic GMP   3',5'-cyclic GMP; 3',5'-guanosine; 3',5'-guanosine monophosphate; cGMP; cyclic 3',5'-guanosine monophosphate; cyclic GMP; cyclic-GMP; cyclic guanosine 3',5'-monophosphate; guanosine 3',5'-cyclic phosphate; guanosine 3',5'-cyclic-monophosphate; guanosine 3',5'-monophosphate; guanosine cyclic-monophosphate; guanosine-cyclic-phosphoric-acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000139053 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956] Pan_troglodytesone2one ENSPTRG00000004730Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]PDE6H
Macaca_mulattaone2one ENSMMUG00000001009Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000004330Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Microcebus_murinusone2one ENSMICG00000006265Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Tupaia_belangerione2one ENSTBEG00000017103Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Felis_catusone2one ENSFCAG00000003029Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Equus_caballusone2one ENSECAG00000014166Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]LOC100067269
Otolemur_garnettiione2one ENSOGAG00000010538Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Vicugna_pacosone2one ENSVPAG00000002447Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Canis_familiarisone2one ENSCAFG00000012874Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]PDE6H
Tarsius_syrichtaone2one ENSTSYG00000014101Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Cavia_porcellusone2one ENSCPOG00000025430Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Ochotona_princepsone2one ENSOPRG00000015117Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000013318Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000006014Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Tursiops_truncatusone2one ENSTTRG00000004238Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Bos_taurusone2one ENSBTAG00000013635Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma). [Source:UniProtKB/Swiss-Prot;Acc:P22571][hgnc]PDE6H
Erinaceus_europaeusone2one ENSEEUG00000003856Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Sorex_araneusone2one ENSSARG00000007150Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Procavia_capensisone2one ENSPCAG00000001312Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Loxodonta_africanaone2one ENSLAFG00000005111Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000009094Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma). [Source:UniProtKB/Swiss-Prot;Acc:O55175][hgnc]
Rattus_norvegicusone2one ENSRNOG00000005947Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma). [Source:UniProtKB/Swiss-Prot;Acc:P61250][hgnc]Pde6h
Echinops_telfairione2one ENSETEG00000002798Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Mus_musculusone2one ENSMUSG00000064330Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:P61249][hgnc]Pde6h
Monodelphis_domesticaone2one ENSMODG00000017940Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Xenopus_tropicalisone2many ENSXETG00000026595Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase gamma-subunit (EC 3.1.4.17) (GMP-PDE gamma). [Source:UniProtKB/Swiss-Prot;Acc:Q13956] [from human gene ENSG00000139053][hgnc]
Xenopus_tropicalisone2many ENSXETG00000025215[hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000005687Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Oryzias_latipesone2many ENSORLG00000014931Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000007162Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000015964Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000006076Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Takifugu_rubripesone2many ENSTRUG00000007982Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Takifugu_rubripesone2many ENSTRUG00000005946Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000015966Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Oryzias_latipesone2many ENSORLG00000004281Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Danio_rerioone2many ENSDARG00000070438hypothetical protein LOC393758 [Source:RefSeq_peptide;Acc:NP_957079][hgnc]LOC100004285
Danio_rerioone2many ENSDARG00000070439hypothetical protein LOC393758 [Source:RefSeq_peptide;Acc:NP_957079][hgnc]LOC100004285
Oryzias_latipesone2many ENSORLG00000004291Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Takifugu_rubripesone2many ENSTRUG00000000372Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]
Oryzias_latipesone2many ENSORLG00000000057Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC 3.1.4.17) (GMP-PDE gamma) [Source:UniProtKB/Swiss-Prot;Acc:Q13956][hgnc]