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Summary sheet information for Effector 'Kinase suppressor of Ras(KSR)-Homo sapiens'
Name Kinase suppressor of Ras(KSR)-Homo sapiens
Description RecName: Full=Kinase suppressor of Ras 1
Class
Family Ser Thr protein kinases
Sub_family Kinase suppressor of Ras(KSR)
type Kinase suppressor of Ras(KSR)
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 17
Gene Start: 22807797
Gene End: 22974545
Ensembl Contig View

Ensembl Genes:
ENSG00000141068

EMBL:
EMBL ID  Description
AC015688  Homo sapiens chromosome 17, clone RP11-19P22, complete sequence.
AC069366  Homo sapiens chromosome 17, clone RP11-720N19, complete sequence.
AK130719  Homo sapiens cDNA FLJ27209 fis, clone SYN03476.
BC042106  Homo sapiens kinase suppressor of ras 1, mRNA (cDNA clone IMAGE:5168484), partial cds.
U43586  Human kinase suppressor of ras-1 (KSR1) mRNA, partial cds.

EntrezGene:
ID  Description
KSR1  kinase suppressor of ras 1

RefSeq DNA:
ID  Description
NM_014238  Homo sapiens kinase suppressor of ras 1 (KSR1), mRNA.

UniGene:
ID  Description
Hs.133534  Kinase suppressor of ras 1, mRNA (cDNA clone IMAGE:5168484)

Proteins
Ensembl Proteins:
ENSP00000381952; ENSP00000268763; ENSP00000381955; ENSP00000381958; ENSP00000323178

Entrez Proteins:
AAC50354.1; AAH42106.1; BAC85413.1

RefSeq Proteins:
ID  Description
NP_055053  kinase suppressor of ras [Homo sapiens].

UniProt:
ID  Description
Q8IVT5-2  UNKNOWN
Q8IVT5-3  UNKNOWN
A8MY87  SubName: Full=Putative uncharacterized protein KSR1;
Q6ZNT2  SubName: Full=cDNA FLJ27209 fis, clone SYN03476;
Q8IVT5  RecName: Full=Kinase suppressor of Ras 1;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Kinase suppressor of Ras(KSR)-Homo sapiens    

InterPro:
ID  Name
IPR008271  Ser_thr_pkin_AS
IPR000719  Prot_kinase_core
IPR001245  Tyr_pkinase
IPR002219  DAG_PE_bd

Pfam:
ID  Description
C1_1  Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase_Tyr  Protein tyrosine kinase

Structure
PDB:
ID

HSSP:
ID  Description
1kbe  SIGNALING PROTEIN
1kbf  SIGNALING PROTEIN
1uwh  KINASE
1uwj  KINASE
2fb8  TRANSFERASE
3c4c  TRANSFERASE
3c4d  TRANSFERASE
3d4q  TRANSFERASE

PSSH:
ID  Description
Q8IVT5  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
601132  KINASE SUPPRESSOR OF RAS 1; KSR1   KSR

Gene Ontology
GO:
GO ID  Description
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0005515  protein binding
GO:0005524  ATP binding
GO:0005622  intracellular
GO:0005737  cytoplasm
GO:0006468  protein amino acid phosphorylation
GO:0007242  intracellular signaling cascade
GO:0007265  Ras protein signal transduction
GO:0008270  zinc ion binding
GO:0016020  membrane
GO:0019992  diacylglycerol binding
GO:0046872  metal ion binding

Pathway
KEGG:
KEGG PATHWAY ID  Name

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000141068 Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5] Pan_troglodytesone2one ENSPTRG00000008900Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000008077Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Macaca_mulattaone2one ENSMMUG00000017888Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Microcebus_murinusone2one ENSMICG00000012881Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Tupaia_belangerione2one ENSTBEG00000013332Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000013714Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Otolemur_garnettiione2one ENSOGAG00000008249Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Felis_catusone2one ENSFCAG00000009211Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Myotis_lucifugusone2many ENSMLUG00000002373[hgnc]
Myotis_lucifugusone2many ENSMLUG00000008218[hgnc]
Bos_taurusone2one ENSBTAG00000006601Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000014739Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000001456Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Cavia_porcellusone2one ENSCPOG00000000932Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000007617Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Tursiops_truncatusone2one ENSTTRG00000008083Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000007048Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Canis_familiarisone2one ENSCAFG00000018638Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]KSR1
Loxodonta_africanaone2one ENSLAFG00000011057Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000015126Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Echinops_telfairione2one ENSETEG00000012028Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Procavia_capensisone2one ENSPCAG00000013912Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Dipodomys_ordiione2one ENSDORG00000012665Kinase suppressor of Ras 1 (mKSR1) (Protein Hb) [Source:UniProtKB/Swiss-Prot;Acc:Q61097][hgnc]
Sorex_araneusone2one ENSSARG00000006926Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Ochotona_princepsone2one ENSOPRG00000005447Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Mus_musculusone2one ENSMUSG00000018334Kinase suppressor of Ras 1 (mKSR1) (Protein Hb) [Source:UniProtKB/Swiss-Prot;Acc:Q61097][hgnc]Ksr1
Rattus_norvegicusone2one ENSRNOG00000012818kinase suppressor of ras 1 [Source:RefSeq_peptide;Acc:NP_001101754][hgnc]Ksr1_predicted
Monodelphis_domesticaone2one ENSMODG00000019224Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Equus_caballusone2one ENSECAG00000019816Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000005665Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Gallus_gallusone2one ENSGALG00000005685Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]KSR1
Xenopus_tropicalisone2one ENSXETG00000021354Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Takifugu_rubripesone2many ENSTRUG00000011530Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000020303Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000011835Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Oryzias_latipesone2one ENSORLG00000009690Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Danio_rerioone2many ENSDARG00000068714Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Danio_rerioone2many ENSDARG00000030933Novel protein similar to human and mouse kinase suppressor of ras (KSR) (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q7T117][hgnc]si:busm1-122b7.1
Takifugu_rubripesone2many ENSTRUG00000004793Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000013663Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000004984Kinase suppressor of Ras 1 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVT5][hgnc]