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Summary sheet information for Effector 'Voltage dependent P/Q type calcium channel-Homo sapiens'
Name Voltage dependent P/Q type calcium channel-Homo sapiens
Description "RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha-1A;AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.1;AltName: Full=Calcium channel, L type, alpha-1 polypeptide isoform 4;AltName: Full=Brain calcium channel I; Short=BI;"
Class
Family Ion channels
Sub_family Voltage dependent calcium channels
type Voltage dependent P/Q type calcium channel
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 19
Gene Start: 13178256
Gene End: 13478038
Ensembl Contig View

Ensembl Genes:
ENSG00000141837

EMBL:
EMBL ID  Description
AB035726  Homo sapiens CACNA1A mRNA for alpha1A-voltage-dependent calcium channel, partial cds, isolate:TMDN-SCA6-001.
AB035727  Homo sapiens CACNA1A mRNA for alpha1A-voltage-dependent calcium channel, complete cds, isolate:TMDN-CNT-001.
AC005305  Homo sapiens chromosome 19, cosmid R34275, complete sequence.
AC008540  Homo sapiens chromosome 19 clone CTC-496P20, complete sequence.
AC011446  Homo sapiens chromosome 19 clone CTC-250I14, complete sequence.
AC022436  Homo sapiens chromosome 19 clone LLNLR-303H1, complete sequence.
AC026805  Homo sapiens chromosome 19 clone LLNLR-268A1, complete sequence.
AC098781  Homo sapiens chromosome 19 clone LLNLR-231C1, complete sequence.
AC124224  Homo sapiens chromosome 19 clone LLNLR-285D11, complete sequence.
AF004883  Homo sapiens neuronal calcium channel alpha 1A subunit isoform 1A-2 mRNA, complete cds.
AF004884  Homo sapiens neuronal calcium channel alpha 1A subunit isoform A-1 mRNA, complete cds.
AF100774  Homo sapiens voltage-dependent P/Q type calcium channel alpha 1A subunit (CACNA1A) mRNA, partial cds.
AF144098  Homo sapiens P/Q type calcium channel alpha1A subunit (CACNA1A) gene, exon 37B and partial cds.
AF152345  Homo sapiens calcium channel alpha 1A subunit (CACNA1A) gene, exons 13 and 14 and partial cds.
S76537  P-type voltage-gated calcium channel alpha 1 subunit homolog [human, H146 small-cell lung carcinoma cells, mRNA Partial, 345 nt].
U06702  Human clone CCA54 mRNA containing CCA trinucleotide repeat.
U79663  Human alpha1A-voltage-dependent calcium channel mRNA, splice form BI-1, partial cds.
U79664  Human alpha1A-voltage-dependent calcium channel mRNA, splice form BI-1 (V1), partial cds.
U79665  Human alpha1A-voltage-sensitive calcium channel mRNA, splice form BI-1-GGCAG, partial cds.
U79666  Homo sapiens alpha1A-voltage-dependent calcium channel mRNA, splice form BI-1-Vi-GGCAG, complete cds.
U79667  Human alpha1A-voltage-dependent calcium channel mRNA, splice form BI-1-V2-GGCAG, partial cds.
U79668  Human alpha1A-voltage-dependent calcium channel mRNA, splice form BI-1-V2,V3, partial cds.
X99897  H.sapiens mRNA for P/Q-type calcium channel alpha1 subunit
Z80114  H.sapiens CACNL1A4 gene, exon 1, and joined mRNA
Z80115  H.sapiens CACNL1A4 gene, exon 2

EntrezGene:
ID  Description
CACNA1A  calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

RefSeq DNA:
ID  Description
NM_001127221  Homo sapiens calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A), transcript variant 3, mRNA.
NM_001127222  Homo sapiens calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A), transcript variant 4, mRNA.

UniGene:
ID  Description
Hs.501632  Neuronal calcium channel alpha 1A subunit isoform A-1

Proteins
Ensembl Proteins:
ENSP00000349520; ENSP00000317661; ENSP00000353362

Entrez Proteins:
AAB33068.1; AAB49674.1; AAB49675.1; AAB49676.1; AAB49677.1; AAB49678.1; AAB61612.1; AAB61613.1; AAB64179.1; AAC26839.1; AAC77460.1; AAD38386.1; AAF03935.1; BAA94765.1; BAA94766.2; CAA68172.1

RefSeq Proteins:
ID  Description
NP_001120693  calcium channel, alpha 1A subunit isoform 3 [Homo sapiens].
NP_001120694  calcium channel, alpha 1A subunit isoform 4 [Homo sapiens].

UniProt:
ID  Description
O00555-2  UNKNOWN
O00555-3  UNKNOWN
O00555-4  UNKNOWN
O00555-5  UNKNOWN
O00555-6  UNKNOWN
O00555-7  UNKNOWN
O95387  SubName: Full=Voltage-dependent P/Q type calcium channel alpha 1A subunit; Flags: Fragment;
Q9NS88  SubName: Full=Alpha1A-voltage-dependent calcium channel;
Q9NS89  SubName: Full=Alpha1A-voltage-dependent calcium channel; Flags: Fragment;
Q9UDC4  SubName: Full=Neuronal-type voltage-gated CA2+ channel class A alpha 1 subunit, VGCC class A alpha 1; Flags: Fragment;
Q9UHM9  SubName: Full=P/Q type calcium channel alpha1A subunit; Flags: Fragment;
Q9UN69  SubName: Full=Calcium channel alpha 1A subunit; Flags: Fragment;
O00555  RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha-1A; AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.1; AltName: Full=Calcium channel, L type, alpha-1 polypeptide isoform 4; AltName: Full=Brain calcium channel I; Short=BI;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Voltage dependent P/Q type calcium channel-Homo sapiens    

InterPro:
ID  Name
IPR005448  VDCC_P/Q_a1su
IPR005447  VDCC_N_a1su
IPR002077  VDCCAlpha1
IPR014873  VDCC_a1su_IQ
IPR005821  Ion_trans

Pfam:
ID  Description
Ion_trans  Ion transport protein
Ion_trans  Ion transport protein
Ca_chan_IQ  Voltage gated calcium channel IQ domain

Structure
PDB:
ID
3BXK

HSSP:
ID  Description
1vyt  ION TRANSPORT/COMPLEX
3bxk  MEMBRANE PROTEIN, SIGNALING PROTEIN
3dvk  MEMBRANE PROTEIN
3dvm  MEMBRANE PROTEIN

PSSH:
ID  Description
Q9NS88  UNKNOWN
Q9NS89  UNKNOWN
O00555  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
601011  CALCIUM CHANNEL, VOLTAGE-DEPENDENT, P/Q TYPE, ALPHA-1A SUBUNIT; CACNA1A   CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 4; CACNL1A4 CaV2.1

Gene Ontology
GO:
GO ID  Description
GO:0000096  sulfur amino acid metabolic process
GO:0005216  ion channel activity
GO:0005244  voltage-gated ion channel activity
GO:0005245  voltage-gated calcium channel activity
GO:0005249  voltage-gated potassium channel activity
GO:0005509  calcium ion binding
GO:0005515  protein binding
GO:0005634  nucleus
GO:0005737  cytoplasm
GO:0005886  plasma membrane
GO:0005891  voltage-gated calcium channel complex
GO:0006006  glucose metabolic process
GO:0006811  ion transport
GO:0006813  potassium ion transport
GO:0006816  calcium ion transport
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0007214  gamma-aminobutyric acid signaling pathway
GO:0007268  synaptic transmission
GO:0007270  nerve-nerve synaptic transmission
GO:0007274  neuromuscular synaptic transmission
GO:0007416  synaptogenesis
GO:0007628  adult walking behavior
GO:0008076  voltage-gated potassium channel complex
GO:0008219  cell death
GO:0008331  high voltage-gated calcium channel activity
GO:0014051  gamma-aminobutyric acid secretion
GO:0014056  regulation of acetylcholine secretion
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0016049  cell growth
GO:0017156  calcium ion-dependent exocytosis
GO:0017158  regulation of calcium ion-dependent exocytosis
GO:0019226  transmission of nerve impulse
GO:0019905  syntaxin binding
GO:0021522  spinal cord motor neuron differentiation
GO:0021590  cerebellum maturation
GO:0021679  cerebellar molecular layer development
GO:0021680  cerebellar Purkinje cell layer development
GO:0021702  cerebellar Purkinje cell differentiation
GO:0021750  vestibular nucleus development
GO:0021953  central nervous system neuron differentiation
GO:0030425  dendrite
GO:0030644  cellular chloride ion homeostasis
GO:0032353  negative regulation of hormone biosynthetic process
GO:0035249  synaptic transmission, glutamatergic
GO:0042133  neurotransmitter metabolic process
GO:0042391  regulation of membrane potential
GO:0042403  thyroid hormone metabolic process
GO:0042445  hormone metabolic process
GO:0042995  cell projection
GO:0043025  cell soma
GO:0043113  receptor clustering
GO:0043524  negative regulation of neuron apoptosis
GO:0048265  response to pain
GO:0048266  behavioral response to pain
GO:0048791  calcium ion-dependent exocytosis of neurotransmitter
GO:0048813  dendrite morphogenesis
GO:0050770  regulation of axonogenesis
GO:0050877  neurological system process
GO:0050883  musculoskeletal movement, spinal reflex action
GO:0050885  neuromuscular process controlling balance
GO:0050905  neuromuscular process
GO:0051899  membrane depolarization
GO:0060024  rhythmic synaptic transmission

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04730  Long-term depression
hsa04010  MAPK signaling pathway
hsa04742  Taste transduction
hsa04930  Type II diabetes mellitus

Panther:
ID  Description
P00039  Metabotropic glutamate receptor group III pathway
P04394  Thyrotropin-releasing hormone receptor signaling pathway
P00037  Ionotropic glutamate receptor pathway
P00040  Metabotropic glutamate receptor group II pathway
P00027  Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Chemicals
DrugBank:
ID  Name  Synonyms
DB00230  Pregabalin  pregabalin
DB00401  Nisoldipine  Nisoldipin; Nisoldipino [INN-Spanish]; Nisoldipinum [INN-Latin]
DB00568  Cinnarizine  
DB00836  Loperamide  
DB01244  Bepridil  Bepadin
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000141837 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555] Pan_troglodytesone2one ENSPTRG00000010561Calcium channel voltage-dependent P/Q type alpha 1A subunit (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q64LJ2][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000009626Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Tursiops_truncatusone2one ENSTTRG00000011945Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Macaca_mulattaone2one ENSMMUG00000003555Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Bos_taurusone2one ENSBTAG00000014828calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [Source:RefSeq_peptide;Acc:NP_001068597][hgnc]CACNA1A
Vicugna_pacosone2one ENSVPAG00000000253Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Otolemur_garnettiione2one ENSOGAG00000001691Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Canis_familiarisone2one ENSCAFG00000016897Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000015081Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Procavia_capensisone2one ENSPCAG00000003931Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Myotis_lucifugusone2one ENSMLUG00000010292Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Felis_catusone2one ENSFCAG00000000486Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Microcebus_murinusone2one ENSMICG00000000823Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Mus_musculusone2one ENSMUSG00000034656Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:P97445][hgnc]Cacna1a
Tarsius_syrichtaone2one ENSTSYG00000013676Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Cavia_porcellusone2one ENSCPOG00000025184Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Ochotona_princepsone2one ENSOPRG00000004000Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Monodelphis_domesticaone2one ENSMODG00000011749Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Rattus_norvegicusone2one ENSRNOG00000002559Class A calcium channel variant riA-II (Fragment). [Source:UniProtKB/TrEMBL;Acc:O70369][hgnc]
Equus_caballusone2one ENSECAG00000016371Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Dipodomys_ordiione2one ENSDORG00000010862Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:P97445][hgnc]
Danio_rerioone2many ENSDARG00000037905Novel protein similar to vertebrate voltage-dependent calcium channel, P/Q type, alpha 1A subunit (CACNA1A) (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q5RHB2][hgnc]cacna1a
Gasterosteus_aculeatusone2one ENSGACG00000012741Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Danio_rerioone2many ENSDARG00000006923[hgnc]LOC569528
Takifugu_rubripesone2many ENSTRUG00000007330Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Takifugu_rubripesone2many ENSTRUG00000002449Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000012624Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000011310Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) [Source:UniProtKB/Swiss-Prot;Acc:O00555][hgnc]