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Summary sheet information for GPCR 'ANGIOTENSIN RECEPTORS_AT1_Homo sapiens'
Name ANGIOTENSIN RECEPTORS_AT1_Homo sapiens
Description RecName: Full=Type-1 angiotensin II receptor;AltName: Full=AT1;AltName: Full=AT1AR;AltName: Full=AT1BR
Class CLASS A
Family ANGIOTENSIN RECEPTORS
Sub_family AT1
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 3
Gene Start: 149898348
Gene End: 149943478
Ensembl Contig View

Ensembl Genes:
ENSG00000144891

EMBL:
EMBL ID  Description
AF245699  Homo sapiens type 1 angiotensin II receptor (AGTR1) gene, complete cds.
AK291541  Homo sapiens cDNA FLJ75705 complete cds, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA.
AY221090  Homo sapiens angiotensin II receptor variant 1 gene, complete cds.
AY436325  Homo sapiens angiotensin II receptor, type 1 (AGTR1) gene, complete cds.
BC022447  Homo sapiens angiotensin II receptor, type 1, mRNA (cDNA clone MGC:25987 IMAGE:4799755), complete cds.
BC068494  Homo sapiens angiotensin II receptor, type 1, mRNA (cDNA clone MGC:87211 IMAGE:30337806), complete cds.
CH471052  Homo sapiens 211000035835664 genomic scaffold, whole genome shotgun sequence.
D13814  Homo sapiens mRNA for angiotensin II type 1b receptor, complete cds.
EU332837  Homo sapiens angiotensin II receptor, type 1 (AGTR1) gene, complete cds.
M87290  Human angiotensin II type 1 receptor mRNA, complete cds.
M91464  Human angiotensinogen II type-1A receptor gene, complete cds.
M93394  Human angiotensin II type-1 receptor (AT1) mRNA, complete cds.
S77410  Homo sapiens type 1 angiotensin II receptor mRNA, complete cds.
X65699  H.sapiens mRNA for angiotensin II receptor
Z11162  H.sapiens gene for angiotensin II

EntrezGene:
ID  Description
AGTR1  angiotensin II receptor, type 1

RefSeq DNA:
ID  Description
NM_000685  Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA.
NM_004835  Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 3, mRNA.
NM_009585  Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 2, mRNA.
NM_031850  Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 4, mRNA.
NM_032049  Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 5, mRNA.

UniGene:
ID  Description
Hs.477887  Angiotensin II type 1 receptor
Hs.709185  UNKNOWN

Proteins
Ensembl Proteins:
ENSP00000385641; ENSP00000385612; ENSP00000384447; ENSP00000273430; ENSP00000384643

Entrez Proteins:
AAA35535.1; AAA35569.1; AAA58370.1; AAB34644.1; AAF70464.1; AAH22447.1; AAH68494.1; AAO65968.1; AAR03503.1; ABY87526.1; BAA02968.1; BAF84230.1; CAA46621.1; CAA77513.1; EAW78906.1

RefSeq Proteins:
ID  Description
NP_000676  angiotensin II receptor, type 1 [Homo sapiens].
NP_004826  angiotensin II receptor, type 1 [Homo sapiens].
NP_033611  angiotensin II receptor, type 1 [Homo sapiens].
NP_114038  angiotensin II receptor, type 1 [Homo sapiens].
NP_114438  angiotensin II receptor, type 1 [Homo sapiens].

UniProt:
ID  Description
Q53YY0  SubName: Full=cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA; SubName: Full=Angiotensin II receptor, type 1; SubName: Full=Angiotensin II receptor, type 1, isoform CRA_b;
Q6NUP5  SubName: Full=Angiotensin II receptor, type 1;
Q8TBK4  SubName: Full=Angiotensin II receptor, type 1;
P30556  RecName: Full=Type-1 angiotensin II receptor; AltName: Full=AT1; AltName: Full=AT1AR; AltName: Full=AT1BR;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR017452  GPCR_Rhodpsn_supfam
IPR001277  CXC_4_rcpt
IPR000248  ATII_rcpt
IPR001186  BK_rcpt_B1
IPR000190  ATII_AT1_rcpt
IPR000276  GPCR_Rhodpsn

Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID
1ZV0

HSSP:
ID  Description

PSSH:
ID  Description
Q53YY0  UNKNOWN
Q6NUP5  UNKNOWN
Q8TBK4  UNKNOWN
P30556  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
106165  ANGIOTENSIN RECEPTOR 1; AGTR1   ANGIOTENSIN II RECEPTOR, VASCULAR TYPE 1; AT2R1 ANGIOTENSIN RECEPTOR 1A; AGTR1A AT1R ANGIOTENSIN RECEPTOR 1B, INCLUDED; AGTR1B, INCLUDED

Gene Ontology
GO:
GO ID  Description
GO:0001558  regulation of cell growth
GO:0001584  rhodopsin-like receptor activity
GO:0001596  angiotensin type I receptor activity
GO:0001822  kidney development
GO:0002018  renin-angiotensin regulation of aldosterone production
GO:0002034  regulation of blood vessel size by renin-angiotensin
GO:0003078  regulation of natriuresis
GO:0004872  receptor activity
GO:0004945  angiotensin type II receptor activity
GO:0004947  bradykinin receptor activity
GO:0004982  N-formyl peptide receptor activity
GO:0004992  platelet activating factor receptor activity
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0006800  oxygen and reactive oxygen species metabolic process
GO:0006935  chemotaxis
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0016021  integral to membrane
GO:0016493  C-C chemokine receptor activity
GO:0016494  C-X-C chemokine receptor activity
GO:0019229  regulation of vasoconstriction
GO:0019722  calcium-mediated signaling
GO:0031711  bradykinin receptor binding
GO:0033864  positive regulation of NAD(P)H oxidase activity
GO:0042127  regulation of cell proliferation
GO:0042312  regulation of vasodilation
GO:0045028  purinergic nucleotide receptor activity, G-protein coupled
GO:0046982  protein heterodimerization activity
GO:0050729  positive regulation of inflammatory response
GO:0051482  elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04614  Renin-angiotensin system
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description
P05911  Angiotensin II-stimulated signaling through G proteins and beta-arrestin

Chemicals
DrugBank:
ID  Name  Synonyms
DB01342  Forasartan  
DB00678  Losartan  
DB00421  Spironolactone  
DB01029  Irbesartan  irbesartan
DB01349  Tasosartan  
DB00966  Telmisartan  BIBR 277; BIBR 277SE; telmisartan
DB00876  Eprosartan  
DB00177  Valsartan  valsartan
DB00796  Candesartan  Candesartan cilexetil
DB01347  Saprisartan  
DB00275  Olmesartan  DE-092; Olmesartan medoximil; Olmesartan medoxomil; olmesartan
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000144891 Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556] Pan_troglodytesone2one ENSPTRG00000015503Type-1 angiotensin II receptor (AT1). [Source:UniProtKB/Swiss-Prot;Acc:Q9GLN9][hgnc]AGTR1
Pongo_pygmaeusone2one ENSPPYG00000014190Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Macaca_mulattaone2one ENSMMUG00000020680Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Microcebus_murinusone2one ENSMICG00000011022Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Tursiops_truncatusone2one ENSTTRG00000009495Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000013739Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Equus_caballusone2one ENSECAG00000001279Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]LOC100059005
Felis_catusone2one ENSFCAG00000000717Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000014281Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Myotis_lucifugusone2one ENSMLUG00000001873Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Bos_taurusone2one ENSBTAG00000016947Type-1 angiotensin II receptor (AT1). [Source:UniProtKB/Swiss-Prot;Acc:P25104][hgnc]AGTR1
Cavia_porcellusone2one ENSCPOG00000007610Type-1 angiotensin II receptor (AT1). [Source:UniProtKB/Swiss-Prot;Acc:Q9WV26][hgnc]
Otolemur_garnettiione2one ENSOGAG00000008654Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Loxodonta_africanaone2one ENSLAFG00000004852Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Procavia_capensisone2one ENSPCAG00000006135Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Rattus_norvegicusone2many ENSRNOG00000010640Type-1B angiotensin II receptor (AT1B) (AT3). [Source:UniProtKB/Swiss-Prot;Acc:P29089][hgnc]Agtr1b
Mus_musculusone2many ENSMUSG00000049115Type-1A angiotensin II receptor (AT1A) (AT1) [Source:UniProtKB/Swiss-Prot;Acc:P29754][hgnc]Agtr1a
Rattus_norvegicusone2many ENSRNOG00000018346Type-1A angiotensin II receptor (AT1) (AT1A). [Source:UniProtKB/Swiss-Prot;Acc:P25095][hgnc]Agtr1a
Mus_musculusone2many ENSMUSG00000054988Type-1B angiotensin II receptor (AT1B) (AT3) [Source:UniProtKB/Swiss-Prot;Acc:P29755][hgnc]Agtr1b
Dipodomys_ordiione2one ENSDORG00000001782[hgnc]
Monodelphis_domesticaone2one ENSMODG00000024750Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Gallus_gallusone2one ENSGALG00000024000Type-1 angiotensin II receptor (AT1). [Source:UniProtKB/Swiss-Prot;Acc:P79785][hgnc]AGTR1
Ornithorhynchus_anatinusone2one ENSOANG00000000457Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Xenopus_tropicalisone2one ENSXETG00000016079Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Danio_rerioone2many ENSDARG00000018616[hgnc]LOC794575
Gasterosteus_aculeatusone2one ENSGACG00000003676Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Oryzias_latipesone2one ENSORLG00000010042Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Takifugu_rubripesone2one ENSTRUG00000017757Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]
Danio_rerioone2many ENSDARG00000045443[hgnc]LOC797102
Tetraodon_nigroviridisone2one ENSTNIG00000012757Type-1 angiotensin II receptor (AT1) (AT1AR) (AT1BR) [Source:UniProtKB/Swiss-Prot;Acc:P30556][hgnc]