Quick search:







Summary sheet information for Effector 'SHC transforming protein 3-Homo sapiens'
Name SHC transforming protein 3-Homo sapiens
Description RecName: Full=SHC-transforming protein 3;AltName: Full=Src homology 2 domain-containing-transforming protein C3; Short=SH2 domain protein C3;AltName: Full=Neuronal Shc; Short=N-Shc;AltName: Full=Protein Rai
Class
Family SHC transforming proteins
Sub_family SHC transforming proteins
type SHC transforming protein 3
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
Expand All Collapse All
Genes
Gene Location:
Chromosome: 9
Gene Start: 90817891
Gene End: 90983502
Ensembl Contig View

Ensembl Genes:
ENSG00000148082

EMBL:
EMBL ID  Description
AL160054  Human DNA sequence from clone RP11-8C21 on chromosome 9 Contains the 5' end of a novel gene (SHC3), a novel gene (HFSE-1), the CSK2 gene for CDC28 protein kinase regulatory subunit 2 (CKSHS2), the 5' end of the gene for SECIS binding protein 2 (SBP2) and three CpG islands.
AL353150  Human DNA sequence from clone RP11-82L18 on chromosome 9 Contains the 3' end of a novel gene (SHC3) and a novel gene.
BC026314  Homo sapiens SHC (Src homology 2 domain containing) transforming protein 3, mRNA (cDNA clone MGC:26094 IMAGE:4819086), complete cds.
D84361  Homo sapiens mRNA for p52 and p64 isoforms of N-Shc, complete cds.

EntrezGene:
ID  Description
SHC3  SHC (Src homology 2 domain containing) transforming protein 3

RefSeq DNA:
ID  Description
NM_016848  Homo sapiens SHC (Src homology 2 domain containing) transforming protein 3 (SHC3), mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000364990; ENSP00000364991; ENSP00000364995

Entrez Proteins:
AAH26314.1; BAA12322.1; BAA12323.1; CAI16864.1; CAI16865.1; CAI41366.1

RefSeq Proteins:
ID  Description
NP_058544  src homology 2 domain containing transforming protein C3 [Homo sapiens].

UniProt:
ID  Description
Q92529-2  UNKNOWN
Q5T7I7  SubName: Full=SHC (Src homology 2 domain containing) transforming protein 3;
Q5T7I8  SubName: Full=SHC (Src homology 2 domain containing) transforming protein 3;
Q92529  RecName: Full=SHC-transforming protein 3; AltName: Full=Src homology 2 domain-containing-transforming protein C3; Short=SH2 domain protein C3; AltName: Full=Neuronal Shc; Short=N-Shc; AltName: Full=Protein Rai;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     SHC transforming protein 3-Homo sapiens    

InterPro:
ID  Name
IPR006020  PTB_PID
IPR006019  PID_domain
IPR000980  SH2
IPR011993  PH_type

Pfam:
ID  Description
SH2  SH2 domain
PID  Phosphotyrosine interaction domain (PTB/PID)

Structure
PDB:
ID

HSSP:
ID  Description
1a07  COMPLEX (TRANSFERASE/PEPTIDE)
1a08  COMPLEX (TRANSFERASE/PEPTIDE)
1a09  COMPLEX (TRANSFERASE/PEPTIDE)
1a1a  COMPLEX (TRANSFERASE/PEPTIDE)
1a1b  COMPLEX (TRANSFERASE/PEPTIDE)
1a1c  COMPLEX (TRANSFERASE/PEPTIDE)
1a1e  COMPLEX (TRANSFERASE/PEPTIDE)
1a81  COMPLEX (TRANSFERASE/PEPTIDE)
1aot  COMPLEX (PROTO-ONCOGENE/EARLY PROTEIN)
1aou  COMPLEX (PROTO-ONCOGENE/EARLY PROTEIN)
1aya  HYDROLASE(SH2 DOMAIN)
1ayb  HYDROLASE(SH2 DOMAIN)
1ayc  HYDROLASE(SH2 DOMAIN)
1ayd  HYDROLASE(SH2 DOMAIN)
1bkl  V-SRC SH2 DOMAIN
1bkm  TRANSFORMING PROTEIN
1blj  PHOSPHORYLATION
1blk  PHOSPHORYLATION
1bm2  HORMONE/GROWTH FACTOR
1bmb  HORMONE/GROWTH FACTOR
1cj1  SIGNALING PROTEIN
1d1z  GENE REGULATION
1f1w  TRANSFERASE
1f2f  TRANSFERASE
1fhs  SH2 DOMAIN
1fu5  PEPTIDE BINDING PROTEIN
1fu6  PROTEIN BINDING
1fyr  HORMONE/GROWTH FACTOR
1ghu  SRC HOMOLOGY 2 DOMAIN
1hcs  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1hct  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1is0  TRANSFERASE
1ju5  PROTEIN BINDING/TRANSFERASE
1jyq  SIGNALING PROTEIN
1jyr  SIGNALING PROTEIN
1jyu  SIGNALING PROTEIN
1kc2  TRANSFERASE
1mil  TRANSFORMING PROTEIN
1mw4  HORMONE/GROWTH FACTOR/TRANSFERASE
1n3h  SIGNALING PROTEIN
1nzl  TRANSFERASE
1nzv  TRANSFERASE
1o41  SIGNALING PROTEIN
1o42  SIGNALING PROTEIN
1o43  SIGNALING PROTEIN
1o44  SIGNALING PROTEIN
1o45  SIGNALING PROTEIN
1o46  SIGNALING PROTEIN
1o47  SIGNALING PROTEIN
1o48  SIGNALING PROTEIN
1o49  SIGNALING PROTEIN
1o4a  SIGNALING PROTEIN
1o4b  SIGNALING PROTEIN
1o4c  SIGNALING PROTEIN
1o4d  SIGNALING PROTEIN
1o4e  SIGNALING PROTEIN
1o4f  SIGNALING PROTEIN
1o4g  SIGNALING PROTEIN
1o4h  SIGNALING PROTEIN
1o4i  SIGNALING PROTEIN
1o4j  SIGNALING PROTEIN
1o4k  SIGNALING PROTEIN
1o4l  SIGNALING PROTEIN
1o4m  SIGNALING PROTEIN
1o4n  SIGNALING PROTEIN
1o4o  SIGNALING PROTEIN
1o4p  SIGNALING PROTEIN
1o4q  SIGNALING PROTEIN
1o4r  SIGNALING PROTEIN
1oo3  PROTEIN BINDING
1oo4  PROTEIN BINDING
1oy2  SIGNALING PROTEIN
1p13  TRANSFERASE
1qad  TRANSFERASE
1qg1  HORMONE/GROWTH FACTOR
1rpy  SIGNALING PROTEIN
1rqq  TRANSFERASE/SIGNALING PROTEIN
1sha  PHOSPHOTRANSFERASE
1shb  PHOSPHOTRANSFERASE
1shc  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1skj  TYROSINE-PROTEIN KINASE
1spr  TRANSFERASE(PHOSPHOTRANSFERASE)
1sps  TRANSFERASE(PHOSPHOTRANSFERASE)
1tce  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1tze  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1x0n  PEPTIDE BINDING PROTEIN
1zfp  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
2aoa  TRANSFERASE
2aob  TRANSFERASE
2aug  SIGNALING PROTEIN
2c9w  TRANSCRIPTION REGULATION
2crh  SIGNALING PROTEIN
2dly  TRANSFERASE
2dvj  SIGNALING PROTEIN
2dx0  HYDROLASE
2ecd  SIGNALING PROTEIN
2ekx  SIGNALING PROTEIN
2eo3  SIGNALING PROTEIN
2eyv  SIGNALING PROTEIN
2eyy  SIGNALING PROTEIN
2eyz  SIGNALING PROTEIN
2h46  HORMONE/GROWTH FACTOR
2h5k  HORMONE/GROWTH FACTOR
2hdv  SIGNALING PROTEIN
2hdx  SIGNALING PROTEIN
2huw  HORMONE/GROWTH FACTOR
2iug  TRANSFERASE
2iuh  TRANSFERASE
2iui  TRANSFERASE
2jyq  TRANSFERASE
2pna  SIGNALLING PROTEIN
2pnb  SIGNALLING PROTEIN
2qms  SIGNALING PROTEIN
3c7i  SPLICING

PSSH:
ID  Description
Q5T7I8  UNKNOWN
Q5T7I7  UNKNOWN
Q92529  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
605263  SHC TRANSFORMING PROTEIN 3; SHC3   SHC-LIKE PROTEIN, NEURONAL; NSHC SHC PROTEIN C; SHCC RAI

Gene Ontology
GO:
GO ID  Description
GO:0004871  signal transducer activity
GO:0005515  protein binding
GO:0005575  cellular_component
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0007242  intracellular signaling cascade
GO:0007265  Ras protein signal transduction
GO:0007417  central nervous system development
GO:0007611  learning or memory
GO:0035249  synaptic transmission, glutamatergic

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04062  Chemokine signaling pathway
hsa05220  Chronic myeloid leukemia
hsa04012  ErbB signaling pathway
hsa04510  Focal adhesion
hsa05214  Glioma
hsa04910  Insulin signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway

Panther:
ID  Description
P00047  PDGF signaling pathway
P00018  EGF receptor signaling pathway
P00021  FGF signaling pathway

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000148082 SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529] Pan_troglodytesone2one ENSPTRG00000021091Neuronal Shc 3 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q6UIM8][hgnc]SHC3
Pongo_pygmaeusone2one ENSPPYG00000019358SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Macaca_mulattaone2one ENSMMUG00000020357Neuronal Shc 3 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q6UIM7][hgnc]
Otolemur_garnettiione2one ENSOGAG00000011519SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Microcebus_murinusone2one ENSMICG00000005323SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Dipodomys_ordiione2one ENSDORG00000005451SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) [Source:UniProtKB/Swiss-Prot;Acc:Q61120][hgnc]
Tursiops_truncatusone2one ENSTTRG00000013042SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000009826SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000015412SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Bos_taurusone2one ENSBTAG00000011375SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]LOC512696
Pteropus_vampyrusone2one ENSPVAG00000003708SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000000349SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000018290SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Ochotona_princepsone2one ENSOPRG00000015036SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Rattus_norvegicusone2one ENSRNOG00000014366SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc). [Source:UniProtKB/Swiss-Prot;Acc:O70143][hgnc]Shc3
Tupaia_belangerione2one ENSTBEG00000003299SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Cavia_porcellusone2one ENSCPOG00000019862SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Equus_caballusone2one ENSECAG00000023729SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Myotis_lucifugusone2one ENSMLUG00000006630SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Mus_musculusone2one ENSMUSG00000021448SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) [Source:UniProtKB/Swiss-Prot;Acc:Q61120][hgnc]Shc3
Loxodonta_africanaone2one ENSLAFG00000013523SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Vicugna_pacosone2one ENSVPAG00000006204SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Canis_familiarisone2one ENSCAFG00000002201SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]LOC476352
Felis_catusone2one ENSFCAG00000004212SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000014866SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Sorex_araneusone2one ENSSARG00000008035SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Procavia_capensisone2one ENSPCAG00000014677SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Echinops_telfairione2one ENSETEG00000013366SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Monodelphis_domesticaone2one ENSMODG00000013379SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Gallus_gallusone2one ENSGALG00000010688SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Danio_rerioone2one ENSDARG00000057731[hgnc]LOC100007176
Oryzias_latipesone2one ENSORLG00000005761SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000016518SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000018760SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) (Neuronal Shc) (N-Shc) (Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529][hgnc]
Takifugu_rubripesone2one ENSTRUG00000010389N-Shc. [Source:UniProtKB/TrEMBL;Acc:Q9PUQ9][hgnc]
Ciona_intestinalisone2many ENSCING00000006400[hgnc]