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Summary sheet information for Effector 'ATP-sensitive inward rectifier potassium channel 1-Homo sapiens'
Name ATP-sensitive inward rectifier potassium channel 1-Homo sapiens
Description "RecName: Full=ATP-sensitive inward rectifier potassium channel 1;AltName: Full=Potassium channel, inwardly rectifying subfamily J member 1;AltName: Full=ATP-regulated potassium channel ROM-K;AltName: Full=Kir1.1;"
Class
Family Ion channels
Sub_family ATP-sensitive inward rectifier potassium channels
type ATP-sensitive inward rectifier potassium channel 1
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 11
Gene Start: 128213125
Gene End: 128242478
Ensembl Contig View

Ensembl Genes:
ENSG00000151704

EMBL:
EMBL ID  Description
AK290797  Homo sapiens cDNA FLJ76032 complete cds, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1), transcript variant rom-k1, mRNA.
BC074752  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 1, mRNA (cDNA clone MGC:103829 IMAGE:30915211), complete cds.
BC136361  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 1, mRNA (cDNA clone MGC:167971 IMAGE:9020348), complete cds.
CH471065  Homo sapiens 211000035833829 genomic scaffold, whole genome shotgun sequence.
S78737  ATP-regulated potassium channel [human, brain, mRNA Partial, 306 nt].
U03884  Human inwardly rectifying K+ channel (ROMK1) mRNA, complete cds.
U12541  Human ROM-K potassium channel protein isoform romk1 mRNA, complete cds.
U12542  Human ROM-K potassium channel protein isoform romk2 mRNA, complete cds.
U12543  Human ROM-K potassium channel protein isoform romk3 mRNA, complete cds.
U12544  Human ROM-K potassium channel protein isoform romk4 mRNA, partial cds.
U12545  Human ROM-K potassium channel protein isoform romk5 mRNA, partial cds.
U65406  Human alternatively spliced potassium channels ROM-K1, ROM-K2, ROM-K3, ROM-K4, ROM-K5, and ROM-K6 (KCNJ1) gene, complete cds.

EntrezGene:
ID  Description
KCNJ1  potassium inwardly-rectifying channel, subfamily J, member 1

RefSeq DNA:
ID  Description
NM_000220  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1), transcript variant rom-k1, mRNA.
NM_153764  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1), transcript variant rom-k2, mRNA.
NM_153765  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1), transcript variant rom-k3, mRNA.
NM_153766  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1), transcript variant rom-k4, mRNA.
NM_153767  Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1), transcript variant rom-k5, mRNA.

UniGene:
ID  Description
Hs.527830  Inwardly rectifying K+ channel (ROMK1)

Proteins
Ensembl Proteins:
ENSP00000316136; ENSP00000316233; ENSP00000376434; ENSP00000376433; ENSP00000376432

Entrez Proteins:
AAA20594.1; AAA61712.1; AAA61713.1; AAA61714.1; AAA61715.1; AAA61716.1; AAB35012.1; AAC51220.1; AAC51221.1; AAC51222.1; AAH74752.1; AAI36362.1; BAF83486.1; EAW67724.1

RefSeq Proteins:
ID  Description
NP_000211  potassium inwardly-rectifying channel J1 isoform a [Homo sapiens].
NP_722448  potassium inwardly-rectifying channel J1 isoform b [Homo sapiens].
NP_722449  potassium inwardly-rectifying channel J1 isoform b [Homo sapiens].
NP_722450  potassium inwardly-rectifying channel J1 isoform b [Homo sapiens].
NP_722451  potassium inwardly-rectifying channel J1 isoform b [Homo sapiens].

UniProt:
ID  Description
P48048-2  UNKNOWN
P48048-3  UNKNOWN
A8K432  SubName: Full=cDNA FLJ76032, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1), transcript variant rom-k1, mRNA;
B2RMR4  SubName: Full=Potassium inwardly-rectifying channel, subfamily J, member 1 (Potassium inwardly-rectifying channel, subfamily J, member 1, isoform CRA_b);
P48048  RecName: Full=ATP-sensitive inward rectifier potassium channel 1; AltName: Full=Potassium channel, inwardly rectifying subfamily J member 1; AltName: Full=ATP-regulated potassium channel ROM-K; AltName: Full=Kir1.1;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     ATP-sensitive inward rectifier potassium channel 1-Homo sapiens    

InterPro:
ID  Name
IPR016449  K_chnl_inward-rec_Kir
IPR013518  K_chnl_inward-rec_Kir_cyto
IPR001838  K_chnl_inward-rec_Kir-like
IPR003268  K_chnl_inward-rec_Kir1.1
IPR013521  K_chnl_inward-rec_Kir_Cr2

Pfam:
ID  Description
IRK  Inward rectifier potassium channel

Structure
PDB:
ID

HSSP:
ID  Description
1n9p  METAL TRANSPORT
1u4e  METAL TRANSPORT
1u4f  ALLERGEN
2e4f  TRANSPORT PROTEIN
2gix  METAL TRANSPORT
2qks  METAL TRANSPORT

PSSH:
ID  Description
P48048  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
600359  POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 1; KCNJ1   RENAL OUTER-MEDULLARY POTASSIUM CHANNEL; ROMK; ROMK1 KIR1.1

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0005242  inward rectifier potassium channel activity
GO:0005244  voltage-gated ion channel activity
GO:0005515  protein binding
GO:0005524  ATP binding
GO:0006811  ion transport
GO:0006813  potassium ion transport
GO:0007588  excretion
GO:0008076  voltage-gated potassium channel complex
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0030955  potassium ion binding

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04960  Aldosterone-regulated sodium reabsorption

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
DB00912  Repaglinide  AG-EE 388 ZW; AG-EE 623 ZW; Repaglinida [INN-Spanish]; Repaglinidum [INN-Latin]; repaglinide
DB01067  Glipizide  Glipizida [INN-Spanish]; Glipizidum [INN-Latin]; Glydiazinamide
DB00350  Minoxidil  Minossidile [Italian]; Minoxidilum [INN-Latin]
DB00672  Chlorpropamide  
DB01382  Glycodiazine  Glidiazine; Glymidine
DB00839  Tolazamide  
DB01124  Tolbutamide  
DB01016  Glibenclamide  Apo-Glibenclamide; Glibenclamida [INN-Spanish]; Glibenclamidum [INN-Latin]; Glyburide
DB00731  Nateglinide  Nateglinide [INN]; SDZ-DJN 608; nateglinide
DB00222  Glimepiride  Glimepirid; Glimepirida; Glimepiridum; Glimepride
DB00414  Acetohexamide  Acetohexamid
DB01120  Gliclazide  1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea; 1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea; Gliclazida [INN-Spanish]; Gliclazidum [INN-Latin]; N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3.3.0)oct-3-yl)urea
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000151704 ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048] Xenopus_tropicalisone2one ENSXETG00000022779ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Pan_troglodytesone2one ENSPTRG00000004468ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]KCNJ1
Pongo_pygmaeusone2one ENSPPYG00000004053Putative uncharacterized protein DKFZp469K0116. [Source:UniProtKB/TrEMBL;Acc:Q5R883][hgnc]
Macaca_mulattaone2one ENSMMUG00000003144ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Microcebus_murinusone2one ENSMICG00000016749ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000004061ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Equus_caballusone2one ENSECAG00000024963ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]LOC100072580
Pteropus_vampyrusone2one ENSPVAG00000016298ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000015770ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000003429ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Loxodonta_africanaone2one ENSLAFG00000005037ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Canis_familiarisone2one ENSCAFG00000010259ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]KCNJ1
Procavia_capensisone2one ENSPCAG00000009506ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Felis_catusone2one ENSFCAG00000013060ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000013422ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Bos_taurusone2one ENSBTAG00000000008ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]KCNJ1
Dipodomys_ordiione2one ENSDORG00000012715ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:O88335][hgnc]
Vicugna_pacosone2one ENSVPAG00000006914ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Ochotona_princepsone2one ENSOPRG00000012192ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000015639ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Tursiops_truncatusone2one ENSTTRG00000005593ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Mus_musculusone2one ENSMUSG00000041248ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:O88335][hgnc]Kcnj1
Myotis_lucifugusone2one ENSMLUG00000016001ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Cavia_porcellusone2one ENSCPOG00000020661ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Rattus_norvegicusone2one ENSRNOG00000008779ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (KAB-1) (Kir1.1). [Source:UniProtKB/Swiss-Prot;Acc:P35560][hgnc]Kcnj1
Monodelphis_domesticaone2one ENSMODG00000004768ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Echinops_telfairione2one ENSETEG00000007687ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000000570ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]100074125
Gallus_gallusone2one ENSGALG00000001167ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]KCNJ1
Oryzias_latipesone2many ENSORLG00000015086ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Takifugu_rubripesone2many ENSTRUG00000007643Inwardly-rectifying potassium channel. [Source:UniProtKB/TrEMBL;Acc:Q1L0L3][hgnc]
Takifugu_rubripesone2many ENSTRUG00000009385ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Danio_rerioone2many ENSDARG00000040312potassium inwardly-rectifying channel, subfamily J, member 1 [Source:RefSeq_peptide;Acc:NP_957329][hgnc]LOC100001284
Oryzias_latipesone2many ENSORLG00000013560ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Danio_rerioone2many ENSDARG00000002666hypothetical protein LOC556608 [Source:RefSeq_peptide;Acc:NP_001092204][hgnc]zgc:165474
Gasterosteus_aculeatusone2one ENSGACG00000006583ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000003768ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000010319ATP-sensitive inward rectifier potassium channel 1 (Potassium channel, inwardly rectifying subfamily J member 1) (ATP-regulated potassium channel ROM-K) (Kir1.1) [Source:UniProtKB/Swiss-Prot;Acc:P48048][hgnc]
Danio_rerioone2many ENSDARG00000068186hypothetical protein LOC541499 [Source:RefSeq_peptide;Acc:NP_001014334][hgnc]zgc:113361
Danio_rerioone2many ENSDARG00000068188hypothetical protein LOC569191 [Source:RefSeq_peptide;Acc:NP_001038643][hgnc]LOC792051
Danio_rerioone2many ENSDARG00000024444si:ch211-244h7.4 (si:ch211-244h7.4), mRNA [Source:RefSeq_dna;Acc:NM_001045176][hgnc]si:ch211-244h7.4
Danio_rerioone2many ENSDARG00000040313hypothetical protein LOC569052 [Source:RefSeq_peptide;Acc:NP_001038640][hgnc]LOC100000712
Danio_rerioone2many ENSDARG00000068189hypothetical protein LOC568823 [Source:RefSeq_peptide;Acc:NP_001038634][hgnc]si:ch211-244h7.6