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Summary sheet information for Effector 'Phosphodiesterase 6-Homo sapiens-3'
Name Phosphodiesterase 6-Homo sapiens-3
Description "RecName: Full=Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Short=GMP-PDE delta;AltName: Full=Protein p17;"
Class
Family Phosphodiesterases
Sub_family Rhodopsin-sensitive cGMP-specific PDEases
type Phosphodiesterase 6
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 2
Gene Start: 232305388
Gene End: 232354220
Ensembl Contig View

Ensembl Genes:
ENSG00000156973

EMBL:
EMBL ID  Description
AC073476  Homo sapiens BAC clone RP11-690I21 from 2, complete sequence.
AF022912  Homo sapiens cGMP phosphodiesterase delta subunit mRNA, complete cds.
AF042833  Homo sapiens phosphodiesterase delta subunit gene, exon 1.
AF042834  Homo sapiens phosphodiesterase delta subunit gene, exons 2, 3 and 4.
AF042835  Homo sapiens phosphodiesterase delta subunit gene, exon 5 and complete cds.
AF045999  Homo sapiens rod cGMP phosphodiesterase delta subunit (PDEd) gene, complete cds.
AJ001626  Homo sapiens mRNA for p17 protein
BC007831  Homo sapiens phosphodiesterase 6D, cGMP-specific, rod, delta, mRNA (cDNA clone MGC:14096 IMAGE:3638562), complete cds.
BT007278  Homo sapiens phosphodiesterase 6D, cGMP-specific, rod, delta mRNA, complete cds.
CH471063  Homo sapiens 211000035834619 genomic scaffold, whole genome shotgun sequence.
CR456980  Homo sapiens full open reading frame cDNA clone RZPDo834C115D for gene PDE6D, phosphodiesterase 6D, cGMP-specific, rod, delta; complete cds, incl. stopcodon.

EntrezGene:
ID  Description
PDE6D  phosphodiesterase 6D, cGMP-specific, rod, delta

RefSeq DNA:
ID  Description
NM_002601  Homo sapiens phosphodiesterase 6D, cGMP-specific, rod, delta (PDE6D), mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000287600; ENSP00000375884

Entrez Proteins:
AAB87872.1; AAC25953.1; AAC39720.1; AAH07831.1; AAP35942.1; AAY24151.1; CAA04880.1; CAG33261.1; EAW70978.1

RefSeq Proteins:
ID  Description
NP_002592  phosphodiesterase 6D, cGMP-specific, rod, delta [Homo sapiens].

UniProt:
ID  Description
A8MWU0  SubName: Full=Putative uncharacterized protein PDE6D; Flags: Fragment;
Q6IB24  SubName: Full=PDE6D protein; SubName: Full=Phosphodiesterase 6D, cGMP-specific, rod, delta, isoform CRA_b; SubName: Full=Putative uncharacterized protein tmp_locus_12;
O43924  RecName: Full=Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Short=GMP-PDE delta; AltName: Full=Protein p17;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR017287  Rhodop-sen_GMP-Pdiesterase_dsu
IPR008015  GMP_PDE_delta

Pfam:
ID  Description
GMP_PDE_delta  GMP-PDE, delta subunit

Structure
PDB:
ID
1KSG
1KSH
1KSJ

HSSP:
ID  Description
1ksg  SIGNALING PROTEIN/HYDROLASE
1ksh  SIGNALING PROTEIN/HYDROLASE
1ksj  SIGNALING PROTEIN/HYDROLASE

PSSH:
ID  Description
Q6IB24  UNKNOWN
O43924  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
602676  PHOSPHODIESTERASE 6D, cGMP-SPECIFIC, ROD, DELTA; PDE6D   RETINAL ROD PHOTORECEPTOR cGMP PHOSPHODIESTERASE, DELTA SUBUNIT; PDED

Gene Ontology
GO:
GO ID  Description
GO:0004114  3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515  protein binding
GO:0007601  visual perception
GO:0016787  hydrolase activity
GO:0050896  response to stimulus

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa00230  Purine metabolism

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB01397   GMP   5'-GMP; E 626; GMP; Guanidine monophosphate; Guanosine 5'-monophosphate; Guanosine 5'-phosphate; Guanosine 5'-phosphorate; Guanosine 5'-phosphoric acid; guanosine monophosphate; guanosine-5'-monophosphate; guanosine-5'-phosphate; guanosine-monophosphate; guanosine-phosphate; guanylate; guanylic acid
HMDB01314   Cyclic GMP   3',5'-cyclic GMP; 3',5'-guanosine; 3',5'-guanosine monophosphate; cGMP; cyclic 3',5'-guanosine monophosphate; cyclic GMP; cyclic-GMP; cyclic guanosine 3',5'-monophosphate; guanosine 3',5'-cyclic phosphate; guanosine 3',5'-cyclic-monophosphate; guanosine 3',5'-monophosphate; guanosine cyclic-monophosphate; guanosine-cyclic-phosphoric-acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000156973 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924] Pongo_pygmaeusone2one ENSPPYG00000013270Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Pan_troglodytesone2one ENSPTRG00000013030Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]PDE6D
Macaca_mulattaone2one ENSMMUG00000019565Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000008050Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000006196Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Tursiops_truncatusone2one ENSTTRG00000009165Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000000568Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Equus_caballusone2one ENSECAG00000018613Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]LOC100064324
Tupaia_belangerione2one ENSTBEG00000009679Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000004743Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Felis_catusone2one ENSFCAG00000002232Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Loxodonta_africanaone2one ENSLAFG00000000190Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Vicugna_pacosone2one ENSVPAG00000006834Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Ochotona_princepsone2one ENSOPRG00000008366Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Canis_familiarisone2one ENSCAFG00000011104Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta). [Source:UniProtKB/Swiss-Prot;Acc:Q9XT54][hgnc]PDE6D
Dipodomys_ordiione2one ENSDORG00000014809Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) [Source:UniProtKB/Swiss-Prot;Acc:O55057][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000010403Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Myotis_lucifugusone2one ENSMLUG00000002640Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Bos_taurusone2one ENSBTAG00000019480Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta). [Source:UniProtKB/Swiss-Prot;Acc:Q95142][hgnc]PDE6D
Procavia_capensisone2one ENSPCAG00000003720Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000014559Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Mus_musculusone2one ENSMUSG00000026239Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) [Source:UniProtKB/Swiss-Prot;Acc:O55057][hgnc]Pde6d
Rattus_norvegicusone2one ENSRNOG00000018610phosphodiesterase 6D, cGMP-specific, rod, delta [Source:RefSeq_peptide;Acc:NP_001102276][hgnc]Pde6d_predicted
Ornithorhynchus_anatinusone2one ENSOANG00000006665Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]100084375
Monodelphis_domesticaone2one ENSMODG00000002486Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Echinops_telfairione2one ENSETEG00000001488Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Gallus_gallusone2one ENSGALG00000007742Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]PDE6D
Xenopus_tropicalisone2one ENSXETG00000022759Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Danio_rerioone2one ENSDARG00000032518hypothetical protein LOC436981 [Source:RefSeq_peptide;Acc:NP_001002708][hgnc]LOC791625
Gasterosteus_aculeatusone2one ENSGACG00000002045Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Oryzias_latipesone2one ENSORLG00000002704Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Takifugu_rubripesone2one ENSTRUG00000005216Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000007139Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (EC 3.1.4.17) (GMP-PDE delta) (p17 protein) [Source:UniProtKB/Swiss-Prot;Acc:O43924][hgnc]
Ciona_savignyione2one ENSCSAVG00000001532[hgnc]
Ciona_intestinalisone2one ENSCING00000003961cGMP phosphodiesterase delta subunit [Source:RefSeq_peptide;Acc:NP_001027639][hgnc]445641
Caenorhabditis_elegansone2one C27H5.1Phosphodiesterase delta-like protein. [Source:UniProtKB/Swiss-Prot;Acc:Q18268][hgnc]pdl-1
Anopheles_gambiaeone2one AGAP011756[hgnc]AgaP_ENSANGG00000011594
Drosophila_melanogasterone2one FBgn0032059[hgnc]CG9296
Aedes_aegyptione2one AAEL003437retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic phosphodiesterase[hgnc]