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Summary sheet information for Effector 'Adenylate cyclase 1-Homo sapiens'
Name Adenylate cyclase 1-Homo sapiens
Description RecName: Full=Adenylate cyclase type 1; EC=4.6.1.1;AltName: Full=Adenylate cyclase type I;AltName: Full=ATP pyrophosphate-lyase 1;AltName: Full=Adenylyl cyclase 1;AltName: Full=Ca(2+)/calmodulin-activated adenylyl cyclase
Class
Family Cyclases
Sub_family Adenylate cyclases
type Adenylate cyclase 1
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 7
Gene Start: 45580646
Gene End: 45729237
Ensembl Contig View

Ensembl Genes:
ENSG00000164742

EMBL:
EMBL ID  Description
AB209496  Homo sapiens mRNA for brain adenylate cyclase 1 variant protein.
AC069008  Homo sapiens BAC clone RP11-815N20 from 7, complete sequence.
AC091439  Homo sapiens BAC clone RP11-497K2 from 7, complete sequence.
AF497515  Homo sapiens adenylate cyclase type I (ADCY1) mRNA, partial cds.
CH236960  Homo sapiens chromosome 7 Scaffold18, whole genome shotgun sequence.
L05500  Human fetal brain adenylyl cyclase mRNA, 3' end.

EntrezGene:
ID  Description
ADCY1  adenylate cyclase 1 (brain)

RefSeq DNA:
ID  Description
NM_021116  Homo sapiens adenylate cyclase 1 (brain) (ADCY1), mRNA.

UniGene:
ID  Description
Hs.192215  Full length insert cDNA clone ZD51B03

Proteins
Ensembl Proteins:
ENSP00000297323

Entrez Proteins:
AAA02907.1; AAM94372.1; AAS07467.1; BAD92733.1; EAL23741.1

RefSeq Proteins:
ID  Description
NP_066939  brain adenylate cyclase 1 [Homo sapiens].

UniProt:
ID  Description
A4D2L8  UNKNOWN
Q59FG4  SubName: Full=Brain adenylate cyclase 1 variant; Flags: Fragment;
Q8NFM5  SubName: Full=Adenylate cyclase type I; EC=4.6.1.1; Flags: Fragment;
Q08828  RecName: Full=Adenylate cyclase type 1; EC=4.6.1.1; AltName: Full=Adenylate cyclase type I; AltName: Full=ATP pyrophosphate-lyase 1; AltName: Full=Adenylyl cyclase 1; AltName: Full=Ca(2+)/calmodulin-activated adenylyl cyclase;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Adenylate cyclase 1-Homo sapiens    

InterPro:
ID  Name
IPR001054  A/G_cyclase

Pfam:
ID  Description
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain

Structure
PDB:
ID

HSSP:
ID  Description
1ab8  LYASE
1azs  COMPLEX (LYASE/HYDROLASE)
1cjk  LYASE/LYASE/SIGNALING PROTEIN
1cjt  LYASE/LYASE/SIGNALING PROTEIN
1cju  LYASE/LYASE/SIGNALING PROTEIN
1cjv  LYASE/LYASE/SIGNALING PROTEIN
1cs4  LYASE/LYASE/SIGNALING PROTEIN
1cul  LYASE/LYASE/SIGNALING PROTEIN
1tl7  LYASE
1u0h  LYASE
1yk9  LYASE
2gvd  LYASE
2gvz  LYASE
3c14  LYASE/LYASE INHIBITOR
3c15  LYASE/LYASE INHIBITOR
3c16  LYASE/LYASE INHIBITOR
3et6  LYASE

PSSH:
ID  Description
Q59FG4  UNKNOWN
A4D2L8  UNKNOWN
Q08828  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
103072  ADENYLATE CYCLASE 1; ADCY1   ADENYLYL CYCLASE 1 ADENYLYL CYCLASE, FETAL BRAIN, TYPE I

Gene Ontology
GO:
GO ID  Description
GO:0000287  magnesium ion binding
GO:0005516  calmodulin binding
GO:0006171  cAMP biosynthetic process
GO:0007242  intracellular signaling cascade
GO:0007616  long-term memory
GO:0008294  calcium- and calmodulin-responsive adenylate cyclase activity
GO:0009190  cyclic nucleotide biosynthetic process
GO:0009755  hormone-mediated signaling
GO:0015031  protein transport
GO:0015450  P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0016849  phosphorus-oxygen lyase activity

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04062  Chemokine signaling pathway
hsa05414  Dilated cardiomyopathy
hsa04540  Gap junction
hsa04912  GnRH signaling pathway
hsa04720  Long-term potentiation
hsa04916  Melanogenesis
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa00230  Purine metabolism
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description
P05731  GABA-B receptor II signaling

Chemicals
DrugBank:
ID  Name  Synonyms
DB00171  Adenosine triphosphate  5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphoric acid; Adenosine, 5'-(tetrahydrogen triphosphate); Adenosine-5'-triphosphate; Adenylpyrophosphoric acid; Triphosphoric acid adenosine ester
DB00640  Adenosine  2'-Deoxyadenosine; Adenine Deoxy Nucleoside; Adenine Deoxyribonucleoside; Adenine Deoxyribose; Adenine Nucleoside; Adenine Riboside; Adenyldeoxyriboside; Deoxyadenosine; Desoxyadenosine; MEDR-640; USAF CB-10; adenosine
DB00131  Adenosine monophosphate  5'-AMP; 5'-Adenosine monophosphate; 5'-Adenylic acid; AMP; Adenosine 5'-(dihydrogen phosphate); Adenosine 5'-monophosphate; Adenosine 5'-phosphate; Adenosine 5'-phosphoric acid; Adenosine phosphate; Adenosine-5'-Monophosphate; Adenosine-5'-monophosphoric acid; Adenosine-5-monophosphoric acid; Adenylate; Adenylic acid; Phosphentaside
HMDB:
ID  Name  Synonyms
HMDB00250   Pyrophosphate   (4-)Diphosphoric acid ion; (P2O74-)Diphosphate; Diphosphate; Pyrometaphosphate; Pyrophosphate; Pyrophosphate tetraanion; Pyrophosphate(4-) ion; Pyrophosphic acid
HMDB00538   Adenosine triphosphate   5'-(tetrahydrogen triphosphate) Adenosine; 5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine triphosphic acid; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adetol; Adynol; Atipi; Atriphos; Cardenosine; Fosfobion; Glucobasin; Myotriphos; Phosphobion; Striadyne; Triadenyl; Triphosphaden; Triphosphoric acid adenosine ester
HMDB00058   Cyclic AMP   Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000164742 Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828] Canis_familiarisone2one ENSCAFG00000012249Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]LOC610703
Oryzias_latipesone2one ENSORLG00000012874Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Danio_rerioapprent_one2one ENSDARG00000068890[hgnc]LOC799749
Pan_troglodytesone2one ENSPTRG00000019161Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]ADCY1
Macaca_mulattaone2one ENSMMUG00000006421Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000003619Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Microcebus_murinusone2one ENSMICG00000004502Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Otolemur_garnettiione2one ENSOGAG00000004687Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Tupaia_belangerione2one ENSTBEG00000007211Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Cavia_porcellusone2one ENSCPOG00000002602Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000008713Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Tursiops_truncatusone2one ENSTTRG00000013348Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Dipodomys_ordiione2one ENSDORG00000000826Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O88444][hgnc]
Equus_caballusone2one ENSECAG00000025044Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Bos_taurusone2one ENSBTAG00000009520Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin- activated adenylyl cyclase). [Source:UniProtKB/Swiss-Prot;Acc:P19754][hgnc]ADCY1
Mus_musculusone2one ENSMUSG00000020431Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:O88444][hgnc]Adcy1
Rattus_norvegicusone2one ENSRNOG00000008276adenylate cyclase 1 [Source:RefSeq_peptide;Acc:NP_001100709][hgnc]Adcy1_predicted
Ochotona_princepsone2one ENSOPRG00000010699Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000005109Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Loxodonta_africanaone2one ENSLAFG00000008570Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Sorex_araneusone2one ENSSARG00000013784Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000017679Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000010109Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Felis_catusone2one ENSFCAG00000011140Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Echinops_telfairione2one ENSETEG00000012133Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Procavia_capensisone2one ENSPCAG00000009653Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Vicugna_pacosone2one ENSVPAG00000002761Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Monodelphis_domesticaone2one ENSMODG00000010195Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Gallus_gallusone2one ENSGALG00000012433Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]ADCY1
Xenopus_tropicalisone2one ENSXETG00000015663Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000017579Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]
Takifugu_rubripesapprent_one2one ENSTRUG00000012530Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:Q08828][hgnc]