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Summary sheet information for Effector 'Tubulin-Homo sapiens-1'
Name Tubulin-Homo sapiens-1
Description RecName: Full=Tubulin alpha-1A chain;AltName: Full=Tubulin B-alpha-1;AltName: Full=Tubulin alpha-3 chain;AltName: Full=Alpha-tubulin 3
Class
Family Tubulins
Sub_family Tubulins
type Tubulin
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 12
Gene Start: 47864847
Gene End: 47869128
Ensembl Contig View

Ensembl Genes:
ENSG00000167552

EMBL:
EMBL ID  Description
AF141347  Homo sapiens hum-a-tub2 alpha-tubulin mRNA, complete cds.
AF141348  Homo sapiens hum-a-tub1 alpha-tubulin mRNA, partial cds.
AK289483  Homo sapiens cDNA FLJ77713 complete cds, highly similar to Homo sapiens tubulin, alpha 3 (TUBA3), mRNA.
BC006468  Homo sapiens tubulin, alpha 1a, mRNA (cDNA clone MGC:2321 IMAGE:3528520), complete cds.
BC050637  Homo sapiens tubulin, alpha 1a, mRNA (cDNA clone MGC:60126 IMAGE:6050536), complete cds.
CH471111  Homo sapiens 211000035831639 genomic scaffold, whole genome shotgun sequence.
K00557  human alpha-tubulin mRNA, 3' end.
X01703  Human gene for alpha-tubulin (b alpha 1)

EntrezGene:
ID  Description
TUBA1A  tubulin, alpha 1a

RefSeq DNA:
ID  Description
NM_006009  Homo sapiens tubulin, alpha 1a (TUBA1A), mRNA.

UniGene:
ID  Description
Hs.654422  CDNA FLJ53743 complete cds, highly similar to Tubulin alpha-3 chain
Hs.703262  UNKNOWN
Hs.704619  UNKNOWN
Hs.713158  Transcribed locus, strongly similar to NP_035783.1 tubulin, alpha 1 [Mus musculus]

Proteins
Ensembl Proteins:
ENSP00000301071

Entrez Proteins:
AAA91575.1; AAD33871.1; AAD33872.1; AAH06468.1; AAH50637.1; BAF82172.1; CAA25855.1; EAW58052.1; EAW58055.1

RefSeq Proteins:
ID  Description
NP_006000  tubulin, alpha 1a [Homo sapiens].

UniProt:
ID  Description
A8K0B8  SubName: Full=cDNA FLJ77713, highly similar to Homo sapiens tubulin, alpha 3 (TUBA3), mRNA; SubName: Full=Tubulin, alpha 3, isoform CRA_a; SubName: Full=Tubulin, alpha 3, isoform CRA_d;
Q9UQM3  SubName: Full=Alpha-tubulin; Flags: Fragment;
Q71U36  RecName: Full=Tubulin alpha-1A chain; AltName: Full=Tubulin B-alpha-1; AltName: Full=Tubulin alpha-3 chain; AltName: Full=Alpha-tubulin 3;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Tubulin-Homo sapiens-1    

InterPro:
ID  Name
IPR008280  Tub_FtsZ_C
IPR017975  Tubulin_CS
IPR002452  Alpha_tubulin
IPR003008  Tubulin_FtsZ
IPR000217  Tubulin

Pfam:
ID  Description
Tubulin  Tubulin/FtsZ family, GTPase domain
Tubulin_C  Tubulin/FtsZ family, C-terminal domain

Structure
PDB:
ID

HSSP:
ID  Description
1ffx  STRUCTURAL PROTEIN
1ia0  TRANSPORT PROTEIN
1jff  STRUCTURAL PROTEIN
1sa0  CELL CYCLE
1sa1  CELL CYCLE
1tub  MICROTUBULES
1tvk  CELL CYCLE, STRUCTURAL PROTEIN
1z2b  CELL CYCLE
2bto  CYTOSKELETAL PROTEIN
2btq  CYTOSKELETAL PROTEIN/COMPLEX
2hxf  TRANSPORT PROTEIN
2hxh  TRANSPORT PROTEIN
2p4n  TRANSPORT PROTEIN
3dco  MOTOR PROTEIN
3du7  CELL CYCLE
3e22  CELL CYCLE
3edl  STRUCTURAL PROTEIN

PSSH:
ID  Description
Q71U36  UNKNOWN
Q9UQM3  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
602529  TUBULIN, ALPHA-1A; TUBA1A   TUBULIN, ALPHA, BRAIN-SPECIFIC B-ALPHA-1 TUBA3

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005198  structural molecule activity
GO:0005525  GTP binding
GO:0005737  cytoplasm
GO:0005874  microtubule
GO:0007017  microtubule-based process
GO:0007018  microtubule-based movement
GO:0019904  protein domain specific binding
GO:0043234  protein complex
GO:0051258  protein polymerization

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000167552 Tubulin alpha-1A chain (Tubulin B-alpha-1) (Tubulin alpha-3 chain) (Alpha-tubulin 3) [Source:UniProtKB/Swiss-Prot;Acc:Q71U36] Pan_troglodytesone2one ENSPTRG00000004901Tubulin alpha-1A chain (Tubulin B-alpha-1) (Tubulin alpha-3 chain) (Alpha-tubulin 3). [Source:UniProtKB/Swiss-Prot;Acc:A5A6J1][hgnc]TUBA1A
Pongo_pygmaeusone2one ENSPPYG00000004481Tubulin alpha-1A chain (Tubulin B-alpha-1) (Tubulin alpha-3 chain) (Alpha-tubulin 3) [Source:UniProtKB/Swiss-Prot;Acc:Q71U36][hgnc]
Equus_caballusone2one ENSECAG00000013798Tubulin alpha-1A chain (Tubulin B-alpha-1) (Tubulin alpha-3 chain) (Alpha-tubulin 3) [Source:UniProtKB/Swiss-Prot;Acc:Q71U36][hgnc]LOC100051840
Canis_familiarisone2one ENSCAFG00000008661Tubulin alpha-1A chain (Tubulin B-alpha-1) (Tubulin alpha-3 chain) (Alpha-tubulin 3) [Source:UniProtKB/Swiss-Prot;Acc:Q71U36][hgnc]LOC610403
Myotis_lucifugusone2one ENSMLUG00000015526Tubulin alpha-1A chain (Tubulin B-alpha-1) (Tubulin alpha-3 chain) (Alpha-tubulin 3) [Source:UniProtKB/Swiss-Prot;Acc:Q71U36][hgnc]
Bos_taurusone2one ENSBTAG00000001489Tubulin alpha-ubiquitous chain (Alpha-tubulin ubiquitous) (Tubulin K- alpha-1) (Fragment). [Source:UniProtKB/Swiss-Prot;Acc:P81947][hgnc]LOC784266
Pteropus_vampyrusone2one ENSPVAG00000004645Tubulin alpha-1A chain (Tubulin B-alpha-1) (Tubulin alpha-3 chain) (Alpha-tubulin 3) [Source:UniProtKB/Swiss-Prot;Acc:Q71U36][hgnc]
Loxodonta_africanaone2one ENSLAFG00000011648Tubulin alpha-1A chain (Tubulin B-alpha-1) (Tubulin alpha-3 chain) (Alpha-tubulin 3) [Source:UniProtKB/Swiss-Prot;Acc:Q71U36][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000008741Tubulin alpha-1A chain (Tubulin B-alpha-1) (Tubulin alpha-3 chain) (Alpha-tubulin 3) [Source:UniProtKB/Swiss-Prot;Acc:Q71U36][hgnc]
Rattus_norvegicusone2one ENSRNOG00000004559Tubulin alpha-1A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1). [Source:UniProtKB/Swiss-Prot;Acc:P68370][hgnc]Tuba1b
Mus_musculusone2one ENSMUSG00000072235Tubulin alpha-1A chain (Tubulin alpha-1 chain) (Alpha-tubulin 1) (Alpha-tubulin isotype M-alpha-1) [Source:UniProtKB/Swiss-Prot;Acc:P68369][hgnc]Tuba1a
Procavia_capensisone2one ENSPCAG00000006800Tubulin alpha-1A chain (Tubulin B-alpha-1) (Tubulin alpha-3 chain) (Alpha-tubulin 3) [Source:UniProtKB/Swiss-Prot;Acc:Q71U36][hgnc]
Xenopus_tropicalisone2one ENSXETG00000011186Tubulin alpha-1A chain (Tubulin B-alpha-1) (Tubulin alpha-3 chain) (Alpha-tubulin 3) [Source:UniProtKB/Swiss-Prot;Acc:Q71U36][hgnc]
Danio_rerioone2many ENSDARG00000001889hypothetical protein LOC641561 [Source:RefSeq_peptide;Acc:NP_001032649][hgnc]zgc:123298
Danio_rerioone2many ENSDARG00000055216Tuba1 protein. [Source:UniProtKB/TrEMBL;Acc:Q8AWD6][hgnc]LOC573122
Caenorhabditis_elegansone2many C44B11.3mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation. MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons. mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis. MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons. [Source: WormBase][hgnc]mec-12
Saccharomyces_cerevisiaemany2many YML085CTubulin alpha-1 chain. [Source:UniProtKB/Swiss-Prot;Acc:P09733][hgnc]TUB1
Saccharomyces_cerevisiaemany2many YML124CTubulin alpha-3 chain. [Source:UniProtKB/Swiss-Prot;Acc:P09734][hgnc]TUB3