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Summary sheet information for Effector 'Tubulin-Homo sapiens-3'
Name Tubulin-Homo sapiens-3
Description RecName: Full=Tubulin alpha-1C chain;AltName: Full=Tubulin alpha-6 chain;AltName: Full=Alpha-tubulin 6
Class
Family Tubulins
Sub_family Tubulins
type Tubulin
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 12
Gene Start: 47945132
Gene End: 47953383
Ensembl Contig View

Ensembl Genes:
ENSG00000167553

EMBL:
EMBL ID  Description
AK223024  Homo sapiens mRNA for tubulin alpha 6 variant, clone: JTH01540.
BC004949  Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:10851 IMAGE:3617714), complete cds.
BC005946  Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:14580 IMAGE:4134187), complete cds.
BC011790  Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:19827 IMAGE:4025017), complete cds.
BC019298  Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:4112 IMAGE:2905506), complete cds.
BC021088  Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:1754 IMAGE:3543481), complete cds.
BC033064  Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:45598 IMAGE:3926854), complete cds.
BC051297  Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:59688 IMAGE:3832363), complete cds.
BC063036  Homo sapiens tubulin, alpha 1c, mRNA (cDNA clone MGC:64889 IMAGE:4397636), complete cds.

EntrezGene:
ID  Description
TUBA1C  tubulin, alpha 1c

RefSeq DNA:
ID  Description
NM_032704  Homo sapiens tubulin, alpha 1c (TUBA1C), mRNA.

UniGene:
ID  Description

Proteins
Ensembl Proteins:
ENSP00000301072; ENSP00000322707

Entrez Proteins:
AAH04949.1; AAH05946.1; AAH11790.1; AAH19298.1; AAH21088.1; AAH33064.1; AAH51297.1; AAH63036.1; BAD96744.1

RefSeq Proteins:
ID  Description
NP_116093  tubulin alpha 6 [Homo sapiens].

UniProt:
ID  Description
Q53GA7  SubName: Full=Tubulin alpha 6 variant; Flags: Fragment;
Q8N532  SubName: Full=TUBA1C protein;
Q9BQE3  RecName: Full=Tubulin alpha-1C chain; AltName: Full=Tubulin alpha-6 chain; AltName: Full=Alpha-tubulin 6;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Tubulin-Homo sapiens-3    

InterPro:
ID  Name
IPR002452  Alpha_tubulin
IPR017975  Tubulin_CS
IPR008280  Tub_FtsZ_C
IPR000217  Tubulin
IPR003008  Tubulin_FtsZ

Pfam:
ID  Description
Tubulin  Tubulin/FtsZ family, GTPase domain
Tubulin_C  Tubulin/FtsZ family, C-terminal domain

Structure
PDB:
ID

HSSP:
ID  Description
1ffx  STRUCTURAL PROTEIN
1ia0  TRANSPORT PROTEIN
1jff  STRUCTURAL PROTEIN
1sa0  CELL CYCLE
1sa1  CELL CYCLE
1tub  MICROTUBULES
1tvk  CELL CYCLE, STRUCTURAL PROTEIN
1z2b  CELL CYCLE
2bto  CYTOSKELETAL PROTEIN
2btq  CYTOSKELETAL PROTEIN/COMPLEX
2hxf  TRANSPORT PROTEIN
2hxh  TRANSPORT PROTEIN
2p4n  TRANSPORT PROTEIN
3dco  MOTOR PROTEIN
3du7  CELL CYCLE
3e22  CELL CYCLE
3edl  STRUCTURAL PROTEIN

PSSH:
ID  Description
Q53GA7  UNKNOWN
Q8N532  UNKNOWN
Q9BQE3  UNKNOWN

Diseases
OMIM:
OMIM ID  Name  Alt Name
600743  TRANSCRIPTION FACTOR AP4; TFAP4   UNKNOWN

Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005198  structural molecule activity
GO:0005515  protein binding
GO:0005525  GTP binding
GO:0005737  cytoplasm
GO:0005874  microtubule
GO:0007017  microtubule-based process
GO:0007018  microtubule-based movement
GO:0043234  protein complex
GO:0051258  protein polymerization

Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection

Panther:
ID  Description

Chemicals
DrugBank:
ID  Name  Synonyms
DB03010  Epothilone B  EPO 906; EPO906; patupilone
DB01873  Epothilone D  KOS-862; epothilone D
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000167553 Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3] Pan_troglodytesone2one ENSPTRG00000004902Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]TUBA1C
Pongo_pygmaeusone2one ENSPPYG00000004482Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Equus_caballusone2one ENSECAG00000009504Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]LOC100051901
Otolemur_garnettiione2one ENSOGAG00000009435Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Microcebus_murinusone2one ENSMICG00000016381Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Felis_catusone2one ENSFCAG00000011871Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Bos_taurusone2many ENSBTAG00000039992Tubulin alpha-1C chain. [Source:UniProtKB/Swiss-Prot;Acc:Q3ZCJ7][hgnc]LOC787568
Tursiops_truncatusone2one ENSTTRG00000004554Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Vicugna_pacosone2one ENSVPAG00000005748Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Myotis_lucifugusone2many ENSMLUG00000010845[hgnc]
Loxodonta_africanaapprent_one2one ENSLAFG00000000921Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Canis_familiarisapprent_one2one ENSCAFG00000008640Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]LOC608781
Bos_taurusone2many ENSBTAG00000037775Similar to tubulin alpha 1 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q862I8][hgnc]LOC787568
Procavia_capensisone2one ENSPCAG00000009131Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Myotis_lucifugusone2many ENSMLUG00000002622[hgnc]
Spermophilus_tridecemlineatusapprent_one2one ENSSTOG00000014366Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Rattus_norvegicusone2one ENSRNOG00000015544Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6). [Source:UniProtKB/Swiss-Prot;Acc:Q6AYZ1][hgnc]Tuba1c
Mus_musculusone2one ENSMUSG00000043091Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) (Alpha-tubulin isotype M-alpha-6) [Source:UniProtKB/Swiss-Prot;Acc:P68373][hgnc]Tuba1c
Cavia_porcellusone2one ENSCPOG00000027111Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Dipodomys_ordiione2one ENSDORG00000015065Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) (Alpha-tubulin isotype M-alpha-6) [Source:UniProtKB/Swiss-Prot;Acc:P68373][hgnc]
Tarsius_syrichtaapprent_one2one ENSTSYG00000013970Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000007195Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000004068Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Ochotona_princepsone2one ENSOPRG00000014947Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Echinops_telfairiapprent_one2one ENSETEG00000004967Tubulin alpha-1C chain (Tubulin alpha-6 chain) (Alpha-tubulin 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQE3][hgnc]
Xenopus_tropicalisone2one ENSXETG00000011187Tubulin, alpha 7. [Source:UniProtKB/TrEMBL;Acc:Q6P8G7][hgnc]
Danio_rerioapprent_one2one ENSDARG00000045367tubulin, alpha 1 [Source:RefSeq_peptide;Acc:NP_919369][hgnc]tuba1
Caenorhabditis_elegansone2many C44B11.3mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation. MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons. mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis. MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons. [Source: WormBase][hgnc]mec-12
Saccharomyces_cerevisiaemany2many YML085CTubulin alpha-1 chain. [Source:UniProtKB/Swiss-Prot;Acc:P09733][hgnc]TUB1
Saccharomyces_cerevisiaemany2many YML124CTubulin alpha-3 chain. [Source:UniProtKB/Swiss-Prot;Acc:P09734][hgnc]TUB3